Article
Multidisciplinary Sciences
Qichen Shen, Zhuizui Huang, Jiachen Yao, Yuanxiang Jin
Summary: This review discusses the modulatory functions of extracellular vesicles (EVs) in the intestine, with a focus on their roles and applications in the clinical therapy of inflammatory bowel disease (IBD). By establishing EV-mediated interaction systems between host intestine and microbiota, the possible mechanisms of IBD pathogenesis and its cure are described.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Folic acid, a water-soluble substance, plays a role in the synthesis of nucleic acids, amino acids, and proteins, as well as in the metabolism of homocysteine. The human body cannot synthesize folic acid and it must be obtained through diet. Folic acid deficiency may lead to anemia and other health issues.
Article
Microbiology
Jiali Chen, Zhicheng Song, Rongmei Ji, Yongxu Liu, Hong Zhao, Lei Liu, Fuchang Li
Summary: The study demonstrated that dietary supplementation with 800 mg/kg chlorogenic acid can significantly improve the growth performance of weaned rabbits by enhancing intestinal structural integrity, improving intestinal epithelium function, and modulating gut microbiota composition and diversity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kairuo Wang, Qian Chen, Li Ding, Yefei Zhu, Xinyue Wang, Mengting Zhou, Meiqi Chang, Manman Pei, Yuanyuan Zhang, Yang Zhang, Yu Chen, Huanlong Qin
Summary: This study developed a mucoadhesive probiotic-mediated therapeutic strategy to achieve bioadhesion and prolong the residence time of oral medication in the intestinal tract. It effectively modulated intestinal inflammation and microbiota, enhancing the therapeutic effect.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Article
Immunology
Arno R. Bourgonje, Geesje Roo-Brand, Paola Lisotto, Mehdi Sadaghian Sadabad, Rosanne D. Reitsema, Marcus C. de Goffau, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen
Summary: The IgG immune response in patients with IBD is mainly directed at intestinal bacterial genera associated with the small intestine microbiota, with lower responses against colonic-type commensal bacteria. These findings suggest a strong immunological exposure to potentially pathogenic intestinal bacteria in patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anqi Zhang, Fang Wang, Delong Li, Chong-Zhi Wang, Haiqiang Yao, Jin-Yi Wan, Chun-Su Yuan
Summary: This study used bibliometric analysis to reveal that gut microbiota has become a hot topic in inflammatory bowel disease (IBD) research worldwide. The research team led by Xavier Ramnik J. attracted widespread attention with their productive work. The most prolific journals in this field were Inflammatory Bowel Diseases, Frontiers in Immunology, and Nutrients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Adelaide Teofani, Irene Marafini, Federica Laudisi, Daniele Pietrucci, Silvia Salvatori, Valeria Unida, Silvia Biocca, Giovanni Monteleone, Alessandro Desideri
Summary: This study investigated the impact of lifestyle and dietary habits on the intestinal microbiota diversity and relative abundance in patients with IBD, identifying specific confounders and covariates that influence the association between certain bacterial taxa and disease status. The results suggest that variables related to an IBD-associated lifestyle and dietary habits play a role in modulating the gut microbiota in IBD patients compared to healthy controls.
Review
Food Science & Technology
Qi Li, Linyan Li, Qiqiong Li, Junqiao Wang, Shaoping Nie, Mingyong Xie
Summary: The incidence of inflammatory bowel disease (IBD) is increasing, and there is a need for safe and effective treatment methods. Natural polysaccharides (NPs) have attracted attention for their efficiency, low toxicity, and wide range of biological activities in treating IBD. This paper focuses on exploring the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbiota.
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Xiaoyin Bai, Lingjuan Jiang, Gechong Ruan, Tingting Liu, Hong Yang
Summary: Inflammatory bowel disease (IBD) is closely related to intestinal dysbiosis. While there is an inverse correlation between Helicobacter pylori infection and IBD, the mechanism underlying the development of IBD remains unclear. H. pylori infection may increase the diversity of the intestinal microbiota, reduce the abundance of Bacteroidetes, increase the abundance of Firmicutes, and produce short-chain fatty acid-producing bacteria, all of which may decrease vulnerability to IBD.
CHINESE MEDICAL JOURNAL
(2022)
Review
Microbiology
Shruti Ahlawat, Pramod Kumar, Hari Mohan, Sandeep Goyal, Krishna Kant Sharma
Summary: The human gut microbiota plays a crucial role in host health, with alterations in composition leading to the development of gastrointestinal disorders. Modulating gut microbiota composition and utilizing advanced treatment methods are key approaches for managing gut disorders in the future.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Fisheries
Peng Yin, Shiwei Xie, Zhenxiao Zhuang, Haohan Fang, Lixia Tian, Yongjian Liu, Jin Niu
Summary: This study found that dietary CGA improves the health of largemouth bass by regulating gene expression related to lipid metabolism, inflammation, and antioxidant enzymes. CGA decreased levels of TG and TC in plasma, reduced NEFA in the liver, and increased mRNA expression of lipolysis enzymes in the liver. Additionally, CGA downregulated the expression of pro-inflammatory cytokines and increased antioxidant enzyme expression in largemouth bass fed HFD.
Article
Multidisciplinary Sciences
Sujin Kang, Jaekyung Kim, Areum Park, Minsoo Koh, Wonji Shin, Gayoung Park, Taeyun A. Lee, Hyung Jin Kim, Heonjong Han, Yongbo Kim, Myung Kyung Choi, Jae Hyung Park, Eunhye Lee, Hyun-Soo Cho, Hyun Woo Park, Jae Hee Cheon, Sungwook Lee, Boyoun Park
Summary: The authors found that TRIM40, an E3 ligase, disrupts cortical actin formation and leads to loss of epithelial barrier integrity. Genetic loss of TRIM40 is protective against experimental colitis in male mice.
NATURE COMMUNICATIONS
(2023)