Article
Pharmacology & Pharmacy
Guillaume Le Guyader, Bernard Do, Ivo B. Rietveld, Pascale Coric, Serge Bouaziz, Jean-Michel Guigner, Philippe-Henri Secretan, Karine Andrieux, Muriel Paul
Summary: The study finds that polymeric micelles improve the bioavailability of rapamycin, with TPGS significantly enhancing solubility and stability, while poloxamer has a more significant influence on skin bioavailability. The formulation of a hydrogel containing 0.1% rapamycin shows stability for up to 3 months and better biodistribution on human skin compared to hydroalcoholic gel formulations.
Article
Pharmacology & Pharmacy
Marco Ruggeri, Rita Sanchez-Espejo, Luca Casula, Raquel de Melo Barbosa, Giuseppina Sandri, Maria Cristina Cardia, Francesco Lai, Cesar Viseras
Summary: The aim of this study was to design and develop curcumin nanocrystals incorporated into natural inorganic hydrogels for topical application. Results showed that the presence of bentonite increased curcumin skin penetration and allowed its radical scavenging properties.
Article
Biochemistry & Molecular Biology
Rosa Alicia Saucedo-Acuna, Karen Zulema Meza-Valle, Juan Carlos Cuevas-Gonzalez, Elsa Gabriela Ordonez-Casanova, Manuel Ivan Castellanos-Garcia, Erasto Armando Zaragoza-Contreras, Genaro Federico Tamayo-Perez
Summary: This study presents a liquid allantoin-enriched pectin hydrogel with hydrophilic behavior for wound healing. The hydrogel exhibits hydrophilic properties and contains functional groups related to healing efficacy. Experimental results show that the hydrogel promotes wound drying and improves interaction between the hydrogel and cells, leading to reduced healing time and complete wound closure in 15 days.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Gisela F. Carreno, Maria Javiera Alvarez-Figueroa, Jose Vicente Gonzalez-Aramundiz
Summary: This research aims to develop a nanostructure of omega-3 and dextran sulfate to improve the bioavailability and therapeutic profiles of substances. The results show that the dextran nanocapsules can effectively encapsulate and release imiquimod, promoting transdermal delivery and retention.
Article
Pharmacology & Pharmacy
Rania S. Abdel-Rashid, Doaa A. Helal, Ahmed Adel Alaa-Eldin, Raghda Abdel-Monem
Summary: This study investigated the potential of polymeric and lipid nanocapsules as carrier systems for miconazole nitrate (MN) topical delivery, showing slow biphasic release, high drug encapsulation efficiency, and improved stability. The encapsulation strategy created formulations with promising results for MN delivery. Polymeric nanocapsules demonstrated higher cell viability and antifungal activity compared to lipid nanocapsules, suggesting potential advantages in superficial and deep fungal infections.
Article
Nanoscience & Nanotechnology
Lei Zhang, Huifeng Du, Xin Sun, Feng Cheng, Wenhan Lee, Jiahe Li, Guohao Dai, Nicholas Xuanlai Fang, Yongmin Liu
Summary: Researchers have developed a new hydrogel material that combines the properties of adhesiveness, toughness, and biocompatibility. By incorporating a double network structure and mussel-inspired polydopamine, the hydrogel shows excellent adhesion on hydrophilic and hydrophobic surfaces, as well as flexibility and high deformation capability. A theoretical framework is established to quantify the contribution of the interpenetrating networks to the overall toughness of the hydrogel, providing guidance for material design.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Lei Zhang, Huifeng Du, Xin Sun, Feng Cheng, Wenhan Lee, Jiahe Li, Guohao Dai, Nicholas Xuanlai Fang, Yongmin Liu
Summary: This study successfully developed mussel-inspired double network hydrogel by combining polydopamine with sodium 2-acrylamido-2-methylpropanesulfonic acid/polyacrylamide hydrogel, achieving customized adhesiveness, toughness, and biocompatibility. The hydrogel showed favorable adhesion on hydrophilic or hydrophobic surfaces, along with excellent flexibility and high deformation capability. A theoretical framework was established to quantify the contribution of interpenetrating networks to the overall toughness of the hydrogel, providing guidance for rational material design.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Noelia Loza-Rodriguez, Aina Millan-Sanchez, Olga Lopez
Summary: The development of a new biocompatible delivery system, known as bigel, for topical application is described in this study. The bigel, composed of 40% colloidal lipid hydrogel and 60% olive oil and beeswax oleogel, showed a lamellar structure with orthorhombic lateral packing and deeper penetration ability for hydrophilic and lipophilic probes. This makes it a promising candidate for effective topical carriers in medical and dermatological applications.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Guanhua Lan, Suping Zhu, Dong Chen, Hua Zhang, Lijin Zou, Yuanlin Zeng
Summary: A novel biocompatible polyzwitterionic hydrogel, PolySBMA, was developed for wound healing, showcasing high stretchability, low swelling, strong skin adhesiveness, and antibacterial properties. The hydrogel, cross-linked with natural polymers QCSMA and GelMA, exhibited excellent mechanical flexibility and adhesiveness to skin tissue, along with good antibacterial properties and biocompatibility, making it promising for acute wound dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Minke Yang, Shaojie Zhao, Chengying Zhao, Jiefen Cui, Yanqi Wang, Xiang Fang, Jinkai Zheng
Summary: In this study, protein-reinforced pectin hydrogel beads were developed to overcome the limitations of porous networks and poor mechanical properties. HBPEC-CAS showed a compact network structure and high encapsulation efficiency of EGC, with the ability to delay its release in an aqueous environment and ensure sufficient release in a simulated gastrointestinal environment. Furthermore, EGC was chemically stabilized in HBPEC-CAS through the inhibition of its epimerization, oxidation, dimerization, and trimerization. These findings offer valuable insights for the tea-based food and beverage industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Kyuha Park, Kyumin Kang, Jungwoo Kim, Sung Dong Kim, Subin Jin, Mikyung Shin, Donghee Son
Summary: The application of soft hydrogels in deformable bioelectronics has gained attention due to their unique features, such as modulus matching. However, their low toughness, low conductivity, and lack of tissue adhesiveness are still major challenges. This study presents a highly tough, strain-dissipative, and skin-adhesive conducting hydrogel for interactive human-machine interfaces.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biology
Sheikh Abdur Rashid, Sajid Bashir, Faiza Naseem, Arshad Farid, Irfan A. Rather, Khalid Rehman Hakeem
Summary: Psoriasis, a chronic inflammatory illness, is linked to other life-threatening diseases. Methotrexate nanoemulsion gel formulation showed effectiveness in treating psoriasis and reducing symptoms, potentially providing a new treatment option.
Article
Biochemistry & Molecular Biology
Chenmin Zheng, Wanping Huang, Yuping Zou, Wensi Huang, Peng Fei, Guoguang Zhang
Summary: In this study, pectin was modified with phenylalanine using an ultra-low temperature enzymatic method to enhance its gel properties. The grafting ratio of phenylalanine amidated pectin was investigated under different reaction conditions. The results showed that phenylalanine amidated pectin can form hydrogel with a certain strength under acidic conditions, and it exhibits sustained and complete drug release, making it a promising sustained-release drug carrier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Minchul Sung, Dae Hyun Shin, Hyo Jung Lee, Kyoung Hee Jang, Kyounghee Shin, Jin Woong Kim
Summary: This study demonstrates a methodology to improve skin permeation of nanoemulsions through associative polymeric micelle-mediated drop-to-skin interactions. Shorter PEO chains of the APMs promote drop-to-skin association, aiding in the penetration of nanoemulsions into the skin. Manipulation of nanoemulsion drop association plays a crucial role in enhancing dermal drug delivery performance.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Jessica Brandao Reolon, Camila Parcianello Saccol, Barbara Felin Osmari, Daiane Britto de Oliveira, Vinicius Costa Prado, Fernanda Licker Cabral, Lucas Saldanha da Rosa, Giancarlo Cervo Rechia, Daniela Bitencourt Rosa Leal, Leticia Cruz
Summary: This study aimed to develop a bilayer film for topical melanoma therapy by incorporating nanocapsules containing 3,3 '-diindolylmethane (DIM) with antitumor activity. The nanofilms showed appropriate behavior for cutaneous application and controlled DIM release profile, and increased the permeation of DIM into the epidermis. The combination of karaya and gellan gum in the bilayer films demonstrated potential in the topical treatment of melanoma.
Article
Materials Science, Biomaterials
Rodrigo Scopel, Manuel A. Falcao, Angelica Regina Cappellari, Fernanda B. Morrone, Silvia S. Guterres, Eduardo Cassel, Andrea M. Kasko, Rubem M. F. Vargas
Summary: In this study, vitamin D(3) functionalized hybrid lipid-polymer nanoparticles were synthesized to target melanoma cells. The nanoparticles showed efficient cellular uptake and hold promise as a delivery vehicle for melanoma treatment.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Food Science & Technology
Mercia Maria Alfinete Sulumindine Inroga, Medelin Marques da Silva, Rufino Fernando Flores Cantillano, Karina Paese, Silvia Staniscuaski Guterres, Simone Hickmann Flores, Alessandro de Oliveira Rios
JOURNAL OF CULINARY SCIENCE & TECHNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Giovana R. Onzi, Nathalia D'Agustini, Solange C. Garcia, Silvia S. Guterres, Paula R. Pohlmann, Daniela D. Rosa, Adriana R. Pohlmann
Summary: Chemotherapy-related cognitive impairment (CRCI) has become a focus of research in the past years due to its potential adverse effects on breast cancer patients. This review provides an overview of the molecular mechanisms linking individual drugs used in breast cancer treatment to CRCI, the clinical characteristics of CRCI in patients, and possible therapeutic interventions. The incidence rates of CRCI in breast cancer vary considerably and may affect more than 50% of treated patients. Although there is currently no standard treatment for CRCI, various pharmacological and non-pharmacological approaches have shown promising results.
Article
Pharmacology & Pharmacy
Max S. Saito, Kelly C. Zatta, Plinio C. Sathler, Priscila S. Furtado, Nadia C. O. Miguel, Flavia S. Frattani, Markus Berger, Vladimir Lavayen, Adriana R. Pohlmann, Silvia S. Guterres
Summary: This study describes the development of fucoidan microparticles containing acetylsalicylic acid for pulmonary delivery to treat cardiovascular diseases. The microparticles showed suitable physicochemical characteristics and had antiplatelet activity, protecting against arterial thrombosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Franciele Aline Bruinsmann, Aline de Cristo Soares Alves, Amanda de Fraga Dias, Luiz Fernando Lopes Silva, Fernanda Visioli, Adriana Raffin Pohlmann, Fabricio Figueiro, Fabio Sonvico, Silvia Staniscuaski Guterres
Summary: In this study, chitosan-coated simvastatin-loaded lipid-core nanocapsules were prepared for nose-to-brain delivery and showed effective antitumor effects against glioblastoma both in vitro and in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
J. G. B. De Marchi, R. Ce, G. Onzi, A. C. S. Alves, N. Santarem, A. Cordeiro da Silva, A. R. Pohlmann, S. S. Guterres, A. J. Ribeiro
Summary: This study aims to improve the absorption of nanoparticle formulation by functionalizing its surface with immunoglobulin G. The functionalized nanoparticles showed adequate size and good entrapment efficiency, and led to a desirable increase in insulin release time. Interactions of nanoparticle components were proven through differential scanning calorimetry, infrared spectroscopy, and paper chromatography.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Tatianny de Araujo Andrade, Luana Heimfarth, Danillo Menezes dos Santos, Marcio Roberto Viana dos Santos, Ricardo Luiz Cavalcanti de Albuquerque-Junior, Agenor Gomes dos Santos-Neto, Guilherme Rodolfo Souza de Araujo, Ana Amelia Moreira Lira, Saulo Santos Matos, Luiza Abrahao Frank, Thallita Kelly Rabelo, Lucindo Jose Quintans-Junior, Jullyana de Souza Siqueira Quintans, Adriano Antunes de Souza Araujo, Mairim Russo Serafini
Summary: The study demonstrated the photoprotective effect of a topical formulation containing hesperetin on rat skin, reducing skin damage induced by UVA-UVB radiation, decreasing erythema, lipid peroxidation, and inflammation, while increasing the activities of antioxidant enzymes.
Article
Pharmacology & Pharmacy
Joao Guilherme Barreto De Marchi, Rodrigo Ce, Lia Francie Ribeiro dos Santos Bruschi, Maira Kerpel dos Santos, Karina Paese, Vladimir Lavayen, Fabio Klamt, Adriana Raffin Pohlmann, Silvia Staniscuaski Guterres
Summary: This study proposes an innovative inhalable powder for lung cancer treatment, which showed effective concentration against lung cancer cells without toxic effects. The formulation is a promising candidate for further research in lung cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Dermatology
Luiza Abrahao Frank, Rafaela Pletsch Gazzi, Adriana Raffin Pohlmann, Silvia Staniscuaski Guterres, Renata Vidor Contri
Summary: This study evaluated the influence of chitosan coating on the skin adhesion and photoprotective effect of a sunscreen. The results showed that chitosan-coated nanoparticles increased the adhesion of the sunscreen on the skin and improved its photoprotective effect under UVA and UVB light.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Milena Fronza Broering, Matheus de Castro Leao, Gustavo Henrique Oliveira da Rocha, Pablo Scharf, Luana Fillipi Xavier, Aline de Cristo Soares Alves, Inar Castro, Chris Reutelingsperger, Mayara Klimuk Uchiyama, Koiti Araki, Silvia Staniscuaski Guterres, Adriana Raffin Pohlmann, Sandra Helena Poliselli Farsky
Summary: This study demonstrates the effectiveness of functionalizing AnxA1 on MLNC in improving local inflammation and tissue repair in experimental colitis.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Anamaria Mendonca Santos, Claudio Carvalho Santana Junior, Jose Adao Carvalho Nascimento Junior, Tatianny de Araujo Andrade, Saravanan Shanmugam, Parimelazhagan Thangaraj, Luiza Abrahao Frank, Mairim Russo Serafini
Summary: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics. The use of cyclodextrins inclusion complexes can improve the physicochemical and pharmacological properties of drugs, leading to better treatment efficacy.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Graziela S. Gomes, Luiza A. Frank, Renata V. Contri, Maria S. Longhi, Adriana R. Pohlmann, Silvia S. Guterres
Summary: This article discusses the use of nanotechnology in combination with immunosuppressants for the topical treatment of psoriasis. Various types of nanocarriers containing immunosuppressive drugs were identified, and they showed improved permeation and therapeutic efficacy compared to the drug in solution. Encapsulation in nanocarriers also reduced toxicity and increased drug targeting.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Nathalie Marte Urena, Catiuscia Padilha de Oliveira, Silvia Staniscuaski Guterres, Adriana Raffin Pohlmann, Oscar Tadeu Ferreira da Costa, Antonio Luiz Boechat
Summary: This study evaluated the activity of lipid-core nanocapsules loaded with diclofenac in an experimental model of adjuvant-induced arthritis. The results showed that these nanocapsules effectively reduced arthritis and preserved joint components. Therefore, they have potential for clinical use.
Review
Chemistry, Multidisciplinary
Danieli R. Dallemole, Taiane M. Ciocheta, Luiza A. Frank, Aline de C. S. Alves, Barbara P. Zoche, Silvia S. Guterres, Karina Paese, Adriana R. Pohlmann
Summary: Lipid-core nanocapsules (LNCs) are core-shell structures with a solid lipid core and a polymer shell. They encapsulate poorly-water soluble drugs and have diffusional barriers differentiating them from previously developed polymeric nanocapsules. This review discusses their supramolecular structure, physico-chemical characterization, interfacial reactions, and applications in treating various diseases. It also describes toxicity and efficacy evaluations in pharmaceutical, medical, and veterinary fields.