期刊
APPLIED SCIENCES-BASEL
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/app10124218
关键词
kiwifruit; persimmon; polyphenols; antioxidants; human serum albumin; binding; molecular docking
类别
资金
- Rashtriya Uchchatar Shiksha Abhiyan (RUSA 2.0) [Policy (TN Multi-Gen), Dept. of Edn, GoI] [F.24-51/2014-U]
The current study attempted to understand the interaction profiles of phytoconstituents in new and traditionally used fruit cultivars with human serum albumin (HSA) in the context of predicting the biological role underin vivoconditions. Therefore, polyphenols, flavonoids, flavanols, tannins, vitamin C, secondary metabolites and their antioxidant capacities of organic kiwifruitActinidia(A.)erianthacv. Bidan (AEB) andA. argutacv. Cheongsan (AAC), as new cultivars grown in Korea, and widely consumedA.deliciosacv. Hayward (ADH) andDiospyros kakiThunb. cv. Fuyu (DKF) were determined and compared. All investigated fruits showed relatively high antioxidant capacities. To complement the bioactivity of these fruits, the binding properties between extracted polyphenols and HSA were determined by 3D-fluorescence spectroscopy and docking studies. The most bioactive was AEB with the highest percentage of binding, following by AAC, ADH and DKF. Our study for the first time unveils the differential binding properties of kiwifruit and persimmon phytoconstituents with HSA. Although cultivars possess virtually the same phytoconstituents, presence of one unique compound significantly alters the binding properties of HSA. The results of fluorescence quenching and molecular docking showed that these fruits possess multiple properties, which have a great potential to be used in industry with emphasis on the formulation of functional foods and medicinal applications.
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