期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 6, 期 7, 页码 3855-3867出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00588
关键词
chitosan; collagen; self-healing hydrogel; dynamic imine linkages; wound dressing; hemostatic
资金
- National Natural Science Foundation of China [21606046]
- Fund for Distinguished Young Scientific Research Talents Plan in Universities of Fujian Province [KLA18064A]
- Military Experimental Animal Special Research Project [SYDW[2017]13]
- Special Fund for Science and Technology Innovation of FAFU [KFA17217A]
- Opening Project of Guangxi Key Laboratory of Clean Pulp AMP
- Papermaking and Pollution Control [2019KF09]
Collagen (COL)-chitosan (CS) composite hydrogels are attracting increasing attention because of their great potential for application as biomaterials. However, conventional COL-CS hydrogels were easily disabled for lack of fully reversible linking in their networks. In this work, we developed a kind of self-healing hydrogel for wound dressing, composed of COL, CS, and dibenzaldehyde-modified PEG(2000) via dynamic imine bonds, and the COL/CS hydrogels showed good thermal stability, injectability, and pH sensitivity, ideally promoting wound-healing performance and hemostatic ability. Furthermore, the hydrogel could monitor multiple human motions, especially the facial expression via strain sensitivity. This work offers a new perspective for the biomass-based hydrogels applied in medical field as wound dressing.
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