Review
Biochemistry & Molecular Biology
Jan Korbecki, Magdalena Gassowska-Dobrowolska, Jerzy Wojcik, Iwona Szatkowska, Katarzyna Barczak, Mikolaj Chlubek, Irena Baranowska-Bosiacka
Summary: This review discusses the crucial role of CXCL1 in inflammation as a chemoattractant for neutrophils, and its involvement in various physiological processes and major non-cancer diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Claudia Torero Gutierrez, Charis Loizides, Iosif Hafez, George Biskos, Katrin Loeschner, Anders Brostrom, Martin Roursgaard, Anne Thoustrup Saber, Peter Moller, Jorid Birkelund Sorli, Niels Hadrup, Ulla Vogel
Summary: Inhalation studies are considered the gold standard for assessing toxicity from airborne materials, but intratracheal instillation can be a simpler and quicker alternative. This study compared the effects of molybdenum disulphide and tungsten particles on pulmonary inflammation and acute phase response using both inhalation and intratracheal instillation methods. Both methods showed similar dose-response relationships for acute phase response, suggesting that intratracheal instillation can be used as a screening tool for particle-induced cardiovascular disease.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pathology
Kazuya Takeuchi, Yusuke Kuroda, Takamasa Numano, Masayuki Kimura, Seigo Hayashi, Satoshi Furukawa
Summary: In this study, intratracheal instillation of sulfuric acid in male rats showed that doses of 20 and 60 mg/kg resulted in death within 4 hours, with the estimated half-lethal dose at 7-20 mg/kg. Lung injuries were observed in macroscopic and histopathological examinations, suggesting that deaths in these groups may have been due to lung injury. The acute toxicity of sulfuric acid by intratracheal instillation was evaluated with double sensitivity compared to inhalation studies.
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jan Korbecki, Iwona Szatkowska, Patrycja Kupnicka, Wojciech Zwierello, Katarzyna Barczak, Iwona Poziomkowska-Gesicka, Jerzy Wojcik, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This paper reviews the role of CXCL1 in diseases of the oral cavity and abdominal organs, highlighting its importance in implantation, placentation, and human pluripotent stem cells. The significance of CXCL1 in gastrointestinal tract diseases, periodontal diseases, and liver cirrhosis, among others, is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jan Korbecki, Agnieszka Maruszewska, Mateusz Bosiacki, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: In this paper, the authors review the role of CXCL1 in various non-cancer diseases of the cardiovascular system, respiratory system, and skin. CXCL1, a cytokine belonging to the CXC sub-family of chemokines, is known to promote neutrophil migration and infiltration. Its significance is described in relation to inflammation-related conditions and the accumulation of neutrophils.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Toshio Kobayashi, Yutaka Oshima, Yasuhiro Tsubokura, Takako Muroi, Shozo Ajimi, Makoto Nakai, Kenji Kawaguchi, Takeshi Sasaki, Naohide Shinohara, Nobuya Imatanaka
Summary: The study found that the early toxic potential of NiO products is associated with their solubility, while the persistence of pulmonary inflammation is not determined by solubility.
JOURNAL OF TOXICOLOGIC PATHOLOGY
(2021)
Article
Toxicology
Qinqing Qian, Yun Zhang, Yuan Chen, Chenqiao Ye, Qiang Feng, Jinqing Tu, Zhenbo Lu, Yilan Xu, Na Ran, Guiying Xing, Zhangsen Yu
Summary: Cerium oxide nanoparticles have unique redox properties and act as excellent antioxidants in biological environments. Research has shown that these nanoparticles could be used as effective antioxidant drugs for various diseases. However, the toxicity of these nanoparticles in living organisms remains controversial and requires further investigation. This study focused on investigating the pulmonary and systemic toxicity of PEGylated CeO(2) nanoparticles in rats and found that high doses induced mild pulmonary inflammation but did not cause severe systemic toxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Toxicology
Toshio Kobayashi, Yasuhiro Tsubokura, Yutaka Oshima, Takeshi Sasaki, Kenji Kawaguchi, Kenji Koga, Kunio Uchida, Naohide Shinohara, Shozo Ajimi, Takakazu Kayashima, Makoto Nakai, Nobuya Imatanaka
Summary: Crystalline silica's toxic potential is associated with its surface electrical properties, but in vivo data on its long-term effects are insufficient. A rat model study revealed that the physico-chemical property, including surface potential, of nanocrystalline silica contributes to its hazard. The study suggests that the in vivo toxic potential of nanosilica may be influenced by both surface properties and other physico-chemical properties.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Seong Kwang Lim, Haewon Kim, Jean Yoo, Woong Kim, Ilseob Shim, Byung-Il Yoon, Pilje Kim, Ig-Chun Eom
Summary: This study investigates the lung damage caused by glycolic acid exposure in rats. The results show that inhalation of glycolic acid leads to weight loss, increased toxic substances in BALF, lung inflammation, and necrosis. These findings indicate that glycolic acid is harmful and toxic to the lungs.
Article
Public, Environmental & Occupational Health
Takashi Marui, Taisuke Tomonaga, Hiroto Izumi, Yukiko Yoshiura, Chinatsu Nishida, Hidenori Higashi, Ke-Yong Wang, Miyako Shijo, Masaru Kubo, Manabu Shimada, Yasuo Morimoto
Summary: Inhalation and instillation of WO3 nanoparticles led to transient increases in neutrophil numbers and levels of CINC-1 and CINC-2 in BALF, but had low toxicity to lung tissue with no histopathological changes observed.
JOURNAL OF OCCUPATIONAL HEALTH
(2022)
Article
Toxicology
Sudartip Areecheewakul, Andrea Adamcakova-Dodd, Ezazul Haque, Xuefang Jing, David K. Meyerholz, Patrick T. O'Shaughnessy, Peter S. Thorne, Aliasger K. Salem
Summary: This study found that sub-acute inhalation exposure to CuO nanoparticles induced pulmonary inflammation and led to increased Cu concentrations in the lungs and changes in lung weight. Furthermore, Cu was translocated to the bloodstream and heart tissue, potentially impacting the kidneys and spleen. The study also showed disruption of trace element homeostasis in secondary organs.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Toxicology
Haewon Kim, Jean Yoo, Yeon-Mi Lim, Eun-Ji Kim, Byung-Il Yoon, Pilje Kim, Seung Do Yu, Ig-Chun Eom, Ilseob Shim
Summary: CPC exhibits high cytotoxicity against A549 cells, leading to cell injury, while exposure of rats to CPC results in weight loss and decreased relative weights of lungs and kidneys. Intratracheal instillation of CPC induces focal inflammation in rats' lungs. TNF-alpha is the most commonly secreted proinflammatory cytokine during CPC exposure, and polymorphonuclear leukocytes are the most sensitive parameters of pulmonary toxicity in vivo.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Juerg Hamacher, Yalda Hadizamani, Hanno Huwer, Ueli Moehrlen, Lia Bally, Uz Stammberger, Albrecht Wendel, Rudolf Lucas
Summary: This study aimed to establish a sequence of alterations in blast-induced lung injury in rats using an advanced blast generator. The results showed that after blast lung injury, significant haemorrhage and neutrophil infiltration occurred, as well as increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory cytokines. Pulmonary oedema developed but recovered within 24 hours.
Review
Toxicology
Chiu-wing Lam, Vincent Castranova, Kevin Driscoll, David Warheit, Valerie Ryder, Ye Zhang, Patti Zeidler-Erdely, Robert Hunter, Robert Scully, William Wallace, John James, Brian Crucian, Mayra Nelman, Richard Mccluskey, Donald Gardner, Roger Renne, Roger Mcclellan
Summary: The mechanisms of particle-induced pathogenesis in the lung remain poorly understood. Neutrophilic inflammation and oxidative stress in the lung are hallmarks of toxicity. Multiple investigations have shown that particle surface reactive oxygen species (psROS) do not significantly contribute to the toxicity of particles in the lung. However, studies have found that alveolar neutrophils play a critical role in particle-induced injury and toxicity in the lung. It is also suggested that neutrophil-centric mechanism may explain animal species differences in responses to poorly soluble particles. This research has important implications for the risk assessment of human exposures to dust particles and environmental particulate matter.
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
Article
Toxicology
YoungHoon Han, YoungMin Song, Geun Woo Kim, ChangSu Ha, JiSun Lee, MinHee Kim, HyeYoung Son, GiYong Lee, Ravi Gautam, Yong Heo
Summary: This study examined the potential transfer of polyethylene microplastics (PE-MPs) from pregnant mice to their offspring through intratracheal instillation. Results showed that PE-MPs could be delivered to neonates from dams, with the highest presence in the lungs. High administration of PE-MPs led to heavier organ weight and decreased enzyme activity in both dams and neonates, suggesting potential systemic toxicity that warrants further investigation.
TOXICOLOGICAL RESEARCH
(2021)
Article
Toxicology
Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Toru Ishidao, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto, Hidenori Higashi
Summary: Our study suggests that cross-linked polyacrylic acid (CL-PAA) potentially induces strong neutrophil inflammation and pulmonary fibrosis in rat and human lungs.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Environmental Sciences
Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kaori Kato, Kazuhiro Yatera, Etsushi Kuroda, Yasuo Morimoto
Summary: This study evaluated the effectiveness of photocatalytic filters in suppressing allergic reactions in living organisms. It showed that photocatalysis of ovalbumin (OVA) using a titanium dioxide (TiO2) filter significantly decreased the number of eosinophils in bronchoalveolar lavage fluid and the concentration of OVA-specific IgE and IgG1 in serum.
Article
Environmental Sciences
Chinatsu Nishida, Kazuhiro Yatera
Summary: Both ambient pollutants and occupational pollutants can cause and worsen lung and respiratory diseases. Particulate matter (PM2.5) is an important ambient pollutant, which can trigger asthma attacks and exacerbate chronic obstructive pulmonary disease in the short term, as well as increase the risk of lung cancer and mortality in the long term. Asbestos and crystalline silica are well-known traditional occupational pollutants leading to pneumoconiosis. Work-related asthma (WRA) has become the most common occupational lung disease in recent years, caused by various agents including natural and synthetic chemicals and irritant gases. Primary preventive interventions that raise awareness of pollutants and reduce the development and exacerbation of diseases caused by air pollutants are crucial in addressing both ambient and occupational pollution.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Engineering, Chemical
Masaru Kubo, Tomoki Matsumoto, Manabu Shimada
Summary: In this study, Pd nanoparticles incorporated into HKUST-1 metal-organic framework (Pd/HKUST-1) were successfully synthesized using a spray synthesis method, and their catalytic activity was evaluated. The synthesized Pd/HKUST-1 exhibited well-dispersed Pd nanoparticles within the HKUST-1 framework and had a high BET surface area. As a catalyst, Pd/HKUST-1 demonstrated a high reaction rate constant for the reduction of 4-nitrophenol.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chinatsu Nishida, Hiroto Izumi, Taisuke Tomonaga, Ke-Yong Wang, Hidenori Higashi, Jun-Ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Yuki Hata, Kazuo Sakurai, Yasuyuki Higashi, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto
Summary: This study investigated the effects of polyacrylic acid (PAA) with different molecular weights on the lungs of rats. The results showed that high molecular weight PAA caused more persistent and severe lung responses compared to low molecular weight PAA. This suggests that molecular weight is an important factor in PAA-induced lung disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yuji Fujii, Shujun Zhou, Manabu Shimada, Masaru Kubo
Summary: A method was developed to synthesize hollow mesoporous nanoparticles with controllable size and shell thickness for drug-delivery applications. Monodispersed hollow mesoporous organosilica (HMOS) and hollow mesoporous silica (HMS) nanoparticles were successfully prepared using soft and hard templating methods. The hollow size of HMOS can be tuned by changing the size of the hard templates, and the shell thicknesses of HMOS and HMS can be adjusted by changing the amount of precursor used.
Article
Biochemistry & Molecular Biology
Kento Nishi, Hiroto Izumi, Taisuke Tomonaga, Chikage Nagano, Yasuo Morimoto, Seichi Horie
Summary: Psychological stress and depression are closely related, and IL-6 is elevated in both conditions. This study investigated the impact of IL-6 on EVs secreted by neural precursor cells and found that IL-6 alters the miRNA composition of EVs, leading to changes in mRNA expression related to nerve regeneration in astrocytes and microglia.
Article
Respiratory System
Koichiro Takahashi, Tomotaka Kawayama, Ayako Takamori, Hiroki Tashiro, Takashi Kinoshita, Koichi Takagi, Kei Yamasaki, Kentaro Machida, Atsushi Kawaguchi, Kazuhiro Yatera, Hiromasa Inoue
Summary: This study aims to compare the safety and efficacy of triple therapy with LAMA/LABA combination therapy for mild-to-moderate COPD patients. The study will also identify baseline characteristics and biomarkers to predict responders and non-responders to triple therapy. The primary endpoint is the change in forced expiration volume after 12 weeks of treatment, and secondary endpoints include responder rates based on assessment tests and respiratory questionnaire scores after 24 weeks of treatment. The results will be disseminated through scientific publications and medical conferences.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Chemistry, Physical
Masaru Kubo, Tomoki Matsumoto, Manabu Shimada
Summary: HKUST-1 was prepared using spray synthesis method with Li doping and defect created via partial replacement of H3BTC with isophthalic acid (IP) to enhance H-2 adsorption capacity. Li-doping and defect creation significantly enhanced H-2 uptake to 3.03 wt% through the coordination of Li ions with carboxylic groups of the created defects via IP replacement.
Review
Respiratory System
Yuji Fujikura, Kohei Somekawa, Toshie Manabe, Nobuyuki Horita, Hiroshi Takahashi, Futoshi Higa, Kazuhiro Yatera, Naoyuki Miyashita, Yoshifumi Imamura, Naoki Iwanaga, Hiroshi Mukae, Akihiko Kawana
Summary: This study aimed to clarify the epidemiology of community-acquired pneumonia (CAP) in Japan through a systematic review of published studies. The results showed that Streptococcus pneumoniae was the most common pathogenic micro-organism, and the epidemiology varied depending on the hospital and outpatient settings.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Respiratory System
Kazuya Tsubouchi, Naoki Hamada, Shoji Tokunaga, Katsuyuki Ichiki, Shohei Takata, Hiroshi Ishii, Yasuhiko Kitasato, Masaki Okamoto, Satoru Kawakami, Kazuhiro Yatera, Masayuki Kawasaki, Masaki Fujita, Makoto Yoshida, Takashige Maeyama, Taishi Harada, Hiroshi Wataya, Ryo Torii, Masashi Komori, Yuichi Mizuta, Kazunori Tobino, Eiji Harada, Hidetake Yabuuchi, Yoichi Nakanishi, Isamu Okamoto
Summary: This study aimed to evaluate disease progression and cause of death in patients with non-idiopathic pulmonary fibrosis (non-IPF) of idiopathic interstitial pneumonia (IIP) and IPF. The results showed that there was not a significant difference in survival rate and incidence of acute exacerbation between the two groups. Chronic respiratory failure was the main cause of death in both groups. Closer monitoring of disease progression and palliative care interventions after acute exacerbation are important for both non-IPF IIP and IPF patients.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Yasuyuki Higashi, Yasuo Morimoto, Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Hidenori Higashi, Ryohei Ono, Kazuki Sumiya, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera
Summary: This study investigated the effects of cross-linked polyacrylic acid (CL-PAA) on the lungs of rats, and found that intratracheal administration of CL-PAA induced persistent inflammation and fibrosis in the lungs.
JOURNAL OF OCCUPATIONAL HEALTH
(2023)
