Article
Obstetrics & Gynecology
Shannon L. Wallace, Youngwu Kim, Erica Lai, Shailja Mehta, Bertille Gaigbe-Togbe, Chiyuan Amy Zhang, Emily C. Von Bargen, Eric R. Sokol
Summary: In this retrospective cohort study, patients undergoing combined pelvic organ prolapse and rectal prolapse surgery had a similar risk of <30-day postoperative complications compared with patients undergoing pelvic organ prolapse-only surgery. Furthermore, patients who underwent combined surgery had a similar risk of recurrent pelvic organ prolapse and subsequent pelvic organ prolapse surgery compared with patients who underwent pelvic organ prolapse-only surgery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Chang Shi, Ying Zhao, Qing Hu, Runqi Gong, Yitong Yin, Zhijun Xia
Summary: This study investigated factors related to pain after TVM surgery, finding a low incidence rate with pain mainly affecting various pelvic areas. Excessive intraoperative bleeding and unsatisfactory postoperative anatomical outcomes were identified as risk factors for postoperative pain, with mesh exposure also playing a role. Most patients experienced pain relief with proper management, with over half potentially requiring mesh removal.
Article
Biotechnology & Applied Microbiology
Quan Zhou, Man Lu, Guo-Sheng Li, Gan-Lu Peng, Yan-Feng Song
Summary: In recent decades, there has been extensive attention on the application of mesh for repairing pelvic floor defects. However, a large body of related literature has not been systematically summarized. This study aimed to summarize and visualize the literature on pelvic organ prolapse repair with mesh using bibliometrics. The findings showed that the reasonable application of mesh and avoiding mesh complications are still the most concerned topics in pelvic organ prolapse research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Zhi-Jing Sun, Xiu-Qi Wang, Jing-He Lang, Tao Xu, Yong-Xian Lu, Ke-Qin Hua, Jin-Song Han, Huai-Fang Li, Xiao-Wen Tong, Ping Wang, Jian-Liu Wang, Xin Yang, Xiang-Hua Huang, Pei-Shu Liu, Yan-Feng Song, Hang-Mei Jin, Jing-Yan Xie, Lu-Wen Wang, Qing-Kai Wu, Jian Gong, Yan Wang, Li-Qun Wang, Zhao-Ai Li, Hui-Cheng Xu, Zhi-Jun Xia, Li-Na Gu, Qing Liu, Lan Zhu
Summary: This study outlined the development of Chinese pelvic floor surgeries related to pelvic organ prolapse over the past 14 years and found that the rate of synthetic mesh procedures increased while that of non-mesh procedures decreased significantly. The rate of transvaginal placement of surgical mesh procedures decreased while the rate of laparoscopic sacrocolpopexy procedures increased significantly.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Anne-Cecile Pizzoferrato, Stephanie Ragot, Louis Verite, Nicolas Naiditch, Xavier Fritel
Summary: The study aimed to assess women's perception of postoperative pelvic floor repair complications and compare it to the Clavien-Dindo classification. The results showed that women's perception of surgical complications differed from the Clavien-Dindo classification, with lack of repair and long-term disability being two major factors contributing to the perception of seriousness.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Renaud de Tayrac, Danielle D. Antosh, Kaven Baessler, Cecilia Cheon, Xavier Deffieux, Robert Gutman, Joseph Lee, Charles Nager, Alexis Schizas, Vivian Sung, Christopher Maher
Summary: This article provides a summary of the evidence-based surgical management pathway for pelvic organ prolapse in the 2021 ICI guidelines and outlines the evidence used to inform these recommendations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Annie Morch, Guillaume Doucede, Pauline Lecomte-Grosbras, Mathias Brieu, Chrystele Rubod, Michel Cosson
Summary: This study investigated the mechanical and biological impact of three different mesh implants on native tissues. It was found that one of the materials did not alter the mechanical behavior of the tissues, while the other two significantly increased rigidity and led to clinical complications. All meshes reduced the geometric lengthening of tissues under repetitive loads, suggesting that mechanical aspects may play a key role in the compatibility of mesh implants in vivo. One of the materials showed better support and adapted more properly to the physiological behavior of native tissues during an animal study.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Obstetrics & Gynecology
F. M. Reid, A. Elders, S. Breeman, R. M. Freeman
Summary: This study is the first to address complications of vaginal mesh used for prolapse surgery alongside data from native tissue and biological xenograft. It demonstrates the complexity of assessing pain and shows that all types of prolapse surgery have low surgical morbidity and a low rate of severe complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Surgery
K. L. C. Van Rest, M. J. C. A. M. Gielen, L. M. Warmerdam, C. R. Kowalik, J. P. W. R. Roovers, W. A. R. Zwaans
Summary: This retrospective case series aimed to identify predictors for reduction of pain after mesh revision surgery in patients with inguinal hernia or pelvic organ prolapse. The study found that a longer duration between the initial implantation of mesh and revision surgery increased the likelihood of pain improvement. However, no significant predictors were found for pain reduction in patients with pelvic organ prolapse.
Review
Biochemistry & Molecular Biology
Amelia Seifalian, Zeinab Basma, Alex Digesu, Vikram Khullar
Summary: This study critically evaluates the use of polypropylene (PP) pelvic mesh in the treatment of pelvic organ prolapse (POP), and proposes the use of advanced materials as an alternative to PP mesh. Results show that the physical properties of PP mesh, including its viscoelastic properties and lack of tissue integration, contribute to complications. The banning of PP mesh in multiple countries highlights the need for the development of alternative pelvic mesh materials.
Article
Engineering, Biomedical
Sofie Husted Laursen, Signe Gellert Hansen, Mehmet Berat Taskin, Menglin Chen, Lise Wogensen, Jens Vinge Nygaard, Susanne Maigaard Axelsen
Summary: This study provides new insights into future pelvic organ prolapse (POP) repair in postmenopausal women by demonstrating the sufficient support and biocompatibility of electrospun polycaprolactone (PCL) meshes coated with stem cells and growth factor in elderly rats in the long term, thus highlighting its potential clinical significance.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Beverly Miller, Wiley Wolfe, James L. Gentry, M. Gregory Grewal, Christopher B. Highley, Raffaella De Vita, Monique H. Vaughan, Steven R. Caliari
Summary: This study describes the first hydrogel biomaterial augmentation of uterosacral ligament suspension (USLS) in a rat model, using an injectable fibrous hydrogel composite. The hydrogel degrades over time and significantly improves the load required for tissue failure, potentially reducing the high failure rate associated with USLS procedures.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Medicine, General & Internal
Maraika O. Robinson, Brian J. Linder
Summary: Pelvic organ prolapse is a common condition that can significantly affect a patient's quality of life. Symptoms include vaginal bulge or pressure, as well as bladder, bowel, or sexual issues. Diagnosis is confirmed through physical examination, which identifies descent of different parts of the vagina. Treatment options range from observation for asymptomatic cases to conservative measures, pessary use, or surgical intervention for symptomatic cases.
Article
Obstetrics & Gynecology
Sarah Kanji, Dante Pascali, Aisling A. Clancy
Summary: The study indicates that in carefully selected patients, short-term complications are not increased when using transvaginal mesh for pelvic organ prolapse repair.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Marine Lallemant, Yasmine Clermont-Hama, Geraldine Giraudet, Chrystele Rubod, Sophie Delplanque, Yohan Kerbage, Michel Cosson
Summary: The aim of the study was to describe the long-term outcomes of Pelvic Organ Prolapse (POP) repair in women under 40 years old. The study found that transvaginal mesh surgery and vaginal native tissue repair had higher recurrence rates compared to sacrohysteropexy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Materials Science, Ceramics
Elahe Bahremandi-Toloue, Zahra Mohammadalizadeh, Shayanti Mukherjee, Saeed Karbasi
Summary: Today, the integration of medical and engineering principles in producing biological replacements has become a hot topic. Tissue engineering utilizes the electrospinning method to create scaffolds, with the addition of ceramics to enhance their mechanical properties and biological behavior, as well as induce other effects such as improved hydrophilicity, antibacterial and antioxidant properties.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Shayanti Mukherjee, Smriti Sharma, Vivek Soni, Amruta Joshi, Amit Gaikwad, Jayesh Bellare, Jyoti Kode
Summary: In this study, a composite coating of ceramic apatite-wollastonite (AW) and polymer chitosan was synthesized by electrophoretic deposition on titanium implants. The coated substrates showed significant positive effects on cell proliferation, growth, and mineralization compared to uncoated titanium samples. The coating was non-toxic to cells and enhanced cell adhesion and protein production.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Cell Biology
I Banakh, Md M. Rahman, C. L. Arellano, D. C. Marks, S. Mukherjee, C. E. Gargett, H. Cleland, S. Akbarzadeh
Summary: This study found that platelet lysate (PL) can be used as a safe and effective serum alternative for bioengineering skin for cell therapies. PL supports the expansion of fibroblasts and directed epidermal stratification, and promotes better transplantation outcomes by regulating the expression of CD90 and FAP. Moreover, PL is rich in growth factors, including TGF-beta 1, which contributes to skin maturation. This research is of great importance for the development of bioengineered skin.
CELL AND TISSUE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yiping Fan, Ryan Wai Kheong Lee, Xiang Wen Ng, Caroline E. Gargett, Jerry Kok Yen Chan
Summary: Improvements in reproductive techniques have increased live birth rates from IVF procedures, but the rate has plateaued recently. Endometrial receptivity deficiencies are identified as the main hindrance for successful implantation in patients with recurrent implantation failure (RIF). The impact of local endometrial injury (LEI) on perivascular endometrial mesenchymal stem/progenitor cells (eMSCs) is unknown, but it may play a role in improving IVF outcomes for RIF patients.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Jyoti Kode, Jitendra Maharana, Asif Amin Dar, Shayanti Mukherjee, Nikhil Gadewal, Dilep Kumar Sigalapalli, Satyanshu Kumar, Debashis Panda, Soumyajit Ghosh, Supriya Suman Keshry, Prabhudutta Mamidi, Soma Chattopadhyay, Trupti Pradhan, Vaishali Kailaje, Sunil Inamdar, Vidula Gujjarwar
Summary: Recent global health concern has led to the investigation of natural medicinal plant resources as alternative treatments for COVID-19 infection and inflammation. In this study, a phytochemical called 6-shogaol was explored as a potential anti-inflammatory and anti-COVID-19 agent. 6-shogaol was found to efficiently inhibit SARS-CoV2 replication and regulate the expression of inflammasome pathway molecules. Compared to existing drugs, 6-shogaol demonstrated similar efficacy and better safety in terms of physicochemical properties and clinical toxicity. This study provides important insights for the further development of 6-shogaol as a potential therapeutic agent against inflammation and viral infections.
Article
Obstetrics & Gynecology
Fiona L. Cousins, Brett D. McKinnon, Sally Mortlock, Harriet C. Fitzgerald, Chenyu Zhang, Grant W. Montgomery, Caroline E. Gargett
Summary: Endometriosis is a serious and chronic condition where tissue similar to the lining of the uterus grows outside of it, leading to severe pelvic pain and infertility. It affects 11% of women and has multiple causes, with retrograde menstruation being a major factor. There is a genetic component to endometriosis, with over 40 genetic risk factors identified, although their specific mechanisms are still being understood.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Meaghan J. Griffiths, Sarah A. . Marshall, Fiona L. . Cousins, Lauren R. . Alesi, Jordan Higgins, Saranya Giridharan, Urooza C. . Sarma, Ellen Menkhorst, Wei Zhou, Alison S. . Care, Jacqueline F. . Donoghue, Sarah J. . Holdsworth-Carson, Peter A. W. . Rogers, Evdokia Dimitriadis, Caroline E. Gargett, Sarah A. Robertson, Amy L. Winship, Karla J. Hutt
Summary: Female cancer survivors are at a higher risk of infertility due to the damaging effects of chemotherapy and radiotherapy on the ovaries. However, the effects of cancer treatments on the uterus have been understudied. This study shows that total-body gamma-irradiation (TBI) damages the uterus, leading to compromised pregnancy success. The pro-apoptotic protein Puma is identified as a key mechanism in TBI-induced uterine damage, suggesting that inhibiting PUMA may be a potential fertility preservation strategy.
Article
Reproductive Biology
Andrea Romano, Sun-Wei Guo, Jan Brosens, Asgerally Fazlebas, Caroline E. Gargett, Stefan Giselbrecht, Martin Gotte, Linda Griffith, Hugh S. Taylor, Robert N. Taylor, Hugo Vankelecom, Charles Chapron, Xiao-Hong Chang, Khaleque N. Khan, Paola Vigano
Summary: This article presents the protocol for a Delphi process to develop a consensus on in vitro methodologies using endometrial cells. By selecting critical methodologies, topics, and items, and conducting surveys and ratings, unbiased guidance for research methods is promoted to increase confidence in the reliability of in vitro models.
REPRODUCTION AND FERTILITY
(2022)
Meeting Abstract
Cell & Tissue Engineering
Kallyanashis Paul, Saeedeh Darzi, Jerome A. Werkmeister, Caroline E. Gargett, Shayanti Mukherjee
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Kallyanashis Paul, Saeedeh Darzi, Mark P. Del Borgo, Fiona L. Cousins, Jerome A. Werkmeister, Caroline E. Gargett, Shayanti Mukherjee
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Shayanti Mukherjee, Saeedeh Darzi, Shanilka Leitan, Jerome Werkmeister, Caroline Gargett
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Shayanti Mukherjee, Saeedeh Darzi, Kallyanashis Paul, Permita Mazumder, Anna Rosamilia, Helmut Thiessan, Jerome Werkmeister, Caroline Gargett
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Saeedeh Darzi, Janet Alappadan, Caroline E. Gargett, Jerome A. Werkmeister, Shayanti Mukherjee
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Obstetrics & Gynecology
Tina Gorsek Sparovec, Philipp Reif, Wolfgang Schoell, Udo R. Markert, Zala Nikita Mihalic, Julia Kargl, Caroline Gargett, Daniela Gold
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Caitlin E. Filby, Katherine A. Wyatt, Sally Mortlock, Fiona L. Cousins, Brett McKinnon, Kate Tyson, Grant W. Montgomery, Caroline E. Gargett
REPRODUCTIVE SCIENCES
(2022)
