Review
Pharmacology & Pharmacy
Yingzhu Zhou, Tao Yang, Kang Liang, Rona Chandrawati
Summary: The study highlights the potential of metal-organic frameworks (MOFs) for therapeutic gas delivery, either through endogenous or exogenous means, with high potential for clinical translation. Challenges in meeting current clinical requirements and future innovative designs to cater to variable healthcare needs are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Preecha Kittikhunnatham, Gabrielle A. Leith, Abhijai Mathur, Jennifer K. Naglic, Corey R. Martin, Kyoung Chul Park, Katherine McCullough, H. D. A. Chathumal Jayaweera, Ryan E. Corkill, Jochen Lauterbach, Stavros G. Karakalos, Mark D. Smith, Sophya Garashchuk, Donna A. Chen, Natalia B. Shustova
Summary: This study investigated the efficient delivery of reactive and toxic gaseous reagents in organic reactions using metal-organic frameworks (MOFs). It was found that MOFs can serve as both gas cargo vehicles and catalysts, leading to high product yields. Moreover, the MOFs can be recycled without sacrificing product yield and crystallinity, indicating the potential of developing multifunctional MOF-based reagent-catalyst cargo vessels as an attractive alternative to toxic pure gases or gas generators.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Subir Kumar Juin, Rosemary Ouseph, Dibson Dibe Gondim, Venkatakrishna Rao Jala, Utpal Sen
Summary: Diabetic nephropathy (DN) is still the main cause of morbidity and mortality in diabetes patients. Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), play a vital role in the development and progression of DN. Aberrant levels of gasotransmitters have been observed in patients with diabetes, and gasotransmitter donors show potential in ameliorating diabetic renal dysfunction. This review provides an overview of the physiological relevance of gasotransmitters and their interaction with other factors in the severity modulation of DN, highlighting the possible therapeutic interventions.
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Biochemistry & Molecular Biology
Amira Moustafa
Summary: Gasotransmitters are gaseous molecules synthesized within the body that play roles in various physiological and pathological processes at the cellular level. Long-term exposure to restraint stress has been shown to negatively impact male reproductive functions in rats, with changes in hormone levels and alterations in the expression of gasotransmitter producing enzymes in the hypothalamus and testes.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Wout Verbeure, Harry van Goor, Hideki Mori, Andre P. van Beek, Jan Tack, Peter R. van Dijk
Summary: Gasotransmitters such as NO, CO, and H2S play significant roles in various physiological processes at low concentrations, which are regulated by gut peptides like gastrin and cholecystokinin, though the relationship between them is poorly understood.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Ajay Kumar, Sheetal Negi, Tejaswini Choudhury, Vishal Mutreja, Sunaina Sunaina, Subash C. Sahoo, Arjun Singh, Surinder K. Mehta, Ramesh Kataria, Vikram Saini
Summary: A novel carboxylate-type organic linker-based luminescent MOF (PUC2) was synthesized and characterized. PUC2 selectively reacts with nitric oxide (NO) and can detect NO production in living cells with high sensitivity. It is not affected by cellular proteins, biologically relevant metals, RNS/ROS, or H2S.
Review
Pharmacology & Pharmacy
Rosalba Siracusa, Vanessa A. Voltarelli, Angela Trovato Salinaro, Sergio Modafferi, Salvatore Cuzzocrea, Edward J. Calabrese, Rosanna Di Paola, Leo E. Otterbein, Vittorio Calabrese
Summary: Oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, and carbon monoxide are gases that play critical physiological roles in the brain. The functional interaction between these gases is complex and intriguing. Considering toxicology concepts becomes imperative when developing therapies involving these gases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Polymer Science
Yuanmeng Fang, Jian Cheng, Zhiqiang Shen, Tao You, Shenggang Ding, Jinming Hu
Summary: Although nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have long been considered as gas pollutants, they are actually endogenous gaseous signaling molecules (GSMs) with important signaling functions and medical applications. Stimuli-responsive nanocarriers have been developed to achieve controlled delivery of GSMs and reduce side effects, with ultrasound being an attractive modality for tracking drug carriers, triggering drug release, and improving drug deposition. This minireview summarizes recent advancements in designing ultrasound-responsive nanocarriers for controlled delivery of GSMs and their biomedical applications. This emerging research direction enables targeted delivery of GSMs to deep tissues, and the combination with ultrasound imaging techniques offers potential for new theranostic platforms.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Silvia Abigail Coavoy-Sanchez, Leonardo Andre da Costa Marques, Soraia Katia Pereira Costa, Marcelo Nicolas Muscara
Summary: Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are important members of the gasotransmitter family, playing central roles in the regulation of physiological and pathophysiological processes, including inflammatory edema. Recent studies have shown the potential anti-inflammatory and antiedematogenic effects of these gasotransmitters. However, there is still much to be understood about the interactions among these gasotransmitters.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Chemistry, Physical
Shabnam Naderlou, Morteza Vahedpour, Douglas M. M. Franz
Summary: In this study, the enhancement of adsorption and dynamics of nitric oxide (NO) and carbon monoxide (CO) in a two-dimensional (Zn)MOF-470 doped with antimicrobial silver (Ag) atoms was evaluated using multi-scale simulations. The results showed that NO binds to Ag stronger than CO, and the decoration of the benzene ring with Ag atoms effectively adsorbed both NO and CO. Furthermore, Ag significantly improved the storage capacity of NO and CO, particularly at low pressures. These simulations suggest that (Zn)MOF-470 and Ag-doped MOFs can enhance the storage capacity and slow release of bioactive NO and CO.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Review
Pharmacology & Pharmacy
Jinming Hu, Yuanmeng Fang, Xumin Huang, Ruirui Qiao, John F. Quinn, Thomas P. Davis
Summary: This article discusses the important role of nitric oxide, carbon monoxide, and hydrogen sulfide as endogenous gaseous signaling molecules, as well as their potential in maintaining homeostasis and treating diseases. Additionally, it introduces the recent development of macromolecular nanocarriers for the local delivery of gaseous signaling molecules.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Artur Palasz, Itiana Castro Menezes, John J. Worthington
Summary: Gasotransmitters may play important roles in the neuromolecular mechanisms of anxiety disorders and have potential therapeutic applications, but further extensive studies are needed to clarify their value in current neuropharmacology.
PHARMACOLOGICAL REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Pingping Fang, Ting Sun, Yonggang Wang, Yanfei Ding, Arun Kumar Pandey, Cheng Zhu, Pei Xu
Summary: This review provides an overview of the recent advances in the biosynthesis and regulation of gaseous signaling molecules in plants and their roles in response to heavy metals (HMs). The exact roles and mechanisms of gasotransmitters in plant HM responses are still fragmented, emphasizing the need for more in-depth studies in this area.
REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karim Zuhra, Csaba Szabo
Summary: Cyanide is traditionally known as a cytotoxic agent inhibiting mitochondrial Complex IV, but recent studies show it has biphasic effects in mammalian cells. At low concentrations, cyanide stimulates ATP production and cell proliferation, while at high concentrations it exhibits toxic effects. The article discusses cyanide's cytotoxic actions and also its potential role as a gasotransmitter in mammalian cells.
Article
Chemistry, Multidisciplinary
Lei Gao, Jian Cheng, Zhiqiang Shen, Guoying Zhang, Shiyong Liu, Jinming Hu
Summary: The covalent grafting of nitric oxide (NO) and carbon monoxide (CO) releasing moiety demonstrated superior antimicrobial effects on Gram-positive bacteria. Furthermore, this treatment showed better therapeutic capacity than vancomycin in a murine skin wound model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Multidisciplinary
Fang-Liang Guo, Zi-Li Zhou, Tao Wu, Jin-Ming Hu, Yuan-Qing Li, Pei Huang, Ning Hu, Shao-Yun Fu, Yang Hong
Summary: This paper investigates the mechanical behaviors of carbon fiber reinforced epoxy composites under cryo-thermal cycling, exploring the roles of cycling number and period. It demonstrates intralaminar and interlaminar damage evolutions and provides a quantitative evaluation of mechanical degradations during cryo-thermal cycling, offering a method for composite design.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Pan Li, Zhongwei Sun, Jiaolong Chen, Yong Zuo, Chunyang Yu, Xiaoning Liu, Zhenyu Yang, Lihua Chen, Enguang Fu, Weihao Wang, Jiacheng Zhang, Zhiqiang Liu, Jinming Hu, Shaodong Zhang
Summary: The study reports on the spontaneous resolution of a pair of homochiral entities from a racemic mixture, showing diastereomeric enrichment at the molecular level. Through crystallization, the homochiral pair has been self-sorted, demonstrating a powerful symmetry breaking attributed to the supramolecular synergy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Editorial Material
Pharmacology & Pharmacy
Jian Zhong, Ruirui Qiao, Wei-En Yuan
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yixin Chang, Qiaoyun Wang, Weizhi Xu, Xumin Huang, Xin Xu, Felicity Y. Han, Ruirui Qiao, Gayathri R. Ediriweera, Hui Peng, Changkui Fu, Kun Liu, Andrew K. Whittaker
Summary: This study reports the synthesis, characterization, and application of gold nanorods (GNRs) coated with highly hydrophilic sulfoxide-containing polymers. The effect of the polymer coating on the cellular uptake and in vivo circulation time of the GNRs was investigated and compared with pegylated GNR counterparts. The results show that these polymer-coated GNRs have promising potential as nanotheranostic particles for the treatment of cancer.
Review
Chemistry, Multidisciplinary
Xiaorui Wang, Jinming Hu, Shiyong Liu
Summary: Cells and organelles have inspired the development of artificial self-assembled nanostructures, such as liposomes and polymersomes. Liposomes and polymersomes, like cellular structures, consist of an aqueous interior enclosed by a bilayer membrane. While liposomes and polymersomes have been extensively studied, polymersomes have low membrane permeability compared to liposomes. Efforts have been made to improve the permeability of polymersomes, but they often result in decreased stability. This Account discusses a traceless cross-linking approach that reconciles the stability and permeability of polymersomes.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Siyue Tao, Zhiqiang Shen, Jian Chen, Zhi Shan, Bao Huang, Xuyang Zhang, Lin Zheng, Junhui Liu, Tao You, Fengdong Zhao, Jinming Hu
Summary: Intervertebral disc degeneration (IVDD) is a highly prevalent and disabling disease, and surgical interventions are typically applied due to the lack of effective cure. This study demonstrates that the local administration of nitric oxide (NO) releasing micellar nanoparticles can efficiently treat IVDD associated with Modic changes in a rat model established by infection with Cutibacterium acnes (C. acnes). The incorporation of photocatalyst and NO donors into the nanoparticles enables the activation of NO release under red light irradiation, leading to antibacterial, anti-inflammatory, and antiosteoclastogenesis effects.
Article
Chemistry, Multidisciplinary
Qiangqiang Shi, Xin Zhou, Jie Xu, Jialin Zhang, Ning Wang, Guoying Zhang, Jinming Hu, Shiyong Liu
Summary: The use of sequence-defined digital polymers for data storage and encryption is gaining attention due to their precision structures and increased stability. A dendritic quaternary-encoded oligourethane has been developed for data encryption, providing high-strength encryption keys for reliable data protection.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Wei Jiang, Zhiqiang Shen, Zixuan Guo, Qin Wang, Quan Li, Jinming Hu, Yucai Wang
Summary: In this study, smart materials capable of adapting to the pathological oxygen levels in tumors were developed to enhance cancer immunotherapy. These materials generate immunogenic stimuli that induce immunogenic cell death, stimulate dendritic cell maturation, and increase the infiltration of cytotoxic T cells into tumors, thus overcoming the oxygen heterogeneity in tumors and boosting immunotherapy.
Review
Chemistry, Multidisciplinary
Aizong Shen, Lei Zhang, Yanbo Xie, Xueyu Zhu, Jinming Hu, Shiyong Liu
Summary: Synthetic polymers have been widely used in biomedical fields for imaging and therapeutic purposes. Discrete polymers, characterized by precise molecular weight and no molecular weight distribution, have shown promising potential in optical imaging, magnetic resonance imaging, and therapeutic applications. The development of efficient synthetic strategies and further (pre)clinical studies are needed to facilitate the clinical translation of discrete polymers into precision nanomedicines.
Article
Engineering, Biomedical
Ishaq Lugoloobi, Wang Yuanhao, Ifra Marriam, Jinming Hu, Mike Tebyetekerwa, Seeram Ramakrishna
Summary: Electrospinning is a widely studied technique for synthesizing nano/micro/macrofibers, offering properties such as solubility, biocompatibility, and degradability. These electrospun fibers find various applications in biomedical materials due to their ability to compound with biopharmaceuticals and nanomaterials sensitive to different modalities. They are seen as intelligent systems for future biomedical applications.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Hongda Lu, Shi-Yang Tang, Jiayuan Zhu, Xumin Huang, Helen Forgham, Xiangke Li, Ao Shen, Guolin Yun, Jinming Hu, Shiwu Zhang, Thomas P. Davis, Weihua Li, Ruirui Qiao
Summary: By nanoengineering liquid metal nanoparticles and using galvanic replacement, diverse core-shell nanostructures including LM@Au, Au@Ga oxide, and hollow Ga oxide nanoparticles are successfully fabricated. LM@Au exhibits exceptional photothermal performance with a conversion efficiency of 65.9%, which is five times that of gold nanoparticles. The high photothermal conversion efficiency and biocompatibility of LM@Au show promising applications in hyperthermia cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Polymer Science
Siyuan Luo, Jiahui Sheng, Xiaoyu Jia, Guoying Zhang, Xiaotian Wang, Jinming Hu
Summary: Nitric oxide (NO) is a gaseous signaling molecule that holds promise as a potential approach for anticoagulant therapy. The targeted delivery of NO exhibits significant advantages and demonstrates efficacy in managing blood coagulation associated with cardiovascular diseases. The authors spotlight the methods employed and recent advancements achieved in macromolecular systems designed to release NO for anticoagulant applications.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Review
Chemistry, Analytical
Guihai Gan, Tengfei Ma, Guoying Zhang, Kewu He, Jinming Hu
Summary: Researchers have visualized and monitored nitric oxide and carbon monoxide to understand their roles in maintaining biological homeostasis. Luminescence-based probes have emerged as a powerful technique for non-invasive, highly selective, and real-time detection and imaging of these gaseous signaling molecules.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)