期刊
MICROBIOLOGYOPEN
卷 9, 期 9, 页码 -出版社
WILEY
DOI: 10.1002/mbo3.1093
关键词
antimicrobial resistance; marine environment; Vibriospp; virulence; whole-genome sequencing
类别
A total of 116Vibrioisolates comprisingV. alginolyticus(n = 53),V. metschnikovii(n = 38),V. anguillarum(n = 21), V. antiquarius(n = 2), andV. fujianensis(n = 2) were obtained from seawater, fish, or bivalve molluscs from temperate Oceanic and Polar Oceanic area around Norway. Antibiotic sensitivity testing revealed resistance or reduced susceptibility to ampicillin (74%), oxolinic acid (33%), imipenem (21%), aztreonam (19%), and tobramycin (17%). Whole-genome sequence analysis of eighteen drug-resistant isolates revealed the presence of genes like beta-lactamases, chloramphenicol-acetyltransferases, and genes conferring tetracycline and quinolone resistance. The strains also carried virulence genes likehlyA,tlh,rtxA to D andaceA, E and F. The genes for cholerae toxin (ctx), thermostable direct hemolysin (tdh), or zonula occludens toxin (zot) were not detected in any of the isolates. The present study shows low prevalence of multidrug resistance and absence of virulence genes of high global concern among environmental vibrios in Norway. However, in the light of climate change, and projected rising sea surface temperatures, even in the cold temperate areas, there is a need for frequent monitoring of resistance and virulence in vibrios to be prepared for future public health challenges.
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