Article
Cell Biology
Jingyuan Li, Xue Wan, Dan Xie, Hui Yuan, Qin Pei, Yanan Luo, Yiyu Chen, Jiawen Xian, Ting Ye
Summary: This study reveals that SPDEF is upregulated in luminal breast cancer and is associated with tumor progression and poor prognosis. Mechanistically, SPDEF promotes cell proliferation, motility, and stemness in luminal BC through the direct transcriptional activation of GALNT7. Clinically, GALNT7 can serve as a noninvasive diagnostic marker for luminal BC, and the combined detection of serum GALNT7 and traditional tumor markers can enhance diagnostic accuracy.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Qian Cai, Hsin-Sheng Yang, Yi-Chen Li, Jiang Zhu
Summary: The PDCD4 gene is located on chromosome 10q24 and encodes the PDCD4 protein, which can inhibit tumor progression and proliferation in breast cancer. Multiple regulators and biological processes control the expression of PDCD4, and its downregulation is associated with shorter overall survival in patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Junchen Li, Lixun Huang, Zinan He, Minggui Chen, Yi Ding, Yuying Yao, Youfa Duan, Zixuan Li, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Xiaoming Li, Jianwei Dai, Lijing Wang, Qian-Qian Zhang
Summary: Andrographolide (Andro), a traditional anti-inflammatory drug, has shown anti-tumor effects in breast cancer treatment by inhibiting cell proliferation and promoting apoptosis via activation of signaling pathways. The study suggests that Andro may exert its potential anti-cancer effects on luminal-like breast cancer by suppressing NF-kappa B expression to regulate miR-21-5p and further promote PDCD4. This indicates that Andro could be a promising antitumor agent for the treatment of luminal-like breast cancer in clinical settings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Lieze Berben, Asier Antoranz, Cindy Kenis, Ann Smeets, Hanne Vos, Patrick Neven, Giuseppe Floris, Hans Wildiers, Sigrid Hatse
Summary: Treating older patients with (breast) cancer presents a challenge due to the delicate balance between treatment benefits and risks, as well as the need to avoid over-treatment or under-treatment. Blood biomarker panels can efficiently assess clinical frailty status in elderly patients, offering valuable insights for personalized therapy.
Article
Oncology
Animesh Kar, Nihal Medatwal, Kajal Rajput, Susmita Mandal, Trishna Pani, Ali Khan, Pankaj Sharma, Ajit Singh Oberoi, Gayatri Vishwakarma, S. V. S. Deo, Mohit Kumar Jolly, Avinash Bajaj, Ujjaini Dasgupta
Summary: This study identified sphingolipid profiles that can distinguish luminal and TNBC subtypes of breast cancer, as well as stratify tumor grades and lymphovascular invasion status. These findings provide valuable evidence for the development of sphingolipids as diagnostic markers and predictors of disease severity in breast cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biology
Agnese Losurdo, Caterina Scirgolea, Giorgia Alvisi, Jolanda Brummelman, Valentina Errico, Luca Di Tommaso, Karolina Pilipow, Federico Simone Colombo, Bethania Fernandes, Clelia Peano, Alberto Testori, Corrado Tinterri, Massimo Roncalli, Armando Santoro, Emilia Maria Cristina Mazza, Enrico Lugli
Summary: By analyzing breast cancer-infiltrating T cells using high-dimensional single-cell technologies, researchers found that a small subset of tissue-resident memory CD8+ T cells with enhanced degranulation capacity is associated with positive prognosis in luminal-like breast cancer, highlighting the potential importance of specific T cell immune microenvironment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Summary: INPP4B functions as a tumor suppressor in triple negative breast cancer by converting PI(3,4)P-2 to PI(3)P. However, in PIK3CA-mutant ER+ breast cancers, INPP4B enhances cell proliferation and tumor growth by promoting PI3K alpha-dependent late endosome formation and trafficking that activates Wnt/beta -catenin signaling.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Medicinal
Fernanda Cardoso da Silva, Douglas Cardoso Brandao, Everton Allan Ferreira, Raoni Pais Siqueira, Helen Soares Valenca Ferreira, Ademar Alves Da Silva Filho, Thaise Goncalves Araujo
Summary: Breast cancer is a global health concern, and resistance to hormone therapy is a major challenge. This review highlights the potential of natural compounds, particularly those from plants, in treating luminal breast cancer and overcoming endocrine resistance.
Article
Oncology
Ting Zhao, Sheng Liu, Nasser H. Hanna, Shadia Jalal, Xinchun Ding, Jun Wan, Cong Yan, Hong Du
Summary: Understanding the mechanisms of MDSC biogenesis, particularly the role of LAL, can facilitate the diagnosis and prognosis of cancer, as well as the development of targeted immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, Research & Experimental
Andrea Walens, Linnea T. Olsson, Xiaohua Gao, Alina M. Hamilton, Erin L. Kirk, Stephanie M. Cohen, Bentley R. Midkiff, Yongjuan Xia, Mark E. Sherman, Nana Nikolaishvili-Feinberg, Jonathan S. Serody, Katherine A. Hoadley, Melissa A. Troester, Benjamin C. Calhoun
Summary: The analysis of breast cancer immune microenvironment using nanoString GeoMx (R) Digital Spatial Profiler revealed that Basal-like breast cancers exhibit increased expression of markers for regulatory T cells. Tumor-infiltrating lymphocytes play a crucial role in chemotherapy response and prognosis. The immune responses in breast cancer differ by subtype, with the possibility of subtype-specific immune profiles impacting prognosis and potential treatment targets.
LABORATORY INVESTIGATION
(2021)
Article
Biochemical Research Methods
Carine Steiner, Pierre Lescuyer, Paul Cutler, Jean-Christophe Tille, Axel Ducret
Summary: The identification of clinically relevant biomarkers is a challenge in oncology. Liquid chromatography coupled to multiple reaction monitoring mass spectrometry (LC-MRM/MS) is an effective technique for measuring proteins in formalin-fixed paraffin-embedded (FFPE) tissues. LC-MRM/MS can accurately quantify a large number of proteins and identify potential biomarkers in tumor samples.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Cell & Tissue Engineering
Sidse Ehnnsen, Henrik J. Ditzel
Summary: Breast cancer stem cells play a crucial role in cancer initiation, therapy resistance, and progression, with recent research focusing on cellular signaling pathways such as the WNT pathway, NF-κB pathway, and cholesterol biosynthesis pathway. Targeting these pathways in combination with standard treatments may improve the prognosis of breast cancer patients.
Article
Biochemistry & Molecular Biology
Vinitha Richard, Madhumathy G. G. Nair, Vishnu S. S. Jaikumar, Sara Jones, Jyothi S. S. Prabhu, Michael J. J. Kerin
Summary: Luminal breast cancer subtypes respond poorly to endocrine and trastuzumab treatments due to cellular heterogeneity arising from the loss of receptor expression. The origins of basal-like and HER2-overexpressing breast cancer subtypes have been attributed to genetic and protein modifications in stem-like cells and luminal progenitor cell populations, respectively. This study aims to identify the fractions of luminal breast cancer cells that share stemness potentials and marker profiles and to elucidate the molecular regulatory mechanism that drives transitions between fractions, leading to receptor discordances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pankaj Gupta, Usha Dutta, Pratyaksha Rana, Manphool Singhal, Ajay Gulati, Naveen Kalra, Raghuraman Soundararajan, Daneshwari Kalage, Manika Chhabra, Vishal Sharma, Vikas Gupta, Thakur Deen Yadav, Lileshwar Kaman, Santosh Irrinki, Harjeet Singh, Yashwant Sakaray, Chandan Krishuna Das, Uma Saikia, Ritambhara Nada, Radhika Srinivasan, Manavjit Singh Sandhu, Raju Sharma, Nitin Shetty, Anu Eapen, Harmeet Kaur, Avinash Kambadakone, Robbert de Haas, Vinay K. Kapoor, Savio George Barreto, Atul K. Sharma, Amol Patel, Pramod Garg, Sujoy K. Pal, Mahesh Goel, Shraddha Patkar, Anu Behari, Anil K. Agarwal, Bhawna Sirohi, Milind Javle, Giuseppe Garcea, Flavio Nervi, Volkan Adsay, Juan Carlos Roa, Ho-Seong Han
Summary: The GB-RADS ultrasound risk stratification system categorizes gallbladder wall thickening into six categories based on features such as symmetry, layered appearance, intramural features, and interface with the liver. This collaborative effort aims to improve the accuracy of detecting malignant lesions and enhance management strategies for gallbladder conditions.
ABDOMINAL RADIOLOGY
(2022)
Review
Oncology
Ismael Riquelme, Pablo Perez-Moreno, Pablo Letelier, Priscilla Brebi, Juan Carlos Roa
Summary: This article reviews the important aspects of piRNAs, including their molecular characteristics, biosynthesis processes, gene expression silencing mechanisms, and their study in GI cancer samples and cell lines. It also discusses the potential clinical utility of piRNAs as biomarkers and therapeutic targets in gastrointestinal cancers.
Article
Health Care Sciences & Services
Pablo Perez-Moreno, Ismael Riquelme, Patricia Garcia, Priscilla Brebi, Juan Carlos Roa
Summary: Gallbladder cancer is an aggressive neoplasm that is often asymptomatic in early stages and is typically diagnosed at an advanced stage. The presence of gallstones is the main risk factor, while other factors such as inflammation can also contribute to the development of gallbladder cancer. Understanding the early carcinogenic mechanisms is crucial for prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Hematology
Franco Izzo, Dan A. Landau
Summary: Blombery et al (1) discovered cytopenias and clonal hematopoiesis in CLL patients undergoing longterm venetoclax treatment, along with unexpected concomitant clonal selection of BAX mutations in normal myeloid cells (see figure).
Article
Cell & Tissue Engineering
Jesus Maria Gomez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng, Yaron Bram, Robert P. Adelson, Tyler M. Lu, Giorgio Inghirami, Jenny Zhaoying Xiang, Raphael Lis, David Redmond, Ryan Schreiner, Sina Y. Rabbany, Dan A. Landau, Robert E. Schwartz, Shahin Rafii
Summary: The heterogeneity of hepatic vascular cells during mouse development was studied through functional and single-cell RNA sequencing. It was found that the acquisition of sinusoidal endothelial cell identity starts during early development and is completed postnatally, with c-Maf playing a critical role in this process.
Article
Cell Biology
Santiago Madera, Franco Izzo, Maria F. Chervo, Agustina Dupont, Violeta A. Chiauzzi, Sofia Bruni, Ezequiel Petrillo, Sharon S. Merin, Mara De Martino, Diego Montero, Claudio Levit, Gabriel Lebersztein, Fabiana Anfuso, Agustina Roldan Deamicis, Maria F. Mercogliano, Cecilia J. Proietti, Roxana Schillaci, Patricia Elizalde, Rosalia I. Cordo Russo
Summary: This study reveals the localization of ErbB-2 protein in the nucleus of TNBC cells and the presence of two different isoforms. By using the Retro-2 inhibitor, ErbB-2 was evicted from the nucleus and TNBC growth was suppressed in preclinical models. The differential subcellular distribution and protein structure play key roles in Retro-2 action. These findings provide new insights for the treatment of TNBC.
CELL DEATH & DISEASE
(2022)
Article
Genetics & Heredity
Anna S. Nam, Neville Dusaj, Franco Izzo, Rekha Murali, Robert M. Myers, Tarek H. Mouhieddine, Jesus Sotelo, Salima Benbarche, Michael Waarts, Federico Gaiti, Sabrin Tahris, Ross Levine, Omar Abdel-Wahab, Lucy A. Godley, Ronan Chaligne, Irene Ghobrial, Dan A. Landau
Summary: Somatic mutations in cancer genes, specifically DNMT3A R882 mutation, can lead to clonal hematopoiesis and alter the differentiation of myeloid progenitor cells. Using multi-modality single-cell sequencing, researchers have identified dysregulated expression of lineage and leukemia stem cell markers, as well as specific DNA methylation patterns associated with DNMT3A mutations. This study sheds light on the downstream consequences of these mutations and provides a potential mechanistic link between genotype and phenotype.
Article
Medicine, General & Internal
Juan C. Roa, Patricia Garcia, Vinay K. Kapoor, Shishir K. Maithel, Milind Javle, Jill Koshiol
Summary: Gallbladder cancer is the most common cancer of the biliary tract and often has a poor prognosis. Early detection is challenging and chronic inflammation plays a significant role in the development of this cancer. Surgical resection is the main curative treatment option, but it is only suitable for a small number of cases.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Biochemistry & Molecular Biology
Ismael Riquelme, Pablo Perez-Moreno, Barbara Mora-Lagos, Carmen Ili, Priscilla Brebi, Juan Carlos Roa
Summary: Gastric cancer is a significant cause of cancer-related deaths, particularly among younger people. Late diagnosis, metastasis, and drug resistance contribute to the high mortality rate of gastric cancer. There is a need for new biomarkers and therapeutic targets. RNA-seq technology has identified long non-coding RNAs (lncRNAs) as potential regulators of cancer cells' signaling pathways, including the PI3K/AKT/mTOR pathway, and they may serve as diagnostic or prognostic biomarkers or therapeutic targets for gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luis Vergara-Gomez, Carolina Bizama, Jun Zhong, Kurt Buchegger, Felipe Suarez, Lorena Rosa, Carmen Ili, Helga Weber, Javiera Obreque, Karena Espinoza, Gabriela Repetto, Juan C. Roa, Pamela Leal, Patricia Garcia
Summary: This study investigated the molecular mechanisms of acquired resistance in gallbladder cancer by developing and characterizing gemcitabine-resistant cell lines. Transcriptome profiling and phosphotyrosine proteomic analyses revealed dysregulated biological processes and signaling pathways, as well as potential therapeutic targets in gallbladder cancer. The findings greatly enhance our understanding of acquired drug resistance in gallbladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sofia Bruni, Florencia L. Mauro, Cecilia J. Proietti, Rosalia Cordo-Russo, Martin A. Rivas, Gloria Inurrigarro, Agustina Dupont, Dario Rocha, Elmer A. Fernandez, Ernesto Gil Deza, Daniel Lopez Della Vecchia, Sabrina Barchuk, Silvina Figurelli, David Lasso, Adrian D. Friedrich, Maria C. Santilli, Maria Regge, Gabriel Lebersztein, Claudio Levit, Fabiana Anfuso, Teresa Castiglione, Patricia Elizalde, Maria F. Mercogliano, Roxana Schillaci
Summary: This study reveals the involvement of MUC4 in hindering the therapeutic effect of trastuzumab in HER2+ breast cancer. By inhibiting TNF alpha, MUC4 expression is decreased and the antitumor effect of trastuzumab is improved.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Maria Elena Reyes, Louise Zanella, Ismael Riquelme, Kurt Buchegger, Barbara Mora-Lagos, Pablo Guzman, Patricia Garcia, Juan C. Roa, Carmen Gloria Ili, Priscilla Brebi
Summary: This study aimed to investigate the frequency and genetic diversity of EBV in gastric cancer (GC) patients in southern Chile. The study found that 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology. The results provide important information for epidemiological follow-up of different EBV subtypes that may cause GC in southern Chile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Bahar Memis, Burcu Saka, Juan Carlos Roa, Sudeshna Bandyopadhyay, Michelle Reid, Pelin Bagci, Berk Kaan Aktas, Ayse Armutlu, Olca Basturk, N. Volkan Adsay
Summary: Eosinophilic cholecystitis is a rare condition characterized by thickening of the gallbladder wall and infiltration of eosinophils, which is most commonly seen in patients with subacute and acute cholecystitis.
Review
Biochemistry & Molecular Biology
Jose Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martinez, Angelo Torres, Rody San Martin, Juan Carlos Roa, Claudia Quezada-Monras
Summary: Glioblastoma (GBM) is a common and malignant brain cancer with poor prognosis. Its low effectiveness is attributed to tumor infiltration into healthy brain tissue, which depends on the interaction between GBM cells and the tumor microenvironment (TME). This review highlights the use of 3D patient-derived glioblastoma organoid cultures as a new platform for studying TME and invasiveness. It discusses the mechanisms involved in GBM-TME interaction and proposes potential prognostic biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)