Location, Location, Location: The Role of Nuclear Positioning in the Repair of Collapsed Forks and Protection of Genome Stability

The nuclear pore complex prevents sister chromatid recombination during replicative senescence

(2020) Paula Aguilera et al.   Nature Communications

Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association

(2020) Jenna M. Whalen et al.   Cell Reports

The Nup84 complex coordinates the DNA damage response to warrant genome integrity

(2019) Hélène Gaillard et al.   NUCLEIC ACIDS RESEARCH

Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage

(2019) Chihiro Horigome et al.   PLoS Genetics

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

(2018) Roxanne Oshidari et al.   Nature Communications

Preserving replication fork integrity and competence via the homologous recombination pathway

(2018) Anissia Ait Saada et al.   DNA REPAIR

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Replication protein A (RPA) SUMOylation positively influences the DNA damage checkpoint response in yeast

(2018) Nalini Dhingra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair

(2017) Vincent Duheron et al.   JOURNAL OF CELL SCIENCE

Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges

(2017) Anissia Ait Saada et al.   MOLECULAR CELL

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

Nuclear Dynamics of Heterochromatin Repair

(2017) Nuno Amaral et al.   TRENDS IN GENETICS

SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination

(2016) Sonia Silva et al.   DNA REPAIR

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL

(2016) Chihiro Horigome et al.   GENES & DEVELOPMENT

The Structure Inventory of the Nuclear Pore Complex

(2016) Thomas U. Schwartz   JOURNAL OF MOLECULAR BIOLOGY

Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins

(2016) Kyle A. Jay et al.   MOLECULAR AND CELLULAR BIOLOGY

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

The nuclear pore complex: understanding its function through structural insight

(2016) Martin Beck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination

(2016) Dmitri Churikov et al.   Cell Reports

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression

(2016) Yee Mon Thu et al.   Cell Reports

Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery

(2016) Taehyun Ryu et al.   Nucleus

Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery

(2016) Taehyun Ryu et al.   Nucleus

Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress

(2016) Néstor García-Rodríguez et al.   Frontiers in Genetics

Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex

(2015) Vincent Géli et al.   BIOESSAYS

Sumoylation regulates EXO1 stability and processing of DNA damage

(2015) Serena Bologna et al.   CELL CYCLE

Preventing replication fork collapse to maintain genome integrity

(2015) David Cortez   DNA REPAIR

Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability

(2015) Xiaofeng A. Su et al.   GENES & DEVELOPMENT

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

(2015) Daniel K.C. Chung et al.   Nature Communications

SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice

(2014) Chihiro Horigome et al.   MOLECULAR CELL

Intramolecular Telomeric G-Quadruplexes Dramatically Inhibit DNA Synthesis by Replicative and Translesion Polymerases, Revealing their Potential to Lead to Genetic Change

(2014) Deanna N. Edwards et al.   PLoS One

SUMO-targeted ubiquitin ligases

(2013) Annie M. Sriramachandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impediments to replication fork movement: stabilisation, reactivation and genome instability

(2013) Sarah Lambert et al.   CHROMOSOMA

Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry

(2013) Bianca M. Sirbu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules

(2013) Andres J. Lopez-Contreras et al.   Cell Reports

Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements

(2013) Claudio P. Albuquerque et al.   PLoS Genetics

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

(2012) Giacomo De Piccoli et al.   MOLECULAR CELL

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

(2011) P Moudry et al.   CELL DEATH AND DIFFERENTIATION

UV stalled replication forks restart by re-priming in human fibroblasts

(2011) Ingegerd Elvers et al.   NUCLEIC ACIDS RESEARCH

DNA damage response to eroded telomeres

(2010) Michael Lisby et al.   CELL CYCLE

SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor

(2010) Y. Xie et al.   GENES & DEVELOPMENT

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair

(2010) Marco Saponaro et al.   PLoS Genetics

The unnamed complex: what do we know about Smc5-Smc6?

(2009) Giacomo De Piccoli et al.   CHROMOSOME RESEARCH

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

(2009) Marian Kalocsay et al.   MOLECULAR CELL

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex

(2009) Basheer Khadaroo et al.   NATURE CELL BIOLOGY

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

Fanconi anemia proteins stabilize replication forks

(2008) Lily Chien Wang et al.   DNA REPAIR

Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

(2008) S. Nagai et al.   SCIENCE