期刊
GENES
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/genes11060645
关键词
SARS-CoV-2; COVID-19; gastrointestinal tract; scRNA-seq
资金
- MD Anderson Pancreatic Cancer Moon Shot Program
- Khalifa Bin Zayed Foundation
- Chan Zuckerberg Initiative [HCA3-0000000147]
- NIH [K22 CA234406-01, T32 CA009599]
- Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research
- MD Anderson Colorectal Cancer Moon Shot Program
- NIH/NCI [P30 CA016672]
- CPRIT SINGLE CORE Facilities [RP180684]
There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genesACE2andTMPRSS2throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressingACE2andTMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据