Article
Microbiology
Yuanzhou Zhang, Yechun Pang, Baiyin Xu, Xingshi Chen, Shunshun Liang, Jingying Hu, Xiaoying Luo
Summary: The study found that folic acid could decrease the invasiveness of SARS-CoV-2 in mice, potentially by inhibiting ACE2 expression. This suggests that folic acid plays an important role in the prevention and control of SARS-CoV-2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Khushwant S. Bhullar, Manal A. Nael, Khaled M. Elokely, Steven J. Drews, Jianping Wu
Summary: Two analogs of the bioactive tripeptide IRW, A9 and A14, were found to lower the interaction between SARS-CoV-2 spike protein and ACE2 in vitro. These peptide analogs showed potential as seed candidates for inhibiting SARS-CoV-2 host cell binding through cellular and computational evaluations.
Article
Multidisciplinary Sciences
Bo Yang, Yuanyuan Jia, Yumin Meng, Ying Xue, Kefang Liu, Yan Li, Shichao Liu, Xiaoxiong Li, Kaige Cui, Lina Shang, Tianyou Cheng, Zhichao Zhang, Yingxiang Hou, Xiaozhu Yang, Hong Yan, Liqiang Duan, Zhou Tong, Changxin Wu, Zhida Liu, Shan Gao, Shu Zhuo, Weijin Huang, George Fu Gao, Jianxun Qi, Guijun Shang
Summary: This study reveals the critical role of SNX27 in regulating ACE2 receptor homeostasis by preventing the entry of ACE2/virus complex into lysosome/late endosome through its interaction with the retromer complex. This mechanism serves as a countermeasure against invasion by ACE2 receptor-utilizing SARS coronaviruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Jose Manuel Condor Capcha, Guerline Lambert, Derek M. Dykxhoorn, Alessandro G. Salerno, Joshua M. Hare, Michael A. Whitt, Savita Pahwa, Dushyantha T. Jayaweera, Lina A. Shehadeh
Summary: Studying the viral entry mechanisms of SARS-CoV-2 is crucial for developing therapeutic approaches for COVID-19, and a simple and effective method has been developed for producing pseudoviruses carrying the SARS-CoV-2 spike, suitable for studying viral infection in various cell lines.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shenghai Jiang, Hao Yang, Zhongming Sun, Yi Zhang, Yan Li, Jida Li
Summary: The activation of ADAM17 by SARS-CoV-2 infection has a dual effect on the development of the disease, increasing release of inflammatory cytokines and dysregulating ACE2. The pathologically activated ADAM17 shows superior features in regulating ACE2 expression and participating in intra cellular replication of the virus compared to the S protein. Therefore, the activation of ADAM17 may represent a weakened immune defense and altered strategies of SARS-CoV-2 infection.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Carolina Scagnolari, Camilla Bitossi, Agnese Viscido, Federica Frasca, Giuseppe Oliveto, Mirko Scordio, Laura Petrarca, Enrica Mancino, Raffaella Nenna, Elisabetta Riva, Corrado De Vito, Fabio Midulla, Guido Antonelli, Alessandra Pierangeli
Summary: Research shows a strong positive correlation between ACE2 expression and ISG15 in patients with respiratory diseases, but no correlation was found between furin and ISG15. Stimulation experiments with type I and III IFNs revealed that only the truncated ACE2 isoform was significantly upregulated in epithelial cells.
Article
Oncology
Maria Laura Saiz, Marta L. De Diego, Dario Lopez-Garcia, Viviana Corte-Iglesias, Aroa Baragano Raneros, Ivan Astola, Victor Asensi, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez
Summary: VPA can reduce the expression of ACE2 and NRP1 receptors, decrease the infectivity of SARS-CoV-2, lower viral yields, potentially affecting virus budding or stability, and dampen the triggered inflammatory response.
CLINICAL EPIGENETICS
(2021)
Article
Microbiology
M. Zaki Jawaid, A. Baidya, R. Mahboubi-Ardakani, Richard L. Davis, Daniel L. Cox
Summary: The emergence of the omicron variant has raised concerns about a potential surge in infections. Molecular dynamics simulations suggest that the omicron spikes have reduced antibody binding strength but weaker receptor binding and lower fusogenicity compared to the delta variant. This indicates potentially lower viral load and disease intensity.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Kuo-Yen Huang, Ming-Shiu Lin, Ting-Chun Kuo, Ci-Ling Chen, Chung-Chih Lin, Yu-Chi Chou, Tai-Ling Chao, Yu-Hao Pang, Han-Chieh Kao, Rih-Sheng Huang, Steven Lin, Sui-Yuan Chang, Pan-Chyr Yang
Summary: The humanized decoy antibody, ACE2-Fc fusion protein, effectively blocks SARS-CoV-2 virus entry and replication by targeting the interaction between the viral spike protein and its cellular receptor. It shows efficient inhibition against different virus strains, including variants with increased infectivity.
EMBO MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tsukasa Uranaka, Akinori Kashio, Rumi Ueha, Taku Sato, Han Bing, Gao Ying, Makoto Kinoshita, Kenji Kondo, Tatsuya Yamasoba
Summary: The study found that ACE2, TMPRSS2, and Furin proteins are widely distributed in the ear tissues of mice, indicating that these tissues are susceptible to SARS-CoV-2 infection.
Review
Biochemistry & Molecular Biology
Shubhadeep Roychoudhury, Anandan Das, Niraj Kumar Jha, Kavindra Kumar Kesari, Shatabhisha Roychoudhury, Saurabh Kumar Jha, Raghavender Kosgi, Arun Paul Choudhury, Norbert Lukac, Nithar Ranjan Madhu, Dhruv Kumar, Petr Slama
Summary: COVID-19 has emerged as a major public health crisis, with potential implications for male fertility due to the possibility of SARS-CoV-2 infection targeting the male reproductive system. The potential for sexual transmission of the virus raises concerns for infected couples.
Review
Agriculture, Dairy & Animal Science
John T. Hancock, Ros C. Rouse, Emma Stone, Alexander Greenhough
Summary: COVID-19, caused by the SARS-CoV-2 virus, is a global issue affecting both humans and some animals like minks. While the susceptibility of most animals is unknown, analyzing protein sequences interacting with SARS-CoV-2 can help estimate their susceptibility. This method may be useful in predicting susceptibility, with the potential to assist in management of risks associated with human/animal contact in the future.
Article
Multidisciplinary Sciences
James A. Torchia, Alexander H. Tavares, Laura S. Carstensen, Da -Yuan Chen, Jessie Huang, Tianshu Xiao, Sonia Mukherjee, Patrick M. Reeves, Hua Tu, Ann E. Sluder, Bing Chen, Darrell N. Kotton, Richard A. Bowen, Mohsan Saeed, Mark C. Poznansky, Gordon J. Freeman
Summary: As the SARS-CoV-2 virus evolves to evade natural antibodies, it also becomes less sensitive to therapeutic antibody drugs. However, an ACE2 decoy provides a neutralizing effect against antibody-resistant variants, including Omicron, without losing its potency. The inclusion of the ACE2 collectrin-like domain in the decoy not only improves its affinity for the viral S protein, but also unexpectedly prolongs its half-life in the blood and is necessary for reducing disease severity and viral replication in Syrian hamsters. The decoys' activity is attributed to their ability to trigger irreversible structural changes in the viral S protein.
Article
Cardiac & Cardiovascular Systems
Alessandra Amendola, Gloria Garoffolo, Paola Songia, Roberta Nardacci, Silvia Ferrari, Giacomo Bernava, Paola Canzano, Veronika Myasoedova, Francesca Colavita, Concetta Castilletti, Giuseppe Sberna, Maria Rosaria Capobianchi, Mauro Piacentini, Marco Agrifoglio, Gualtiero Ivanoe Colombo, Paolo Poggio, Maurizio Pesce
Summary: The study found that cardiac stromal cells are susceptible to SARS-CoV-2 infection and produce variable viral yields, potentially leading to cardiac injury and explaining the high number of complications observed in severe COVID-19 cases.
CARDIOVASCULAR RESEARCH
(2021)
Article
Virology
Chen Huang, Yu Jiang, Jie Yan
Summary: This study identified that some animals lack key receptors for binding to SARS-CoV-2, potentially reducing their susceptibility to the virus. Additionally, it was found that Ace2 in animals may have lower affinity for SARS-CoV-2 binding compared to human ACE2. The research sheds light on the human-to-animal transmission of SARS-CoV-2.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Physics, Multidisciplinary
P. Castillo-Castillo, P. D. Arjona-Villicana, J. Acosta-Elias
REVISTA MEXICANA DE FISICA
(2019)
Article
Computer Science, Interdisciplinary Applications
Jordi Ramirez-Elias, Miguel Ramirez-Elias, Jesus Acosta-Elias, Guadalupe Dorantes-Mendez, Alfonso Alba, Martin O. Mendez, Guillermina Guerrero-Mora, Juha M. Kortelainen, Mirja Tenhunen
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
(2019)
Article
Computer Science, Information Systems
Pedro David Arjona-Villicana, Costas C. Constantinou, Alexander S. Stepanenko, Jesus Acosta-Elias