期刊
FRONTIERS IN NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2020.00506
关键词
intracerebral hemorrhage; hemorrhagic stroke; corticospinal tract integrity; spinal cord changes; collagenase mice model
资金
- HKSCI Fund, HMRF [05162936]
- National Basic Research Program of China (973 program) [2014CB502200]
- National Natural Science Foundation of China [81701243, 81971165]
- Natural Science Fund of Guangdong Province [2020A1515010038]
- Pearl River S&T Nova Program of Guangzhou [201710010047]
- Presidential Foundation of Zhujiang Hospital of Southern Medical University [yzjj2018rc03]
- Hong Kong Scholars Program [XJ2016055]
Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. Currently, there is no promising treatment that improves prognosis significantly. While a thorough investigation of the pathological process within the primary site of injury in the brain has been conducted by the research field, the focus was mainly on gray matter injury, which partly accounted for the failure of discovery of clinically efficacious treatments. It is not until recent years that white matter (WM) injury in the brain after subcortical ICH was examined. As WM tracts form networks between different regions, damage to fibers should impair brain connectivity, resulting in functional impairment. Although WM changes have been demonstrated in the brain after ICH, alterations distant from the initial injury site down in the spinal cord are unclear. This longitudinal study, for the first time, revealed prolonged morphological changes of the contralesional dorsal corticospinal tract (CST) in the spinal cord 5 weeks after experimental ICH in mice by confocal microscopy and transmission electron microscopy, implying that the structural integrity of the CST was compromised extensively after ICH. Given the important role of CST in motor function, future translational studies targeting motor recovery should delineate the treatment effects on CST integrity.
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