Review
Oncology
Ester Gonzalez-Sanchez, Javier Vaquero, Maite G. Fernandez-Barrena, Juan Jose Lasarte, Matias A. Avila, Pablo Sarobe, Maria Reig, Mariona Calvo, Isabel Fabregat
Summary: TGF-beta signaling plays a dual role in HCC, acting as a tumor suppressor at early stages but promoting progression later on. It can also impact the tumor microenvironment and drive immune evasion of cancer cells. Targeting the TGF-beta pathway may be an effective therapeutic option for HCC, but biomarkers are crucial for patient selection.
Article
Cell Biology
Ganghua Yang, Qinhong Xu, Yong Wan, Lei Zhang, Lin Wang, Fandi Meng
Summary: This study demonstrated the crucial role of circ-CSPP1 in hepatocellular carcinoma (HCC) by regulating the expression of miR-493-5p and HMGB1, thereby suppressing HCC development both in vitro and in vivo.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Weiwei Liu, Lu Zheng, Rongguiyi Zhang, Ping Hou, Jiakun Wang, Linquan Wu, Jing Li
Summary: High expression of circ-ZEB1 and PIK3CA is associated with poor prognosis in HCC. Circ-ZEB1 promotes the expression of PIK3CA by silencing miR-199a-3p, affecting HCC proliferation and apoptosis.
Article
Pharmacology & Pharmacy
Tsung-Teng Huang, Chuan-Mu Chen, Lih-Geeng Chen, Ying-Wei Lan, Tse-Hung Huang, Kong Bung Choo, Kowit-Yu Chong
Summary: This study demonstrates that 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-Glucoside (THSG) can attenuate lung fibrosis and reduce lung injury by regulating multiple signaling pathways. THSG affects extracellular matrix deposition, fibronectin expression, oxidative stress, and autophagy. Therefore, THSG may be a potential drug for the treatment of pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xiaomiao Ye, Yanwen Hang, Yi Lu, Dandan Li, Fangfang Shen, Ping Guan, Jian Dong, Ludong Shi, Wei Hu
Summary: This study demonstrates the activation of pyroptosis during myocardial ischemia/reperfusion injury and its role in reperfusion injury. Circ-NNT promotes pyroptosis and myocardial I/R injury by acting as a miR-33a-5p sponge to regulate USP46. The circ-NNT -> miR-33a-5p -> USP46 signaling axis may be a potential target for developing cardio-protective agents to improve the clinical outcome of reperfusion therapy.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Xiwu Ouyang, Lei Yao, Guodong Liu, Shiqing Liu, Liansheng Gong, Yao Xiao
Summary: This study identified an AR/circ-LNPEP/miR-532-3p/RAB9A signaling axis involved in regulating HCC cell invasion under hypoxic conditions, providing a rationale for developing novel therapies for HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Wenfang Bao, Jialin Wang, Kailing Fan, Yong Gao, Jingde Chen
Summary: Ferroptosis, a distinct iron-dependent programmed cell death mechanism, has been suggested as a potential approach in cancer therapy. This study identified PIAS3 as a driver of ferroptosis in HCC and revealed the regulatory axis of PIAS3/TGF-beta/TXNIP, providing a potential avenue for employing ferroptosis in HCC treatment.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tian-Yi Zhang, Ting Chen, Wan-Ying Hu, Ji-Chang Li, Meng-Yao Guo
Summary: This study investigated the toxic effects of NH3 exposure on tracheal cells in chickens and LMH cells. NH3 exposure induced autophagy in tracheal tissues, and differential expression of circRNAs was observed. The circ-IFNLR1/miR-2188-5p/RNF182 pathway was found to be involved in NH3-induced autophagy, providing new insights for the study of environmental toxicology.
Article
Medicine, General & Internal
Burhanettin Yalcinkaya, Esra Guzel Tanoglu, Didem Tastekin, Sadrettin Pence
Summary: HCC patients showed downregulated expression levels of miR-33a, miR-203b, and miR-361-3p, implicating their potential involvement in tumor pathogenesis and suggesting their utility as noninvasive biomarkers for cancer therapy.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Giulia Antoniali, Emiliano Dalla, Giovanna Mangiapane, Xiaolong Zhao, Xinming Jing, Yi Cheng, Veronica De Sanctis, Dilara Ayyildiz, Silvano Piazza, Mengxia Li, Gianluca Tell
Summary: Increasing evidence suggests the important roles of microRNA biogenesis in the development and progression of lung cancer, with APE1 involved in the onco-miRNAs biogenesis. In this study, we identified a signature of 13 miRNAs strongly correlated with APE1 expression in lung cancer, and functional enrichment analysis revealed their relevance in cancer cell proliferation and survival. We also found that APE1 regulates DICER1 expression through miR-33a and miR-130b, shedding light on DICER1 regulation and its implications in lung cancer chemoresistance and invasiveness.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Jiang Liu, Peng Duan, ChunYang Xu, DingBo Xu, YongHua Liu, Juanjuan Jiang
Summary: This study demonstrated that circ-ITCH alleviated renal inflammation and fibrosis in diabetic nephropathy through regulating the miR-33a-5p/SIRT6 axis.
INFLAMMATION RESEARCH
(2021)
Article
Biology
Mitsuo Kato, Maryam Abdollahi, Ragadeepthi Tunduguru, Walter Tsark, Zhuo Chen, Xiwei Wu, Jinhui Wang, Zhen Bouman Chen, Feng-Mao Lin, Linda Lanting, Mei Wang, Janice Huss, Patrick T. Fueger, David Chan, Rama Natarajan
Summary: Researchers found that miR-379 plays a role in DKD by reducing adaptive mitophagy, protecting miR-379KO mice from DKD features, revealing its importance in metabolic processes. Targeting miR-379 could offer therapeutic options for DKD.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, Mayuko Ichimura, Koichi Tsuneyama, Koichi Matsuzaki, Toshiaki Nakano, Junko Hirohara, Toshihito Seki, Kazuichi Okazaki, M. Eric Gershwin, Makoto Naganuma
Summary: Patients with primary biliary cholangitis (PBC) are at higher risk for developing hepatocellular carcinoma (HCC), especially in the presence of comorbidities like excessive alcohol consumption. This study found that the balance of Smad signals may serve as a biomarker to predict the likelihood of HCC occurrence in PBC patients. Shifting favorably Smad phospho-isoforms through therapies could potentially reduce the risk of PBC-related HCC development.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Biochemistry & Molecular Biology
Huajun Wang, Guangying Zheng, Miaomiao Sun, Yingjie Chi
Summary: This study found that circ-POLR3A promotes cell viability, migration, and invasion in TGF-beta 2-induced SRA01/04 cells by targeting the miR-31/TXNIP axis. Circ-POLR3A can enhance the protein expression of TXNIP by sponging miR-31, and silencing miR-31 can partially reverse the effects of circ-POLR3A absence on cell behavior.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kaiqin Sheng, Yuecheng Wu, Hanbin Lin, Menghan Fang, Chaorong Xue, Xu Lin, Xinjian Lin
Summary: Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a critical immune suppressor in human cancers, similar to programmed cell death 1 ligand (PD-L1). The study reveals that transcription factors ETS-1 and ETS-2 bind to the Siglec-15 promoter, enhancing its transcription and expression in hepatocellular carcinoma (HCC) cells. Transforming growth factor beta-1 (TGF-beta 1) upregulates ETS-1 and ETS-2 expression and facilitates their binding to the Siglec-15 promoter. TGF-beta 1 also activates the Ras/C-Raf/MEK/ERK1/2 signaling pathway, leading to phosphorylation of ETS-1 and ETS-2, which in turn increases the transcription and expression of Siglec-15. These findings provide valuable insights into the molecular regulation of Siglec-15 and its potential for HCC immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)