Article
Endocrinology & Metabolism
Haixia Du, Yanpeng Ma, Xiqiang Wang, Yong Zhang, Ling Zhu, Shuang Shi, Shuo Pan, Zhongwei Liu
Summary: Skeletal muscle atrophy is commonly observed in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance. Exposure to advanced glycation end products (AGEs) induces reactive oxygen species (ROS) generation, activating the PERK/FOXO1 signaling pathway, resulting in skeletal muscle atrophy and insulin resistance. FOXO1 silencing significantly inhibits skeletal muscle atrophy and insulin resistance without affecting ROS production.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Cell Biology
Manuel Portero-Otin, M. Pia de la Maza, Jaime Uribarri
Summary: Insulin resistance is commonly observed during aging and is a major factor in chronic nontransmissible diseases. Diet, particularly the intake of advanced glycation end products (AGEs), plays a significant role in causing insulin resistance. Clinical trials and animal studies suggest that reducing dietary AGE intake can improve insulin resistance.
Review
Nutrition & Dietetics
Marco Mouanness, Henry Nava, Christelle Dagher, Zaher Merhi
Summary: Recent studies have found that dietary advanced glycation end products (AGEs) play a significant role in reproductive and metabolic dysfunctions associated with polycystic ovary syndrome (PCOS). AGEs are reactive molecules formed by the non-enzymatic glycation process between reducing sugars and proteins, lipids, or nucleic acids. This review discusses the involvement of AGEs in key elements of the PCOS phenotype and pathophysiology and suggests targeting AGEs as a potential novel approach to treating PCOS symptoms.
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Nutrition & Dietetics
Mei-Chou Lai, Wayne-Young Liu, Shorong-Shii Liou, I-Min Liu
Summary: The study found that hesperetin, a citrus flavonoid, can counteract the pathophysiological changes of Alzheimer's disease induced by advanced glycation end-products (AGEs). The underlying mechanisms include reducing oxidative stress and apoptosis, regulating protein expression, and decreasing endoplasmic reticulum stress.
Article
Endocrinology & Metabolism
Xue-Meng Zhang, Yuan Gao, Meng-Xue Yang, Xiao-Di Zheng, Rui Zhang, Yue-Yue Wu, Miao Zeng, Qian Yang, Zhi-Yan Yu, Jun Liu, Bing-Bing Zha, Bo Yang
Summary: Diabetic kidney disease (DKD) is a complication of diabetes, and early detection is crucial. This study found that the noninvasive lens AGEs fluorescence detection method can be used to predict the occurrence of DKD, providing clinical value in diagnosing DKD in patients with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Melinda Csongova, Jean L. J. M. Scheijen, Marjo P. H. van de Waarenburg, Radana Gurecka, Ivana Koborova, Tamas Tabi, Eva Szoko, Casper G. Schalkwijk, Katarina Sebekova
Summary: Alpha-dicarbonyls and advanced glycation end products (AGEs) may contribute to insulin resistance through various mechanisms. Young insulin-resistant individuals without diabetes show alterations in the alpha-dicarbonyls-AGEs-sRAGE axis, with higher levels of 3-deoxyglucosone. These markers are independently associated with insulin sensitivity, with sex-specific differences. Further research is needed to determine if reducing dicarbonyl stress can improve insulin resistance.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Ophthalmology
Johanna Rankenberg, Stefan Rakete, Brandie D. Wagner, Jennifer L. Patnaik, Christian Henning, Anne Lynch, Marcus A. Glomb, Ram H. Nagaraj
Summary: The levels of AGEs in human lens capsules during cataract surgery were found to be similar between diabetic and non-diabetic patients, except for significantly higher levels of glucosepane in diabetic patients, which may explain the similar incidence of posterior capsule opacification between the two groups.
EXPERIMENTAL EYE RESEARCH
(2021)
Editorial Material
Biochemistry & Molecular Biology
Afreen Khanam, Saheem Ahmad, Arbab Husain
Summary: This article discusses the pathophysiological significance of advanced glycation end products (AGEs) and their receptor in diabetic nephropathy (DN).
CURRENT PROTEIN & PEPTIDE SCIENCE
(2023)
Review
Immunology
Xiaokang Wang, Jingqian Zhao, Yuanqing Li, Jiaoyu Rao, Gengrui Xu
Summary: Proteinuria and nephrotic syndrome are symptoms of kidney diseases caused by direct or indirect damage to podocytes. Inflammation plays a crucial role in the development and progression of diabetic nephropathy, the leading cause of end-stage renal disease worldwide. The impact of podocyte damage on metabolic and inflammatory disorders has been documented. Epigenetic and endoplasmic reticulum stress are also observed in diabetic nephropathy. Targeting inflammation pathway and endoplasmic reticulum stress in podocytes may offer potential therapies to prevent the progression of diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Klaudia Gutowska, Krzysztof Czajkowski, Alina Kurylowicz
Summary: Advanced glycation end products (AGEs) play a crucial role in cellular dysfunction caused by hyperglycemia, and their accumulation in the extracellular matrix is a key factor in obesity-related adipose tissue dysfunction. By binding to their receptor (RAGE), AGEs affect various intracellular pathways, leading to impaired adipocyte differentiation, metabolism, and secretory activity. Inhibiting AGE production and accumulation, as well as interfering with the activated metabolic pathways, may be a promising therapeutic strategy for restoring normal adipose tissue function and combating obesity-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jiao Wang, Wei Cai, Jiao Yu, Honghong Liu, Shasha He, Lingyan Zhu, Jixiong Xu
Summary: This study explored the association between gut microbiota characteristics and glycometabolic profiles in mice fed high-AGE diets. The results showed that high-AGE diets altered the composition and structure of gut microbiota, and induced insulin resistance in mice. The loss of butyrate-producing bacteria might impair the colonic epithelial barrier, leading to chronic low-grade inflammation.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Integrative & Complementary Medicine
Sumira Mukhia, Palash Mandal, D. K. Singh, Devendra Singh
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Environmental Sciences
Dipayan Das, Debasmita Ghosh, Palash Mandal
Summary: The study aimed to determine the appropriate genotype and concentration of biosynthesized silver nanoparticles for preserving mulberry leaves at the postharvest stage. The results showed that silver nanoparticles effectively prevented xylem blockage, retained chlorophyll content, and inhibited microbial proliferation. Additionally, the biosynthesized silver nanoparticles exhibited superior preservation effects compared to conventional silver nitrate, with minimal reactive oxygen species accumulation and better retention of membrane integrity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Farhin Patel, Kirti Parwani, Dhara Patel, Palash Mandal
Summary: Research has shown that a combination therapy of probiotics and metformin can help prevent ethanol-induced liver injury by reducing inflammation and oxidative stress and regulating lipid metabolism.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Kirti Parwani, Farhin Patel, Dhara Patel, Palash Mandal
Summary: This study discovers the strong antiglycative potential of Swertiamarin (SM), showcasing its ability to reduce oxidative stress, prevent epithelial mesenchymal transition, and decrease the pathogenesis of diabetic nephropathy caused by methylglyoxal (MG) in kidney cells. Additionally, SM downregulates the expression of interleukin-6, tumor necrosis factor-alpha, and interleukin-1 beta in this process.
Article
Chemistry, Multidisciplinary
Md Salman Haydar, Dipayan Das, Suravi Ghosh, Palash Mandal
Summary: The study focused on exploring the optimal conditions for biogenic synthesis of iron oxide nanoparticles using aqueous extracts of mature tea leaves as a waste product. The synthesized FeNPs exhibited good stability, antimicrobial activity against soil microbes, and dose-dependent antioxidant activity. The characterization of the nanoparticles showed spherical to irregular morphology with crystalline nature, and the FeNPs had a zeta potential value indicating strong stability.
Article
Plant Sciences
Md Salman Haydar, Suravi Ghosh, Palash Mandal
Summary: This study evaluated the bio-effectiveness of iron oxide and EDTA functionalized iron oxide nanoparticles as a nano-micronutrient fertilizer on the growth and development of mulberry plants. Results showed that the application of these nanoparticles significantly improved morpho-physiochemical attributes in plants, indicating their potential to replace traditional iron fertilizer.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Cell Biology
Farhin Patel, Kirti Parwani, Priyashi Rao, Dhara Patel, Rakesh Rawal, Palash Mandal
Summary: The study demonstrates that the combination of probiotic V and metformin can alleviate ethanol-induced intestinal barrier dysfunction and oxidative stress, while promoting anti-inflammatory responses.
MEDIATORS OF INFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Kirti Parwani, Farhin Patel, Pranav Bhagwat, Haritha Dilip, Dhara Patel, Vijay Thiruvenkatam, Palash Mandal
Summary: The study investigated the potential of Swertiamarin (SM) in preventing diabetic nephropathy (DN) induced by advanced glycation end products (AGEs) in high fat diet-streptozotocin-induced diabetic rats. The results showed that SM could ameliorate DN by inhibiting oxidative stress induced by AGEs and preventing their binding to the receptor for advanced glycation end products (RAGE), suggesting a promising therapeutic effect in diabetes-related kidney complications.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Cell Biology
Dhara Patel, Dixa Sharma, Palash Mandal
Summary: Ethanol consumption has significant effects on the human body, including alcoholic liver disease and adipose tissue dysfunction. Factors such as gut dysbiosis and impaired adipose tissue metabolism contribute to the development of these conditions. Therefore, therapeutic approaches for liver cirrhosis patients should focus on modifying the gut-liver-adipose tissue network.
MEDIATORS OF INFLAMMATION
(2022)
Review
Gastroenterology & Hepatology
Dixa Sharma, Palash Mandal
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common type of liver disease worldwide, and its prevalence is increasing at an alarming rate. The development and variability of NAFLD and its complications are influenced by genetic and environmental factors. Recent advances in combining genetic variants associated with NAFLD into polygenic risk scores (PRS) have improved the translation of genetic factors into a clinical context.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dhara Patel, Chirayu Desai, Deepmala Singh, Virupakshi Soppina, Kirti Parwani, Farhin Patel, Palash Mandal
Summary: Alcoholic liver disease (ALD) alters gut microbiota and tight junctions, leading to inflammation in the liver. The study found that a synbiotic (a combination of aged garlic extract and Lactobacillus rhamnosus MTCC1423) reduces oxidative stress and inflammation in the colon of an ALD model.
Review
Immunology
Hiral Aghara, Prashsti Chadha, Devangi Zala, Palash Mandal
Summary: Alcoholic liver disease (ALD) is a significant threat to human health, with complex mechanisms and biological processes involved in its progression. Herbal medicine shows promise, although more research is needed. Nanoparticle-mediated therapy is a new treatment approach with potential for ALD treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Palash Mandal, Farhin Patel, Kirti Parwani
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Pharmacology & Pharmacy
Arunika Subba, Ram Kumar Sahu, Shiv Bhardwaj, Palash Mandal
PHARMACOGNOSY RESEARCH
(2019)
