Article
Medicine, Research & Experimental
Raanan Greenman, Michal Segal-Salto, Neta Barashi, Ophir Hay, Avi Katav, Omer Levi, Ilan Vaknin, Revital Aricha, Sarit Aharoni, Tom Snir, Inbal Mishalian, Devorah Olam, Johnny Amer, Ahmad Salhab, Rifaat Safadi, Yaakov Maor, Palak Trivedi, Christopher J. Weston, Francesca Saffioti, Andrew Hall, Massimo Pinzani, Douglas Thorburn, Amnon Peled, Adi Mor
Summary: CCL24 is involved in fibrosis and inflammation in liver and its inhibition can reduce liver injury. This study found that blocking CCL24 improves inflammation, fibrosis, and cholestasis in PSC, and reduces proliferation and senescence of cholangiocytes.
Article
Allergy
Justine Calise, Nahir Garabatos, Veronique Bajzik, Mary Farrington, David Robinson, David Jeong, Marco Londei, Erik Wambre
Summary: IL-33 plays a role in modulating circulating allergen-specific T-cell responses, with ST2 expression specifically associated with T(H)2A cell activation. IL-33 selectively amplifies pathogenic T(H)2 cell effector functions in allergy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Jorge Sanchez, Andres Sanchez, Marlon Munera, Elizabeth Garcia, Juan-Felipe Lopez, Margarita Velasquez-Lopera, Ricardo Cardona
Summary: The study found that IgE responses against eosinophil proteins may contribute to chronic inflammation in patients with atopic dermatitis and chronic spontaneous urticaria. Cross-reactivity between EPX and TPO could explain thyroid problems in CSU patients.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Julieta Alcain, Alejandra del Pilar Infante Cruz, Gabriela Barrientos, Silvia Vanzulli, Gabriela Salamone, Monica Vermeulen
Summary: The study demonstrates that histamine can interact with H3R and H4R to promote allergic symptoms and inhibit inflammatory response, leading to an increased proportion of regulatory T lymphocytes and myeloid suppressor cells, which play important roles in the development of allergic contact dermatitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Yang Xi, Yu-Qin Deng, Han-Da Li, Wo-Er Jiao, Jin Chen, Jian-Jun Chen, Ze-Zhang Tao
Summary: The study aimed to evaluate the clinical application and effectiveness of eosinophil cationic protein-myeloperoxidase (ECP-MPO) test paper in patients with allergic rhinitis (AR) before and after treatment. The results showed that the ECP-MPO test paper can effectively detect ECP in nasal secretions and its results are consistent with other detection methods. The chromogenic grade of the test paper can reflect the symptom severity and specific cytokine and chemokine levels in AR patients.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Allergy
Celine Vandamme, Marja Rytkonen-Nissinen, Tapio Lonnberg, Jukka Randell, Rauno J. Harvima, Tuure Kinnunen, Tuomas Virtanen
Summary: Our study reveals the heterogeneity of allergen-specific T(H)2 cells at the single-cell level, which is of great significance for improving immune monitoring after allergen immunotherapy and designing targeted immunomodulatory approaches.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Julien Ringuet, Caroline Lajoie, Serge Bourgault, David Simonyan, Marie-Claude Houle
Summary: The study aimed to identify the best method of cutaneous testing and brimonidine concentration for patch testing, with scratch PT proving to be an essential tool and 5% brimonidine concentration demonstrating the highest sensitivity for scratch PT.
CONTACT DERMATITIS
(2022)
Article
Allergy
Corinne Keet, Mihaela Plesa, Daria Szelag, Wayne Shreffler, Robert Wood, Joan Dunlop, Roger Peng, Jennifer Dantzer, Robert G. Hamilton, Alkis Togias, Michael Pistiner
Summary: This study compared the diagnostic test characteristics of different tests in screening high-risk infants for peanut allergy. The results suggest that measurement of only Ara h 2-sIgE should be considered if screening is performed before peanut introduction.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Bert Ruiter, Neal P. Smith, Elizabeth Fleming, Sarita U. Patil, Barry K. Hurlburt, Soheila J. Maleki, Wayne G. Shreffler
Summary: Peanut protein induces RALDH2 in human APCs through signaling receptors TLR1/TLR2, leading to RA production and promoting IL-5 secretion and gut-homing integrin expression in T(H)2 cells.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Burcin Beken, Velat Celik, Pinar Gokmirza Ozdemir, Mehtap Yazicioglu
Summary: The study found that children over 24 months of age showed larger histamine and allergen wheal sizes compared to those under 24 months. Older children had maximum histamine reactivity at 15 minutes, while younger children showed maximum reactivity at 10 minutes. Individual factors such as age, body mass index, or atopy may influence the skin prick test results.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Maria Anna Bruusgaard-Mouritsen, Bettina Margrethe Jensen, Lars K. Poulsen, Jeanne Duus Johansen, Lene Heise Garvey
Summary: This study evaluated the reactivity of different molecular weight PEGs in skin prick tests and investigated cross-sensitization patterns in PEG allergy. The results showed that skin test reactivity to PEG can decrease over time, but titrated SPT with increasing concentrations of PEG 20,000 can be diagnostic.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karthikkumar Venkatachalam, Sicheng Zhong, Mariam Dubiel, Grzegorz Satala, Bassem Sadek, Holger Stark
Summary: The study evaluated the in vivo antidepressant and anxiolytic effects of the newly developed multiple-active ligand ST-2300 in mice, showing promising results in reducing immobility time and increasing anxiolytic effects. Importantly, the structural features of ST-2300 provide a rationale for a multiple-pharmacological approach to target H3R/5-HT2A/5-HT2C.
Article
Integrative & Complementary Medicine
Wen-Yan Yu, Liang-Xiao Ma, Yuan Tian, Jie-Dan Mu, Zhou Zhang, Tian-Yi Sun, Xu Qian, Jun-Xiang Wang
Summary: This study found that TN (transverse needling) treatment can improve the uterine inflammatory environment and alleviate dysmenorrhea by suppressing the eotaxin/CCR3 axis. The results of this study support acupuncture as a promising approach for dysmenorrhea, while emphasizing the importance of selecting appropriate needling techniques.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Allergy
Marion Carrette, Laure Couderc, Michael Bubenheim, Alexandra Vidal, Asmynour Youssouf, Olivier Boyer, Christophe Marguet, Jeremie Martinet
Summary: The study found that in vitro tests can be used to replace oral food challenge (OFC) for diagnosing peanut allergy in children. When Ara h 2-sIgE ≤ 7 kU(A)/L and BAT ≤ 6%, patients do not need to adjust their diet and do not need an OFC.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Veterinary Sciences
John Klier, Daniela Lindner, Sven Reese, Ralf S. Mueller, Heidrun Gehlen
Summary: This study compared results of four allergy tests from healthy and asthma-affected horses, finding that the tests could not reliably differentiate between the two groups and showed individual variability. A clear positive reaction on the allergen inhalation provocation test was detected in only two asthma-affected horses, suggesting the involvement of cell-mediated hypersensitivity in equine asthma.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2021)