期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 142, 期 -, 页码 290-296出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2016.01.040
关键词
Iron oxide nanoparticles; Mycophenolic acid; Immunosuppressive drug; Magnetic resonance imaging; Drug delivery
资金
- Ministry of Oceans and Fisheries, Korea
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI14C3266]
- Korea Health Promotion Institute [HI14C3266020015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Korea Institute of Marine Science & Technology Promotion (KIMST) [201503092] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5 nm and 5 nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor a, with a minimal concentration of MPA. In conclusion, IOW may have potential applications in both efficient drug delivery and MRI. (C) 2016 Elsevier B.V. All rights reserved.
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