Article
Chemistry, Physical
Xiaoyu Wu, Xiangkun Huan, Yimiao Zhu, Gang Yang, Hao Yang, Zhenfeng Wu, WenWen Xu
Summary: Molecular dynamics simulations were used to investigate covalently functionalized carbon nanotubes (f-CNTs) loaded with doxorubicin (DOX) and LL 37. f-CNTs were functionalized with carboxyl, hydroxyl, and amine groups. The adsorption of DOX molecules and LL-37 was studied in different molar proportions. The binding energy, radial distribution function, and conformational changes of the peptide were analyzed. The study revealed that hydroxyl-functionalized CNTs are suitable carriers in a 1:1 ratio of DOX to LL-37, while amine-functionalized CNTs are suitable carriers in a 2:1 ratio. These findings have implications for dual drug delivery systems.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Niloufar Targhazeh, Masomeh Maleki, Forough Alemi, Bahman Yousefi
Summary: This study successfully linked DOX to the surface of pH-sensitive polyhydroxy glycerol-grafted graphene oxide nanoparticles, and assessed its loading capacity, release efficiency, and cytotoxicity using various molecular tests. The results showed that the nanocarrier had no significant toxic effect on healthy tissues, indicating its high potential for drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Rui Sang, Bradley Stratton, Alexander Engel, Wei Deng
Summary: Conventional treatments for colorectal cancer severely impact advanced patients' therapeutic effects. The development of nanomedicines has led to liposomal delivery systems being considered promising for CRC treatment. Recent reviews have focused on preclinical research and drug delivery, but our review provides the latest advances in liposome technology for CRC with strong potential for clinical translation.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Maria Julia Martin, Pamela Azcona, Veronica Lassalle, Claudia Gentili
Summary: The study evaluated the aptitude of magnetic nanotheranostics for colorectal cancer treatment by enhancing cell death through the administration of DOXO via MNPs, further confirming its achievement of apoptosis through chromatin compaction and cytoplasmic protrusions. Additionally, MNPs were found to possess potential characteristics as magnetic therapy and vectoring tools.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gyeongyun Go, Chang-Seuk Lee, Yeo Min Yoon, Ji Ho Lim, Tae Hyun Kim, Sang Hun Lee
Summary: This study developed PrP(C)-Apt-functionalized doxorubicin-oligomer-AuNPs for targeted drug delivery to colorectal cancer cells. Treatment with these nanoparticles induced reactive oxygen species generation and inhibited mitochondrial functions in CRC cells, leading to decreased proliferation and increased apoptosis compared to free Dox. These findings suggest that PrP(C)-Apt DOA may be a more effective treatment for CRC than traditional anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ghazal Rastegar, Mohammad Musa Salman, Shashank R. Sirsi
Summary: The use of drug-loaded microbubbles for targeted drug delivery, particularly in cancer treatment, has been extensively studied. However, the loading capacity of microbubbles has been limited. In this study, a novel approach was introduced to load doxorubicin in crystallized form in the core of polymeric microcapsules, creating remotely loaded microbubbles (RLMBs). These RLMBs exhibited a significantly higher drug payload compared to physically loaded microcapsules. Furthermore, the drug release of RLMBs was investigated under ultrasound field, showing a remarkable capability for on-demand drug release.
Article
Chemistry, Physical
Muhammad Qamar, Ghulam Abbas, Muhammad Afzaal, Muhammad Y. Naz, Abdul Ghuffar, Muhammad Irfan, Stanislaw Legutko, Jerzy Jozwik, Magdalena Zawada-Michalowska, Abdulnour Ali Jazem Ghanim, Saifur Rahman, Usama M. Niazi, Mohammed Jalalah, Fahad Salem Alkahtani, Mohammad K. A. Khan, Ewelina Kosicka
Summary: This study investigated the optical properties and electric field enhancement of gold nanorods, and found that they have high efficiency in targeted drug delivery. The experimental results also revealed the potential of gold nanorods in anticancer applications.
Article
Chemistry, Multidisciplinary
Jiaming Song, Naiyu Cui, Shixun Sun, Xinyue Lu, Yuxuan Wang, Haoyu Shi, Eui-Seok Lee, Heng-Bo Jiang
Summary: By studying the affinity of different oxygen-containing functional groups for doxorubicin, we found that hydroxyl groups showed stronger affinity than epoxy groups. Therefore, the drug loading capacity of graphene can be adjusted by modifying the ratio of hydroxyl to epoxy groups on its surface.
Article
Pharmacology & Pharmacy
Yufeng Chang, Wen Rui, Miaomiao Zhang, Shuwen Zhou, Lin Qiu, Pengfei Cui, Huaanzi Hu, Pengju Jiang, Xuancheng Du, Xinye Ni, Cheng Wang, Jianhao Wang
Summary: In this study, a convenient method was used to prepare DOX loaded DDSs with high reproducibility and drug loading. The DDSs showed uniform particle size, good biocompatibility, and decent anticancer performance.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biophysics
Sylwia Michlewska, Zuzana Garaiova, Veronika Subjakova, Marcin Holota, Ma lgorzata Kubczak, Marika Grodzicka, Elzbieta Okla, Nikolaos Naziris, Lucja Balcerzak, Paula Ortega, Francisco Javier de la Mata, Tibor Hianik, Iveta Waczulikova, Maria Bryszewska, Maksim Ionov
Summary: In this study, we combined dendritic and liposomal carriers and analyzed the biochemical and biophysical properties of these formulations. Lipid-coated dendritic carriers showed significantly improved transfection profiles and lower toxicity to erythrocyte membranes compared to noncomplexed components. The nanometric size, low polydispersity index, and reduced positive zeta potential of these complexes make them attractive for future drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Jong-Soo Choi, Jae-Won Park, Young-Bae Seu, Kyung-Oh Doh
Summary: FLLD, a folate-incorporated liposomal formulation of cholesteryl Dox, demonstrated enhanced cytotoxicity in FR-positive KB cells, promising as an anticancer drug with improved targeting effect compared to LLD.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biology
Shirin Mollazadeh, Mostafa Yazdimamaghani, Rezvan Yazdian-Robati, Somayeh Pirhadi
Summary: This study used molecular dynamics simulations to compare the opening of 3-fold and 4-fold pores in APO-Fr under acidic conditions. The results showed that the 3-fold pores had more hydrophilic residues on their surface, leading to increased flexibility and easier opening. The drug Doxorubicin mainly interacted with hydrophilic residues on the APO-Fr surface through hydrogen bonds, making it difficult for hydrophobic drugs to load into APO-Fr during the partial disassembly process. However, interactions between the protein and Doxorubicin through hydrogen bonds and π-π interactions facilitated the penetration of Doxorubicin into APO-Fr via the open pores. Therefore, increasing the disassembly of openings can enhance the encapsulation capacity and facilitate the loading of hydrophobic drugs into the internal cavity of APO-Fr.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Physical
Sina Karimzadeh, Babak Safaei, Tien-Chien Jen
Summary: The study investigated the effects of alcohol consumption on the efficiency of the SWCNT and DOX complex using molecular dynamic simulations. Results showed that in systems containing ethanol molecules, the encapsulation of DOX molecules in SWCNTs was decreased, and VdW interactions were also reduced.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Abdolhalim Torrik, Shamim Zaerin, Mahdi Zarif
Summary: Multidrug resistance is a major obstacle to the success of anticancer treatments. This study used molecular dynamics simulations to investigate the co-loading of anticancer drugs Doxorubicin and Imatinib using carbon nanotubes coated with Chitosan and Polyethylene Glycol polymers. The results showed that the number of polymer chains affects the drug loading, and Chitosan polymer has a more significant impact on the loading process.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Gulen Melike Demirbolat, Levent Altintas, Sukran Yilmaz, Taibe Arsoy, Mahmut Sozmen, Ismail Tuncer Degim
Summary: An effective, dual-drug loaded nanocarrier system was developed for the treatment of fibrosarcoma. The hybrid nanoparticles, composed of zinc oxide quantum dots and chitosan, decorated with PEG-linked folic acid, demonstrated high efficacy after loading imatinib mesylate and dexketoprofen trometamol. The prepared nanosystems were characterized and evaluated in vitro and in vivo, showing promising results in tumor growth inhibition.
JOURNAL OF MICROENCAPSULATION
(2022)
Article
Pharmacology & Pharmacy
Gamze Camlik, Isil Ozakca, Besa Bilakaya, Arif Tanju Ozcelikay, Adrian Joshua Velaro, Siddhanshu Wasnik, Ismail Tuncer Degim
Summary: Diabetes is a leading cause of death worldwide. New technologies have led to the development of effective antihyperglycemic drugs that can deliver active molecules. Studies have shown that nanostructures, such as quantum dots, can be administered orally and have significant blood glucose-reducing effects. This study investigated the use of carbon quantum dots to transport insulin orally and found that they can protect insulin from gastrointestinal enzymes. Additionally, it was discovered that carbon quantum dots can increase cellular response and metabolism, leading to an anti-hyperglycemic effect.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Basak Simitcioglu, Isik Didem Karagoz, Sibel Ilbasmis-Tamer, Ugur Tamer
Summary: This study found that the molecular weight of the polymer and the terminal groups can affect the surface morphology of nanoparticles and the drug encapsulation efficiency. Resomers with acid terminal function showed higher encapsulation and reaction efficiency. High molecular weight Resomers exhibited selective cytotoxicity, especially in the treatment of prostate cancer, suggesting potential for extended-release drug delivery systems.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ayse Nur Oktay, Nevin Celebi, Sibel Ilbasmis-Tamer, Guelnur Take Kaplanog
Summary: The aim of this study was to develop and characterize flurbiprofen-loaded cyclodextrin-based nanogel formulations for dermal application. The results showed that the nanogel formulations had good properties in terms of pH, viscosity, dynamic rheological measurements, and drug content. In vitro and ex vivo experiments demonstrated that the nanogels could be effective and stable formulations for the treatment of hydrophobic molecule skin diseases.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sibel Ilbasmis-Tamer, Mustafa Turk, Sefika Evran, Ismail Hakki Boyaci, Hakan Ciftci, Ugur Tamer
Summary: “The objective of this study was to prepare stable starch-coated copper nanoparticles (Cu-SNPs) by a green synthesis method and evaluate their apoptotic and necrotic effects on Capan 1 pancreatic cancer cell line. The Cu-SNPs showed antimicrobial effects on Staphylocossus and Enterococcus and exhibited cytotoxic, necrotic, and apoptotic effects on the Capan 1 cell line.”
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Clinical Neurology
Ismail Daldal, Alpaslan Senkoylu, Ismail Tuncer Degim, Sibel Ilbasmis Tamer, Suna Omeroglu, Saadet Ozen Akarca Dizakar, Hakan Hamdi Celik, Muhammet Bora Uzuner, Alper Kurtoglu, Dilek Yapar, Aliekber Yapar
Summary: The present study aimed to evaluate the effectiveness of carbon nanotubes (CNTs) / hydroxyapatite-tricalcium phosphate (HA-TCP) composite in a posterolateral spinal fusion model. The results showed that the CNTs/HA-TCP composite can significantly improve fusion compared to using CNTs alone. Therefore, the CNTs/HA-TCP composite may be a promising substitute for synthetic bone grafts in spinal fusion.
Article
Materials Science, Multidisciplinary
Basak Kavrak, Derya Yetkin, Ismail Tuncer Degim, Furkan Ayaz
Summary: Quantum dots are widely used in medicine and biology for their biocompatibility and fluorescent properties, particularly in in vivo imaging and drug delivery. However, their immunomodulatory roles have often been overlooked. In our study, we aimed to develop novel carbon quantum dots for drug delivery and anti-inflammatory effects. We tested these dots on activated mammalian macrophages and found that their immunomodulatory activities varied depending on the functional groups.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Chemistry, Physical
Cigdemnaz Ersoz Okuyucu, Gokce Dicle Kalaycioglu, Demet Kacaroglu, Ayse Kevser Ozden, Nihal Aydogan
Summary: This study presents a dual chemo/photothermal therapy for breast cancer using doxorubicin (DOX) and gold nanoparticles (AuNPs) loaded nanostructured lipid carriers (DOX+AuNPs)@NLCs. Different geometries of AuNPs (AuNSs, AuNRs, and AuNCs) were loaded in NLCs to enhance their photothermal heating capacity. The release of DOX from NLCs was triggered by NIR irradiation. AuNRs showed the highest heating potential with a temperature increase of 22 degrees C in 5 minutes. The cytotoxic effect of (DOX+AuNRs)@NLCs was the highest among all formulations, achieving 81% growth inhibition in MDA-MB-231 breast cancer cells under 5 minutes of NIR application. The study suggests that the geometry of AuNPs affects their photothermal capability, and the combination of DOX and local hyperthermia provided by AuNPs can greatly enhance cellular damage.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Gokce Dicle Kalaycioglu, Burcu Okmen Altas, Nihal Aydogan
Summary: The shape and surface charge of gold nanoparticles play a crucial role in determining their potential for photothermal therapy and cellular uptake efficiency. Cube-shaped nanoparticles exhibit stronger cationic interactions with model membranes, while rod-shaped nanoparticles show higher cellular uptake efficiency, especially with more realistic model membranes.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Pharmacology & Pharmacy
Cigdem Yucel, Gokce Seker Karatoprak, Sibel Ilbasmis-Tamer, Ismail Tuncer Degim
Summary: An innovative approach to enhance the skin permeation, anti-aging, and antioxidant effects of ferulic acid (FA)-loaded aspasomal formulations was developed and evaluated in this study. The optimized formulation showed positive results, with effective FA permeability and better antioxidant and anti-aging effects compared to the free drug. The study also demonstrated the physical stability of the lyophilized ASPs and the maintenance of FA content during storage. These findings suggest the potential usefulness and effectiveness of the developed FA-loaded ASPs for improving skin permeation and slowing skin aging with topical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Gamze Camlik, Besa Bilakaya, Yildiz Ozsoy, Ismail Tuncer Degim
Summary: This study aimed to explore the use of CQDs as an alternative delivery system for insulin supplementation in Alzheimer's Disease (AD). Insulin-loaded Ins-CQDs and in-situ Gel-Ins-CQDs were developed and their release kinetics and penetrations through nasal mucosa were determined. The results showed that Gel-Ins-CQDs exhibited controlled release over time and could be used for the treatment of AD via the nasal route.
JOURNAL OF MICROENCAPSULATION
(2023)
Review
Pharmacology & Pharmacy
Gamze Camlik, Yildiz Ozsoy, Ismail Tuncer Degim
Summary: This article proposes a new approach based on quorum sensing of viruses to prevent viral communication and restrict the spread of COVID-19, aiming to reduce its side effects. The use of functionalized quantum dots nanoparticles coupled with carbon atoms can enhance drug delivery efficacy, while carbon quantum dots can help minimize toxic effects. Additionally, doping boron atoms into the structure may further enhance synergistic effects.
ISTANBUL JOURNAL OF PHARMACY
(2022)
Review
Pharmacology & Pharmacy
Hazal Ezgi Gultekin, Fatmanur Tugcu Demiroz, Serdar Tort, Fusun Acarturk
Summary: This review provides an overview of the use of 3DP technologies in the pharmaceutical field, including their working principles and critical process parameters. It also presents a novel approach to evaluate the application of 3DP technologies in the treatment of different diseases.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
