Editorial Material
Clinical Neurology
Hugh S. Markus
Summary: PVS are physiological spaces surrounding blood vessels, and their dilation may indicate dysfunction. PVS are important for waste removal and fluid circulation in the brain, but the factors associated with their enlargement are still unknown.
Review
Biochemistry & Molecular Biology
Bo Fu, Hong Ma, Di Liu
Summary: During fertilization and embryo development, the cellular totipotency undergoes changes, with some embryonic stem cells being able to convert to a totipotent state. In the process of somatic cell nuclear transfer (SCNT), however, the establishment of totipotency in cloned embryos is often compromised. This review explores practical strategies for inducing 2-cell-like cells (2CLCs) in the study of cloned embryo development and suggests that these cell models can offer new opportunities for improving SCNT efficiency.
Review
Cell Biology
Arif Istiaq, Kunimasa Ohta
Summary: The ribosome plays a critical role in the translation process and is also involved in reverting cellular potency to a multipotent state. This phenomenon has potential implications for cancer cell reprogramming and cancer therapy.
Review
Cell Biology
Serena Ricci, Pietro Cacialli
Summary: This review summarizes recent advancements in stem cell (gene) therapy as potential tools for treating metabolic disorders, discussing promising results observed in human patients and critical hurdles preventing the transition of this approach from the laboratory to the clinic.
Review
Biochemistry & Molecular Biology
Jiang Qian, Xue Gao, Ya-Di Wang, Xue-Ling Li, Jun Hu, Jun-Hong Lu
Summary: Stem cells have shown great potential for tissue regeneration and repair due to their unlimited self-renewal and differentiation capabilities. However, the complex interactions between niches and stem cells, along with the limitations of current systems or methods, pose challenges to the multi-faceted applications of stem cells. Emerging evidence suggests that synchrotron infrared microspectroscopy may offer a promising non-invasive technology for stem cell research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Andrew J. Lawrence, Marco A. Prado
Summary: This editorial explains the changes made to the Journal of Neurochemistry in the past year and provides insights into new developments and opportunities. The aim of these changes is to increase transparency and support early career researchers, ultimately improving the value of the journal for authors and readers, and establishing it as a leading platform for the dissemination of exciting new research on the regulation of the nervous system.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Orthopedics
Madhan Jeyaraman, Sathish Muthu, Arun Gulati, Naveen Jeyaraman, G. S. Prajwal, Rashmi Jain
Summary: Researchers are continually developing new technologies for the treatment of knee osteoarthritis, including cell-based therapies and exosomal therapy. These new technologies can improve the quality of cartilage and alleviate symptomatic pain, potentially becoming the future direction for the management of knee osteoarthritis.
Review
Immunology
Hong You, Malcolm K. Jones, Deanne J. Whitworth, Donald P. McManus
Summary: Schistosomes, parasites causing schistosomiasis, have a complex life cycle involving infection of freshwater snails and mammals. Stem cells play a key role in facilitating adaptation to new environments and reproductive processes in different life cycle stages of the parasite. Establishment of stem cell lines in schistosomes may provide valuable resources for studying stem cell biology and developing new intervention strategies for schistosomiasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Yufei Wu, Adrian M. Pegoraro, David Weitz, Paul M. Janmey, Sean Sun
Summary: The study developed a computational model of cell growth and proteome increase to analyze the correlation between cell volume and nuclear volume in eukaryotes. It was found that the transport rates between cytoplasm and nucleoplasm and ribosome assembly play crucial roles in determining cell growth rate and the cell/nucleus volume ratio. The research suggests that optimizing kinetic and transport parameters together is necessary to regulate cell growth and volume ratios.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
H. Tu, E. Xiao, O. Liu
Summary: Mesenchymal stem cells (MSCs) hold promise in regenerative medicine, but their functions are influenced by various factors, including the microbiota. This article highlights the role of microbiota in modulating the functions of MSCs, focusing on self-renewal ability, multiple differentiation potential, and immunomodulation capacity. Clinical trials and model research on the effects of microbiota in stem cell therapy are reviewed, and the underlying mechanisms of the interaction between microbiota and MSCs are discussed.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Cell Biology
Sophia J. Hafner, Martin D. Jansson, Kubra Altinel, Kasper L. Andersen, Zehra Abay-Norgaard, Patrice Menard, Martin Fontenas, Daniel M. Sorensen, David M. Gay, Frederic S. Arendrup, Disa Tehler, Nicolai Krogh, Henrik Nielsen, Matthew L. Kraushar, Agnete Kirkeby, Anders H. Lund
Summary: Translational regulation plays a crucial role in pluripotency maintenance and cell differentiation. This study reveals ribosome heterogeneity through rRNA 2'-O-methylation during early development and differentiation, indicating a direct role for ribosomes in regulating translation during cell fate acquisition.
DEVELOPMENTAL CELL
(2023)
Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Kamalakannan Vijayan, Ling Wei, Elizabeth K. K. Glennon, Christa Mattocks, Natasha Bourgeois, Bart Staker, Alexis Kaushansky
Summary: Malaria remains a global health burden despite efforts to combat it. While malaria deaths have decreased over the past decade, progress towards eradication has slowed. Resistance to antimalarial drugs is a substantial and growing problem.
Review
Biotechnology & Applied Microbiology
Soheila Montazersaheb, Ali Ehsani, Ezzatollah Fathi, Raheleh Farahzadi, Ilja Vietor
Summary: Autophagy is a fundamental process that helps cells adapt to metabolic stress by degrading and recycling intracellular components. It plays a crucial role in various aspects of allogeneic hematopoietic stem cell transplantation (HSCT), including the survival and function of hematopoietic stem cells, T-cell differentiation, antigen presentation, and responsiveness to cytokine stimulation. However, the overall role of autophagy in HSCT remains unclear, highlighting the need for further understanding to improve transplant outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Junhua Xie, Freddy Haesebrouck, Lien Van Hoecke, Roosmarijn E. Vandenbroucke
Summary: Bacterial extracellular vesicles (bEVs) have been shown to play a crucial role in the pathogenesis of various diseases. This article thoroughly discusses the contribution of bEVs in disease pathogenesis, their potential as diagnostic biomarkers, and their application as therapeutic targets.
TRENDS IN MICROBIOLOGY
(2023)
