Article
Polymer Science
Vladimir Subr, Tereza Ormsby, Pavel Sacha, Jan Konvalinka, Tomas Etrych, Libor Kostka
Summary: The study focused on the impact of the linker between the polymer backbone and biotin, the number of biotins per polymer chain in ELISA or pull-down assays, and the position of biotin on the polymer chain. A novel chain transfer agent suitable for RAFT polymerization was developed to functionalize polymer precursors and simplify the synthesis of semitelechelic antibody mimetic materials. Optimized iBodies with a lengthened linker between the polymer backbone and biotin increased ELISA sensitivity up to 5 times.
Article
Pharmacology & Pharmacy
Irina Le-Deygen, Anastasia Safronova, Polina Mamaeva, Yana Khristidis, Ilya Kolmogorov, Anna Skuredina, Peter Timashev, Elena Kudryashova
Summary: The severe course of COVID-19 can lead to long-term pulmonary diseases, and developing new effective drug formulations, including inhalation administration, is crucial. This study proposes a method for creating lipid-polymer delivery systems using liposomes decorated with mucoadhesive mannosylated chitosan for fluoroquinolones and pirfenidone. The interactions between drugs and liposomes of different compositions are studied, and the role of the polymer shell in stabilizing vesicles and delaying the drug release is demonstrated. Results show prolonged accumulation of moxifloxacin in lung tissues after a single endotracheal administration in mice.
Article
Biochemistry & Molecular Biology
Alexander A. Beketov, Ivan Mikhailov, Anatoly A. Darinskii
Summary: The structure of vesicles formed by DMPC liposomes externally conjugated with branched polyglycerol-dendrons and linear PEG in water solution was simulated using the DPD method. It was found that modification of the liposome's outer surface with hydrophilic dendrons has little effect on the vesicle's size and shape, as well as the lipid membrane's morphology, until certain critical thresholds are exceeded.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei-Ting Du, Yen-Ling Kuan, Shiao-Wei Kuo
Summary: In this study, a poly(cyclohexene carbonate) (PCHC) was synthesized through alternative ring-opening copolymerization. The results showed that PCHC blends with poly(vinyl phenol) (PVPh) were miscible due to intermolecular hydrogen bonding. However, the weak hydrogen bonding interactions resulted in a negative deviation in the glass transition temperatures (T-g).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Hafeez Ur Rehman, Stefan Cord-Landwehr, Volha Shapaval, Simona Dzurendova, Achim Kohler, Bruno M. Moerschbacher, Boris Zimmermann
Summary: The increasing demand for chitin and chitosan in various industries necessitates rapid and high-throughput analysis methods. This study compared high-throughput microplate-based FTIR and FT-Raman methods with their manual counterparts, and found that the predictive accuracy of the high-throughput methods was comparable to the well-established LC-MS and 1H NMR methods. Therefore, high-throughput FTIR and FT-Raman methods have the potential to be efficient and cost-effective substitutes for traditional methods.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Anne M. Talkington, Morgan D. McSweeney, Timothy Wessler, Marielle K. Rath, Zibo Li, Tao Zhang, Hong Yuan, Jonathan E. Frank, M. Gregory Forest, Yanguang Cao, Samuel K. Lai
Summary: PEGylation is commonly used to prolong the circulation time of protein therapeutics and nanomedicines. However, individuals exposed to PEGylated therapeutics may develop antibodies specific to PEG, increasing the risk of hypersensitivity and accelerated drug clearance. In this study, a PBPK model was developed to investigate the impact of anti-PEG antibodies on the pharmacokinetics and biodistribution of PEGylated drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Justyna Kapral-Piotrowska, Jakub W. Strawa, Katarzyna Jakimiuk, Adrian Wiater, Michal Tomczyk, Wieslaw I. Gruszecki, Bozena Pawlikowska-Pawlega
Summary: This report discusses the effects of newly isolated flavone derivatives HZ4 and SP9 from Hottonia palustris L. and Scleranthus perennis L. on membranes. Experimental results showed that these compounds interact with the polar head group region of lipid bilayers, causing changes in the spectral regions. NMR analyses confirmed the localization of these compounds in the polar heads zone. These findings are crucial for determining the biological activities and medicinal usability of these compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Mariona Estape Senti, Caroline A. de Jongh, Kim Dijkxhoorn, Johan J. F. Verhoef, Janos Szebeni, Gert Storm, C. Erik Hack, Raymond M. Schiffelers, Marcel H. Fens, Peter Boross
Summary: In this study, the consequences and mechanisms of complement activation by anti-PEG antibodies interacting with various types of PEGylated lipid-based nanoparticles were investigated. The activation of complement by anti-PEG antibodies can compromise the integrity of nanoparticles, leading to premature drug release or exposure to serum proteins. The levels of pre-existing anti-PEG IgM antibodies in plasma of healthy donors correlated with the degree of complement activation induced upon exposure to PEGylated liposomes and mRNA LNPs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Justyna Gawel, Justyna Milan, Jacek Zebrowski, Dariusz Ploch, Ireneusz Stefaniuk, Malgorzata Kus-Liskiewicz
Summary: Biomaterial engineering approaches involve using a combination of bioactive molecules to promote cell proliferation and create scaffolds for regeneration. This study focused on composite materials made from chitosan, hydroxyapatite, and riboflavin. The films produced showed a porous structure and interconnection between chitosan and apatite. The composite material exhibited antibacterial and antioxidant properties, as well as enhanced cell proliferation and migration, suggesting its potential in bone tissue engineering applications.
SCIENTIFIC REPORTS
(2023)
Article
Polymer Science
Anna P. Constantinou, Kaiwen Zhang, Birsen Somuncuoglu, Bailin Feng, Theoni K. Georgiou
Summary: An ABCA tetrablock terpolymer with excellent thermogelling properties in aqueous solutions has been identified by tuning the architecture of ethylene glycol-based tetrablock terpolymers. The polymer architecture governing their solubility, micellization, thermoresponsive, and rheological properties.
Article
Polymer Science
Qianyu Lin, Chen Chuan Lim, Cally Owh, Joey Hui Min Wong, Valerie Ow, Belynn Sim, Yi Jian Boo, Michelle P. Y. Yew, Yi Hao Leow, Liangfeng Guo, Jason Y. C. Lim, Xian Jun Loh
Summary: Thermogels are a type of supramolecular hydrogels that undergo reversible sol-gel phase transitions and their unique properties depend on the hydrophilic-hydrophobic balance of the constituent polymers. Most thermogelling polymers use polyethylene glycol (PEG) as the hydrophilic segment, but this study introduces PEG-free amphiphilic polymers comprising only polyethylenimine (PEI) and polypropylene glycol (PPG) as the hydrophilic and hydrophobic segments, respectively. These polymers can self-assemble into micelles and supramolecular gel matrices. By modifying the PEI-PPG copolymers with benzyl groups, the resulting thermogel properties can be conveniently modulated. The hydrophobic-hydrophilic balance of the copolymers can also be adjusted to tune the critical gelation concentrations, gelation temperatures, and gel viscoelastic properties. In addition, the PEI segment exhibits pH-responsiveness, allowing for further alteration of thermogel viscoelasticity through pH adjustment. The convenience of postsynthetic functionalization, new material properties, and dual stimuli-responsiveness of these polycationic PEI-PPG thermogels can potentially offer a vast material design space for many unique applications.
Article
Polymer Science
Aleksander Smolarkiewicz-Wyczachowski, Halina Kaczmarek, Jaroslaw Piskorz, Marta Ziegler-Borowska
Summary: In this study, chitosan films modified by photosensitive BODIPY compounds with and without iodine atoms were prepared and their stability under thermal and UV radiation conditions was investigated. The results showed that BODIPY dyes exhibited good photochemical stability in solid chitosan matrix, but the compound with iodine atoms showed slightly lower stability compared to the one without. Additionally, BODIPY dyes did not affect the thermal stability of chitosan, but their decomposition temperature was lower in the presence of chitosan.
Article
Chemistry, Multidisciplinary
Franziska Buchner, Thorren Kirschbaum, Amelie Venerosy, Hugues Girard, Jean-Charles Arnault, Benjamin Kiendl, Anke Krueger, Karin Larsson, Annika Bande, Tristan Petit, Christoph Merschjann
Summary: This study provides spectroscopic evidence for the emission of solvated electrons from detonation nanodiamonds upon excitation with both deep ultraviolet and visible light, and highlights the crucial role of surface termination in the emission process. These findings open new perspectives for solar-driven emission of solvated electrons in an aqueous phase using nanodiamonds.
Article
Biochemistry & Molecular Biology
Jianqing Peng, Qin Wang, Mingyang Guo, Chunyuan Liu, Xuesheng Chen, Ling Tao, Ke Zhang, Xiangchun Shen
Summary: In this study, a CS-coated liposome loaded with OMT was used for the treatment of lethal RSV infection. The CS-coated liposome enhanced the distribution and retention of OMT in lung tissue, effectively alleviating RSV infection. Thus, the CS-coated liposome could be a potential inhalable nanocarrier for preventing pulmonary infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Vy Ha Nguyen Tran, Thuan Thi Nguyen, Sebastian Meier, Jesper Holck, Hang Thi Thuy Cao, Tran Thi Thanh Van, Anne S. Meyer, Maria Dalgaard Mikkelsen
Summary: This study cloned an endo-alpha(1,3)-fucoidanase encoding gene Mef2 from a marine bacterium and characterized its functional properties, showing its activity and specificity in fucoidan hydrolysis, as well as unveiling new structural details.
Article
Biology
Igor D. Zlotnikov, Dmitriy A. Streltsov, Natalya G. Belogurova, Elena V. Kudryashova
Summary: Polymeric micelles based on chitosan (or cyclodextrin) and oleic acid with different modification degrees were synthesized as promising drug carriers. The incorporation of antibiotics moxifloxacin or rifampicin into the micelles was confirmed by spectroscopy, and the fluorescent properties of the micelles were significantly changed. The micellar systems enhanced the antibacterial effect of the antibiotics and showed improved pharmacokinetic parameters compared to free forms.
Article
Biochemistry & Molecular Biology
Igor D. D. Zlotnikov, Natalia V. V. Dobryakova, Alexander A. A. Ezhov, Elena V. V. Kudryashova
Summary: A strategy is proposed to enhance the efficacy and selectivity of cytotoxic agents against cancer cells by utilizing the differences in morphology and microenvironment between tumor and healthy cells. The developed enhanced formulations of cytotoxic agents, including efflux inhibitors and ion channel inhibitors, demonstrate increased permeability in A549 cells and a protective effect on healthy HEK293T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Linara R. Yakupova, Anna A. Skuredina, Pavel O. Markov, Irina M. Le-Deygen, Elena V. Kudryashova
Summary: We developed new drug carriers for meropenem using hydroxypropyl-beta-cyclodextrin (HPCD) polymers with different linkers (HMD, CA, SA). The obtained polyester and polyurethane nanoparticles (120-200 nm) were characterized by NMR and FTIR-spectroscopy. The study showed that HPCD polymers can form complexes with meropenem and have a high encapsulation efficiency of up to 82%. Among them, HPCD-HMD and HPCD-SA polymers increase the stability of meropenem in aqueous solutions, while HPCD-CA polymer has a negative effect on the stability. The HPCD-HMD polymer shows potential as a highly efficient drug delivery system for meropenem.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Irina Le-Deygen, Anastasia Safronova, Polina Mamaeva, Yana Khristidis, Ilya Kolmogorov, Anna Skuredina, Peter Timashev, Elena Kudryashova
Summary: The severe course of COVID-19 can lead to long-term pulmonary diseases, and developing new effective drug formulations, including inhalation administration, is crucial. This study proposes a method for creating lipid-polymer delivery systems using liposomes decorated with mucoadhesive mannosylated chitosan for fluoroquinolones and pirfenidone. The interactions between drugs and liposomes of different compositions are studied, and the role of the polymer shell in stabilizing vesicles and delaying the drug release is demonstrated. Results show prolonged accumulation of moxifloxacin in lung tissues after a single endotracheal administration in mice.
Article
Pharmacology & Pharmacy
Igor D. Zlotnikov, Dmitriy A. Streltsov, Alexander A. Ezhov, Elena V. Kudryashova
Summary: The low effectiveness of chemotherapy is due to low target bioavailability of drugs and the efflux process. To overcome this, polymeric micellar systems based on chitosan grafted with fatty acids (different types) were developed to increase the solubility and bioavailability of drugs and enhance interaction with tumor cells. Adjuvants, such as eugenol, were also used to enhance the accumulation and retention of drugs in tumor cells. pH- and temperature-sensitive micelles showed high entrapment efficiency and prolonged drug release. The combined micellar drugs significantly increased the penetration of cytostatics into cancer cells and inhibited efflux.
Article
Pharmacology & Pharmacy
Anna A. Skuredina, Linara R. Yakupova, Tatiana Yu. Kopnova, Irina M. Le-Deygen, Natalya G. Belogurova, Elena V. Kudryashova
Summary: Respiratory infectious diseases are challenging, and current treatments with ceftriaxone, meropenem, and levofloxacin have severe side effects. Cyclodextrins (CDs) and CD-based polymers are proposed as drug delivery systems to overcome these challenges. CD polymers exhibit higher binding affinity for levofloxacin compared to drug-CD complexes, and increase the drugs' binding affinity for human serum albumin (HSA) up to 100 times. The encapsulation of drugs in CD carriers leads to a decreased change in protein secondary structure. The drug-CD carrier-HSA complexes demonstrate satisfying antibacterial activity in vitro and maintain the drug's microbiological properties over 24 hours. The proposed carriers show promise for prolonged drug release.
Article
Medicine, General & Internal
Igor D. D. Zlotnikov, Alexander A. A. Ezhov, Maksim A. A. Vigovskiy, Olga A. A. Grigorieva, Uliana D. D. Dyachkova, Natalia G. G. Belogurova, Elena V. V. Kudryashova
Summary: Visualization of drug-cell interactions enhances drug bioavailability, selectivity, and effectiveness. CLSM and FTIR spectroscopy were used to study antibacterial drug interactions with latent bacterial cells, offering potential solutions to multidrug resistance and severe cases. The mechanism of rifampicin penetration into E. coli cells was explored by monitoring changes in cell wall components and intracellular proteins. Efflux inhibition and drug delivery systems for macrophages were also investigated using FTIR and CLSM techniques.
Article
Biochemistry & Molecular Biology
Anna A. Efimova, Anton S. Popov, Alexey V. Kazantsev, Pavel I. Semenyuk, Irina M. Le-Deygen, Nikolay V. Lukashev, Alexander A. Yaroslavov
Summary: pH-sensitive liposomes with embedded AMS showed rapid cargo release when pH was altered, but the mechanism is not yet fully understood. This article presents the details of fast cargo release based on ATR-FTIR spectroscopy and molecular modeling. The findings are relevant to the potential use of AMS-containing pH-sensitive liposomes for drug delivery.
Article
Pharmacology & Pharmacy
Igor D. Zlotnikov, Natalya G. Belogurova, Irina V. Poddubnaya, Elena V. Kudryashova
Summary: Chitosan nanogels loaded with antibacterial drugs and adjuvants can be used as a new strategy for the treatment of bacterial infections in the gastrointestinal tract. The antibacterial activity of these nanogels was studied using E. coli and Lactobacilli models, and it was shown that certain combinations of antibiotics and adjuvants were effective in inhibiting E. coli while having weaker effects on Lactobacilli. The nanogels were found to be well absorbed on the mucosal model, providing prolonged release at the target location.
Article
Chemistry, Medicinal
Igor D. Zlotnikov, Maria P. Davydova, Milan R. Danilov, Sergey S. Krylov, Natalya G. Belogurova, Elena V. Kudryashova
Summary: The study demonstrated the effectiveness of joint delivery of antibiotics and adjuvants into pathogens using a polymer carrier. The method improved antibiotic stability, increased antibiotic and adjuvant concentration in pathogen cells, and inhibited bacterial resistance.
Article
Engineering, Biomedical
Irina M. M. Le-Deygen, Polina V. V. Mamaeva, Anna A. A. Skuredina, Anastasia S. S. Safronova, Natalia G. G. Belogurova, Elena V. V. Kudryashova
Summary: The aim of this paper is to design a combined system for the simultaneous delivery of rifampicin and levofloxacin for potential inhalation administration. The system incorporates rifampicin into liposomal vesicles with chitosan-β-cyclodextrin conjugates and levofloxacin into cyclodextrin tori. The physicochemical properties and drug release kinetics of the obtained systems were comprehensively studied, and high antibacterial activity against B. subtilis and E. coli was demonstrated.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Anna A. Skuredina, Tatiana Yu. Kopnova, Natalya G. Belogurova, Elena V. Kudryashova
Summary: We propose a drug delivery system based on cyclodextrin polymer for ciprofloxacin, which demonstrates sustained release and improves the interaction with human serum albumin, enhancing its antibacterial properties.
CHEMISTRY-SWITZERLAND
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)