Article
Materials Science, Biomaterials
Pei Liu, Hongyao Du, Zhuoli Wu, Hua Wang, Juan Tao, Lianbin Zhang, Jintao Zhu
Summary: The study introduces a facile and effective method for enhancing the hydrophilicity and anti-adhesive properties of porous polymer microneedles through a polydopamine and poly(ethylene glycol) coating strategy, demonstrating superior performance in dermal interstitial fluid extraction. This technology is not only applicable to polymers like polysulfone, but can also be extended to other commonly used hydrophobic polymers in the medical field.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Pharmacology & Pharmacy
Kristyna Dvorakova, Petr Stepanek, Jirina Kroupova, Jarmila Zbytovska
Summary: Transdermal drug delivery is a non-invasive method with advantages over conventional routes of administration. However, the skin barrier needs to be modulated with enhancers, and currently there is a lack of enhancers with low toxicity and reversible effects. A study found that a series of new N-alkylmorpholines showed enhanced transdermal and dermal delivery, with the most effective derivatives having 10-14 carbons. The enhancers interacted predominantly with stratum corneum lipids.
Article
Medicine, Research & Experimental
Hazel Garvie-Cook, Magdalena Hoppel, Richard H. Guy
Summary: This article illustrates the application of confocal Raman microspectroscopy and imaging to investigate the performance of topical and transdermal drug products at the formulation-skin interface. These techniques provide qualitative and potentially semi-quantitative insights into the interaction between the delivery system and the skin, drug transfer mechanisms, changes in drug solubility, and drug absorption and clearance within the skin.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Medicinal
Viliana Gugleva, Nadezhda Ivanova, Yoana Sotirova, Velichka Andonova
Summary: Phenolic compounds have various benefits for human health, but their utilization in cutaneous formulations faces challenges. Currently, including them in lipid-based nanocarriers to enhance stability and bioavailability is a strategic approach.
Review
Pharmacology & Pharmacy
Danielle van Staden, Richard K. K. Haynes, Joe M. M. Viljoen
Summary: Self-emulsification is a formulation technique that improves oral drug delivery by enhancing solubility and bioavailability. It provides a simplified method for delivering lipophilic drugs by producing emulsions upon moderate agitation and dilution. It is also a promising approach for topical drug delivery, offering simplified production procedures and unlimited upscaling possibilities.
Article
Chemistry, Medicinal
Danielle van Staden, Richard K. Haynes, Joe M. Viljoen
Summary: Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that provide superior drug protection and control over drug concentration profiles, making them a promising option for oral drug delivery. Dermal spontaneous emulsions have also gained interest due to their ability to deliver drugs across mucus membranes and skin layers.
Review
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran, Hariprasad Ranganathan, Arjunan Karuppaiah, Habibur Rahman
Summary: Recent advancements in drug delivery technologies have led to the emergence of nanotechnology as a potential tool in cancer therapeutics. Solid lipid nanoparticles (SLNs) have shown great potential for drug delivery, clinical medicine, and overcoming challenges in cancer therapy. Further research is needed to better understand the biological responses of SLNs and develop therapeutics with reduced side effects. This review focuses on the development, mechanisms, and applications of SLNs in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ammar S. Al Khafaji, Maureen D. Donovan
Summary: Nanoparticles administered via the nasal cavity demonstrated uptake through various endocytic pathways, with continued uptake observed even after exposure to pharmacological inhibitors. The study revealed that a combination of endocytic pathways are involved in the transfer of nanoparticles into the nasal mucosa. Additionally, non-energy-dependent pathways for nanoparticle uptake were observed following exposure to general metabolic inhibitors, highlighting the potential for lipid nanoparticles in local and systemic drug delivery following nasal administration.
Article
Pharmacology & Pharmacy
Cornelia M. Keck, Em-on Chaiprateep, Henriette Dietrich, Soma Sengupta
Summary: Professional skin treatments can improve skin hydration and penetration efficacy of active ingredients. The type of professional skin treatment, lipophilicity of the active ingredients, and the time of application all have significant impacts on penetration efficacy.
Review
Chemistry, Multidisciplinary
Claire Richard, Stephanie Cassel, Muriel Blanzat
Summary: Dermal/transdermal drug delivery is increasingly important for enhancing treatment activity and reducing toxicity by avoiding systemic absorption of drugs. This paper reviews the structure of the skin, parameters affecting drug diffusion, and strategies for improving dermal drug delivery, focusing on advanced carriers like vesicular systems. The review presents the state of the art and new trends in the field to optimize cutaneous and transcutaneous drug penetration.
Article
Dermatology
Soraya Babaie, Mohammad Charkhpour, Maryam Kouhsoltani, Hamed Hamishehkar, Ana Claudia Paiva-Santos
Summary: By using lipid-based nanovesicles, buprenorphine and bupivacaine can be co-delivered to effectively target pain receptors concentrated in the skin, resulting in potent dermal anesthesia.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Gruber, Aaroh Anand Joshi, Patrick Graff, Jose Luis Cuellar-Camacho, Sarah Hedtrich, Daniel Klinger
Summary: Polymeric nanogels are potential nonirritating nanocarriers for topical delivery. Amphiphilic nanogels containing hydrophilic networks with hydrophobic domains can overcome the limitations of conventional hydrophilic networks, improving encapsulation of hydrophobic therapeutics and tailored interactions with the skin barrier.
Article
Pharmacology & Pharmacy
Federica Sommonte, Ilaria Arduino, Rosa Maria Iacobazzi, Mattia Tiboni, Federico Catalano, Roberto Marotta, Martina Di Francesco, Luca Casettari, Paolo Decuzzi, Angela Assunta Lopedota, Nunzio Denora
Summary: After 20 years of research, nanoscale delivery systems for biologicals in nanomedicine have become clinically relevant. Microfluidic-based production of solid lipid nanoparticles (SLNs) is shown to be efficient in encapsulating and delivering lysozyme (LZ), with smaller size and higher encapsulation efficacy compared to conventional methods. This study demonstrates the potential of microfluidic production of SLNs for encapsulation and delivery of complex biological molecules.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yaser Alkhatib, Gabriele Blume, Jana Thamm, Frank Steiniger, Dana Kralisch, Dagmar Fischer
Summary: The study successfully incorporated the lipophilic CoQ10 into BNC using various post-synthesis techniques. Penetration studies showed distribution of CoQ10 in different layers of skin. Using lipidic colloidal carriers, water-insoluble drugs can be loaded onto BNC, offering new possibilities for applications in pharmacy and medicine.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Kyumin Mo, Ayoung Kim, Soohyun Choe, Miyoung Shin, Hyunho Yoon
Summary: Lipid nanoparticles (LNPs) composed of ionized lipids, helper lipids, and cholesterol have potential for gene therapies and vaccines by facilitating intracellular transport and avoiding endosomal compartments. Solid lipid nanoparticles (SLNs) derived from physiologically acceptable lipids provide high structural stability and biocompatibility, and have been used to enhance drug delivery for cancer treatments. SLNs have shown promising results in breast cancer treatment, improving the therapeutic efficacy of drugs.
Article
Obstetrics & Gynecology
Fatemeh Ahangari, Azizeh Farshbaf-Khalili, Yousef Javadzadeh, Mohammad Adibpour, Behnaz Sadeghzadeh Oskouei
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Chemistry, Analytical
Arezou Taghvimi, Samin Hamidi, Yousef Javadzadeh
JOURNAL OF SEPARATION SCIENCE
(2019)
Article
Pediatrics
Shirin Osouli Tabrizi, Mojgan Mirghafourvand, Abdollah Jannat Dost, Sakineh Mohammad-Alizadeh-Charandabi, Yousef Javadzadeh, Robabe Seyedi
WORLD JOURNAL OF PEDIATRICS
(2019)
Article
Biochemical Research Methods
Arezou Taghvimi, Ahad Bavili Tabrizi, Siavoush Dastmalchi, Yousef Javadzadeh
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2019)
Article
Integrative & Complementary Medicine
Zahra Ghorbani, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh Charandabi, Yousef Javadzadeh
COMPLEMENTARY THERAPIES IN MEDICINE
(2019)
Article
Chemistry, Analytical
Neghin Rashtchi Jabbari, Arezou Taghvimi, Siavoush Dastmalchi, Yousef Javadzadeh
JOURNAL OF SEPARATION SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Arezou Taghvimi, Samin Hamidi, Yousef Javadzadeh, Siavoush Dastmalchi, Mahnaz Tabibiazar
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2020)
Article
Engineering, Chemical
Seraj Mohaghegh, Karim Osouli-Bostanabad, Hossein Nazemiyeh, Yousef Javadzadeh, Alireza Parvizpur, Mohammad Barzegar-Jalali, Khosro Adibkia
ADVANCED POWDER TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Yahya Rahimpour, Abbas Delazar, Samad Nejad Ebrahimi, Mahsa Sabernavaei, Parina Asgharian
Summary: The study found that the volatile oil and extracts of Ferulago stellata have strong antioxidant and antimicrobial activity, as well as a rich source of healthy fatty acids. These findings suggest that Ferulago stellata has significant potential for pharmaceutical, cosmetic, and food industries.
RESEARCH JOURNAL OF PHARMACOGNOSY
(2022)
Article
Pharmacology & Pharmacy
Fariba Heshmati Afshar, Abbas Delazar, Yahya Rahimpour, Niloufar Moharrer Navaei, Solmaz Asnaashari, Paring Asgharian
Summary: The study on Nepeta racemosa revealed the presence of various chemical compounds, particularly phenolic compounds, which play an important role as antioxidant agents.
RESEARCH JOURNAL OF PHARMACOGNOSY
(2021)
Review
Pharmacology & Pharmacy
Yahya Rahimpour, Abbas Delazar, Solmaz Asnaashari, Parina Asgharian
Summary: The Ferulago genus, belonging to the Umbelliferae family, consists of 49 species mainly found in Asia, Europe, and Africa. This genus has been traditionally used for various medicinal purposes and as a preservative and flavoring agent. Its main components, such as monoterpenes, sesquiterpenes, coumarin, furanocoumarin, flavonoids, and terpenoids, contribute to its antimicrobial, antioxidant, anticoagulant, antidiabetic, Alzheimer's, and larvicidal properties.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shadi Jahed Orange, Arezou Taghvimi, Siavoush Dastmalchi, Yousef Javadzadeh
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2020)
Review
Pharmacology & Pharmacy
Saeideh Allahyari, Yousef Javadzadeh
PHARMACEUTICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Arezou Taghvimi, Siavoush Dastmalchi, Yousef Javadzadeh
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2019)
Article
Obstetrics & Gynecology
Sevil Hakimi, Faranak Farhan, Azizeh Farshbaf-Khalili, Parvin Dehghan, Yousef Javadzadeh, Shamsi Abbasalizadeh, Bagher Khalvati
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2018)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)