期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.01543
关键词
Streptococcus pneumoniae; pneumococcus; pneumolysin; cholesterol-dependent cytolysin; invasive pneumococcal disease; vaccine
类别
资金
- NIAID [U01-AI124302, R01-AI110618, R01-12111585]
- ALSAC
Streptococcus pneumoniaeis an opportunistic pathogen responsible for widespread illness and is a major global health issue for children, the elderly, and the immunocompromised population. Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) and key pneumococcal virulence factor involved in all phases of pneumococcal disease, including transmission, colonization, and infection. In this review we cover the biology and cytolytic function of PLY, its contribution toS. pneumoniaepathogenesis, and its known interactions and effects on the host with regard to tissue damage and immune response. Additionally, we review statins as a therapeutic option for CDC toxicity and PLY toxoid as a vaccine candidate in protein-based vaccines.
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