Article
Biochemistry & Molecular Biology
Noelia Lander, Miguel A. Chiurillo, Roberto Docampo
Summary: Trypanosoma cruzi is a unicellular parasite responsible for Chagas disease, with a digenetic life cycle alternating between mammalian and insect hosts. This parasite must adapt to various environmental conditions such as temperature, nutrient availability, pH, and oxidative stress, which are regulated by signaling pathways. This review will focus on the signaling pathways and second messengers involved in the responses to these environmental changes.
MOLECULAR MICROBIOLOGY
(2021)
Article
Microbiology
Beate Schwer, Angad Garg, Ana M. Sanchez, Mindy A. Bernstein, Bradley Benjamin, Stewart Shuman
Summary: Inositol pyrophosphate dynamics regulate the phosphate homeostasis regulon in fission yeast through lncRNA-mediated transcription interference. A genetic screen identified several proteins that are involved in IPP toxicosis and shed light on its determinants.
Article
Microbiology
Beate Schwer, Angad Garg, Ana M. Sanchez, Mindy A. Bernstein, Bradley Benjamin, Stewart Shuman
Summary: This study explored the role of IPP in regulating phosphate homeostasis in fission yeast and uncovered several proteins required for IPP toxicity, including Gde1, Spx1, and Vtc2/4, which possess specific enzymatic functions. The research revealed the involvement of Spx1 in transmitting the IP8 signal to the RNA processing machinery.
Article
Biochemistry & Molecular Biology
Brian S. Mantilla, Karunakaran Kalesh, Nathaniel W. Brown, Dorothea Fiedler, Roberto Docampo
Summary: This study identified potential targets of 5-IP7 in Trypanosoma cruzi using pull-down experiments and mass spectrometry analysis, revealing new functional roles of 5-IP7 in this divergent eukaryote and providing potential new targets for chemotherapy.
MOLECULAR MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roberto Docampo, Guozhong Huang
Summary: Trypanosoma cruzi and the T. brucei group of parasites are neglected diseases affecting millions of people globally. These microorganisms have complex life cycles involving insect vectors and mammalian hosts, and possess unique signaling pathways and receptor adaptations that differentiate them from their mammalian counterparts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Microbiology
Geun-Don Kim, Danye Qiu, Henning Jacob Jessen, Andreas Mayer
Summary: Cells need to balance the demand for inorganic phosphate (P-i) for synthesizing nucleic acids and phospholipids with the negative bioenergetic effects of P-i by reducing nucleotide hydrolysis energy. They stabilize intracellular P-i to compromise between biosynthetic needs and bioenergetic effects. The homeostasis of P-i in eukaryotes uses Syg1/Pho81/Xpr1 (SPX) domains, which are receptors for inositol pyrophosphates. Polymerization and storage of P-i in vacuoles support yeast metabolism and declining ATP and inositol pyrophosphates may indicate impending P-i limitation.
Review
Biochemistry & Molecular Biology
Boah Lee, Seung Ju Park, Sehoon Hong, Kyunghan Kim, Seyun Kim
Summary: IPMK is a promiscuous enzyme with broad substrate specificity, phosphorylating multiple inositol phosphates and phosphatidylinositol 4,5-bisphosphate. In addition to its catalytic actions, IPMK can control signaling events via direct protein-protein interactions. It plays pleiotropic roles in physiological and pathological conditions.
MOLECULES AND CELLS
(2021)
Article
Biochemistry & Molecular Biology
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. B. Shears, Ingo B. B. Leibiger, Per-Olof Berggren, Christopher J. J. Barker
Summary: MINPP1 is an enzyme responsible for metabolizing inositol hexakisphosphate and inositol 1,3,4,5,6 pentakisphosphate in mammalian cells. Our study shows that cytosolic expression of MINPP1 reduces cell growth and lowers the concentration of phosphatidylinositol 3,4,5-trisphosphate. These findings highlight the importance of MINPP1's confinement to the endoplasmic reticulum.
Review
Biochemistry & Molecular Biology
Becky Tu-Sekine, Sangwon F. Kim
Summary: Cells rely on nutrients to provide energy and carbon building blocks, and interact with the inositol phosphate signaling network to meet cellular needs in response to energy storage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Javier Paz-Ares, Maria Isabel Puga, Monica Rojas-Triana, Iris Martinez-Hevia, Sergio Diaz, Cesar Poza-Carrion, Miguel Minambres, Antonio Leyva
Summary: This article reviews the importance of phosphorus in plant growth and the adaptive mechanisms plants have developed to cope with phosphorus limitation. Research has identified several signaling molecules involved in the regulation of the phosphorus starvation rescue system, and complex interactions between phosphorus and other nutrients have been discovered. Improving phosphorus use efficiency can enhance plant uptake and utilization of phosphorus.
Review
Agronomy
Tao Wu, Chuang Wang, Bei Han, Zhu Liu, Xinyu Yang, Wei Wang, Guangda Ding, John P. Hammond, Philip J. White, Fangsen Xu, Lei Shi
Summary: Phosphorus (P) is essential for plant growth and development, and inositol pyrophosphates (PP-InsPs) serve as important nutrient messengers in signaling P status. This review highlights the biosynthesis of PP-InsPs and their regulation by plant P status, the impact of PP-InsPs on SPX domain-containing proteins in P status signaling, the effects of inositol pyrophosphates on auxin and jasmonate signaling, and the potential crosstalk between P status signaling and phytohormone signaling mediated by inositol pyrophosphates. The interaction between inositol pyrophosphates and their binding proteins is crucial for plant P status and developmental responses to different P supply.
Article
Biochemistry & Molecular Biology
Long Wang, Xianqing Jia, Yuxin Zhang, Lei Xu, Benoit Menand, Hongyu Zhao, Houqing Zeng, Liam Dolan, Yiyong Zhu, Keke Yi
Summary: The study revealed the crucial roles of CrPTC1 and CrVTC4 genes in polyP accumulation in vacuoles of chlorophyte algae. Phylogenetic analysis showed the conservation of certain SPX proteins in the common ancestor of green plants, with differential expression patterns in various plant types.
Review
Cell Biology
Lei Li, Kun-Hsiang Liu, Jen Sheen
Summary: This article reviews the multifaceted roles of nutrients in plants, discussing the regulation of signaling networks by sugars, nitrate, and phosphate, as well as key regulators newly discovered. The paper highlights the dynamic nutrient, energy, growth, and stress signaling networks that coordinate systemwide transcriptional, translational, and metabolic reprogramming and respond to environmental stimuli.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37
(2021)
Article
Multidisciplinary Sciences
Hyungyu Min, Wooseob Kim, Sehoon Hong, Sungkyu Lee, Jinguk Jeong, Seyun Kim, Rho H. Seong
Summary: This study reveals that inositol polyphosphate multikinase (IPMK) is a crucial regulator of Treg cell differentiation downstream of TCR signaling, and deficiency of IPMK leads to abnormal T cell activation and impaired Treg cell differentiation and function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Michael Plank
Summary: TOR and PKA signaling pathways play important roles in growth regulation and nutrient sensing in Saccharomyces cerevisiae. This review explores the association between these pathways, focusing on shared target proteins. It discusses the potential direct regulation and cross-talk between TOR and PKA, as well as the transcriptional responses elicited by these pathways.