Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jan Novak, Tana Machackova, Jan Krejci, Julie Bienertova-Vasku, Ondrej Slaby
Summary: Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation is one of the last options for patients with terminal refractory heart failure. The prognosis of patients after heart transplantation is influenced by rejection and allograft vasculopathy, with monitoring requiring invasive and uncomfortable procedures. MiRNAs play a potential role in the pathophysiology of rejection and may be used in clinical practice for diagnosis and prediction of rejection occurrence.
Article
Cardiac & Cardiovascular Systems
Carmela Napolitano, Giorgia Grutter, Paola Francalanci, Antonio Amodeo, Aurelio Secinaro
Summary: Heart transplant recipients undergo postoperative screening to exclude complications. Cardiac magnetic resonance imaging is a non-invasive tool for monitoring graft health. We describe a case of a female heart transplant recipient with worsening clinical condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, Research & Experimental
Zhichao Wu, Jialiang Liang, Wei Huang, Lin Jiang, Christian Paul, Xiang Gao, Perwez Alam, Onur Kanisicak, Meifeng Xu, Yigang Wang
Summary: Heart transplantation is the gold standard treatment for end-stage heart failure, but complications such as allograft rejection and infections are common. Recent studies have shown the potential of mesenchymal stem cells in alleviating allograft rejection during heart transplantation.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Zhe Yang, Fei Han, Tao Liao, Haofeng Zheng, Zihuan Luo, Maolin Ma, Jiannan He, Lei Li, Yongrong Ye, Rui Zhang, Zhengyu Huang, Yannan Zhang, Qiquan Sun
Summary: Artemisinin demonstrates significant immunosuppressive effects in rat cardiac transplantation model, attenuating rejection reactions and prolonging allograft survival. By targeting multiple effector cells, artemisinin effectively reduces T cell-mediated rejection and antibody-mediated rejection, showing potential for clinical use in transplant rejection prevention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sharon Chih, Aun Yeong Chong, Vladimir Dzavik, Derek Y. Y. So, Natasha Aleksova, George A. Wells, Jordan Bernick, Christopher B. Overgaard, Ellamae Stadnick, Lisa M. Mielniczuk, Rob S. B. Beanlands, Heather J. Ross
Summary: This study aimed to determine predictors of early coronary artery disease (CAD) after heart transplantation. Heart transplant recipients were evaluated for one year for coronary anatomic-physiologic changes and the related predictors. The study found that fibrotic plaque on optical coherence tomography and index of microcirculatory resistance could predict CAD progression early posttransplant.
CIRCULATION-HEART FAILURE
(2023)
Article
Surgery
Oscar A. Mendiz, Paul Gamboa, Maria F. Renedo, Gustavo A. Lev, Liliana E. Favaloro, Alejandro M. Bertolotti
Summary: Cardiac allograft vasculopathy (CAV) is a fibro-proliferative disease affecting coronary arteries post-heart transplantation. Despite often being clinically silent, IVUS is a reliable and safe technique for detecting angiographically silent CAV in heart transplant patients, with potential long-term clinical impact. Further large multicenter studies are needed to validate these findings.
CLINICAL TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study identified and validated a urinary proteomic signature for the surveillance of cardiac allograft vasculopathy (CAV). The proteins in the signature may offer insights into CAV pathological processes and warrant further investigation into personalized treatment targets.
Review
Immunology
Hanwen Zhang, Zhuonan Li, Wei Li
Summary: Macrophages, as a critical part of the immune system, play important roles in transplantation rejection. M1 and M2 macrophages have different functions in acute and chronic rejection, respectively, contributing to tissue damage and poor allograft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Huijuan Zou, Bingxia Ming, Jun Li, Yifan Xiao, Lin Lai, Ming Gao, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed that HMGB1 contributes to the progression of CAV/fibrosis by promoting the activation of the TGF-β1/Smad signaling pathway, and neutralizing HMGB1 can prolong allograft survival and attenuate fibrosis. Targeting HMGB1 may be a potential therapeutic strategy for inhibiting cardiac allograft fibrosis and dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Roberto Scarsini, Matteo Tebaldi, Francesca Rubino, Sara Sgreva, Giovanni Vescovo, Marco Barbierato, Andrea Vicere, Domenico Galante, Concetta Mammone, Mattia Lunardi, Domenico Tavella, Gabriele Pesarini, Gianluca Campo, Antonio Maria Leone, Flavio Luciano Ribichini
Summary: DM is not associated with an increased risk of vessel-oriented cardiac adverse events (VOCE) in patients undergoing physiology-guided coronary revascularization. However, insulin-dependent diabetes mellitus (IDDM) represents a phenotype at high risk of VOCE.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Surgery
Brian A. Bergmark, Thomas A. Zelniker, Miae Kim, Mandeep R. Mehra, Garrick C. Stewart, Deborah S. Page, Erica L. Woodcome, Michael M. Givertz
Summary: Early aspirin use after orthotopic heart transplantation was associated with lower rates of cardiac allograft vasculopathy, particularly in patients with episodes of allograft rejection.
CLINICAL TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Guillaume Coutance, Eva Desire, Jean-Paul Duong Van Huyen
Summary: Despite advances in immunosuppression, allograft rejection remains a significant complication after heart transplantation. The current invasive diagnostic method has limitations, thus innovative strategies are needed to improve the accuracy of diagnosis.
Article
Materials Science, Multidisciplinary
Cheng Deng, Chenyuan Wang, Wenpei Fu, Lujuan Wu, Qiaofeng Jin, Li Zhang, Wen Zhang, Wei Li, Mingxing Xie
Summary: This study evaluated the efficacy of a FK506-loaded microneedle (FK506 MN) in treating acute rejection in heart transplantation. The results showed that FK506 MN could successfully alleviate acute rejection and prolong allograft survival. In addition, it also reduced T cell and macrophage infiltration as well as the secretion of certain cytokines.
MATERIALS & DESIGN
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sharon Chih, Christiane C. Wiefels, Rob S. B. Beanlands
Summary: Heart transplantation is an effective therapy for end-stage heart disease, but Cardiac allograft vasculopathy (CAV) is a common and life-threatening complication post-transplantation. Cardiac PET shows high diagnostic accuracy for CAV and helps in patient risk stratification.
SEMINARS IN NUCLEAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Roberto Scarsini, Simone Fezzi, Gabriele Pesarini, Paolo Alberto Del Sole, Gabriele Venturi, Concetta Mammone, Michele Marcoli, Alessia Gambaro, Domenico Tavella, Michele Pighi, Flavio Ribichini
Summary: The physiological pattern of disease has an influence on the QFR/iFR discordance, with the physiological pattern being the only variable significantly associated with discordance. QFR demonstrates good diagnostic accuracy in assessing myocardial ischemia independently of the pattern of coronary disease.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Andrea Pacchioni, Antonio Mugnolo, Jorge Sanz Sanchez, Gregory A. Sgueglia, Gabriele Pesarini, Michele Bellamoli, Salvatore Sacca, Flavio Ribichini, Bernhard Reimers, Gabriele Luigi Gasparini
Summary: This study found that the distal radial approach (DRA) significantly reduced the incidence of forearm radial artery occlusion compared to the traditional transradial approach (TRA). DRA showed advantages in reducing time-to-hemostasis and maintaining radial artery blood flow during hemostasis.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Mattia Lunardi, Michele Pighi, Adrian Banning, Bernhard Reimers, Fausto Castriota, Fabrizio Tomai, Gabriele Venturi, Gabriele Pesarini, Roberto Scarsini, Rafail Kotronias, Damiano Regazzoli, Matteo Maurina, Roberto Nerla, Giovanni De Persio, Flavio Luciano Ribichini
Summary: Vascular complications (VC) are a common problem in transcatheter aortic valve implantation (TAVI), affecting about 20% of procedures. This study reports on the incidence, management, and long-term outcomes of VC following TAVI. The results show that major VC have an impact on long-term survival after TAVI, while minor VC do not significantly affect survival. The use of covered stents to manage VC at the access site has no impact on the long-term clinical outcome of TAVI.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Gabriele Venturi, Roberto Scarsini, Michele Pighi, Rafail A. Kotronias, Anna Piccoli, Mattia Lunardi, Paolo Del Sole, Andrea Mainardi, Alessia Gambaro, Domenico Tavella, Giovanni L. De Maria, Rajesh Kharbanda, Gabriele Pesarini, Adrian Banning, Flavio Ribichini
Summary: The volume of contrast to creatinine clearance ratio (CV/CrCl) is a useful indicator of the risk of acute kidney injury (AKI) in patients undergoing percutaneous interventional procedures, and it is associated with adverse outcomes after transcatheter aortic valve implantation (TAVI).
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
G. Castaldi, S. Fezzi, M. Widmann, C. Mammone, F. Rizzetto, M. Lia, D. Prati, M. Pighi, G. Pesarini, D. Tavella, R. Scarsini, F. Ribichini
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Cardiac & Cardiovascular Systems
Roberto Scarsini, Michele Pighi, Andrea Mainardi, Leonardo Portolan, Paolo Springhetti, Concetta Mammone, Francesco Della Mora, Diego Fanti, Domenico Tavella, Leonardo Gottin, Corinna Bergamini, Giovanni Benfari, Gabriele Pesarini, Flavio Luciano Ribichini
Summary: This study found that CMD is more severe in patients with LFLGAS compared with NFHGAS, and it is associated with low-flow state, left atrial dysfunction, and reduced cardiac performance.
Editorial Material
Cardiac & Cardiovascular Systems
Michele Bellamoli, Julien Vanoost, Mariana Goncalves, Enrico Ammirati, Benjamin Honton
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Darren Mylotte, Simone Fezzi
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Curio, Arif A. Khokhar, Alessandro Beneduce, Darren Mylotte, Simone Fezzi, Won-Keun Kim, Adriana Zlahoda-Huzior, Francesco Giannini, Dariusz Dudek
Summary: Valve-in-valve transcatheter aortic valve implantation (TAVI) is a common treatment for failed surgical aortic valves. This study presents a stepwise technique using the ACURATE neo2 valve to optimize commissural alignment in TAVI procedures. The technique was tested using a patient-specific 3D-printed aortic root model and demonstrated successful alignment and implantation.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Simone Fezzi, Daixin Ding, Roberto Scarsini, Jiayue Huang, Paolo Alberto Del Sole, Qiang Zhao, Gabriele Pesarini, Andrew Simpkin, William Wijns, Flavio Ribichini, Shengxian Tu
Summary: This study demonstrated that angiography-derived physiology can provide a reliable assessment of coronary circulation in patients with severe aortic stenosis, showing good accuracy in predicting FFR and stable evaluation results.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Letter
Cardiac & Cardiovascular Systems
Simone Fezzi, William Gibson, Max Wagener, Darragh Murphy, Eileen Coen, Patrick W. Serruys, Yoshinobu Onuma, Faisal Sharif
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Mahmoud Abdelshafy, Ahmed Elkoumy, Hesham Elzomor, Mohammad Abdelghani, Ruth Campbell, Ciara Kennedy, William Kenny Gibson, Simone Fezzi, Philip Nolan, Max Wagener, Shahram Arsang-Jang, Sameh K. Mohamed, Mansour Mostafa, Islam Shawky, Briain MacNeill, Angela McInerney, Darren Mylotte, Osama Soliman
Summary: Membranous septum length and implantation depth are independent predictors of new permanent pacemaker requirement after transcatheter aortic valve implantation (TAVI) using the Evolut platform.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Simone Fezzi, Jiayue Huang, William Wijns, Shengxian Tu, Flavio Ribichini
Summary: Physiology-guided coronary revascularization has been proven effective in improving clinical outcomes, but it may lead to more cardiovascular events in patients with acute coronary syndromes. One major drawback is the potential delay in treating non-flow-limiting but vulnerable coronary plaques. This case report highlights the clinical significance of assessing the physiological severity and plaque vulnerability of non-culprit lesions using novel techniques such as Murray's law-based QFR (muQFR) and radial wall strain (RWS).
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Gianluca Castaldi, Simone Fezzi, Maddalena Widmann, Micaela Lia, Francesca Rizzetto, Concetta Mammone, Sara Pazzi, Solange Piccolo, Verdiana Galli, Michele Pighi, Gabriele Pesarini, Daniele Prati, Valeria Ferrero, Roberto Scarsini, Domenico Tavella, Flavio Ribichini
Summary: The aim of this study was to assess coronary microvascular dysfunction (CMD) in patients with Takotsubo syndrome (TTS) using the angiography-derived index of microcirculatory resistance (IMR) and its correlation with clinical presentation. The results showed that CMD is common in TTS patients and is inversely correlated with left ventricular function.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)