Article
Microbiology
Rowena Alves Coelho, Maria Helena Galdino Figueiredo-Carvalho, Fernando Almeida-Silva, Vanessa Brito de Souza Rabello, Gabriela Rodrigues de Souza, Leandro Stefano Sangenito, Luna Sobrino Joffe, Andre Luis Souza dos Santos, Maria Cristina da Silva Lourenco, Marcio L. Rodrigues, Rodrigo Almeida-Paes
Summary: This study discovered substances with antifungal activity against CBM agents from a collection of drugs previously approved for use in human diseases, and benzimidazoles showed the highest selectivity.
Article
Dermatology
Armando Guevara, Andreia Ferreira Nery, Marcia de Souza Carvalho Melhem, Lucas Bonfietti, Anderson Messias Rodrigues, Ferry Hagen, Jamile Ambrosio de Carvalho, Zoilo Pires de Camargo, Bruna Jacomel F. de Souza Lima, Vania Aparecida Vicente, Rosane Christine Hahn
Summary: Chromoblastomycosis primarily affects the poor population in Brazil, especially those involved in agricultural activities, with F. pedrosoi being the main etiological agent. Itraconazole, voriconazole, and terbinafine showed the highest antifungal activity.
Article
Immunology
Clare Logan, Manuraj Singh, Natalya Fox, Gordon Brown, Sreedhar Krishna, Kristiana Gordon, Derek Macallan, Tihana Bicanic
Summary: Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissue that is difficult to treat. The lack of standardized therapeutic approach and limited evidence for treatment options contribute to its chronicity. This case study presents a successful treatment of a chronic CBM lesion of the hand using a combination of posaconazole and topical imiquimod, an immune response modifier. The clinical and histopathological improvement of the lesion was demonstrated, suggesting the potential of antifungal therapy with adjunctive immunotherapy for CBM.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Luisa Dan Favilla, Tatiana Sobianski Herman, Camila da Silva Goersch, Rosangela Vieira de Andrade, Maria Sueli Soares Felipe, Anamelia Lorenzetti Bocca, Larissa Fernandes
Summary: This study successfully generated a novel mutant of the dematiaceous fungal genus Fonsecaea by gene deletion and homologous recombination. The mutant showed differences in nutrient supply, viability, and growth compared to the wild-type and reconstituted strains. These findings contribute to a better understanding of the biology and pathogenicity of chromoblastomycosis causative agents.
Review
Immunology
Luiz Felipe Domingues Passero, Italo Novais Cavallone, Walter Belda Jr
Summary: Chromoblastomycosis (CBM) is a neglected human disease caused by pigmented dematiaceous fungi, mainly affecting people working in agriculture in low-income countries. Despite some understanding of resistance and susceptibility in CBM, effective vaccines are still lacking. Limited progress has been made in treatment, with the use of immunomodulators showing promise.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Anna Malkova, Irina Dovgaluk, Dmitry Kudlay
Summary: COVID-19 infection affects the detection and immune response of tuberculosis (Tbc), and it is important to understand the immune response alterations in latent tuberculosis infection and in tuberculosis patients with SARS-CoV-2 infection. The findings suggest that COVID-19 may lead to disturbed immune responses and increase the risk of developing severe tuberculosis.
Article
Medicine, Research & Experimental
Le Lv, Ziyang Chen, Wenhui Bai, Jiahui Hao, Zhengang Heng, Caijin Meng, Lin Wang, Xianglan Luo, Xinmiao Wang, Yanjun Cao, Jiao He
Summary: This study aimed to explore the efficacy of THDCA on ulcerative colitis and to reveal its mechanisms of action. The results showed that THDCA can significantly alleviate colitis and exert its effects by regulating the Th1/Th2 and Th17/Treg balance.
Article
Ophthalmology
Xingyi Guo, Weiyu Dang, Na Li, Ying Wang, Deming Sun, Hong Nian, Ruihua Wei
Summary: Fenofibrate can effectively alleviate inflammation in lacrimal glands in a model of autoimmune dry eye, potentially making it a novel therapeutic agent for SS-associated dacryoadenitis by activating the PPAR-alpha/LXR-beta signaling pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Immunology
Mengxian Zhou, Ruyi Qu, Xuewei Yin, Yan Qiu, Yuan Peng, Bin Liu, Yane Gao, Hongsheng Bi, Dadong Guo
Summary: In this study, the regulatory effects of prednisone acetate (PA) on the Th1/Th2 and Th17/Treg balance in experimental autoimmune uveitis (EAU) through modulating the Notch signaling pathway were investigated. The results showed that activation of the Notch signaling pathway resulted in a severe imbalance of the Th17/Treg and Th1/Th2 ratios, while PA treatment significantly alleviated ocular inflammation, inhibited activation of the Notch signaling pathway, and restored the Th1/Th2 and Th17/Treg balance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Mathematics, Interdisciplinary Applications
Qiantong Liang, Wing-Cheong Lo
Summary: This paper investigated a mathematical model of the interactions between Th1 and Th2 cells with Treg cell inhibition and stochastic effects to study the preference of outcomes and noise-induced hopping among different states. The results showed that under small noise effects, the high-Th2-low-Th1 state is more attractive due to the stronger inhibitory effect of Treg cells on Th1 cell development, with the attractiveness of states mainly affected by extrinsic noise in Th2 cell signaling.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Agriculture, Dairy & Animal Science
Guang M. Liu, Jia J. Lu, Wei X. Sun, Gang Jia, Hua Zhao, Xiao L. Chen, Gang Tian, Jing Y. Cai, Rui N. Zhang, Jing Wang
Summary: This study aimed to investigate the effect of AKG on gut immunity in LPS-challenged piglets by modulating the Th17/Treg immune response signaling pathway. The results showed that dietary AKG supplementation improved growth performance, enhanced ileal morphological structure, and regulated the expression of various immune factors, thereby alleviating LPS-induced intestinal inflammation. Therefore, the addition of AKG to the diet can enhance the growth performance of piglets and improve intestinal immunity.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Chemistry, Medicinal
Lei Wang, Xiaoxiao Jia, Qing Yu, Sijia Shen, Yuyan Gao, Xixi Lin, Weixi Zhang
Summary: Piper nigrum extract has a protective role in OVA-induced food allergy by inhibiting Th2 cell response and regulating the Th17/Treg balance.
PHYTOTHERAPY RESEARCH
(2021)
Article
Immunology
Christiane Desel, Peter J. Murray, Christian H. K. Lehmann, Lukas Heger, Dennis Christensen, Peter Andersen, Matthias Mack, Diana Dudziak, Roland Lang
Summary: This study investigated the recruitment of monocytes and neutrophils to the site of injection and draining lymph nodes after vaccination with the TDB-containing adjuvant CAF01 in a protein-based vaccine. Monocytes and neutrophils played different roles in adjuvant-stimulated Th1/Th17 responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Haoran Zhang, Ziqiao Yuan, Ying Zhu, Zihang Yuan, Jie Wang, Cheng Nong, Shaoyun Zhou, Qianhui Tang, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: The study aimed to investigate the role of Th17/Treg imbalance in TP-induced hepatic excessive immune response to exogenous LPS. Results showed that TP led to an excessive immune response in the liver to exogenous LPS, accompanying liver injury and Th17/Treg imbalance.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Thamrong Wongchang, Panwadee Pluangnooch, Suradej Hongeng, Adisak Wongkajornsilp, Dean Thumkeo, Kitipong Soontrapa
Summary: Allergic contact dermatitis (ACD) is a type IV hypersensitivity mediated by Th1/Th17 immune response. A novel immunosuppressant, the DYRK1B inhibitor, was found to reduce ear inflammation and inhibit Th1 and Th17 cell differentiation while promoting Treg differentiation. This is potentially a promising novel agent for ACD treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biophysics
Andre Correa Amaral, Pedro H. Saavedra, Ana Camila Oliveira Souza, Maryanne Trafani de Melo, Antonio Claudio Tedesco, Paulo Cesar Morais, Maria Sueli Soares Felipe, Anamelia Lorenzetti Bocca
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Infectious Diseases
A. M. M. Basso, R. J. A. De Castro, T. B. de Castro, H. Guimaraes, V. L. P. Polez, E. R. Carbonero, V. H. Pomin, C. Hoffmann, M. F. Grossi-de-Sa, A. H. Tavares, A. L. Bocca
Article
Microbiology
Haroldo C. de Oliveira, Luna S. Joffe, Karina S. Simon, Rafael F. Castelli, Flavia C. G. Reis, Arielle M. Bryan, Beatriz S. Borges, Lia C. Soares Medeiros, Anamelia L. Bocca, Maurizio Del Poeta, Marcio L. Rodrigues
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Genetics & Heredity
Amanda Bombassaro, Gabriela X. Schneider, Flavia F. Costa, Aniele C. R. Leao, Bruna S. Soley, Fernanda Medeiros, Nickolas M. da Silva, Bruna J. F. S. Lima, Raffael J. A. Castro, Anamelia L. Bocca, Valter A. Baura, Eduardo Balsanelli, Vania C. S. Pankievicz, Nyvia M. C. Hrysay, Rosana H. Scola, Leandro F. Moreno, Conceicao M. P. S. Azevedo, Emanuel M. Souza, Renata R. Gomes, Sybren de Hoog, Vania A. Vicente
FRONTIERS IN GENETICS
(2020)
Article
Cell Biology
Pedro Henrique Burgel, Clara Luna Marina, Pedro H. V. Saavedra, Patricia Albuquerque, Stephan Alberto Machado de Oliveira, Paulo Henrique de Holanda Veloso Janior, Raffael Araujo de Castro, Heino M. Heyman, Carolina Coelho, Radames J. B. Cordero, Arturo Casadevall, Joshua D. Nosanchuk, Ernesto S. Nakayasu, Robin C. May, Aldo Henrique Tavares, Anamelia Lorenzetti Bocca
MEDIATORS OF INFLAMMATION
(2020)
Article
Microbiology
Clara Luna Marina, Pedro Henrique Burgel, Daniel Paiva Agostinho, Daniel Zamith-Miranda, Lucas de Oliveira Las-Casas, Aldo Henrique Tavares, Joshua Daniel Nosanchuk, Anamelia Lorenzetti Bocca
Article
Infectious Diseases
G. S. Silva, D. A. Silva, F. Guilhelmelli, M. S. Jeronimo, M. R. D. Cardoso-Miguel, P. H. Burgel, R. J. A. Castro, S. A. M. de Oliveira, I Silva-Pereira, A. L. Bocca, A. H. Tavares
Summary: The study shows that using Zymosan can enhance the immune function of phagocytes against Paracoccidioides brasiliensis, contributing to a protective immune response.
Article
Chemistry, Multidisciplinary
Danielle Galdino de Souza, Debora Silva Santos, Karina Smidt Simon, Jose Athayde Vasconcelos Morais, Luisa Coutinho Coelho, Thyago Jose Arruda Pacheco, Ricardo Bentes Azevedo, Anamelia Lorenzetti Bocca, Cesar Augusto Melo-Silva, Joao Paulo Figueiro Longo
Summary: Diets rich in omega-3 fatty acids, such as fish oil, can modulate inflammatory responses and cell membrane composition. This study found that the use of lipid nanoemulsion containing fish oil significantly reduced fibrotic progression and inflammation in an experimental model of pulmonary fibrosis.
Article
Immunology
Lucas de Oliveira Las-Casas, Clara Luna Freitas Marina, Raffael Junio Araujo de Castro, Luisa Coutinho Coelho, Sonia Nair Bao, G. Sybren de Hoog, Vania Aparecida Vicente, Larissa Fernandes, Anamelia Lorenzetti Bocca
Summary: This study demonstrated for the first time that different species of Fonsecaea produce extracellular vesicles (EVs) in response to nutritional conditions, and these EVs can modulate the production of pro- and anti-inflammatory cytokines and nitric oxide by bone marrow-derived macrophages (BMDMs). The size, content, and morphology of the EVs were also affected by growth conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Raffael Junio Araujo de Castro, Marco Tulio Aidar Mariano Rego, Fabiana S. Brandao, Ana Laura Alfonso Perez, Janice Lisboa De Marco, Marcio Jose Pocas-Fonseca, Connie Nichols, J. Andrew Alspaugh, Maria Sueli S. Felipe, Alexandre Alanio, Anamelia Lorenzetti Bocca, Larissa Fernandes
Summary: This research demonstrated that fluorescently tagged Cryptococcus neoformans mutants can be valuable tools for studying the pathogen, improving research efficiency. By studying the mutants, it was found that the engineered fluorescent strains not only exhibit a viable but nonculturable (VBNC) phenotype, but also unveil posttranscriptional mechanisms associated with dormant C. neoformans cells.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Luisa Dan Favilla, Tatiana Sobianski Herman, Camila da Silva Goersch, Rosangela Vieira de Andrade, Maria Sueli Soares Felipe, Anamelia Lorenzetti Bocca, Larissa Fernandes
Summary: This study successfully generated a novel mutant of the dematiaceous fungal genus Fonsecaea by gene deletion and homologous recombination. The mutant showed differences in nutrient supply, viability, and growth compared to the wild-type and reconstituted strains. These findings contribute to a better understanding of the biology and pathogenicity of chromoblastomycosis causative agents.
Article
Endocrinology & Metabolism
Andreia Biolchi Mayer, Henrique de Oliveira Amaral, Danilo Gustavo R. de Oliveira, Gabriel Avohay Alves Campos, Priscilla Galante Ribeiro, Solange Cristina Rego Fernandes, Adolfo Carlos Barros de Souza, Raffael Hinio Araijo de Castro, Anamelia Lorenzetti Bocca, Marcia Renata Mortari
Summary: This study synthesized three bioinspired peptides based on fraternine and tested their effects in a Parkinson's disease model. The peptides fra-10 and fra-14 improved motor coordination, but most of the peptides were toxic at the applied doses. All three peptides reduced the intensity of lesion-induced rotations. The peptide fra-24 increased the number of TH+ neurons in the substantia nigra and reduced the concentration of the cytokine TNF-alpha, suggesting it has neuroprotective effects in Parkinson's disease.
Article
Medicine, Research & Experimental
Theo Ghelfenstein-Ferreira, Anastasia Saade, Alexandre Alanio, Stephane Bretagne, Raffael Araujo de Castro, Samia Hamane, Elie Azoulay, Swann Bredin, Sarah Delliere
Summary: Although invasive pulmonary aspergillosis is more commonly seen in immunocompromised hosts, patients with severe influenza and COVID-19 can also develop this condition. Proper diagnostic tools for invasive aspergillosis in severe COVID-19 patients need to be defined.
MEDICAL MYCOLOGY CASE REPORTS
(2021)