4.6 Article

Broken sleep predicts hardened blood vessels

期刊

PLOS BIOLOGY
卷 18, 期 6, 页码 -

出版社

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3000726

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资金

  1. NHLBI from National Heart, Lung, and Blood Institute [HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]
  2. NCATS [UL1-TR-000040, UL1-TR-001079, UL1-TR001420]
  3. NIH NHLBI [R35HL135818]
  4. NHLBI [R01 HL098433]

向作者/读者索取更多资源

Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common risk factors have been accounted for. Improving sleep quality may thus represent one preventive strategy for lowering inflammatory status and thus atherosclerosis risk, reinforcing public health policies focused on sleep health.

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