Article
Plant Sciences
Emmanuel O. Adeyoju, Clement O. Ajayi, Awodayo O. Adepiti, Anthony A. Elujoba
Summary: This study compared the antimalarial activity of methanol and water extracts of MAMA Powder against Plasmodium berghei-infected mice, finding that the water extract exhibited higher efficacy and can be optimized for chloroquine-resistant malaria, aiding in the production of various dosage forms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Hae Soo Yun, Sylvatrie-Danne Dinzouna-Boutamba, Sanghyun Lee, Zin Moon, Dongmi Kwak, Dong-Il Chung, Yeonchul Hong, Man Hee Rhee, Youn-Kyoung Goo
Summary: The extract of Petasites japonicus shows potential antimalarial effects by inhibiting the proliferation of Plasmodium parasites and improving hematological parameters. These effects may be attributed to the inhibition of platelet activation related to attenuated glycoprotein VI downstream signaling.
Article
Microbiology
Hae-Soo Yun, Sylvatrie-Danne Dinzouna-Boutamba, Sanghyun Lee, Zin Moon, Dongmi Kwak, Man-Hee Rhee, Dong-Il Chung, Yeonchul Hong, Youn-Kyoung Goo
Summary: The study evaluated the antimalarial activity of Ranunculus japonicus extract against different strains of malaria parasites, showing significant inhibition of both chloroquine-sensitive and resistant strains. In infected mice, the extract demonstrated potent antimalarial activity with improved hepatic, renal, and hematologic parameters, indicating no apparent toxicity.
Article
Infectious Diseases
Prapaporn Chaniad, Tachpon Techarang, Arisara Phuwajaroanpong, Natharinee Horata, Abdi Wira Septama, Chuchard Punsawad
Summary: This study aims to identify potential antimalarial drug candidates from the medicinal plant ingredients of the Kheaw Hom remedy. The ethanolic extract of Globba malaccensis rhizomes exhibited promising antimalarial activity both in vitro and in vivo, which could be a starting point for antimalarial drug development.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ali Mijoba, Esteban Fernandez-Moreira, Nereida Parra-Gimenez, Sandra Espinosa-Tapia, Zuleyma Blanco, Hegira Ramirez, Jaime E. Charris
Summary: A series of benzocycloalkanone derivatives were synthesized as potential antimalarial and antitrypanosomal agents. The compounds were prepared through direct coupling of preformed 4-substituted benzaldehyde and indanone or tetralone substitutes using aldol condensation. Only three compounds showed significant antimalarial activity, while all compounds exhibited marginal activity as trypanocidals. Further investigation is warranted for this new class of Michael acceptor agents.
Article
Multidisciplinary Sciences
Gizachew Kassahun Bizuneh, Getnet Tadege, Betelhem Sirak, Abyot Endale Gurmu, Betelhem Anteneh Adamu, Aschalew Mulatu Tefera, Yeniewa Kerie Anagaw
Summary: This study aimed to determine the in vivo antimalarial activity of the 80% methanol extract and solvent fractions of Cucumis ficifolius roots against Plasmodium berghei infection in mice. The results showed that the root extract of Cucumis ficifolius had a promising suppression of parasitemia and potential antiplasmodial activity.
Article
Integrative & Complementary Medicine
Sakaewan Ounjaijean, Voravuth Somsak
Summary: This study evaluated the antimalarial potential of combination dihydroartemisinin (DHA) and Gymnema inodorum leaf extract (GIE) therapy against Plasmodium berghei in a mouse model. The results showed that the 60/40 ratio of DHA and GIE demonstrated significantly higher antimalarial activity and enhanced the antimalarial effects of DHA.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Hegira Ramirez, Jose Dominguez, Esteban Fernandez-Moreira, Juan Rodrigues, Miguel Rodriguez, Jaime E. Charris
Summary: The study successfully synthesized a new series of chalcones and evaluated their antimalarial efficacy. Some of the compounds showed high inhibitory activity and potentially slow down the progression of malaria through inhibition of hemozoin formation. The study also discussed critical aspects of the structure-activity relationship.
Article
Pharmacology & Pharmacy
Jerome Dormoi, Remy Amalvict, Mathieu Gendrot, Bruno Pradines
Summary: The untreated malaria can quickly progress to severe forms, and drug resistance poses a threat to malaria protection efforts worldwide. Therefore, the development of new chemotherapy is necessary. This study contributes new data on the use of methylene blue (MB) in combination with common antimalarial drugs for the treatment of malaria and cerebral malaria. The results show that the combination of MB and AQ is a good candidate for preventing cerebral malaria.
Article
Medicine, Research & Experimental
Atharva R. Bhide, Mansi Suri, Sapna Katnoria, Sukhbir Kaur, Yugandhara B. Jirwankar, Vikas D. Dighe, Anil B. Jindal
Summary: This study evaluated the pharmacokinetics, biodistribution, and antimalarial efficacy of artemether-loaded polymeric nanorods. The results showed that nanorods had higher plasma concentration and lower elimination rate compared to nanospheres. In vitro and in vivo experiments demonstrated that nanorods had better parasitic inhibition and chemosuppression, leading to a higher survival rate in malaria-infected mice compared to free artemether.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Fernanda Valerio Lopes, Pedro Henrique Fazza Stroppa, Juliane Aparecida Marinho, Roberta Reis Soares, Lara de Azevedo Alves, Priscila Vanessa Zabala Capriles Goliatt, Clarice Abramo, Adilson David da Silva
Summary: This study evaluated the antimalarial activity of triazole derivatives, with compound 5 showing promising potential for further development in antimalarial chemotherapy. In vitro and in vivo studies showed that compound 5 had significant parasitemia suppression and minimal cytotoxicity, making it a leading candidate for future research in antimalarial drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Stephenie C. Alaribe, Akolade R. Oladipupo, Goodness C. Uche, Maryan U. Onumba, Duncan Ota, Olufunsho Awodele, Wellington A. Oyibo
Summary: The study evaluated the antimalarial activity of a polyherbal mixture and its constituent plants, showing significant antiplasmodial effects in various assays. While the herbal mixtures demonstrated parasite suppression and prophylaxis comparable to positive controls, they had lower parasite clearance rates. The combination of herbal plants may produce synergistic or additive effects against malaria, suggesting their use as traditional remedies warrant further investigation for clinical usefulness.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Microbiology
Fidelia Ijeoma Uche, Xiaozhen Guo, Jude Okokon, Imran Ullah, Paul Horrocks, Joshua Boateng, Chenggang Huang, Wen-Wu Li
Summary: This study investigates the in vitro and in vivo antiplasmodial activities of BBIQ alkaloids and their analogues, showing promising results with significant anti-parasitic effects at low concentrations. Cycleanine and its semisynthetic analogues demonstrate improved potency and selectivity, with potential as leads for further drug development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Loeki Enggar Fitri, Agustina Tri Endharti, Hafshah Yasmina Abidah, Alif Raudhah Husnul Khotimah, Heni Endrawati
Summary: The study aimed to investigate the effectiveness and cytotoxicity of fractions 14 and 36K of Streptomyces hygroscopicus subsp. Hygroscopicus metabolite extract as antimalarial compounds against Plasmodium berghei in vitro. The results showed that both fractions have antimalarial activity, with fraction 14 having higher potency.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
John Oludele Olanlokun, Mercy Toluwase Ekundayo, Oluwakemi Ebenezer, Neil Anthony Koorbanally, Olufunso Olabode Olorunsogo
Summary: The African Mistletoe plant has anti-malarial properties, with its hexane fraction showing excellent efficacy against both susceptible and resistant strains of malaria parasites. It reduces parasite load, improves hematological parameters, increases heme, and decreases hemozoin content in infected mice. Friedelan-3-one, a major component, may be responsible for this activity.
INFECTION AND DRUG RESISTANCE
(2021)