期刊
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
卷 17, 期 11, 页码 1475-1484出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacr.2020.06.033
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Background: Tumor response to therapy is often assessed by measuring change in liver lesion size between consecutive MRIs. However, these evaluations are both tedious and time-consuming for clinical radiologists. Purpose: In this study, we sought to develop a convolutional neural network to detect liver metastases on MRI and applied this algorithm to assess change in tumor size on consecutive examinations. Methods: We annotated a data set of 64 patients with neuroendocrine tumors who underwent at least two consecutive liver MRIs with gadoxetic acid. We then developed a 3-D neural network using a U-Net architecture with ResNet-18 building blocks that first detected the liver and then lesions within the liver. Liver lesion labels for each examination were then matched in 3-D space using an iterative closest point algorithm followed by Kuhn-Munkres algorithm. Results: We developed a deep learning algorithm that detected liver metastases, co-registered the detected lesions, and then assessed the interval change in tumor burden between two multiparametric liver MRI examinations. Our deep learning algorithm was concordant in 91% with the radiologists' manual assessment about the interval change of disease burden. It had a sensitivity of 0.85 (95% confidence interval (95% CI): 0.77; 0.93) and specificity of 0.92 (95% CI: 0.87; 0.96) to classify liver segments as diseased or healthy. The mean DICE coefficient for individual lesions ranged between 0.73 and 0.81. Conclusions: Our algorithm displayed high agreement with human readers for detecting change in liver lesions on MRI, offering evidence that artificial intelligence-based detectors may perform these tasks as part of routine clinical care in the future. Copyright (C) 2020 American College of Radiology
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