Article
Engineering, Biomedical
Dongkai Zhu, Yangping Liu, Jeremy L. Gilbert
Summary: Adhesion properties of silicone hydrogel contact lenses are crucial for their performance and comfort in the eye. This study developed a new testing method to study adhesive interactions of different silicone contact lenses under dehydrating conditions, highlighting the importance of hydration state on adhesion.
ACTA BIOMATERIALIA
(2021)
Article
Biophysics
Nguyen-Phuong-Dung Tran, Ming-Chien Yang, Phuong Lan Tran-Nguyen
Summary: Silicone hydrogel lenses were prepared by copolymerizing PDMS-PEGMA macromer (PGP) with various substances, showing higher water uptake ability and oxygen permeability. They also exhibited good optical transparency, anti-protein deposition, and non-cytotoxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Ophthalmology
Joanna Stachura, Patryk Mlyniuk, Waldemar Bloch, Alfonso Jimenez-Villar, Ireneusz Grulkowski, Bartlomiej J. Kaluzny
Summary: This study found that continuous wear of silicon hydrogel soft contact lenses can lead to changes in the geometry of the anterior surface of the cornea, particularly in hyperopic patients. The variations in epithelial thickness affect the higher order aberrations of the cornea.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Biophysics
Nguyen-Phuong-Dung Tran, Ming-Chien Yang, Nur Hasanah, Phuong Lan Tran-Nguyen
Summary: Silicone hydrogels were synthesized via photoinitiated free radical polymerization, and their water content and oxygen permeability were linearly proportional to the hydrophilic PEGMA content. High PEGMA content resulted in higher water content, lower oxygen permeability, and lower contact angle.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Ophthalmology
Carlos Carpena-Torres, Cristina Pastrana, Candela Rodriguez-Pomar, Maria Serramito, Gonzalo Carracedo
Summary: This study aims to evaluate the comfort, visual function, and in vivo wettability after inserting hydrogel and silicone hydrogel contact lenses, as well as to determine the appropriate time for evaluating these parameters. The results showed that comfort, high-contrast visual acuity, and contrast sensitivity significantly improved over time, while in vivo wettability declined. Except for comfort and contrast sensitivity, all the parameters stabilized within 10 minutes after inserting the contact lenses. Additionally, there were differences in in vivo wettability and visual acuity between hydrogel and silicone hydrogel contact lenses.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Chemistry, Applied
Dandan Liu, Yipeng Zang, Ziwei Hu, Chenrui Yu, Zhenxing Han, Mengmeng Wang, Maodong Xu, Xiaofeng Zhao, Wenjin Yue, Guangjun Nie
Summary: KH-570@HEMA hydrogel was synthesized to balance vision correction and drug sustained release in drug-loaded soft contact lens. The hydrogel composition was optimized using conditional maximum method, achieving high transmittance, oxygen permeability and wettability. Molecular imprinting technique improved the loading capacity and release time, potentially solving the issue of drug-loaded SCLs.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Engineering, Biomedical
Tomasz Sulinski, Natalia Nowak, Jedrzej Szymanski, Jacek Pniewski
Summary: This paper describes the surface differences of a range of silicone-hydrogel lenses using reflectance confocal microscopy, and reveals that light reflection is correlated with material parameters such as water content and surface modulus. The proposed analysis method allows for differentiation between lenses with and without surface modifications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Ophthalmology
Hiroko Iwashita, Takashi Itokawa, Takashi Suzuki, Yukinobu Okajima, Koji Kakisu, Yuichi Hori
Summary: The measured contact angles (CAs) on soft contact lenses (SCLs) were affected by the use of 2-MPC solutions and hyaluronate acid (HA), with silicone hydrogel SCLs showing higher CAs. The interaction between tear supplements and SCLs may vary based on ingredient agents, surface treatment of the lenses, and components of the supplements.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Angel Sanchez-Garcia, Javier Gonzalez-Perez
Summary: The study evaluated the positioning, recovery time, and decentration of various designs of toric silicone-hydrogel contact lenses at different times. Results showed differences in performance among the lenses, with Air Optix Aqua for Astigmatism and Biofinity Toric showing better outcomes in decentration and recovery.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Chemistry, Physical
Akihiro Hiroki, Atsushi Kimura, Mitsumasa Taguchi
Summary: With the expansion of global use and market of soft contact lenses (SCLs), contamination by disposable SCLs has become a potential threat to the environment. This study developed new biodegradable SCL materials based on plant-derived cellulose using a radiation crosslinking technique. The highly transparent hydrogels obtained showed excellent physicochemical and biological properties.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Anepmete Wong, Melissa Fallon, Vildan Celiksoy, Salvatore Ferla, Carmine Varricchio, David Whitaker, Andrew J. Quantock, Charles M. Heard
Summary: This study investigated a composite drug delivery system to enhance the corneal delivery of econazole for the treatment of fungal keratitis. The results showed that this delivery system significantly increased the amount of drug delivered to the cornea, potentially improving the clinical response to fungal keratitis.
Article
Polymer Science
Amel Oucif, Nabila Haddadine, Dria Zakia, Naima Bouslah, Ahmed Benaboura, Khaled Beyaz, Bendiba Guedouar, M. Samy El-Shall
Summary: Different ratios of poly (HEMA-co-HEA) hydrogels were successfully prepared for therapeutic soft contact lenses applications, with the hydrogels containing HEA showing improved microstructure and swelling capacity. In vitro studies revealed a non-Fickian drug release behavior for all hydrogel ratios, with the 40/60 ratio exhibiting the highest drug release/loading capacity. These findings suggest that the corresponding hydrogel is a promising material for sustainable drug release in curative SCLs.
Article
Multidisciplinary Sciences
Malake Sarmout, Yutang Xiao, Xiao Hu, Aiym Rakhmetova, Leo H. Koole
Summary: Soft contact lenses are being explored as a method for delivering ophthalmic drugs. Traditional methods have limitations, but this study introduces a new asymmetric drug loading method using polymeric microparticles. The drug is transferred from the lens to the cornea, resulting in higher drug absorption compared to eye drops. This new method offers a practical and reproducible means of delivering ophthalmic drugs through soft contact lenses.
Article
Ophthalmology
Deniz Ozarslan Ozcan, Sait Coskun Ozcan
Summary: This study evaluated the efficacy of two silicone-hydrogel contact lenses as bandages after corneal crosslinking surgery. The Lotrafilcon B lens showed significantly smaller epithelial defect sizes on post-operative Day 1 and Day 2 compared to the Balafilcon A lens. There was no significant difference in re-epithelialization time and pain levels between the two lens types.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2021)
Review
Environmental Sciences
Shalini Sanyal, Venkatesh Ravula
Summary: Pesticide exposure leads to deterioration of ocular health and various eye conditions such as irritation, tear overproduction, surface abrasions, and decreased visual acuity. Eye tissues absorb pesticides more quickly and are more susceptible to damage. Current methods of mitigating pesticide-induced toxicity, such as topical eye drops, have limited efficacy due to low bioavailability and short duration. Contact lenses and nanoparticle-based drug delivery systems show promise in increasing bioavailability and prolonging drug effects. This review focuses on the futuristic aspects of using contact lenses for drug delivery and corneal protection from ocular toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)