Article
Chemistry, Inorganic & Nuclear
Zhen-Feng Wang, Xiao-Ling Nai, Yue Xu, Feng-Hua Pan, Fu-Shun Tang, Qi-Pin Qin, Lin Yang, Shu-Hua Zhang
Summary: Four novel rhodium(iii) complexes were synthesized and found to exhibit selective cytotoxicity against cisplatin-resistant lung carcinoma cells. One of the complexes, a fluorescent imaging agent, showed high anticancer activity in the cell nucleus.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Yan Yang, Cheng-Ming Wang, Feng-Hua Pan, Qi-Pin Qin, Qiu-Ji Xie, Qing Chen, Hong Liang
Summary: The newly synthesized cyclometallated Ir(III)-quinoline complexes exhibit potent anticancer activity and can serve as specific cell imaging probes, efficiently inducing apoptosis and autophagy, with potential value in inhibiting tumor growth.
DALTON TRANSACTIONS
(2021)
Article
Immunology
Jun-Jian Lu, Zhi-Chang Xu, Hou Zhu, Lin-Yuan Zhu, Xiu-Rong Ma, Rui-Rui Wang, Rong-Tao Li, Rui-Rong Ye
Summary: In this study, a series of cyclometalated iridium(III) complexes and polypyridyl ruthenium(II) complexes were synthesized and their antifungal activities against drug-resistant Candida albicans were investigated, as well as their combination therapy with fluconazole (FLC). Among them, the combination of iridium(III) complex Ir2 and FLC showed strong antifungal activity. Mechanism studies revealed that they could inhibit hyphae and biofilm formation, damage mitochondrial function, and accumulate intracellular ROS. Thus, the combination therapy of iridium(III) complexes with FLC holds promise for improving the treatment efficiency of fungal infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jian Zhao, Ya Gao, Weiyu He, Wei Wang, Weiwei Hu, Yanyan Sun
Summary: The study developed two iridium(III) compounds, Ir-1 and Ir-3, containing glutathione S-transferase inhibitor (GSTi) for cancer treatment. These complexes exhibited synergistic effects in inhibiting cancer cells. The cytotoxicity of Ir-1 and Ir-3 was found to be higher than unfunctionalized iridium compounds Ir-2 and Ir-4, and they exerted their effects by generating ROS and inhibiting GST activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Paulina Kalle, Marina A. Kiseleva, Sergei Tatarin, Daniil E. Smirnov, Alexander Y. Zakharov, Viktor V. Emets, Andrei Churakov, Stanislav Bezzubov
Summary: The study investigates the structural, electronic, and optical properties of N-unsubstituted and N-methylated 2-(2-thienyl)perimidines using DFT/TDDFT calculations. The results show that these ligands have the potential to be used in the construction of light-harvesting iridium(III) complexes. The resulting iridium(III) dye exhibited panchromatic absorption up to 1000 nm and performed well in dye-sensitized solar cells.
Review
Chemistry, Multidisciplinary
Yan-Lin Li, Ai-Juan Li, Sheng-Li Huang, Jagadese J. Vittal, Guo-Yu Yang
Summary: This review focuses on the design and syntheses of Ru(N^N)3 and Ir(C^N)2(X^N) functionalized architectures of metal-organic frameworks (MOFs), covalent-organic frameworks (COFs), metallasupramolecules, organic supramolecules and supramolecular organic frameworks (SOFs), as well as their photocatalytic applications.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Jiayi Zhu, Yan Liu, Zhao Zhang, Xili Yang, Feng Qiu
Summary: In this study, we designed and synthesized two complexes as photosensitizers, which exhibited strong phosphorescence and high toxicity against cancer cells. These complexes rapidly accumulated in lysosomes after entering cancer cells, and when exposed to light irradiation, they produced a large amount of oxidizing stress substances, eventually leading to cancer cell death. This provides promising potential application in photodynamic therapy.
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Morris E. Olumba, Hanah Na, Alan E. Friedman, Thomas S. Teets
Summary: In this study, a facile [4 + 4] coordination-driven self-assembly of cyclometalated iridium(III) using linear aryldiisocyanide bridging ligands (BLs) is demonstrated. A family of nine new [Ir(C^N)2(μ-BL)](4)(4+) coordination cages was prepared with isolated yields of 40-83%, and detailed photophysical studies revealed the nature of the luminescent triplet states in these complexes. This work illustrates that aromatic diisocyanide ligands enable coordination-driven assembly of inert iridium(III) nodes under mild conditions, producing supramolecular coordination complexes with desirable photophysical properties.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Hongdong Shi, Yi Wang, Simin Lin, Jingxue Lou, Qianling Zhang
Summary: Iridium complexes are widely used as molecular sensors due to their rich photophysical properties, such as large Stokes shifts, long emission lifetimes, environment-sensitive emissions, and high luminescence quantum yields. This paper reviews the recent development and application of iridium complexes as probes for various substances, and discusses the outlook for iridium-based probes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Simon De Kreijger, Olivier Schott, Ludovic Troian-Gautier, Emilie Cauet, Garry S. Hanan, Benjamin Elias
Summary: Two new cyclometalated Ir(III) diimine complexes were used as photosensitizers for homogeneous hydrogen evolution reaction, showing high stability and efficiency compared to previous systems.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Angela Vivancos, Delia Bautista, Pablo Gonzalez-Herrero
Summary: This study reports the synthesis, structure, photophysical properties, and electrochemistry of the first series of Pt(IV) tris-chelates bearing cyclometalated aryl-NHC ligands. The complexes exhibit significant photostability, long-lived phosphorescence, and potential application for Pt(IV) emitters with tunable properties.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jing Yang, Hao-Ji Fang, Qian Cao, Zong-Wan Mao
Summary: The cytometalated iridium(III)-metformin conjugates were synthesized for the first time to treat hypoxic cancer cells by alleviating hypoxia through mitochondria respiration inhibition. They display 10-fold higher cytotoxicity, emerging anti-metastasis, and anti-inflammatory activities compared to a metformin-free Ir(III) complex and cisplatin against hypoxic cancer cells.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Mansoor Akhtar, Ali Muhammad Arif, Shifa Ullah Khan, Guo-Gang Shan, Hong-liang Xu, Zhong-Min Su
Summary: Density functional theory calculations were employed to investigate the geometric structures, electronic properties, and second-order nonlinear optical (NLO) properties of two synthesized iridium(iii) complexes with different substituted ancillary ligands. The first hyperpolarizabilities were found to be easily modulated by the introduction of different units, and the changes in properties could be qualitatively explained by means of the charge transfer pattern. The theoretical investigation of these complexes is expected to aid in designing high-performance and versatile NLO materials.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Sohnel, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: In this study, organometallic complexes with a piano-stool structure and di- or tridentate ligand systems were reported, showing improved biological activity and impact on cytotoxic activity.
INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
R. Nishanth Rao, Sushovan Jena, Manjima Mukherjee, Barnali Maiti, Kaushik Chanda
Summary: Heterocyclic moieties are essential for 80% of commercial medicines, yet many synthetic methods are not sustainable, prompting the need for eco-friendly strategies like microwave-assisted synthesis and nanoparticle-catalysed synthesis. Other sustainable methods include solvent-free synthesis, ionic liquid-supported synthesis, organic synthesis in water, sonochemical synthesis, and combinatorial synthesis.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Editorial Material
Oncology
Kaushik Chanda
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Ramdas Nishanth Rao, Kaushik Chanda
Summary: 2-Aminopyridine is a versatile moiety for synthesizing diverse biological molecules, with a simple design, low side reactions, and easy identification of toxicity-causing metabolites.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Remya Kopilakkal, Kaushik Chanda, Musuvathi Motilal Balamurali
Summary: This study aimed to isolate, characterize, and evaluate the hepatoprotective potential of Clerodendrum paniculatum flower extracts. The alcoholic extract showed high antioxidant potential and hepatoprotective effects, reducing levels of liver enzymes and improving protein content. Analyses revealed the presence of key constituents responsible for the hepatoprotective activity, suggesting better activity in isolated fractions with rich flavonoid content.
Article
Chemistry, Multidisciplinary
Sreerama Rajasekhar, Soumyadip Das, Ramanathan Karuppasamy, Balamurali Musuvathi Motilal, Kaushik Chanda
Summary: In this study, a series of thiazolidine derivatives were evaluated for their inhibitory effects using structure-based drug design. Different scoring utilities and molecular dynamics simulations were used to assess the improved screening progress. The potential of the compounds 1k and 1j as effective inhibitor candidates for tuberculosis treatment were revealed through machine learning algorithms.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Soumyadip Das, Kaushik Chanda
Summary: The effective synthesis of noble-metal nanocrystals with controllable shapes allows for manipulation of their physicochemical characteristics and improvement of their performance in various applications. The shapes of nanocrystals play a crucial role in their facet-dependent catalytic activity and have a significant impact on organic synthesis. This review paper provides a comprehensive overview of recent developments in the synthesis of noble-metal nanocrystals and their catalytic activities in organic synthesis.
Article
Biochemistry & Molecular Biology
Upala Dasmahapatra, Sreerama Rajasekhar, Grandhe Neelima, Barnali Maiti, Ramanathan Karuppasamy, Poornima Murali, M. M. Balamurali, Kaushik Chanda
Summary: This study designed 16 new disubstituted 1,3-thiazetidines derivatives and evaluated their potential as anti-tubercular agents using in silico methods. The results showed that several compounds could be effective anti-tubercular agents. These findings have implications for the development of safer and non-toxic drugs against tuberculosis.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Chemistry, Inorganic & Nuclear
Md. Gulzar Ahmad, Kaushik Chanda
Summary: The dramatic rise in population has led to an increased demand for raw materials and energy assets, but these resources cannot be easily provided in the same shares. Ionic liquid-supported metal catalysts have demonstrated excellent performance in organic synthesis and are more efficient, environmentally friendly, cost-effective, and reusable compared to other types of metal catalysts.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Brindha Jayachandran, Thansila N. Parvin, M. Mujahid Alam, Kaushik Chanda, M. M. Balamurali
Summary: Protein crosslinking is essential for the fabrication of biomaterials, and the chemical method is widely used, involving the formation of bonds between proteins and chemical compounds. This review discusses various protein crosslinking strategies, reactions, properties, and applications.
Article
Chemistry, Physical
Prabhakara Madivalappa Davanagere, Mrinmoy De, Kaushik Chanda, Barnali Maiti
Summary: An efficient and novel bifunctional ionic liquid-supported (S)-proline organocatalyst was developed for the synthesis of highly functionalized tetrahydropyridines. The reaction involved five components and allowed for the simultaneous generation of five bonds and two stereogenic centers with excellent diastereo- and enantioselectivities. The catalyst could be recycled five times without significant loss of activity.
Article
Chemistry, Organic
Soumyadip Das, Kaushik Chanda
Summary: An ongoing challenge in the pharmaceutical sector is developing sustainable synthesis methods for benzimidazoles, which are important building blocks for pharmacologically active molecules. This study introduces a one-pot telescopic approach using a deep eutectic solvent (DES) medium to synthesize disubstituted benzimidazole derivatives. By utilizing choline chloride/glycerol/H2O as the DES medium, the best performance was achieved in terms of reaction efficiency. The findings provide an alternative synthetic technique for the efficient synthesis of disubstituted benzimidazoles.
SYNTHESIS-STUTTGART
(2023)
Review
Chemistry, Multidisciplinary
Sushovan Jena, Kaushik Chanda
Summary: Heterocyclic moieties are important in drug discovery, and C-N and C-O bond formation reactions are the main synthetic sequence for generating heterocyclic molecules. However, there are challenges in these reactions, such as expensive ligands, limited substrate scope, waste generation, and high temperature conditions. Therefore, it is crucial to uncover new eco-friendly synthetic strategies using microwave-assisted synthesis, which offers shorter reaction time, tolerance for functional groups, and less waste production. This review article provides a comprehensive overview of the potential application of microwave-assisted synthetic routes for the synthesis of diverse heterocycles via mechanistic pathways.
Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Md Gulzar Ahmad, M. M. Balamurali, Kaushik Chanda
Summary: The Click reaction involving Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) is a powerful tool for developing complex architectures. It has facilitated the synthesis of drug molecules with enhanced flexibility, reliability, specificity, and modularity. Click chemistry has been widely applied in organic synthesis, particularly in reactions with biocompatible precursors. In pharmaceutical research, it is extensively used for drug delivery applications due to its biocompatibility and inertness towards other biological components. This review discusses the applications and uniqueness of various click-derived transition metal complexes, as well as the potential of Click chemistry in other applied sciences.
CHEMICAL SOCIETY REVIEWS
(2023)