Article
Public, Environmental & Occupational Health
P. Lloyd-Hazlegreaves, L. Hayes, M. S. Pearce
Summary: This study explores the relationship between physical inactivity and dementia prevalence using global data. The findings suggest a positive association between inactivity and dementia, with a stronger relationship in men than in women. The study highlights the importance of public health interventions to improve physical activity levels and reduce the risk of dementia on a global scale.
Review
Clinical Neurology
Natan Feter, Jayne S. Leite, Luisa Silveira da Silva, Julia Cassuriaga, Danilo de Paula, Gabriela Wunsch Lopes, Pedro Rodrigues Curi Hallal, I-Min Lee, Airton Jose Rombaldi
Summary: This review examines the impact of physical inactivity on dementia and finds that the overall impact ranges from 6.6% to 16.6%.
ALZHEIMERS & DEMENTIA
(2023)
Article
Behavioral Sciences
Jimmy Kim, Jonghyuk Park, Toshio Mikami
Summary: This study investigates the effect of physical inactivity on cognitive function and a depressive-like state in mice using a novel housing cage called the physical inactivity (PI) cage. The results show that physical inactivity leads to a decline in cognitive function and the onset of a depressive-like state, while regular low-intensity exercise can prevent these negative effects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Weixin Li, Kun-Woo Rafael Kim, Donglan Zhang, Bian Liu, Christine M. Dengler-Crish, Ming Wen, Lu Shi, Xi Pan, Yian Gu, Yan Li
Summary: This study aimed to summarize evidence on the cost-effectiveness of physical activity interventions to prevent and manage cognitive decline and dementia. The findings suggest that physical activity interventions can be cost-effective in individuals without dementia, but the results are mixed for individuals with existing dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Ignacio Stingl-Zuniga, Claudio Farias-Valenzuela, Paloma Ferrero-Hernandez, Adilson Marques, Leandro F. M. Rezende, Antonio Castillo-Paredes, Carlos Cristi-Montero, Kabir P. Sadarangani, Gerson Ferrari
Summary: By analyzing data from a Chilean National Health Survey, this study found that reducing sitting time and increasing physical activity could prevent a significant number of deaths in Chilean adults. Specifically, reducing sitting time to less than 4 hours per day and maintaining physical activity could prevent approximately 10,477 deaths or 9.5% of all deaths.
Article
Behavioral Sciences
Jonghyuk Park, Jimmy Kim, Toshio Mikami
Summary: A lack of physical exercise can lead to cognitive decline and mental deterioration, while regular exercise can improve these symptoms. Irisin has been identified as an exercise-inducible myokine that improves cognitive impairment. Plasma irisin levels increase during exercise, and a lack of exercise may reduce plasma irisin levels, leading to a decline in cognitive function.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Cell Biology
Josh Turknett, Thomas R. Wood
Summary: This article highlights the importance of lifestyle and environment in the development of Alzheimer's Disease. It suggests that previous approaches focusing solely on biological processes have been inadequate, and calls for a holistic approach that incorporates cognitive demand as a primary factor for intervention.
Article
Behavioral Sciences
Felipe Jacques Sanches, Jessica Cardia de Melo, Sabrina Palha Ferreira, Luzia Aparecida Trinca, Omar Gurrola Arambula, Flavia Helena Pereira Padovani, Arthur Oscar Schelp, Rogerio Martins Amorim
Summary: Episodic memory in elderly dogs declines similar to humans, regardless of gender and size, which may be related to the physiological aging process or preclinical pathological manifestation of cognitive impairment. Further studies are needed to evaluate episodic-like memory in dogs with canine cognitive dysfunction syndrome to better understand its physiological and pathological behavior in canine species.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Wenyi Li, Jiwei Jiang, Xinying Zou, Yuan Zhang, Mengfan Sun, Ziyan Jia, Wei Li, Jun Xu
Summary: This study aimed to investigate the potential risk factors and cerebral perfusion in patients with subjective cognitive decline (SCD). The results showed that family history of dementia and higher cerebral blood flow in the left parahippocampal gyrus were independently associated with SCD.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Cell Biology
N. F. Shur, L. Creedon, S. Skirrow, P. J. Atherton, I. A. MacDonald, J. Lund, P. L. Greenhaff
Summary: In the UK, it is projected that by 2035, people over the age of 65 will make up 23% of the population, with those over 85 accounting for 5%. Ageing is associated with changes in muscle metabolism and structure, but it is unclear how much of these changes are due to aging itself or sedentary behavior. Research on aging, physical activity, and muscle health is crucial for understanding the aging process and improving overall well-being.
AGEING RESEARCH REVIEWS
(2021)
Review
Nutrition & Dietetics
Ligia J. Dominguez, Nicola Veronese, Laura Vernuccio, Giuseppina Catanese, Flora Inzerillo, Giuseppe Salemi, Mario Barbagallo
Summary: A combination of factors contribute to cognitive decline, with age being the main independent risk factor. Prevention of cognitive decline and dementia emphasizes the crucial role of diet, physical activity, and lifestyle factors.
Article
Clinical Neurology
Maud M. van Dinther, Astrid E. Hooghiemstra, Esther Bron, Adriaan E. Versteeg, Anna Leeuwis, Tugba E. Kalay, Justine Moonen, Sanne H. Kuipers, Walter Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie J. Staals, Robert van Oostenbrugge, Heart-Brain Connection consortium
Summary: Impaired cerebral blood flow (CBF) at baseline is associated with faster cognitive decline in VCI and normal aging. Our results suggest that low CBF precedes and contributes to the development of vascular cognitive impairment. CBF determined by ASL might be used as a biomarker to monitor disease progression or treatment responses in VCI.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Multidisciplinary
Marina Maffoni, Antonia Pierobon, Cira Fundaro
Summary: This paper proposes a new screening tool called MASCoD, with English and Italian versions, and explores its preliminary adoption on a pilot sample. The tool shows promise in helping professionals make differential diagnosis and predict the risk of developing severe cognitive impairment over time, allowing for personalized care. It is brief, easily embeddable in usual clinical assessment, and can be administered by different professionals.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Feifei Jia, Yanyan Li, Min Li, Fenglin Cao
Summary: The study found that cognitive reserve can attenuate the association between subjective cognitive decline and the risk of developing dementia. Particularly in the low cognitive reserve group, the association between subjective cognitive decline and dementia was more significant.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Sara Mondini, Veronica Pucci, Sonia Montemurro, Raffaella Ida Rumiati
Summary: This study highlights the importance of education and occupation in predicting cognitive performance in older adults, with higher levels of education and occupation associated with better resistance to cognitive decline. Cognitive reserve plays a crucial role in predicting performance across different levels of cognitive ability.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Inge Scheper, Roy P. C. Kessels, Inti A. Brazil, Dirk Bertens
Summary: This study investigated the effects of errorless learning (EL) compared to trial-and-error learning (TEL) on memory performance in patients with acquired brain injury (ABI) and healthy controls. The results showed that EL was beneficial for memory performance in both ABI patients and controls, and this advantage was not influenced by the amount of errors made during learning.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Clinical Neurology
Ralf W. J. Weijs, Daria A. Shkredova, Anna C. M. Brekelmans, Dick H. J. Thijssen, Jurgen A. H. R. Claassen
Summary: This study systematically reviewed and meta-analyzed longitudinal studies to examine the relationship between global cerebral blood flow (CBF) changes and cognitive decline in subjects with Alzheimer's disease. Although cross-sectional studies found lower CBF in patients with cognitive decline, longitudinal studies did not support this association. However, the small sample sizes of these studies may have limited their power to detect small effect sizes, and larger studies are needed to further investigate this issue.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Liselotte De Wit, Roy P. C. Kessels, Andrea M. Kurasz, Priscilla Amofa, Deirdre O'Shea, Michael Marsiske, Melanie J. Chandler, Vitoria Piai, Taylor Lambertus, Glenn E. Smith
Summary: This study examines the differences in declarative learning, conceptual repetition priming, and procedural learning between individuals with aMCI and cognitively unimpaired controls. The results show significant differences in declarative learning, moderate differences in conceptual repetition priming, and minimal differences in procedural learning. These findings suggest that individuals with aMCI may retain intact procedural learning abilities.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Review
Endocrinology & Metabolism
Ronney B. Panerai, Patrice Brassard, Joel S. Burma, Pedro Castro, Jurgen A. H. R. Claassen, Johannes J. van Lieshout, Jia Liu, Samuel Je Lucas, Jatinder S. Minhas, Georgios D. Mitsis, Ricardo C. Nogueira, Shigehiko Ogoh, Stephen J. Payne, Caroline A. Rickards, Andrew D. Robertson, Gabriel D. Rodrigues, Jonathan D. Smirl, David M. Simpson
Summary: This study improved the evaluation method of cerebral autoregulation (CA) by introducing guidelines for data acquisition, analysis, and reporting, and proposed new recommendations to reflect recent advances in the field. The implementation of these recommendations is crucial for improving the reliability and reproducibility of studies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Geriatrics & Gerontology
Dorien L. Oostra, Wouter L. Vos, Marcel G. M. Olde Rikkert, Minke S. Nieuwboer, Marieke Perry
Summary: This study aimed to develop and pilot test a digital monitoring tool (REMIND) for the wellbeing and resilience of informal caregivers in dementia care, in order to provide timely support and prevent caregiver burden and crisis admissions of persons with dementia.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Psychiatry
Mina A. Jacob, Mengfei Cai, Vera van de Donk, Mayra Bergkamp, Jose Marques, David G. Norris, Roy P. C. Kessels, Jurgen A. H. R. Claassen, Marco Duering, Anil M. Tuladhar, Frank-Erik de Leeuw
Summary: The study investigated the relationship between baseline severity and progression of cerebral small vessel disease (SVD) on MRI markers and incident dementia over a 14-year follow-up period. The results showed that both baseline SVD severity and SVD progression were independently associated with an increased risk of all-cause dementia. Slowing SVD progression may delay the onset of dementia.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Endocrinology & Metabolism
Rachel A. M. Heutz, Ralf W. J. Weijs, Rianne A. A. de Heus, Jurgen A. H. R. Claassen
Summary: We discussed the current evidence of antihypertensive treatment in people with dementia, exploring both the potential benefits and harms. Our conclusion is that there is insufficient evidence to support the claim of an increased risk of cerebral hypoperfusion with antihypertensive treatment in dementia, and there is growing evidence contradicting this claim.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Psychology
Inge Scheper, Inti A. Brazil, Jurgen A. H. R. Claassen, Dirk Bertens, Sofie Geurts, Roy P. C. Kessels
Summary: Alzheimer's disease leads to a decline in memory and learning ability. This study investigated the impact of positive and negative feedback on memory performance and behavior adjustment in early-stage AD patients. Results showed that errorless learning had a beneficial effect on memory performance, but this effect was not significantly different between AD patients and healthy controls. No group differences were found in the probabilistic learning task. Errors during learning may interfere with storage or retrieval of object locations for AD patients.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Kamran Abbasi, Parveen Ali, Virginia Barbour, Kirsten Bibbins-Domingo, Marcel G. M. Olde Rikkert, Andy Haines, Ira Helfand, Richard Horton, Bob Mash, Arun Mitra, Carlos Monteiro, Elena N. Naumova, Eric J. Rubin, Tilman Ruff, Peush Sahni, James Tumwine, Paul Yonga, Chris Zielinski
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Editorial Material
Obstetrics & Gynecology
Kamran Abbasi, Parveen Ali, Virginia Barbour, Kirsten Bibbins-Domingo, Marcel G. M. Olde Rikkert, Andy Haines, Ira Helfand, Richard Horton, Bob Mash, Arun Mitra, Carlos Monteiro, Elena N. N. Naumova, Eric J. J. Rubin, Tilman Ruff, Peush Sahni, James Tumwine, Paul Yonga, Chris Zielinski
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Nursing
Kamran Abbasi, Parveen Ali, Virginia Barbour, Kirsten Bibbins-Domingo, Marcel G. M. Olde Rikkert, Peng Gong, Andy Haines, Ira Helfand, Richard C. Horton, Bob Mash, Arun Mitra, Carlos A. Monteiro, Elena N. Naumova, Eric J. Rubin, Tilman A. Ruff, Peush Sahni, James Tumwine, Paul Yonga, Chris Zielinski
INTERNATIONAL NURSING REVIEW
(2023)
Article
Geriatrics & Gerontology
Liza De Dobbeleer, Myrthe Manouk Swart, Merle Anne Joelle Geerds, Remco Johan Baggen, Anne-Jet Sophie Jansen, Rudi Tielemans, Hugo Silva, Siddhartha Lieten, Kurt Barbe, Geeske Peeters, Miriam Marie Rose Vollenbroek-Hutten, Rene Johannes Franciscus Melis, Ivan Bautmans
Summary: The Eforto (R) system, consisting of a rubber bulb connected to a smartphone app and a telemonitoring platform, was developed for (self-)monitoring grip strength and muscle fatigability. The validity and reliability of Eforto (R) in measuring muscle fatigability were evaluated in older community-dwelling individuals and hospitalized patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Geeske Peeters, Almar A. L. Kok, Simone de Bruin, Cretien van Campen, Maud Graff, Minke Nieuwboer, Martijn Huisman, Barbara van Munster, Eddy van der Zee, Martien J. Kas, Marieke Perry, Debby L. Gerritsen, Elisabeth Vreede-Chabot, Anne-Mei The, Hein P. J. van Hout, Franka C. Bakker, Wilco P. Achterberg, Jenny T. van der Steen, Carolien Smits, Rene Melis, Marcel G. M. Olde Rikkert
Summary: The concept of resilience, which refers to the system's ability to bounce back after stress, is gaining interest across various fields. This paper argues that resilience is relevant throughout all stages of cognitive decline, and a socioecological, multisystem perspective is needed to understand and support individuals with cognitive decline. The paper provides evidence and examples to substantiate this argument. Resilience can help to understand responses to risk factors and inform personalized prevention, as well as interventions to strengthen recovery and coping mechanisms in care for people with cognitive decline. The application of resilience in this field opens new horizons for research and improving health and social care for the increasing population with cognitive decline.
Article
Geriatrics & Gerontology
Anna Martine Petronella Verwiel, Martin Pulvermann, Nadine Heleen Smit, Rene Johannes Franciscus Melis
Summary: The validity and reliability of two versions of a frailty index (FI) based on the short form (SF) of the TOPICS-MDS questionnaire were assessed in this study. It was found that the reliability of the TOPICS-SF-FI depends on the presence of disease information.
EUROPEAN GERIATRIC MEDICINE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Roel Boumans, Rene Melis, Tibor Bosse, Serge Thill
Summary: Social robots capable of verbal dialogues have been shown to be potentially useful in explaining medical tests and procedures. A study conducted at a music festival and medical institutions demonstrated that participants were satisfied with the explanations provided by the social robots, and their clarity ratings increased after undergoing the actual physical examinations.
COMPANION OF THE ACM/IEEE INTERNATIONAL CONFERENCE ON HUMAN-ROBOT INTERACTION, HRI 2023
(2023)