Review
Medicine, Research & Experimental
Wendi Wang, Wei Lei, Lina Jiang, Siqi Gao, Shijun Hu, Zi-Gang Zhao, Chun-Yu Niu, Zhen-Ao Zhao
Summary: MSCs, derived from various sources and with low immunogenicity, have been widely used for the treatment of ARDS. Recent studies suggest that MSCs can ameliorate ARDS through multiple mechanisms, such as modulating immune/inflammatory cells, attenuating endoplasmic reticulum stress, and inhibiting pulmonary fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Ju-Pi Li, Kang-Hsi Wu, Wan-Ru Chao, Yi-Ju Lee, Shun-Fa Yang, Yu-Hua Chao
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has posed a significant global public health challenge. Despite mass vaccination, the emergence of novel viral variants has increased the risks of reinfections and vaccine breakthrough infections. Cytokine storm leading to acute respiratory distress syndrome is the major cause of mortality in COVID-19 patients. Mesenchymal stem cells (MSCs) have immunomodulatory, tissue repair, and antiviral properties, making them a potential treatment for COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Critical Care Medicine
Ellen A. Gorman, Jennifer Rynne, Hannah J. Gardiner, Anthony J. Rostron, Jonathan Bannard-Smith, Andrew M. Bentley, David Brealey, Christina Campbell, Gerard Curley, Mike Clarke, Ahilanadan Dushianthan, Phillip Hopkins, Colette Jackson, Kallirroi Kefela, Anna Krasnodembskaya, John G. Laffey, Cliona McDowell, Margaret McFarland, Jamie McFerran, Peter McGuigan, Gavin D. Perkins, Jonathan Silversides, Jon Smythe, Jacqui Thompson, William S. Tunnicliffe, Ingeborg D. M. Welters, Laura Amado-Rodriguez, Guillermo Albaiceta, Barry Williams, Manu Shankar-Hari, Daniel F. McAuley, Cecilia M. O'Kane
Summary: This study investigated the safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) in COVID-19-related ARDS. The results showed that ORBCEL-C did not improve surrogate outcomes of pulmonary organ dysfunction. Evaluation: 7/10.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tetiana Bukreieva, Hanna Svitina, Viktoriia Nikulina, Alyona Vega, Oleksii Chybisov, Iuliia Shablii, Alina Ustymenko, Petro Nemtinov, Galyna Lobyntseva, Inessa Skrypkina, Volodymyr Shablii
Summary: This study investigated the effects of mesenchymal stem cell (MSC) transplantation on severe COVID-19 patients. The results showed that triple MSC transplantation was safe and did not cause severe adverse reactions. CT imaging revealed that MSC transplantation resulted in significantly lower fibrotic changes in the lung compared to conventional anti-viral treatment. Additionally, MSC therapy improved lymphocyte recovery and reduced inflammation markers in the peripheral blood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Hamid Reza Aghayan, Fatemeh Salimian, Atefeh Abedini, Samrand Fattah Ghazi, Masud Yunesian, Sepideh Alavi-Moghadam, Jalil Makarem, Keivan Majidzadeh-A, Ali Hatamkhani, Maryam Moghri, Abbas Danesh, Mohammad Reza Haddad-Marandi, Hassan Sanati, Fereshteh Abbasvandi, Babak Arjmand, Pourya Azimi, Ardeshir Ghavamzadeh, Ramin Sarrami-Forooshani
Summary: This study aimed to evaluate the safety of intravenous injection of placenta-derived mesenchymal stem cells (PL-MSCs) in patients with COVID-19-induced acute respiratory distress syndrome (ARDS). The results demonstrated that the administration of PL-MSCs was safe and feasible, with no adverse events observed. There were no significant differences in clinical and laboratory parameters between the treatment and control groups. Further studies are needed to evaluate the efficacy of this treatment modality using higher cell doses and repeated injections.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Yuling Luo, Shanhui Ge, Qingui Chen, Shan Lin, Wanmei He, Mian Zeng
Summary: This study explored whether overexpression of FoxM1 promotes the therapeutic effect of BMSCs on ARDS. The results showed that FoxM1 overexpression significantly decreased pathological variations, protein concentration, oxidative stress, and cytokine levels. Furthermore, FoxM1 enhanced the protective effect of BMSCs on endothelial cell injury through the activation of the Wnt/beta-catenin signaling pathway.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Beth H. Shaz, Bryan D. Kraft, Jesse D. Troy, Emily Poehlein, Lingye Chen, Lynn Cheatham, Raha Manyara, Khalid Hanafy, Linda Brown, Margaret Scott, Ralph Palumbo, Frank Vrionis, Joanne Kurtzberg
Summary: This study explores the feasibility and safety of using allogeneic human umbilical cord derived mesenchymal stromal cells (hCT-MSCs) for treating COVID-19-related acute respiratory distress syndrome (ARDS). The results show that this treatment method is feasible and safe in clinical practice, without any related adverse reactions. However, further research is needed to explore its safety and efficacy.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Ramana Vaka, Saad Khan, Bin Ye, Yousef Risha, Sandrine Parent, David Courtman, Duncan J. Stewart, Darryl R. Davis
Summary: Inflammatory mediators implicated in the progression of COVID-19 ARDS do not alter the viability and paracrine production of three leading cell products under clinical evaluation, further validating their potential for treating severe COVID-19 ARDS.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Article
Respiratory System
Cecilia Lopez-Martinez, Paula Martin-Vicente, Juan Gomez de Ona, Ines Lopez-Alonso, Helena Gil-Pena, Elias Cuesta-Llavona, Margarita Fernandez-Rodriguez, Irene Crespo, Estefania Salgado del Riego, Raquel Rodriguez-Garcia, Diego Parra, Javier Fernandez, Javier Rodriguez-Carrio, Francisco Jose Jimeno-Demuth, Alberto Davalos, Luis A. Chapado, Eliecer Coto, Guillermo M. Albaiceta, Laura Amado-Rodriguez
Summary: In this study, researchers identified two transcriptomic clusters in critically ill COVID-19 patients based on peripheral blood transcriptomes. One cluster was characterized by interferon-related expression and the other promoted B-cell activation. These clusters had different ICU outcomes, suggesting different pathogenetic mechanisms. The findings demonstrate the potential of transcriptomics in identifying patient endotypes for personalized therapies in severe COVID-19.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Computer Science, Artificial Intelligence
Longxi Zhou, Xianglin Meng, Yuxin Huang, Kai Kang, Juexiao Zhou, Yuetan Chu, Haoyang Li, Dexuan Xie, Jiannan Zhang, Weizhen Yang, Na Bai, Yi Zhao, Mingyan Zhao, Guohua Wang, Lawrence Carin, Xigang Xiao, Kaijiang Yu, Zhaowen Qiu, Xin Gao
Summary: Knowledge on long-term complications of COVID-19 is limited, especially in CT scans of survivors. A deep learning-based method was developed to calculate an optimal window for each scan and remove irrelevant tissues, making subvisual abnormalities visible in lung CT scans.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Multidisciplinary Sciences
Lorenzo Porta, Sih-Shiang Huang, Chen Wei, Chin-Hua Su, Wan-Ting Hsu, Wang-Huei Sheng, Chien-Chang Lee
Summary: A study in Italy found that the use of methylprednisolone did not significantly reduce 30-day mortality in patients diagnosed with SARS-CoV-2. However, the use of methylprednisolone in severe patients with cardiovascular or respiratory comorbidities can reduce the incidence of shock or acute respiratory failure.
Article
Cell Biology
Kun Xiao, Wanxue He, Wei Guan, Fei Hou, Peng Yan, Jianqiao Xu, Ting Zhou, Yuhong Liu, Lixin Xie
CELL DEATH & DISEASE
(2020)
Article
Cell Biology
Kun Xiao, Lei Song, Ye Hu, Wanxue He, Fei Hou, Peng Yan, Jianqiao Xu, Kaifei Wang, Yi Tao, Dan Li, Lixin Xie
Summary: This study identified a set of miRNAs, with miR-18a-5p playing a crucial role in the response to IR, particularly in IR-mediated apoptosis and oxidative stress. The findings provide insight into the molecular mechanisms underlying lung IR and have important clinical implications for transplantation procedures.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Immunology
Fei Hou, Kun Xiao, Li Tang, Lixin Xie
Summary: Different types of lung macrophages play diverse roles and possess unique characteristics in lung diseases. Understanding the similarities and differences among these macrophages is crucial for the study of lung diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Dianyuan Zhao, Fengjiao Yang, Yang Wang, Site Li, Yang Li, Fei Hou, Wenting Yang, Di Liu, Yuandong Tao, Qian Li, Jing Wang, Fuchu He, Li Tang
Summary: Tissue-derived signals regulate the identity and function of Kupffer cells through the BMP9/BMP10/ALK1 signaling pathway, while ALK1 is dispensable for the maintenance of macrophages.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
