Article
Multidisciplinary Sciences
Genta Ito, Takahiro Takazono, Naoki Hosogaya, Naoki Iwanaga, Shogo Miyazawa, Satoki Fujita, Hideaki Watanabe, Hiroshi Mukae
Summary: This retrospective observational study evaluated the factors influencing the start date of the influenza epidemic season and the total number of infected persons per 1,000,000 population in 47 prefectures of Japan. Using a Japanese health insurance claims database, single and multiple regression analyses were conducted to assess the relationship between the start time of the epidemic and various factors such as absolute humidity, total visitors, and total population. The study found that the earlier the climate became suitable for virus transmission and the higher the human mobility, the earlier the epidemic season tended to begin.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Namrata Prasad, Tiffany A. Walker, Ben Waite, Tim Wood, Adrian A. Trenholme, Michael G. Baker, Colin McArthur, Conroy A. Wong, Cameron C. Grant, Q. Sue Huang, E. Claire Newbern
Summary: The study reveals that adults with certain chronic medical conditions are at a higher risk of RSV-related hospitalizations, with CHF and COPD patients having the highest risk. Age plays a role in the relationship between certain chronic conditions and RSV risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Diego Rodriguez-Alvarez, Cristina Rodriguez-De Tembleque, Emilio Cendejas-Bueno, Elena Perez-Costa, Jesus Diez-Sebastian, Pedro De la Oliva
Summary: This study found that exposure to secondhand smoke increases the risk of pulmonary bacterial superinfection and the need for invasive mechanical ventilation in severely ill infants with acute bronchiolitis. Tobacco smoke significantly impacts the risk of lower respiratory tract infections in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Microbiology
Kim Stobbelaar, Thomas C. Mangodt, Winke Van der Gucht, Lise Delhaise, Jasmine Andries, Valerie Gille, Cyril Barbezange, Annemieke Smet, Benedicte Y. De Winter, Jozef J. De Dooy, Tom Schepens, Els L. I. M. Duval, Paul Cos, Philippe G. Jorens, Stijn Verhulst, Peter L. Delputte
Summary: The respiratory syncytial virus (RSV) is the leading cause of viral lower respiratory tract infections (LRTI) in children worldwide, and is associated with significant morbidity and mortality rates. This study found that patients with a single RSV infection had higher disease severity compared to patients with RSV co-infections, suggesting that the presence of viral co-infections could influence the course of RSV bronchiolitis. Further investigation is needed to guide physicians in early treatment decisions for patients who may benefit from current or future treatment options.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pediatrics
Lise Beier Havdal, Hakon Boas, Terese Bekkevold, Anne-Marte Bakken Kran, Astrid Elisabeth Rojahn, Ketil Stordal, Sara Debes, Henrik Dollner, Svein Arne Nordbo, Bjorn Barstad, Elisebet Haarr, Liliana Vazquez Fernandez, Britt Nakstad, Christopher Inchley, Elmira Flem
Summary: Young age, comorbidity, and having siblings were identified as risk factors for more severe disease in children hospitalized with RSV infection.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Joseph P. McGinley, Gu Lung Lin, Deniz Oner, Tanya Golubchik, Daniel O'Connor, Matthew D. Snape, Olivier Gruselle, Annefleur C. Langedijk, Joanne Wildenbeest, Peter Openshaw, Harish Nair, Jeroen Aerssens, Louis Bont, Federico Martinon-Torres, Simon B. Drysdale, Andrew J. Pollard
Summary: The study evaluated the association between the severity of RSV disease and host age, viral load, and RSV subtypes. Younger infants were more likely to have severe RSV disease, while older infants, higher viral load, and RSV-A were associated with fever. RSV-A and RSV-B caused similar disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Ting Shi, Sophie Vennard, Francis Jasiewicz, Rory Brogden, Harish Nair
Summary: RSV-ARI in adults with comorbidities is a significant burden, with limited data available. This study estimated the incidence, hospitalization rate, and in-hospital case fatality ratio of RSV-ARI in this population, and found an association between the disease and any comorbidity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Ziheng Feng, Lili Xu, Zhengde Xie
Summary: This article reviews the receptors and host factors associated with RSV infection, finding that RSV can bind to multiple receptors and utilize various host factors for infection. The identification and understanding of these receptors and factors are crucial for gaining insight into the pathogenesis of RSV infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Keita Wagatsuma, Iain S. Koolhof, Yugo Shobugawa, Reiko Saito
Summary: The study found that the earlier onset week of HRSV epidemic season in Japan is associated with increased number of inbound overseas travelers, higher mean temperature, and relative humidity. These factors contribute to an earlier onset week of the season.
Article
Critical Care Medicine
Tristan W. Clark, Kate R. Beard, Nathan J. Brendish, Ahalya K. Malachira, Samuel Mills, Cathleen Chan, Stephen Poole, Sean Ewings, Nick Cortes, Esther Nyimbili, Laura Presland
Summary: The study aimed to evaluate the impact of mPOCT on influenza detection and clinical outcomes in hospitalized patients. The results showed that the mPOCT group had a higher rate of influenza detection, more timely and appropriate antiviral treatment, and isolation facility use, which contributed to improved clinical outcomes.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Microbiology
Sebastien A. Felt, Yan Sun, Agnieszka Jozwik, Allan Paras, Maximillian S. Habibi, David Nickle, Larry Anderson, Emna Achouri, Kristen A. Feemster, Ana Maria Cardenas, Kedir N. Turi, Meiping Chang, Tina V. Hartert, Shaon Sengupta, Christopher Chiu, Carolina B. Lopez
Summary: Kinetics of defective viral genome accumulation in RSV A infection in humans are associated with clinical outcomes, with early detection of DVGs potentially linked to mild disease and late detection linked to severe disease.
NATURE MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Immunology
Christiana Smith, Yanling Huo, Kunjal Patel, Kirk Fetters, Shannon Hegemann, Sandra Burchett, Russell Van Dyke, Adriana Weinberg
Summary: In HIV-exposed but uninfected infants born in the United States, respiratory virus infections, particularly with RSV and parainfluenza, are associated with hospitalization risk. HEU infants demonstrate robust antibody responses to vaccine antigens, differing from HUU infants.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Samadhan J. Jadhao, Binh Ha, Courtney McCracken, Tebeb Gebretsadik, Christian Rosas-Salazar, James Chappell, Suman Das, Tina Hartert, Larry J. Anderson
Summary: RSV infection plays a major role in respiratory tract diseases in infants and throughout life. The RSV antibody enzyme-linked immunoassay is sensitive for detecting infant infection, and the two G EIAs can indicate the group of an earlier primary infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Weiling Qiu, Chen Zheng, Shumin Huang, Yuanyuan Zhang, Zhimin Chen
Summary: This study aimed to explore the epidemiological trend and clinical characteristics of respiratory syncytial virus (RSV) infection among inpatient children with lower respiratory tract infection (LRTI) before and during the COVID-19 pandemic. The study found that RSV infection was still an important cause of hospitalization in children with LRTI, and its proportion increased gradually. RSV infection was more common in infants under 1-year old but showed a trend of increasing in older children. The incidence of RSV infection continued to rise in autumn, and the difference in seasonal distribution was narrowed.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Immunology
Nasamon Wanlapakorn, Kirsten Maertens, Sompong Vongpunsawad, Jiratchaya Puenpa, Thao Mai Phuong Tran, Niel Hens, Pierre Van Damme, Anais Thiriard, Dominique Raze, Camille Locht, Yong Poovorawan, Elke Leuridan
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Nawarat Posuwan, Nasamon Wanlapakorn, Sompong Vongpunsawad, Palittiya Sintusek, Elke Leuridan, Pierre Van Damme, Yong Poovorawan
Article
Public, Environmental & Occupational Health
Rujipat Wasitthankasem, Napaporn Pimsingh, Khuandao Treesun, Nawarat Posuwan, Preeyaporn Vichaiwattana, Chompoonut Auphimai, Ilada Thongpan, Sissades Tongsima, Sompong Vongpunsawad, Yong Poovorawan
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2020)
Article
Immunology
Nasamon Wanlapakorn, Jiratchaya Puenpa, Thanunrat Thongmee, Donchida Srimuan, Thaksaporn Thatsanathorn, Sompong Vongpunsawad, Yong Poovorawan
Article
Multidisciplinary Sciences
Jira Chansaenroj, Watchaporn Chuchaona, Fajar Budi Lestari, Siripat Pasittungkul, Sirapa Klinfueng, Nasamon Wanlapakorn, Sompong Vongpunsawad, Chintana Chirathaworn, Yong Poovorawan
Article
Multidisciplinary Sciences
Nungruthai Suntronwong, Sirapa Klinfueng, Sumeth Korkong, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Sompong Vongpunsawad, Yong Poovorawan
Summary: The study monitored the genetic variation of seasonal influenza A and B viruses in Thailand, revealing evolution away from vaccine strains in A(H1N1)pdm09 and A(H3N2), with dominant strains belonging to specific clades/subclades. There were additional amino acid substitutions observed, and antigenic drift was facilitated at specific epitopes. In contrast, the circulating influenza B virus remained antigenically similar to its vaccine strain. The findings provide insights into genetic divergence from vaccine strains, which could potentially aid in updating vaccines.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Thanyarat Chaibun, Jiratchaya Puenpa, Tatchanun Ngamdee, Nimaradee Boonapatcharoen, Pornpat Athamanolap, Anthony Peter O'Mullane, Sompong Vongpunsawad, Yong Poovorawan, Su Yin Lee, Benchaporn Lertanantawong
Summary: The researchers developed an ultrasensitive electrochemical biosensor based on isothermal rolling circle amplification for rapid detection of SARS-CoV-2, capable of detecting as low as 1 copy/mu L of N and S genes in clinical samples. The sensor showed a 100% concordance with qRT-PCR results in clinical sample evaluation.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Public, Environmental & Occupational Health
John Mauleekoonphairoj, Sompong Vongpunsawad, Apichai Khongphatthanayothin, Koonlawee Nademanee, Yong Poovorawan
PATHOGENS AND GLOBAL HEALTH
(2021)
Editorial Material
Oncology
Sungpil Yoon, Xiaoju Wang, Sompong Vongpunsawad, Gerard Tromp, Helena Kuivaniemi
FRONTIERS IN ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Natthaphon Nanakorn, Theerakamol Pengsakul, Kannika Bunrod, Suwich Thammapalo, Pathomporn Prikchoo, Sompong Vongpunsawad, Yong Poovorawan
Summary: This study investigated a probable outbreak of chikungunya virus (CHIKV) in Satun province, Thailand during the rainy season in 2018, with 39% of samples testing positive for CHIKV RNA or antibodies. The CHIKV strain in Satun province belonged to the Indian Ocean lineage, continuing to evolve and causing outbreaks in the region.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Virology
Jiratchaya Puenpa, Kamol Suwannakarn, Jira Chansaenroj, Chompoonut Auphimai, Nasamon Wanlapakorn, Sompong Vongpunsawad, Yong Poovorawan
Summary: Eleven full-length genome sequences of 2019 EV-A71 C1 strains isolated from HFMD patients in Thailand from 2019 to early 2020 were described, showing the emergence of multiple lineages through recombination. Bayesian-based phylogenetic analysis indicated that the 2019 EV-A71 C1 Thai strains share a common ancestor with variants in Europe. The substitution rate for the 2019 EV-A71 C1 genome was estimated to be similar to that observed in previous outbreaks. These findings are crucial for understanding the evolution of EV-A C1 during the ongoing HFMD outbreak and its relevance to disease outcomes in children worldwide.
ARCHIVES OF VIROLOGY
(2021)
Article
Infectious Diseases
Ilada Thongpan, Preeyaporn Vichaiwattana, Sompong Vongpunsawad, Yong Poovorawan
Summary: The seasonality and prevalence of HRV and RSV infections among young children in Thailand were altered by the global coronavirus pandemic in 2020. An upsurge of HRV infection began in July and was subsequently replaced by a surge of RSV infection from September onward, peaking in October. The delayed RSV season in 2020 was predominantly associated with RSV-A.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Multidisciplinary Sciences
Watchaporn Chuchaona, Jira Chansaenroj, Jiratchaya Puenpa, Sarawut Khongwichit, Sumeth Korkong, Sompong Vongpunsawad, Yong Poovorawan
Summary: Human norovirus is a common cause of non-bacterial acute gastroenteritis that can lead to outbreaks and exists in multiple forms. The variant GII.4 Hong Kong of this virus shows significant differences from existing strains and did not evolve from the currently prevalent GII.4 Sydney lineage, highlighting the potential for widespread transmission in susceptible populations.
Article
Immunology
Siyuan Hu, Nicola Logan, Jiratchaya Puenpa, Nasamon Wanlapakorn, Sompong Vongpunsawad, Yong Poovorawan, Brian J. Willett, Margaret J. Hosie
Summary: The study suggests that adjusting the timing of the first MMR vaccination according to the level of acquired maternal immunity could enhance vaccine immunogenicity and expedite measles eradication.