Article
Biology
Rachel E. Hardy, Injae Chung, Yizhou Yu, Samantha H. Y. Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M. Martins, Marion MacFarlane, Kenneth R. Pryde
Summary: Antipsychotic drugs, including the newer generation ones, can induce mitochondrial toxicity that leads to movement disorders. It is important to understand the underlying mechanisms to minimize these adverse effects.
Article
Psychiatry
Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Bolla
Summary: The cases of three outpatients with bipolar I disorder and schizoaffective disorder, who had low adherence to treatment, were treated with cariprazine as a monotherapy on a two-times a week schedule. After four weeks of treatment, all three patients showed response and remission, and this result was sustained for several months. The long half-lives of cariprazine and its active metabolites seem to provide effective treatment with a two-times a week administration.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Youyi Zhang, Fei Ye, Tongtong Zhang, Shiyun Lv, Liping Zhou, Daohai Du, He Lin, Fei Guo, Cheng Luo, Shujia Zhu
Summary: Ketamine, as a non-competitive channel blocker of NMDA receptors, can produce rapid and long-lasting antidepressant effects. The S-ketamine enantiomer is found to be the more active antidepressant, with its binding pocket in the NMDA receptor involving key amino acids for interaction.
Editorial Material
Biochemistry & Molecular Biology
Colin Brownlee
Summary: A new study has identified the major components that enable the Venus flytrap to fire action potentials, revealing the recruitment of different ion channels and transporters that give rise to this unique plant behavioral response.
Article
Chemistry, Physical
Rhys D. Barker, Yuqi Yu, Leonardo De Maria, Linus O. Johannissen, Nigel S. Scrutton
Summary: In order to rationally engineer flavin-dependent halogenases (FDHs), it is important to understand the reaction mechanism and substrate interactions in the active site. This study presents the most likely mechanism for halogenation based on molecular dynamics simulations and density functional theory cluster models of FDH PrnA.
Article
Psychiatry
Elena Ivanova, Desislava Maslinkova, Nadia Polnareva, Vihra Milanova
Summary: This study reports two cases of young patients with predominantly negative symptoms during treatment with cariprazine. The results show that after 18 months of treatment, cariprazine significantly improved negative symptoms, global functioning, and clinical impression. Therefore, cariprazine may be a successful alternative for young schizophrenic patients with a predominance of negative symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Endocrinology & Metabolism
Li Wang, Chao-Chao Yu, Jia Li, Qing Tian, Yan-Jun Du
Summary: This review mainly discusses the relationship between the hypothalamic nuclei, related neuropeptides, brainstem, peripheral signals, and obesity, as well as mechanisms of acupuncture on obesity, exploring the current evidence and therapeutic targets for mechanism of action of acupuncture in obesity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Susanne Prokop, Peter Abranyi-Balogh, Benjamin Barti, Marton Vamosi, Miklos Zoldi, Laszlo Barna, Gabriella M. Urban, Andras David Toth, Barna Dudok, Attila Egyed, Hui Deng, Gian Marco Leggio, Laszlo Hunyady, Mario van der Stelt, Gyorgy M. Keseru, Istvan Katona
Summary: The PharmacoSTORM single-molecule imaging technique combines fluorescent ligands and immunolabeling to provide a new approach for molecular pharmacology research at the cellular and subcellular levels, enabling precise quantification of drug-target interactions. By studying cariprazine binding to D3 dopamine receptors, the technique allows for accurate measurement of drug-target interactions and sheds light on its neurobiological substrate.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Wei Luo, Kaiyue Wang, Jingyi Luo, Yingchen Liu, Jiawen Tong, Mengting Qi, Yue Jiang, Yong Wang, Zhiqing Ma, Juntao Feng, Bin Lei, He Yan
Summary: The main component of orange peel essential oil, limonene, has antibacterial, antiseptic, and antitumor activity, and is of great value in agriculture. It has been found that limonene exhibits excellent antiviral activity against tobacco mosaic virus (TMV), and it triggers a hypersensitive response in tobacco. Limonene also enhances defense enzyme activity and the expression of defense-related genes, as well as the accumulation of salicylic acid. Furthermore, it has been shown to induce plant resistance against various pathogens in pot experiments.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Clinical Neurology
Thomas Aubel
Summary: Schizophrenia is a chronic mental disorder characterized by positive, negative, and cognitive symptoms, requiring long-term treatment. Pharmacologic therapy, including the use of antipsychotics like cariprazine, has been shown to be effective in managing the symptoms of schizophrenia. Multiple trials have demonstrated the efficacy of cariprazine in treating schizophrenia, making it a valuable option for patients with inadequate response to previous treatments.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Review
Biotechnology & Applied Microbiology
Sherin Jacob, R. Reshmy, Sherly Antony, Aravind Madhavan, Raveendran Sindhu, Mukesh Kumar Awasthi, Mohammed Kuddus, Santhosh Pillai, Sunita Varjani, Ashok Pandey, Parameswaran Binod
Summary: Nanocellulose is a biodegradable, biocompatible, and renewable nano-sized component that offers mechanical strength and chemical stability. It can reduce environmental contamination through various bioremediation techniques using bio-adsorbents. Further study of the mechanism and application of nanocellulose is crucial for the development of effective bioremediation strategies and its implementation in tissue engineering.
Review
Chemistry, Inorganic & Nuclear
Xiaolin Xiong, Liu-Yi Liu, Zong-Wan Mao, Taotao Zou
Summary: This article discusses the methods for deciphering the mechanism of action of metal complexes and provides selected examples with in-depth mechanistic insights.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Psychiatry
Ricardo Coentre, Rodrigo Saraiva, Carolina Sereijo, Pedro Levy
Summary: Cariprazine, a new atypical antipsychotic, has shown positive effects in the treatment of early psychosis based on three case reports. The use of low doses of Cariprazine may be effective in improving psychotic symptoms in patients experiencing first-episode psychosis. Further studies with longer follow-up are recommended to confirm the efficacy of Cariprazine in the early stages of psychosis.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Agronomy
Xile Deng
Summary: This review provides insights into the mechanisms of herbicide safeners, analyzes existing problems, and anticipates future research directions and potential strategies for the development of new safeners. The aim of this paper is to uncover the mechanisms of safeners and offer guidance for the development of new safeners.
Review
Green & Sustainable Science & Technology
Matthew Zhi Yeon Ting, Kwong Soon Wong, Muhammad Ekhlasur Rahman, Selowara Joo Meheron
Summary: This study reviews the impact of wetting-drying action on concrete deterioration in marine environment and identifies the influential factors. It discusses the physical, mechanical properties, and corrosion resistance of concrete exposed to wetting-drying action. Limited research works are identified on the synergy between physical and chemical deteriorations.
JOURNAL OF CLEANER PRODUCTION
(2021)
