Article
Cell Biology
Francesca Cuomo, Carmela Dell'Aversana, Teresa Chioccarelli, Veronica Porreca, Francesco Manfrevola, Chiara Papulino, Vincenzo Carafa, Rosaria Benedetti, Lucia Altucci, Gilda Cobellis, Gilda Cobellis
Summary: Maintaining energy balance is crucial for human health. This study highlights the role of Hif3 alpha in the transformation of white adipocytes to brown adipocytes, which activates beneficial thermogenesis and rewires energy metabolism. These findings have important implications for combating obesity and type 2 diabetes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena Gonzalez, Yara Alyahyawi, Alan Cunningham, Aysegul Erdem, Frank Schnutgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle A. C. Reed, Lorena Arranz, Ulrich L. Guenther, Paloma Garcia
Summary: This study identifies a novel metabolic crosstalk between AML and stromal cells, where AML cells stimulate stromal cells to secrete acetate for their own consumption. Transcriptome analysis and metabolic NMR analysis show that stromal cells exhibit a higher rate of glycolysis when co-cultured with AML cells. It is also found that acetate in stromal cells is derived from pyruvate via chemical conversion under the influence of reactive oxygen species (ROS) transferred from AML cells via gap junctions.
Review
Biochemistry & Molecular Biology
Wan-Li Cheng, Shao-Jung Li, Ting- Lee, Ting-Wei Lee, Cheng-Chih Chung, Yu-Hsun Kao, Yi-Jen Chen
Summary: Chronic intake of fructose may contribute to metabolic diseases and cardiac inflammation, with recent findings highlighting the significant role of the small intestine in fructose metabolism. Overconsumption of fructose leads to dysbiosis of the gut microbiota, increased intestinal permeability, and activation of host inflammation, affecting cardiac health.
Review
Neurosciences
Eun Hee Ahn, Seong Su Kang, Xia Liu, Xuebing Cao, Soo Young Choi, Laura Musazzi, Patrick Mehlen, Keqiang Ye
Summary: Chronic constipation is a prominent prodromal symptom in Parkinson's disease, and the repression of BDNF and Netrin-1 by C/EBP beta may contribute to gastrointestinal and brain dysfunctions in PD. Reduced levels of BDNF and Netrin-1 in PD patients, possibly mediated by C/EBP beta, lead to dopaminergic neuronal loss and motor dysfunctions, suggesting a potential early diagnostic biomarker for PD.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Immunology
Rongrong Zhou, Dan He, Jing Xie, Qingyijun Zhou, Hongliang Zeng, Hongmei Li, Luqi Huang
Summary: American ginseng demonstrates immunomodulatory effects in CTX-induced mice, especially the combined treatment of polysaccharides and ginsenosides showing significant results in restoring intestinal morphology and improving immune system function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Adrian Cortes-Martin, Carlos Eduardo Iglesias-Aguirre, Amparo Meoro, Maria Victoria Selma, Juan Carlos Espin
Summary: The study found that pomegranate extract nutraceutical has an effect on the gut microbiota in poly-medicated MetS patients, particularly in anti-hypertensive treatments. This provides a new complementary approach for MetS therapy.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Manas Ranjan Saha, Priyankar Dey
Summary: Plants belonging to the genera Acacia have shown potential benefits for metabolic health at the intestinal level including increasing beneficial gut bacteria and reducing harmful pathogens, providing anti-inflammatory effects and potentially improving gut barrier function to prevent endotoxin translocation and limit low-grade inflammation associated with metabolic diseases.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Hongcai Li, Siqi Yang, Lingjia Fan, Lin Luo, Wenzhi Lei, Pei Tan, Tianli Yue, Zhenpeng Gao
Summary: A tea called Mulberry leaf Fu tea (FM) can improve type 2 diabetes by regulating gut microbiota and short-chain fatty acids. FM inhibits α-glucosidase, promotes the growth of beneficial microorganisms, and increases the levels of acetic acid, propionic acid, and butyric acid.
Article
Biochemistry & Molecular Biology
Heather Karner, Chiu-Ho Webb, Sarah Carmona, Yu Liu, Benjamin Lin, Micaela Erhard, Dalen Chan, Pierre Baldi, Robert C. Spitale, Sha Sun
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Benedicte Elena-Herrmann, Emilie Montellier, Anne Fages, Reut Bruck-Haimson, Arieh Moussaieff
SCIENTIFIC REPORTS
(2020)
Editorial Material
Immunology
Carolina Magdalen Greco, Paolo Sassone-Corsi
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Karen Brami-Cherrier, Robert G. Lewis, Marlene Cervantes, Yu Liu, Paola Tognini, Pierre Baldi, Paolo Sassone-Corsi, Emiliana Borrelli
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Tomoki Sato, Carolina Magdalen Greco
Summary: Circadian rhythms play a central role in regulating physiological and metabolic processes by dynamically influencing gene expression through epigenetic changes. Evidence suggests that oxidative stress and redox balance are controlled by circadian rhythms and in turn affect the clock system. Disruption of circadian rhythms leads to oxidative stress accumulation and disturbances in redox balance, along with significant changes in the epigenomic landscape.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Kevin B. Koronowski, Carolina M. Greco, He Huang, Jin-Kwang Kim, Jennifer L. Fribourgh, Priya Crosby, Lavina Mathur, Xuelian Ren, Carrie L. Partch, Cholsoon Jang, Feng Qiao, Yingming Zhao, Paolo Sassone-Corsi
Summary: This study reveals the crucial role of Kbhb in hepatic metabolism, especially under ketogenic conditions. By investigating the functional impact of Kbhb on key metabolic enzymes, the global effect of protein Kbhb was uncovered, shedding new light on the role of ketone bodies in metabolic regulation.
Article
Multidisciplinary Sciences
Carolina M. Greco, Kevin B. Koronowski, Jacob G. Smith, Jiejun Shi, Paolo Kunderfranco, Roberta Carriero, Siwei Chen, Muntaha Samad, Patrick-Simon Welz, Valentina M. Zinna, Thomas Mortimer, Sung Kook Chun, Kohei Shimaji, Tomoki Sato, Paul Petrus, Arun Kumar, Mireia Vaca-Dempere, Oleg Deryagian, Cassandra Van, Jose Manuel Monroy Kuhn, Dominik Lutter, Marcus M. Seldin, Selma Masri, Wei Li, Pierre Baldi, Kenneth A. Dyar, Pura Munoz-Canoves, Salvador Aznar Benitah, Paolo Sassone-Corsi
Summary: The study investigated the interaction between feeding and the liver clock by reconstituting Bmal1 in hepatocytes, finding that BMAL1 and CEBPB cooperate to regulate daily liver metabolic transcriptional programs. The liver clock and feeding rhythm are sufficient to drive temporal carbohydrate homeostasis, while liver rhythms tied to redox and lipid metabolism require communication with the skeletal muscle clock, highlighting peripheral clock cross-talk.
Article
Multidisciplinary Sciences
Gloria Pascual, Diana Dominguez, Marc Elosua-Bayes, Felipe Beckedorff, Carmelo Laudanna, Claudia Bigas, Delphine Douillet, Carolina Greco, Aikaterini Symeonidi, Inmaculada Hernandez, Sara Ruiz Gil, Neus Prats, Coro Bescos, Ramin Shiekhattar, Moran Amit, Holger Heyn, Ali Shilatifard, Salvador Aznar Benitah
Summary: The study suggests that dietary palmitic acid (PA), but not oleic acid or linoleic acid, may promote metastasis in oral carcinomas and melanoma in mice. The PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with stable deposition of histone H3 lysine 4 trimethylation by methyltransferase Set1A. Furthermore, the proregenerative state of tumor-activated Schwann cells induced by PA may play a role in long-term stimulation of metastasis.
Article
Multidisciplinary Sciences
Paul Petrus, Jacob G. Smith, Kevin B. Koronowski, Siwei Chen, Tomoki Sato, Carolina M. Greco, Thomas Mortimer, Patrick-Simon Welz, Valentina M. Zinna, Kohei Shimaji, Marlene Cervantes, Daniela Punzo, Pierre Baldi, Pura Munoz-Canoves, Paolo Sassone-Corsi, Salvador Aznar Benitah
Summary: Life on Earth relies on molecular clocks and intertissue communication to regulate circadian and metabolic rhythms, with the central clock playing a crucial role in governing metabolic rhythms.
Article
Multidisciplinary Sciences
Desiree Bartolini, Rita Marinelli, Anna Maria Stabile, Tiziana Frammartino, Angela Guerrini, Stefano Garetto, Jacopo Lucci, Anna Migni, Linda Zatini, Giada Marcantonini, Mario Rende, Francesco Galli
Summary: It has been found that wheat germ oil, rich in vitamin E, can prevent lipotoxicity in human liver cells. The effects of wheat germ oil vitamin E on gene expression differ from those of pure vitamin E, and this can be captured using precision nutrition tools.
Article
Biochemistry & Molecular Biology
Desiree Bartolini, Linda Zatini, Anna Migni, Tiziana Frammartino, Angela Guerrini, Stefano Garetto, Jacopo Lucci, Isabelle Franco Moscardini, Giada Marcantonini, Anna Maria Stabile, Mario Rende, Francesco Galli
Summary: This study compared the effects of different forms of vitamin D (VD) on liver cell lipotoxicity and found that all the forms showed similar efficacy in reducing the levels of lipotoxicity. However, they generated different gene fingerprints, suggesting diverse cytoprotective mechanisms.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
N. Matesanz, V. Viana-Huete, M. A. Zuriaga, V. Zorita, A. Ferrer-Perez, M. Amoros-Perez, R. Carriero, P. Kunderfranco, C. M. Greco, J. J. Fuster
Article
Multidisciplinary Sciences
Paola Tognini, Muntaha Samad, Kenichiro Kinouchi, Yu Liu, Jean-Christophe Helbling, Marie-Pierre Moisan, Kristin L. Eckel-Mahan, Pierre Baldi, Paolo Sassone-Corsi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)