Article
Biochemistry & Molecular Biology
Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Weng
Summary: Trytanthrin, a natural compound found in Ban-Lan-Gen, has anti-inflammatory and anti-viral properties. Two derivatives, A1 and A6, showed higher cytotoxicity in HCC cells and targeted multiple aspects of cancer cell growth, making them potential candidates for clinical applications.
Article
Chemistry, Medicinal
Jingwen Feng, Songlin Li, Bing Zhang, Namin Duan, Rui Zhou, Shike Yan, Jeevithan Elango, Ning Liu, Wenhui Wu
Summary: FGFC1, an active compound isolated from marine fungi, has been found to possess anti-cancer, anti-oxidative, and anti-inflammatory activity. This study demonstrated that FGFC1 significantly inhibited proliferation and colony formation, induced cell cycle arrest and apoptosis in EGFR-mutant PC9 cells. Transcriptome analysis revealed that FGFC1 down-regulated genes related to the NF-kappa B pathway in PC9 cells. The inhibitory effects of FGFC1 were enhanced by the NF-kappa B inhibitor PDTC. Furthermore, intraperitoneal injection of FGFC1 inhibited xenograft growth and decreased the expression of Ki-67, p-p65, IL-6, and TNF-alpha in tumors. These findings suggest that FGFC1 exerts its anti-cancer activity in NSCLC through the inhibition of the NF-kappa B signaling pathway.
Article
Medicine, Research & Experimental
Jia-Peng Lin, Mao-Hua Huang, Zhi-Ting Sun, Lei Chen, Yu-He Lei, Yu-Qing Huang, Ming Qi, Shu-Ran Fan, Shou-Guo Chen, Chi-Wing Chung, Mei-Ching Chan, Jun-Shan Liu, Min Hu, Min-Feng Chen, Wen-Cai Ye, Yue-Yue Chen, Li-Juan Deng
Summary: The study aimed to evaluate the effect of periplocin on inhibiting hepatocellular carcinoma (HCC) and further determine its mechanisms. The findings revealed that periplocin inhibited HCC progression by G2/M arrest, apoptosis, and suppression of myeloid-derived suppressor cells (MDSCs) accumulation through the blockade of the AKT/NF-κB pathway. These results suggest that periplocin has the potential to be developed as an effective therapeutic agent for HCC.
Article
Biochemistry & Molecular Biology
EunJin Bang, Cheol Park, Hyun Hwangbo, Jung-Hyun Shim, Sun-Hee Leem, Jin Won Hyun, Gi-Young Kim, Yung Hyun Choi
Summary: Diabetic retinopathy (DR) is a complex complication of diabetes characterized by vision loss, caused by the build-up of reactive oxygen species (ROS) due to hyperglycemia. In this study, spermidine, a natural polyamine with antioxidant effects, was investigated for its potential to inhibit high glucose-induced oxidative stress in human retinal pigment epithelial (RPE) cells. The results showed that spermidine effectively reduced cytotoxicity and apoptosis in high glucose-treated RPE cells by inhibiting mitochondrial ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Zhuo Han, Xingming Zhao, E. Zhang, Jiahui Ma, Hao Zhang, Jianjiang Li, Weidong Xie, Xia Li
Summary: The study elucidated the mechanism of resistomycin in promoting apoptosis and cell cycle arrest in human hepatocellular carcinoma, indicating that the p38 MAPK signaling pathway may play an important role in this process.
Article
Immunology
Ying Tang, Shiyi Yang, Minshan Yao, Minxuan Yang, Lixiang Wei, Hong Chen, Junyan Lin, Yao Huang, Li Lin, Zhendong Qin
Summary: Hemolytic disease in grass carp leads to oxidative damage and cell death, mediated by the release of cell-free hemoglobin and activation of inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Anlong Li, Yonglin He, Chun Yang, Nan Lu, Jiajia Bao, Sijia Gao, Felycia Fernanda Hosyanto, Xintong He, Huichao Fu, Huajian Yan, Ningyu Ding, Lei Xu
Summary: Methylprednisolone promotes the proliferation of mycobacteria in macrophages by suppressing cellular ROS production and IL-6 secretion through down-regulating NF-κB and up-regulating DUSP1 expression. BCI, an inhibitor of DUSP1, can reduce the level of DUSP1 in infected macrophages and inhibit the proliferation of intracellular mycobacteria by promoting cellular ROS production and IL-6 secretion.
Article
Biochemistry & Molecular Biology
Yanjie Guo, Ruofei Li, Xiaoqian Dang
Summary: Aberrant chondrocyte apoptosis and inflammation are critical causes of osteoarthritis (OA) development. This study demonstrates the relationship between S100A10 and OA, showing that S100A10 plays a role in regulating inflammation and cell apoptosis through the ROS/NF-κB pathway.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Anurag Kumar Gautam, Pranesh Kumar, Ritu Raj, Dinesh Kumar, Bolay Bhattacharya, P. S. Rajinikanth, Kumarappan Chidambaram, Tarun Mahata, Biswanath Maity, Sudipta Saha
Summary: In this study, it was found that dimethyl itaconate (DI) can effectively inhibit the development of hepatocellular carcinoma (HCC) in vivo by regulating multiple signaling pathways and molecular mechanisms. Through the modulation of mitochondrial apoptosis, the NF-kappa B pathway, and metabolomic profiles, DI shows promising anti-HCC activity in DEN-induced HCC rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Haina Wang, Rui Wang, Dan Huang, Sihan Li, Beibei Gao, Zhijie Kang, Bo Tang, Jiajun Xie, Fanzhi Yan, Rui Liang, Hua Li, Jinsong Yan
Summary: The study demonstrates that HHT can inhibit the growth and spread of HCC cells through various pathways, including reducing cell proliferation, inhibiting colony formation, preventing cell invasion and migration, inducing cell cycle arrest, and promoting apoptosis. The apoptosis induced by HHT is mainly achieved through the activation of the Hippo pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Chemical
Gehad Subaiea, Ahmed Alafnan, Abdulwahab Alamri, Talib Hussain, Shimaa Mahmoud Hassoun, Amr Selim Abu Lila, El-Sayed Khafagy, Ahmed A. A. Katamesh
Summary: "Umo Ishi" is a novel written by Kenzaburo Oe, in which the author reflects on and pursues peace and justice through a review of history and reality. Set against the backdrop of the Chinese resistance during World War II, the novel portrays the devastation of war on ordinary people and the distortion of human nature through the lives and inner monologues of different characters. By depicting the brutality of war and the complexity of human nature, the novel explores the meaning and impact of war on humanity, and calls for the pursuit of peace.
Article
Environmental Sciences
Ajay Kumar, Sandeep Kaur, Kritika Pandit, Varinder Kaur, Sharad Thakur, Satwinderjeet Kaur
Summary: The study found that the Obea fraction extracted from O. bracteata exhibits strong antioxidant properties and cytotoxicity, showing significant antiproliferative activity against human osteosarcoma MG-63, human neuroblastoma IMR-32, and human lung cancer A549 cell lines. Antioxidant and cytotoxic potential were attributed to the presence of catechin, kaempferol, onosmin A, and epicatechin in the Obea fraction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Buyun Kim, Ki Yong Lee, Byoungduck Park
Summary: Alzheimer's disease is a severe neurodegenerative disorder characterized by distinct pathological features. The nuclear factor-κB plays a crucial role in neuronal inflammation. Isoorientin (ISO) shows potential as a promising therapeutic drug candidate for the treatment and prevention of AD.
Article
Pharmacology & Pharmacy
Yuan Wang, Jinfeng Cui, Guona Zheng, Man Zhao, Zengfang Hao, Hongguang Lian, Yuehong Li, Wenxin Wu, Xianghong Zhang, Juan Wang
Summary: This study provides new insights into the molecular mechanisms underlying the cytotoxicity of Ochratoxin A in gastric cells, mainly involving the ROS-mediated endoplasmic reticulum stress pathway and subsequent cell cycle arrest, apoptosis, and autophagy.
Article
Biochemistry & Molecular Biology
Huan Liu, Wenchao Zhang, Lijie Jin, Shasha Liu, Liying Liang, Yanfei Wei
Summary: This study investigates the anticancer mechanism of Plumbagin (PLB) and its potential connections with oxidative stress, genotoxicity, and cell cycle arrest. The results indicate that PLB significantly inhibits HCC cell viability and colony formation, induces G2/M cell cycle arrest, oxidative stress, and DNA damage. These effects can be attenuated by NAC pretreatment. PLB triggers a DNA damage response by activating ATM, Chk1, Chk2, and p53. Furthermore, the key modulator of the G2/M transition factor, cdc25C, is downregulated in an ROS-dependent manner. Inhibition of the ATM-p53 pathway can reduce the occurrence of G2/M cell cycle arrest. Therefore, ROS-mediated oxidative stress plays a crucial role in PLB-induced G2/M cell cycle arrest mediated by the ATM-p53 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Eltayeb E. M. Eid, Salasawati Hussin, Mohammed Abdullah Alshawsh
Summary: Probiotics supplementation in patients with CRC has been shown to improve quality of life, reduce complications, enhance gut microbiota diversity, and inhibit pro-inflammatory cytokine production. Their use also leads to reduced chemotherapy side effects, improved surgical outcomes, shorter hospital stays, and decreased risk of death. Larger clinical trials are needed to confirm the efficacy, dosage, and interactions with chemotherapeutics agents of probiotics.
Review
Biochemistry & Molecular Biology
Mohammed Abdullah Alshawsh, Abdulsamad Alsalahi, Salah Abdalrazak Alshehade, Sultan Ayesh Mohammed Saghir, Ahmad Faheem Ahmeda, Raghdaa Hamdan Al Zarzour, Ayman Moawad Mahmoud
Summary: This review evaluates the differences in gene expression patterns and NAFLD/NASH progression pathways between two common dietary animal models, HFD-fed and MCD diet-fed animals. The study shows that both HFD and MCD diet can regulate the expression of genes and proteins involved in lipid metabolism, inflammation, oxidative stress, and fibrogenesis pathways. The MCD diet model can spontaneously develop liver fibrosis within a short period of time, while the HFD model shows milder fibrosis.
Article
Physics, Condensed Matter
Yunpeng Liu, Lin Dong, Jiangshan Zheng, Suriani Ibrahim, Mohd Faizul Mohd Sabri, Nazia Abdul Majid
Summary: A switchable metasurface based on phase transmission material of vanadium dioxide (VO2) has been proposed in this study, which can achieve perfect absorption and reflection effects in the terahertz frequency range. The structure is insensitive to the incident angle and shows potential for various applications.
SUPERLATTICES AND MICROSTRUCTURES
(2022)
Review
Biochemistry & Molecular Biology
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Muhammad Miftahussurur, Mohammed Abdullah Alshawsh
Summary: The gut microbiota is a complex and diverse ecosystem that plays a significant role in metabolizing drugs and xenobiotics, potentially altering their activity and toxicity, thus influencing the body's response to these substances.
Article
Oncology
Sareh Kamran, Ajantha Sinniah, Mahfoudh A. M. Abdulghani, Mohammed Abdullah Alshawsh
Summary: Cancer is a life-threatening disease and remains one of the leading causes of death worldwide. Chemoresistance, severe toxicity, relapse, and metastasis are major challenges in cancer therapy. Terpenoids, derived from plant sources, have shown diverse anticancer activities and can inhibit different stages of cancer progression. Significant progress has been made in understanding the mechanism of action and signaling pathways through which terpenoids exert their anticancer effects.
Article
Computer Science, Artificial Intelligence
Abeer AlSereidi, Sarah Qahtan M. Salih, R. T. Mohammed, A. A. Zaidan, Hassan Albayati, Dragan Pamucar, A. S. Albahri, B. B. Zaidan, Khaled Shaalan, Jameel Al-Obaidi, O. S. Albahri, Abdulah Alamoodi, Nazia Abdul Majid, Salem Garfan, M. S. Al-Samarraay, A. N. Jasim, M. J. Baqer
Summary: This paper presents a unique sequence processing methodology for distributing anti-SARS-CoV-2 mAbs to eligible high-risk patients. The proposed method effectively identifies the most eligible patients at each local distribution hospital and protects their privacy.
INTERNATIONAL JOURNAL OF INFORMATION TECHNOLOGY & DECISION MAKING
(2022)
Article
Infectious Diseases
Asma Mohammed Al-Sayaghi, Abdelkodose Mohammed Al-Kabsi, Maisa Siddiq Abduh, Sultan Ayesh Mohammed Saghir, Mohammed Abdullah Alshawsh
Summary: This study investigates the antibacterial activities and mechanism of action of Yemeni Sidr honey (SH) and Manuka honey (MH) against Escherichia coli. Both kinds of honey showed remarkable inhibitory effects on bacterial growth, suggesting their potential as remedies for skin infections and bacterial wound infections.
Article
Multidisciplinary Sciences
Mahfoudh A. M. Abdulghani, Salah Abdulrazak Alshehade, Sareh Kamran, Mohammed Abdullah Alshawsh
Summary: The study investigated the toxic effects of MSG on the uterus in rats, revealing alterations in hormone levels and changes in uterine structure. Therefore, caution should be exercised when using MSG, especially for females at risk of hormonal abnormalities.
Article
Polymer Science
Hassan A. Almoustafa, Mohammed Abdullah Alshawsh, Fouad Saleih R. Al-Suede, Salah Abdulrazak Alshehade, Amin Malik Shah Abdul Majid, Zamri Chik
Summary: PEG-coated PLGA nanoparticles are used for cancer treatment due to their biocompatibility, nonimmunogenicity, and ability to accumulate in tumor sites. In this study, HA-PEG-PLGA NPs were tested on a mouse model of breast cancer metastasis and showed significant inhibition of tumor growth and less metastasis compared to control and Free DOX groups. Further studies on pharmacokinetics and toxicity are needed before clinical research.
Article
Chemistry, Medicinal
Salah Abdalrazak Alshehade, Raghdaa Hamdan Al Zarzour, Michael Mathai, Nelli Giribabu, Atefehalsadat Seyedan, Gurjeet Kaur, Fouad Saleih Resq Al-Suede, Amin Malik Shah Abdul Majid, Vikneswaran Murugaiyah, Hassan Almoustafa, Mohammed Abdullah Alshawsh
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and Orthosiphon aristatus has been shown to inhibit its progression. Feeding C57BL/6 mice with O. aristatus extract for 8 weeks reduced liver enzyme levels and decreased serum glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, and atherogenic risk index. Histological analysis also revealed a reversal of hepatic fat accumulation and reduced NAFLD severity. Furthermore, O. aristatus demonstrated antioxidant and anti-inflammatory activities. Overall, the primary mechanism of action of O. aristatus in treating NAFLD appears to be its antioxidant activity.
Article
Biochemistry & Molecular Biology
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Ahmad Faheem Ahmeda, Michael Mathai, Mohammed Abdullah Alshawsh
Summary: This study aimed to assess the impact of Propionibacterium freudenreichii (PF) probiotic on azoxymethane (AOM)-induced colorectal cancer (CRC), investigate its effects on gut microbiota diversity in rats, and evaluate its potential anti-proliferative activity against HCT116 CRC cells. The results showed that PF reduced the formation of colonic aberrant crypt foci (ACF), suppressed lipid peroxidation, enhanced gut microbiota diversity, and exhibited anti-proliferative activity against CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Purwo Sri Rejeki, Mohammed Abdullah Alshawsh, Yudith Annisa Ayu Rezkitha, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: This study aimed to determine the influence of H. pylori resistance on the diversity and abundance of the stomach microbiome. Bacterial DNA was extracted from biopsy samples, and microbiome community analysis was conducted. The results showed that resistant samples exhibited higher diversity and evenness than sensitive samples. The abundance of H. pylori decreased in the triple-resistant samples with increasing cohabitation of pathogenic bacteria, which may support antimicrobial resistance.
Review
Pharmacology & Pharmacy
Mohd Amir Kamaruzzaman, Muhammad Hibatullah Romli, Razif Abas, Sharmili Vidyadaran, Mohamad Taufik Hidayat Baharuldin, Muhammad Luqman Nasaruddin, Vishnumukkala Thirupathirao, Sreenivasulu Sura, Kabul Warsito, Nurul Huda Mohd Nor, Muhammad Amsyar Azwaruddin, Mohammed Abdullah Alshawsh, Mohamad Aris Mohd Moklas
Summary: This review examines the effects of cannabinoid modulation on glial cells and cognitive function in animal models of Alzheimer's disease. It finds that cannabinoid agonists reduce escape latency and improve object recognition ability in rodents, as well as decrease the accumulation of A beta plaques and inhibit glial cell markers and pro-inflammatory markers. These findings suggest that modulation of glial cells through cannabinoid stimulation may enhance cognitive function by reducing inflammation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Mustafa Ahmed Alshagga, Zahurin Mohamed, Norazlina Mohamed, Atefehalsadat Seyedan, Yan Pan, Sharoen Yu Ming Lim, Mohammed Abdullah Alshawsh
Summary: This study aims to determine the effects of Catha edulis and its bioactive alkaloid, cathinone, on liver histology, gene expression of inflammatory biomarkers in white adipose tissue, hypothalamus, and histomorphological bone parameters. The results showed that the plant extract and cathinone displayed a marked reduction of liver fatty changes. Both treatments were associated with minimal fat steatosis in the liver of obese mice, possibly by upregulation of anti-inflammatory gene expression in adipose tissue.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Review
Medicine, Research & Experimental
Maimonah Eissa Al-Masawa, Mohammed Abdullah Alshawsh, Chiew Yong Ng, Angela Min Hwei Ng, Jhi Biau Foo, Ubashini Vijakumaran, Revatyambigai Subramaniam, Nur Azurah Abdul Ghani, Kenneth Whitaker Witwer, Jia Xian Law
Summary: sEV therapy has been proposed as a possible solution for endogenous skin regeneration. A systematic review and meta-analysis found that sEV interventions promoted skin regeneration in diabetic and non-diabetic animal models and influenced various aspects of wound healing. However, the evaluation of potential adverse effects and adherence to guidelines are still lacking.