Review
Chemistry, Medicinal
Mahtab Zarei, Shaghayegh Adeli, Shabnam Hosseini, Elnaz Daneshzad
Summary: This study comprehensively reviewed the effect of flaxseed on appetite perception. Although the results were inconsistent, some studies found a significant reduction in hunger and appetite, as well as an increase in fullness and satiety.
PHYTOTHERAPY RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Lizeth Cifuentes, Andres Acosta
Summary: Food intake and energy expenditure are crucial for regulating body weight, and the brain plays a vital role in integrating physiological signals and hedonic cues. This review discusses the mechanisms of appetite regulation and methods for measuring food intake.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Review
Behavioral Sciences
Eunice Mah, DeAnn J. Liska, Shellen Goltz, YiFang Chu
Summary: The underconsumption of fiber is concerning due to its association with obesity and cardiometabolic diseases. Adding fiber to consumer products is a practical strategy for addressing this issue. Most fiber types do not significantly affect appetite ratings and energy intakes, but certain viscous fibers and oat fiber may reduce appetite ratings. The variability in research methods and limited studies on fibers contribute to the instability of the current evidence base.
Article
Food Science & Technology
Sashie Abeywickrema, Mei Peng
Summary: Recent studies have shown that exposure to different portion sizes can influence portion alterations in future meals. This study aimed to explore whether tableware sizes can also affect portion size perception and eating behavior. The results revealed significant changes in post-meal satiety and energy intake for participants served with small or large jars compared to medium-sized jars. While small tableware initially reduced energy intake, it led to increased intake at the following meal and overall daily energy intake. These findings suggest that small tableware may not be an effective long-term solution for addressing overeating and related health issues.
Article
Behavioral Sciences
Paige M. Cunningham, Liane S. Roe, John E. Hayes, Marion M. Hetherington, Kathleen L. Keller, Barbara J. Rolls
Summary: A questionnaire (RISE-Q) was developed to characterize reasons for meal termination with 47 influencing factors identified and separated into five distinct scales through factor analysis. Physical Satisfaction and Planned Amount were found to be the most frequently reported reasons for meal termination. The RISE-Q scales showed significant correlations with satiation-related scales, BMI, and measures of typical meal size, indicating potential clinical utility for targeted weight-management interventions.
Review
Plant Sciences
M. Boix-Castejon, E. Roche, M. Olivares-Vicente, F. J. Alvarez-Martinez, M. Herranz-Lopez, V. Micol
Summary: Food intake behavior is influenced by physiological and psychological processes, and the neuroendocrine regulation of food intake involves signals that modulate appetite, satiety, and hunger. Natural plant compounds are being studied for their potential in appetite control, but the research lacks conclusive physiological data, such as anthropometric evaluations and hormone analysis. More systematic clinical studies are needed to decode the hormone patterns regulating hunger and satiety and to correlate brain connectivity with appetite and satiety.
Article
Behavioral Sciences
Laleh NabizadehAsl, Suleyman Nahit Sendur, Barbaros Ozer, Incilay Lay, Tomris Erbas, Zehra Buyuktuncer
Summary: This study aimed to investigate the acute and short-term effects of prebiotics, probiotics, and their combination on appetite, energy intake, and satiety-related hormones. The results showed that the prebiotic and probiotic drinks significantly reduced energy intake compared to the control drink, but there were no significant differences in hunger-satiety scores, serum glucose, insulin, peptide YY, ghrelin, obestatin, and adiponectin concentrations. Further studies are needed to better understand the role of prebiotics and probiotics in satiety-related mechanisms.
Article
Behavioral Sciences
Raphaelle Jacob, Veronique Provencher, Shirin Panahi, Angelo Tremblay, Vicky Drapeau
Summary: This study aimed to assess if eating behaviours mediate the association between satiety responsiveness and energy intake. The results suggest that susceptibility to hunger and food cravings partly explain the susceptibility to overeating among individuals with low satiety responsiveness.
Article
Nutrition & Dietetics
Tania Sanchez-Murguia, Nathaly Torres-Castillo, Lisset Magana-de la Vega, Sarai Citlalic Rodriguez-Reyes, Wendy Campos-Perez, Erika Martinez-Lopez
Summary: This study analyzed the relationship between polymorphisms in ghrelin and leptin receptor genes and dietary intake and appetite assessment. The results showed that these polymorphisms were associated with differential responses to a standardized meal, characterized by higher postprandial ghrelin levels and increased dietary sugar intake.
Article
Behavioral Sciences
Kendall Poovey, Erica Ahlich, Sarah Attaway, Diana Rancourt
Summary: Dysfunctional processing of hunger and satiety cues is an important risk factor for disordered eating. This study found that hunger/satiety-specific interoceptive sensibility is associated with binge eating, purging, and cognitive restraint, independent of general interoceptive measures. These findings highlight the importance of targeting hunger/satiety-specific interoception in interventions for disordered eating.
Article
Nutrition & Dietetics
Angela M. Horgan, Gundula R. Palmbach, Julia M. Jordan, Holly S. Callahan, Kaatje E. Meeuws, David S. Weigle, Mario Kratz, Jonathan Q. Purnell
Summary: This study investigated the effect of an off-protocol meal on total caloric consumption, hunger, and satiety in a long-term ad libitum feeding study. The results showed that the off-protocol meal increased daily caloric intake without affecting appetite ratings. There was a slight reduction in intake the following day, but no change in appetite scores. Protein intake was inversely associated with daily caloric intake.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Behavioral Sciences
Elanor C. Hinton, Sam D. Leary, Latife Comlek, Peter J. Rogers, Julian P. Hamilton-Shield
Summary: The study did not find evidence for differences in the effects of different conditions on satiety and eating speed. Future research could consider testing the impact of rating fullness on multiple meals over a longer period. Additionally, although some weak evidence was found that levels of satiety responsiveness may influence the effects of the manipulation, only a weak relationship with eating speed was identified.
Article
Medicine, General & Internal
Young-Rock Hong, Sandhya Yadav, Ryan Suk, Alexandra M. Lee, Faith A. Newsome, Crystal N. Johnson-Mann, Michelle Cardel, Kathryn M. Ross
Summary: This cross-sectional study found that individuals who underwent bariatric surgery had improved physical activity and eating behaviors compared to those eligible for surgery, but the improvements were still suboptimal. Efforts are needed to incorporate physical activity and a healthy diet into postbariatric care.
Review
Nutrition & Dietetics
Lisa M. Sanders, Yong Zhu, Meredith L. Wilcox, Katie Koecher, Kevin C. Maki
Summary: Results from systematic review and meta-analysis suggest that consumption of whole grain foods, compared with refined grain foods, significantly impacts subjective appetite, which may partly explain the inverse associations between whole grain intake and risk of overweight, obesity, and weight gain over time.
ADVANCES IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yanlin He, Xing Cai, Hailan Liu, Krisitine M. Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu
Summary: The translation discusses how obesity is primarily caused by consuming excessive calories beyond energetic requirements, while the underlying drivers have not been fully defined. The study found that activating specific neural pathways can regulate different types of feeding behavior, driven by either hunger or non-hunger cues.
MOLECULAR PSYCHIATRY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Medicine, Research & Experimental
Sofia K. Konstantinidou, Georgia Argyrakopoulou, Nicholas Tentolouris, Vangelis Karalis, Alexander Kokkinos
Summary: This review highlights the association between baroreflex sensitivity (BRS) and obesity, suggesting that obesity and its related metabolic disorders can influence baroreflex functionality and decrease BRS. Obesity potentiates sympathetic nervous system activity and can lead to inflammation and cardiovascular events. BRS is also affected by factors such as diabetes, oxidative stress, aging, and gender. However, physical exercise, bariatric surgery, and weight loss can improve BRS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Nutrition & Dietetics
Emilia Papakonstantinou, Christina Oikonomou, George Nychas, George D. Dimitriadis
Summary: Chrononutrition, which involves controlling meal timing, meal sequencing, and dietary interventions, plays a significant role in regulating postprandial glycemia and insulin resistance. Weight loss, lifestyle interventions, and individualized carbohydrate reduction can effectively improve glycemic control and insulin sensitivity in preventing and treating type 2 diabetes.
Article
Environmental Sciences
Emilia Papakonstantinou, Marina Xaidara, Vassiliki Siopi, Marianna Giannoglou, George Katsaros, Georgios Theodorou, Eirini Maratou, Kalliopi-Anna Poulia, George D. Dimitriadis, Panagiotis N. Skandamis
Summary: This study investigated the glycemic responses to three types of spaghetti No 7 with different protein and soluble fiber content. The results showed that all three types of spaghetti No 7 had low glycemic index values and lower peak glucose values compared to glucose or white bread. Regardless of soluble fiber and/or protein content, all three types of spaghetti No 7 attenuated postprandial glycemic response, offering advantages to glycemic control.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Ilias N. Migdalis, Ioannis M. Ioannidis, Nikolaos Papanas, Athanasios E. Raptis, Alexios E. Sotiropoulos, George D. Dimitriadis
Summary: This study investigated the major risk factors for the development and progression of DCKD and found that elevated triglycerides, high systolic blood pressure, and poor glycemic control are associated with an increased risk of CKD in T2DM. These risk factors should be addressed in treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Endocrinology & Metabolism
George D. Dimitriadis, Vaia Lambadiari
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Styliani Ntavidi, Panagiota Katsanou, George Marakomichelakis, Maria-Iosifina Kasdagli, Eleni Antiochou, Ioulia Mpali, Anda-Monica Kakou, Konstantinos Tsioufis, George Dimitriadis, Vaia Lambadiari
Summary: The aim of this study was to assess the association between the stages of diabetic peripheral neuropathy (DPN) and hypertension (HTN) in a Greek population with diabetes. The multivariate analysis showed that non-dippers had a significantly higher risk of developing medium-to-severe DPN compared to dippers, while females had a significantly lower risk of developing moderate/severe DPN compared to males.
Review
Nutrition & Dietetics
Sofia Tsitsou, Nikolaos Zacharodimos, Kalliopi-Anna Poulia, Kalliopi Karatzi, George Dimitriadis, Emilia Papakonstantinou
Summary: Time-restricted feeding (TRF) may be effective for weight loss and improvement of glycemic control and insulin sensitivity in individuals with overweight/obesity. However, more high-quality studies are needed.
Article
Biochemistry & Molecular Biology
Foteini Lympaki, Marianna Giannoglou, Emmanuella Magriplis, Dionysia Lydia Bothou, Varvara Andreou, George D. Dimitriadis, Giorgos Markou, Antonis Zampelas, Georgios Theodorou, George Katsaros, Emilia Papakonstantinou
Summary: The effects of spirulina consumption were investigated in two clinical trials, and the results showed that it can lower postprandial glucose levels and have advantages in glycemic control and hypertension.
Letter
Oncology
Ilias Pessach, Georgia Argyrakopoulou, Fotios Petropoulos, Irene Rapti, Fotios Danglis, Enkeleida Trajce, Eleni Chandrinou
LEUKEMIA & LYMPHOMA
(2023)
Review
Nutrition & Dietetics
Sofia Tsitsou, Christina Athanasaki, George Dimitriadis, Emilia Papakonstantinou
Summary: Dietary fiber (DF) consumption has been associated with improved glycemic control in epidemiological and long-term interventional studies. However, its acute effects are not yet clear. This systematic review aims to elucidate the postprandial effects of DF in starchy products on glycemia and insulinemia. It was shown that soluble DF does not clearly affect glycemia in individuals with normal weight, while resistant starch may be more effective in flattening glycemic responses. Concerning insulinemia, both soluble DF and resistant starch have mixed results, with either favorable or no effects. Data on insoluble DF and glucose metabolism are scarce. The same mixed results for glycemia can be seen in healthy volunteers with overweight/obesity, while resistant starch seems to improve insulinemic responses. Finally, more studies need to examine the acute effects of DF in starchy foods on glucose metabolism and insulin secretion in individuals facing glucose abnormalities. Additionally, more studies are needed to prove whether ingesting high-fiber carbohydrate-containing products per se can result in blunted glycemic and insulinemic responses and which DF type and amount are more effective.
Review
Endocrinology & Metabolism
Stamatia Simati, Alexander Kokkinos, Maria Dalamaga, Georgia Argyrakopoulou
Summary: The obesity paradox refers to the observation that certain chronic diseases show a protective association between body mass index (BMI) and clinical outcomes. However, this association may be influenced by factors such as limitations of BMI, unintended weight loss due to chronic illness, different phenotypes of obesity, and cardiorespiratory fitness levels. Recent evidence suggests that cardioprotective medications, obesity duration, and smoking status also play a role in the obesity paradox.
CURRENT OBESITY REPORTS
(2023)
Article
Nutrition & Dietetics
Konstantinos Stefanakis, Alexander Kokkinos, Stamatia Simati, Georgia Argyrakopoulou, Sofia K. Konstantinidou, Matina Kouvari, Ajay Kumar, Bhanu Kalra, Christos S. Mantzoros
Summary: This study measured the levels of all proglucagon-derived peptides (PGDPs) in response to three mixed meal tolerance tests (MMTs), comparing postprandial PGDP responses between lean and obese subjects and between high-fat and high-carbohydrate meals. The results showed that the fat and carbohydrate content of a meal can significantly affect the postprandial levels of PGDPs, and the presence of leanness or obesity also influences the circulating levels of select PGDPs.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Aikaterini Kountouri, Emmanouil Korakas, Eirini Maratou, Ignatios Ikonomidis, Konstantinos Balampanis, Stavros Liatis, Nikolaos Tentolouris, Panagiotis Toulas, Foteini Kousathana, Christophoros Giatzakis, George D. D. Dimitriadis, Vaia Lambadiari
Summary: This study observed 39 Greek patients with FPLD and found that most patients' genetic mutations were not associated with the lipodystrophic phenotype. However, treatment with metreleptin significantly improved glycemic and lipidemic control in some patients. Further large-scale studies are needed to understand the genetic and allelic heterogeneity of the disease and predict treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Georgia Argyrakopoulou, Sofia K. Konstantinidou, Maria Dalamaga, Alexander Kokkinos
Summary: Bariatric surgery is an effective and long-lasting weight loss method, but it may lead to nutritional deficiencies. The key to preventing these deficiencies is preoperative screening and proper supplementation, along with lifelong personalized medical care.
CURRENT NUTRITION REPORTS
(2022)