Detection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

(2020) Renaud La Joie et al.   Science Translational Medicine

Transmission of tauopathy strains is independent of their isoform composition

(2020) Zhuohao He et al.   Nature Communications

Dural lymphatics regulate clearance of extracellular tau from the CNS

(2019) Tirth K. Patel et al.   Molecular Neurodegeneration

In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model

(2019) Petar Marinković et al.   BRAIN

Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain

(2019) Sven Gottschalk et al.   Nature Biomedical Engineering

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease

(2019) Sandra Sanabria Bohórquez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

(2019) Heiko Kroth et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body–like pathology

(2019) Juan A. Gerez et al.   Science Translational Medicine

Tau binding protein CAPON induces tau aggregation and neurodegeneration

(2019) Shoko Hashimoto et al.   Nature Communications

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Evidence of corticofugal tau spreading in patients with frontotemporal dementia

(2019) Eun-Joo Kim et al.   ACTA NEUROPATHOLOGICA

Image scanning microscopy

(2019) Ingo Gregor et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

(2019) Chih Hung Lo et al.   Alzheimers & Dementia

Tau PET imaging with 18F-PI-2620 in patients with Alzheimer's disease and healthy controls: a first-in-human study

(2019) Andre Mueller et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

(2019) Maria Calvo-Rodriguez et al.   Acta Neuropathologica Communications

High‐Speed Large‐Field Multifocal Illumination Fluorescence Microscopy

(2019) Zhenyue Chen et al.   Laser & Photonics Reviews

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

(2018) Peter Verwilst et al.   CHEMICAL SOCIETY REVIEWS

In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510

(2018) Ai Ishikawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models

(2018) Ruiqing Ni et al.   JOURNAL OF NUCLEAR MEDICINE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography

(2018) Ruiqing Ni et al.   Neurophotonics

Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging

(2018) Qian Wu et al.   EBioMedicine

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

(2017) Petra Füger et al.   NATURE NEUROSCIENCE

In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line

(2017) Naruhiko Sahara et al.   Frontiers in Neurology

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

(2016) Kathleen M. Schoch et al.   NEURON

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

(2015) Hamid Shirani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antibody-Derived In Vivo Imaging of Tau Pathology

(2014) S. Krishnaswamy et al.   JOURNAL OF NEUROSCIENCE

Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells

(2013) F. Lassailly et al.   BLOOD

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spectral Discrimination of Cerebral Amyloid Lesions after Peripheral Application of Luminescent Conjugated Oligothiophenes

(2012) Bettina M. Wegenast-Braun et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

In Vivo Near-Infrared Fluorescence Imaging of Matrix Metalloproteinase Activity after Cerebral Ischemia

(2009) Jan Klohs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans ,trans )-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]

(2008) Ana Velasco et al.   FEBS LETTERS

Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy

(2007) Patrice Delobel et al.   AMERICAN JOURNAL OF PATHOLOGY