期刊
ACS CATALYSIS
卷 10, 期 15, 页码 8542-8556出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c02115
关键词
dicarbofunctionalization; nickel catalysis; alkenes; selectivity
资金
- National Institutes of Health, National Institute of General Medical Sciences [GM-127778]
- National Science Foundation [CHE-1654483]
- Alfred P. Sloan Foundation [FG-2018-10354]
- Camille and Henry Dreyfus Foundation [TC-19-019]
1,2-Dicarbofunctionalization of alkenes has emerged as an efficient synthetic strategy for preparing substituted molecules by coupling readily available alkenes with electrophiles and/or nucleophiles. Nickel complexes serve as effective catalysts owing to their tendency to undergo facile oxidative addition and slow beta-hydride elimination, and their capability to access both two-electron and radical pathways. Two-component alkene functionalization reactions have achieved high chemo-, regio-, and stereoselectivities by tethering one of the coupling partners to the alkene substrate. Three-component reactions, however, often incorporate directing groups to control the selectivity. Only a few examples of directing-group-free difunctionalizations of unactivated alkenes have been reported. Therefore, great opportunities exist for the development of three-component difunctionalization reactions stereoselectivities.
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