Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit

(2019) Alfred Fillol-Salom et al.   MOLECULAR CELL

Carbapenemases in Enterobacteriaceae: Detection and Antimicrobial Therapy

(2019) Xiaoyan Cui et al.   Frontiers in Microbiology

Antibiotics: past, present and future

(2019) Matthew I Hutchings et al.   CURRENT OPINION IN MICROBIOLOGY

Protein determinants of dissemination and host specificity of metallo-β-lactamases

(2019) Carolina López et al.   Nature Communications

Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing

(2019) Thomas A. Hamilton et al.   Nature Communications

Composition and Diversity of CRISPR-Cas13a Systems in the Genus Leptotrichia

(2019) Shinya Watanabe et al.   Frontiers in Microbiology

Phage-inducible chromosomal islands are ubiquitous within the bacterial universe

(2018) Alfred Fillol-Salom et al.   ISME Journal

Tailor-made gene silencing of Staphylococcus aureus clinical isolates by CRISPR interference

(2018) Yusuke Sato’o et al.   PLoS One

CRISPR-Based Antibacterials: Transforming Bacterial Defense into Offense

(2018) Adrienne C. Greene   TRENDS IN BIOTECHNOLOGY

Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids

(2018) Michelle M. C. Buckner et al.   mBio

Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice

(2018) Geeta Ram et al.   NATURE BIOTECHNOLOGY

Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan

(2017) N. Yamamoto et al.   JOURNAL OF HOSPITAL INFECTION

Air guns used in offshore oil exploration can kill tiny marine life

(2017) Jeff Tollefson   NATURE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Reflecting on the final report of the O'Neill Review on Antimicrobial Resistance

(2016) Laura J V Piddock   LANCET INFECTIOUS DISEASES

The diversity-generating benefits of a prokaryotic adaptive immune system

(2016) Stineke van Houte et al.   NATURE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Bacteriophage-mediated spread of bacterial virulence genes

(2015) José R Penadés et al.   CURRENT OPINION IN MICROBIOLOGY

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria

(2015) Ido Yosef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

(2014) Robert J Citorik et al.   NATURE BIOTECHNOLOGY

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

(2014) David Bikard et al.   NATURE BIOTECHNOLOGY

Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation

(2009) Masato Suzuki et al.   Cell Host & Microbe

Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations

(2009) Carles Ubeda et al.   MOLECULAR MICROBIOLOGY