Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
出版年份 2020 全文链接
标题
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
作者
关键词
-
出版物
Nature Communications
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-07-03
DOI
10.1038/s41467-020-16991-2
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
- (2019) Maja M Janas et al. NUCLEIC ACIDS RESEARCH
- Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases
- (2018) Varman T. Samuel et al. Cell Metabolism
- Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
- (2018) Donald J. Foster et al. MOLECULAR THERAPY
- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
- Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
- (2018) Maja M. Janas et al. Nature Communications
- GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
- (2018) Aaron D. Springer et al. Nucleic Acid Therapeutics
- The Nonclinical Safety Profile of GalNAc-conjugated RNAi Therapeutics in Subacute Studies
- (2018) Maja M. Janas et al. TOXICOLOGIC PATHOLOGY
- An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema
- (2018) Jingxuan Liu et al. RNA
- Current and future pharmacological therapies for NAFLD/NASH
- (2017) Yoshio Sumida et al. JOURNAL OF GASTROENTEROLOGY
- The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury
- (2017) Lucía Barbier-Torres et al. Nature Communications
- Emerging therapies for NASH - the future is now
- (2017) Andreas Geier et al. Expert Review of Clinical Pharmacology
- JNK at the crossroad of obesity, insulin resistance, and cell stress response
- (2017) Giovanni Solinas et al. Molecular Metabolism
- Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum
- (2016) Timothy Hardy et al. Annual Review of Pathology-Mechanisms of Disease
- Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
- (2016) Devin P. Champagne et al. IMMUNITY
- Oxidative stress and lipotoxicity
- (2016) Amy K. Hauck et al. JOURNAL OF LIPID RESEARCH
- Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
- (2016) Giovanni Musso et al. NATURE REVIEWS DRUG DISCOVERY
- Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
- (2016) Henriette Kirchner et al. Molecular Metabolism
- Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling
- (2015) Rohit A Sinha et al. Autophagy
- Nonalcoholic fatty liver disease: Update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine
- (2015) Mazen Noureddin et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The carbon tetrachloride model in mice
- (2015) D Scholten et al. LABORATORY ANIMALS
- Knocking down disease: a progress report on siRNA therapeutics
- (2015) Anders Wittrup et al. NATURE REVIEWS GENETICS
- Genetic and epigenetic regulation of gene expression in fetal and adult human livers
- (2014) Marc Bonder et al. BMC GENOMICS
- Regulation of Oxidative Stress by Methylation-Controlled J Protein Controls Macrophage Responses to Inflammatory Insults
- (2014) Nicolás Navasa et al. JOURNAL OF INFECTIOUS DISEASES
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective
- (2014) Aaron M. Gusdon et al. Oxidative Medicine and Cellular Longevity
- Obesity accelerates epigenetic aging of human liver
- (2014) S. Horvath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats
- (2014) Kelly K. Andringa et al. Redox Biology
- DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery
- (2013) Markus Ahrens et al. Cell Metabolism
- Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease
- (2013) Susan K. Murphy et al. GASTROENTEROLOGY
- MCJ/DnaJC15, an Endogenous Mitochondrial Repressor of the Respiratory Chain That Controls Metabolic Alterations
- (2013) K. M. Hatle et al. MOLECULAR AND CELLULAR BIOLOGY
- Hepatic RNA interference: delivery by synthetic vectors
- (2013) Matthew T. Haynes et al. Drug Delivery and Translational Research
- Mitochondrial Complex I Plays an Essential Role in Human Respirasome Assembly
- (2012) David Moreno-Lastres et al. Cell Metabolism
- High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
- (2010) Rohit Kohli et al. HEPATOLOGY
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
- (2009) Nancy L. Heard-Costa et al. PLoS Genetics
- Respiratory Active Mitochondrial Supercomplexes
- (2008) Rebeca Acín-Pérez et al. MOLECULAR CELL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More