Article
Cell Biology
Xianfeng Gao, Xiaoya Wang, Huaiqiang He, Yang Cao
Summary: The study found that LINC02308 was significantly overexpressed in glioma, and a high level of LINC02308 was associated with poor prognosis. Silencing LINC02308 inhibited proliferation and promoted apoptosis of glioma cells, and suppressed tumor growth in a xenograft mouse model. Finally, it was demonstrated that LINC02308 promoted glioma tumorigenesis by acting as a sponge of miR-30e-3p to upregulate TM4SF1 and activate the AKT/mTOR pathway.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Oncology
Jinpeng Hu, Guoqing Zhang, Yongfeng Wang, Kai Xu, Lian Chen, Gang Luo, Jinkun Xu, Hao Li, Dongmei Pei, Xiang Zhao, Zhengting Guo, Xinqiao Li, Shengliang Zong, Yang Jiang, Zhitao Jing
Summary: This study identifies a novel circular RNA, circGNB1, which is upregulated in glioma and closely associated with poor prognosis. Functional assays reveal that circGNB1 overexpression promotes the viability, proliferation, invasion, and neurosphere formation of glioma stem cells. Mechanistically, circGNB1 upregulates the expression of oncogene XPR1 by sponging miR-515-5p and miR-582-3p. XPR1, in turn, promotes the malignant phenotype of glioma stem cells through upregulating IL6 expression and activating JAK2/STAT3 signaling. Additionally, the RNA binding protein IGF2BP3 binds to and stabilizes circGNB1, thus enhancing its effects on glioma stem cells. This study uncovers the crucial role of circGNB1 in tumorigenesis and malignant progression of glioma, providing a promising cancer biomarker.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Jinghan Hua, Xiaolin Wang, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang, Wenchu Lin
Summary: circVAPA promotes the progression of small cell lung cancer through the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
Article
Cell Biology
Jiaping Pei, Hui Dou, Xiaozhao Deng
Summary: This study reveals that up-regulation of circFAM53B promotes the progression of glioma by regulating the miR-532-3p/c-MET/PI3K/AKT pathway.
Article
Clinical Neurology
Kai Guo, Lingling Fang, Mingjian Li, Aizheng Li, Na Liu
Summary: The study aimed to investigate the expression, biological function, and molecular mechanism of long non-coding RNA (lncRNA) KTN1 antisense RNA 1 (KTN1-AS1) in glioblastoma (GBM) tumor progression. The results showed that KTN1-AS1 was upregulated in GBM tissues and cell lines, and it promoted the proliferation, migration, and invasion of GBM cells. The study also revealed that KTN1-AS1 targeted miR-505, which was downregulated in GBM. Furthermore, KTN1-AS1 upregulated several target oncogenes of miR-505, including ZEB2, HMGB1, and RUNX2, in GBM cells. In conclusion, the highly expressed KTN1-AS1 in GBM played an oncogenic role in GBM progression by targeting miR-505.
BEHAVIOURAL NEUROLOGY
(2023)
Article
Oncology
Jie Ling Zhang, Hui Fen Zheng, Kai Li, Yi Ping Zhu
Summary: This study investigates the role of miR-495-3p and HMGB1 in colorectal cancer (CRC). The findings suggest that miR-495-3p inhibits the progression of CRC by downregulating HMGB1 expression, indicating its potential as a therapeutic target for CRC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yujie Guo, Xiaoyan Xu, Tian Tang, Lin Sun, Xiong Zhang, Xia Shen, Dan Li, Lixin Wang, Libo Zhao, Peng Xie
Summary: In this study, it was discovered that miR-505 inhibits the replication of Borna disease virus 1 (BoDV-1) by down-regulating the expression of its target gene HMGB1, leading to the inhibition of autophagy activation.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Oncology
Zeqiang Liu, Zheng Yang, Lu He
Summary: This study investigated the effect of miR-29a-3p in glioma exosomes on the proliferation and apoptosis levels of U251 glioma cells under hypoxia. The results showed that miR-29a-3p expression level was lower in plasma exosomes of glioma patients compared to normal subjects. In vitro experiments demonstrated that miR-29a-3p overexpression significantly decreased U251 glioma cell proliferation and promoted apoptosis. The study suggests that miR-29a-3p carried by exosomes could serve as a novel diagnostic marker and potential inhibitory molecule for glioma cells.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Cell Biology
Chenlong Li, Yan Liu, Zhonghua Lv, Hongshan Zheng, Zhenzhe Li, Jixing Zhang, Hongbo Bao, Sibin Zhang, Jinsheng Xiong, Hua Jin, Lei Yu, Siqi Ai, Yingjie Wang, Xu Xiao, Tianqi Su, Peng Liang
Summary: This study identified the novel biomarker panel consisting of the circHECTD1/miR-296-3p/SLC10A7 axis, which is critical for glioma tumorigenesis and invasiveness, representing a potential therapeutic target for intervening in glioma progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chuntang Qin, Shuyan Liu, Weibin Chen, Dan Xue, Tianli Guo, Baojiang Wu
Summary: The study aims to explore the biological function and mechanism of circ_0082319 in the progression of hepatocellular carcinoma (HCC). The results suggest that circ_0082319 acts as a sponge for miR-505-3p to regulate PTK2 expression, thereby affecting HCC cell proliferation, invasion, and angiogenesis. HuR also plays a role in facilitating circ_0082319 expression and promoting HCC cell growth and metastasis through the miR-505-3p/PTK2 axis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Cell Biology
Chong Li, Shiyu Feng, Ling Chen
Summary: In TMZ-resistant glioma, high expression of MSC-AS1 was found to be associated with reduced overall survival rate, while inhibition of MSC-AS1 decreased IC50 value of TMZ, promoted apoptosis, and affected PI3K/Akt pathway. Further investigation revealed that MSC-AS1 acted as a miR-373-3p sponge and miR-373-3p targeted CPEB4 directly, influencing TMZ sensitivity. Silencing miR-373-3p reversed the promoting effect of MSC-AS1 or CPEB4 knockdown on TMZ sensitivity, indicating a potential regulatory mechanism for chemoresistance.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Neurosciences
Xuepei Li, Junwen Guan, Zhou Jiang, Shuting Cheng, Wang Hou, Junjie Yao, Zhengrong Wang
Summary: The study revealed that M2 microglial exosomes promote the proliferation and migration of gliomas by regulating tumor-related protein expression and reducing apoptosis. miR-7239-3p is recruited to glioma cells by exosomes and inhibits Bmal1 expression in the glioma microenvironment.
NEUROSCIENCE BULLETIN
(2021)
Article
Peripheral Vascular Disease
Shiliang Liu, Jing Gao, Jianbin Chen
Summary: The study revealed that TUG1 promotes angiogenesis in HUVECs by modulating the miR-505-3p/VEGFA axis, affecting cell proliferation, migration, and tube formation capabilities.
MICROVASCULAR RESEARCH
(2021)
Article
Cell Biology
Canxin Liang, Yanhua Peng, Huiping Sun, Lijuan Wang, Liubing Jiang, Shuangfa Zou
Summary: The study reveals that KCNQ1OT1 is involved in hepatic ischemia reperfusion injury and promotes pyroptosis through the regulation of miR-142a-3p/HMGB1/TLR4/NF-kappa B pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Neurosciences
Jiakai Chen, Handong Wang, Junjun Wang, Wenhao Niu, Chulei Deng, Mengliang Zhou
Summary: Accumulated evidence suggests that NEAT1 promotes glioma progression by acting as a sponge for miR-128-3p. The NEAT1/miR-128-3p/ITGA5 axis is involved in glioma initiation and progression, offering a potential novel strategy for treatment. NEAT1 competitively binds to miR-128-3p to enhance ITGA5 expression, activating the FAK signaling pathway and promoting cell growth in glioma.
MOLECULAR NEUROBIOLOGY
(2021)