Article
Gastroenterology & Hepatology
Yong Yi, Min-Cheng Yu, Pei-Yao Fu, Gao Liu, Pei-Yun Zhou, Ruo-Yu Guan, Cheng Zhou, Bao-Ye Sun, Shuang-Jian Qiu
Summary: This study found that MNS1 is highly expressed in HCC, correlated with poor patient survival, and promotes HCC growth and metastasis by activating the PI3K/AKT signaling pathway, as well as exerting oncogenic effects through modulation of beta-catenin.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Chen Hang, Shanojie Zhao, Tiejun Wang, Yan Zhang
Summary: In this study, UBE3C was identified as an oncogenic factor in breast cancer growth and metastasis. High nuclear UBE3C expression in breast cancer tissues was associated with worse overall survival. Knockdown of UBE3C inhibited cell proliferation, migration and invasion in breast cancer cells, while overexpression of UBE3C had the opposite effects. UBE3C promoted beta-catenin nuclear accumulation and activated the Wnt/beta-catenin signaling pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Wei Zheng, Guo-Liang Shen, Ke-Yang Xu, Qiao-Qiao Yin, Tian-Chen Hui, Zhe-Wen Zhou, Cheng-An Xu, Shou-Hao Wang, Wen-Hao Wu, Ling-Fei Shi, Hong-Ying Pan
Summary: Lnc524369 is significantly upregulated in liver cancer cells and human HCC tissues, and its overexpression is associated with the proliferation, migration, and invasion of liver cancer cells. YWHAZ and RAF1 proteins, as well as YWHAZ mRNA, are overexpressed in liver cancer, and their overexpression can be attenuated by Lnc524369 overexpression. Lnc524369 and its downstream target YWHAZ and RAF1 are negatively associated with overall survival time.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Oncology
Jun Zhang, Xian Zhang, Shasha Yang, Yanqiu Bao, Dongyuan Xu, Lan Liu
Summary: The study demonstrated that higher FOXH1 expression is associated with poor overall survival in lung cancer patients. Knockdown of FOXH1 inhibited lung cancer cell proliferation, migration, invasion, and cycle, highlighting FOXH1's potential as a therapeutic target in certain types of lung cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Suping Tang, Jun Ni, Bohua Chen, Fei Sun, Jinbo Huang, Songshi Ni, Zhiyuan Tang
Summary: Our study found that PAFAH1B3 is upregulated in LUAD tissues and cells compared with noncancerous tissues and cells. It is positively correlated with distant metastasis, TNM stage, and poor clinical outcome, and serves as an independent prognostic risk factor for LUAD. Silencing PAFAH1B3 suppresses proliferation, invasion, and EMT, while increasing the cell population in the G0-G1 phases. Additionally, knockdown of PAFAH1B3 increases E-cadherin level and decreases N-cadherin level, inhibiting tumorigenesis and neutrophil infiltration in the xenograft tumor model.
Article
Oncology
Gaopeng Li, Guoliang Wang, Fenqing Chi, Yuqi Jia, Xi Wang, Quankai Mu, Keru Qin, Xiaoxia Zhu, Jing Pang, Baixue Xu, Guangen Feng, Yuhu Niu, Tao Gong, Hongwei Zhang, Xiushan Dong, Ting Liu, Jinfeng Ma, Zefeng Gao, Kai Tao, Feng Li, Jun Xu, Baofeng Yu
Summary: Postoperative plasma ePD-L1 level is an important prognostic indicator for gastric cancer patients after surgery, with high levels significantly correlating with poor survival, while level changes can bring significant survival benefits.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yu You, Diguang Wen, Lu Zeng, Jiao Lu, Xiao Xiao, Yucheng Chen, Hua Song, Zuojin Liu
Summary: ALKBH5 is highly expressed in hepatocellular carcinoma (HCC) and is associated with worse prognosis. It promotes the proliferation and metastasis of HCC cells and recruits macrophages through the ALKBH5/MAP3K8 axis, thus promoting HCC growth and metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Xiaoyun Hu, Guosheng Yuan, Qi Li, Jing Huang, Xiao Cheng, Jinzhang Chen
Summary: High expression of DHX32 is associated with reduced overall survival in HCC patients. DHX32 upregulation induces EMT, promotes mobility and proliferation of HCC cells, and enhances tumor growth in vivo. Silencing DHX32 reverses EMT, inhibits malignancy behaviors of HCC cells, and suppresses tumor growth.
ANNALS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chao Li, Li -fang Lv, Mu-ge Qi-Li, Rui Yang, Yu-jing Wang, Shuang-shuang Chen, Ming-xiu Zhang, Tian-yu Li, Tong Yu, Yu-hong Zhou, Hai-hai Liang, Hong-li Shan, Xue-lian Li
Summary: In this study, the researchers found that serpinE2 can be translocated into cardiac fibroblasts through endocytosis by interacting with membrane proteins LRP1 and uPAR. This process activates the ERK1/2 and β-catenin signaling pathways, consequently promoting collagen production.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
A-hui Fan, Xiaojuan Zhao, Hao Liu, Danxiu Li, Tongtong Guo, Jiehao Zhang, Lili Duan, Hao Cheng, Yongzhan Nie, Daiming Fan, Xiaodi Zhao, Yuanyuan Lu
Summary: This study found that elevated expression of eEF1A1 is correlated with poor prognosis in colorectal cancer (CRC). Inhibition of eEF1A1 can suppress CRC cell proliferation and induce cell cycle arrest. Analysis identified that mitogen-activated protein kinases (MAPKs) signaling pathway is enriched in the high-eEF1A1 expression group.
Article
Oncology
Fei Gao, Jilai Yin, Yongcun Wang, Hao Li, Daping Wang
Summary: miR-182 overexpression is positively correlated with distant metastasis in cervical cancer patients. It promotes the growth of cervical cancer cells and affects the progression of cervical cancer through the Wnt/β-catenin axis and its downstream genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Dongying Wang, Shuying Wu, Jiaxing He, Luguo Sun, Hongming Zhu, Yuxuan Zhang, Shanshan Liu, Xuefeng Duan, Yanhong Wang, Tianmin Xu
Summary: FAT4 overexpression regulates PD-L1 N-glycosylation and cell membrane localization in a beta-catenin-dependent manner, inhibiting tumor immune escape in cervical cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Rui Ma, Yunpeng Liu, Xiaofang Che, Ce Li, Ti Wen, Kezuo Hou, Xiujuan Qu
Summary: Colorectal cancers with the BRAF V600E mutation have upregulated PD-L1 expression. This study found that PD-L1 is highly expressed in both the nucleus and cytoplasm. In the nucleus, PD-L1 translocation is facilitated by p-ERK and it interacts with THRAP3 to upregulate BUB1 expression, thus accelerating cell cycle progression and promoting cell proliferation. Additionally, BRAF V600E mutated CRC cells upregulate PD-L1 expression via the transcription factor LEF-1. These findings reveal a novel role of nPD-L1 in promoting cell cycle progression in an immune-independent manner in BRAF V600E mutated CRC.
Review
Oncology
Kaoru Abiko, Junzo Hamanishi, Noriomi Matsumura, Masaki Mandai
Summary: In this article, we demonstrated that PD-L1 expression in ovarian cancer is induced by IFN-gamma from lymphocytes in the tumor microenvironment. PD-L1 expression was found to be unstable and influenced by stromal infiltration of cytotoxic lymphocytes. This study highlights the importance of understanding the complex immune microenvironment of ovarian cancer to identify reliable biomarkers and develop new treatment strategies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Jianlong Wang, Bin Liu, Jiewei Cao, Lianmei Zhao, Guiying Wang
Summary: MIR31HG is upregulated in colorectal cancer patients and its high expression is associated with poor prognosis. GSEA analysis suggests that MIR31HG may be involved in tumorigenesis through modulation of focal adhesion, extracellular matrix organization, integrin cell surface interactions, and focal adhesion-PI3K-Akt-mTOR signaling pathway. Functional experiments demonstrate that silencing of MIR31HG can significantly inhibit migration, invasion, growth, and colony formation in colorectal cancer cells, and alter the expression of key genes related to tumorigenesis.
CANCER MANAGEMENT AND RESEARCH
(2022)