Article
Oncology
Liangyou Gu, Wenlei Zhao, Junnan Xu, Baojun Wang, Qiang Cheng, Donglai Shen, Yundong Xuan, Xupeng Zhao, Hongzhao Li, Xin Ma, Xu Zhang
Summary: This study compared the outcomes of transperitoneal robotic partial nephrectomy (TRPN) and retroperitoneal robotic partial nephrectomy (RRPN) for complete upper pole renal masses. The results showed no significant differences between the two surgical approaches in terms of operating time, renal artery clamping time, and postoperative complications. However, TRPN was associated with greater estimated blood loss. Multivariate analysis identified that RENAL score was independently associated with the achievement of treatment success.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Rodney H. Breau, Dean A. Fergusson, Greg Knoll, Kristen McAlpine, Christopher Morash, Sonya Cnossen, Luke T. Lavallee, Ranjeeta Mallick, Antonio Finelli, Michael A. S. Jewett, Bradley C. Leibovich, Jonathan A. Cook, Anil Kapoor, Frederic Pouliot, Jonathan Izawa, Ricardo Rendon, Ilias Cagiannos
Summary: The study found that inducing renal hypothermia during partial nephrectomy did not effectively preserve kidney function in patients with normal or mildly impaired renal function, and had no significant impact on surgical outcomes or patient-reported quality of life.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Wenlei Zhao, Yancai Ding, Dong Chen, Yundong Xuan, Zhiqiang Chen, Xupeng Zhao, Bin Jiang, Baojun Wang, Hongzhao Li, Chengliang Yin, Xin Ma, Gang Guo, Liangyou Gu, Xu Zhang
Summary: This study compared the perioperative outcomes of robotic partial nephrectomy via transperitoneal and retroperitoneal approaches for completely lower pole renal tumors. The results showed no significant differences between the two approaches in terms of blood loss, operative time, ischemia time, postoperative complications, and tumor size. Therefore, both approaches are feasible options for completely lower pole renal tumors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Haichang Li, Yuning Hu, Dongning Lu, Jingyun Wang, Yanze Lin, Xugang Zhong, Yixuan Mou, Cenchao Yao, Zhida Wang, Xinyu Zhang, Qijun Wo, Hanbo Liu, Feng Liu, Dahong Zhang, Heng Wang
Summary: Based on a retrospective analysis, this study compared the feasibility and safety of zero ischaemia robotic-assisted laparoscopic partial nephrectomy (RALPN) after preoperative superselective transarterial embolization (STE) to standard RALPN and off-clamp RALPN. The results showed that zero ischaemia RALPN can preserve more renal function and provide a safe and feasible surgical method for patients with renal tumors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregoire Cazalas, Clement Klein, Gilles Piana, Eric De Kerviler, Afshin Gangi, Philippe Puech, Cosmina Nedelcu, Remi Grange, Xavier Buy, Marc-Antoine Jegonday, Pierre Bigot, Charles Karim Bensalah, Victor Gaillard, Geraldine Pignot, Philippe Paparel, Lionel Badet, Clement Michiels, Jean Christophe Bernhard, Olivier Rouviere, Nicolas Grenier, Clement Marcelin
Summary: Percutaneous-guided thermal ablation and robotic-assisted partial nephrectomy are effective treatments for T1b renal cancer; however, thermal ablation has a higher local recurrence rate.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Karl-Friedrich Kowalewski, Marie Angela Sidoti Abate, Manuel Neuberger, Marietta Kirchner, Regina Krisam, Luisa Egen, Caelan Max Haney, Fabian Siegel, Maurice-Stephan Michel, Patrick Honeck, Philipp Nuhn, Niklas Westhoff, Maximilian Christian Kriegmair
Summary: This study is a randomised controlled feasibility trial comparing robotic-assisted partial nephrectomy (RAPN) and open partial nephrectomy (OPN) for renal neoplasms. The primary endpoint is the feasibility of recruitment, and secondary endpoints include perioperative results and health-related quality of life. Results will be disseminated through peer-reviewed scientific journals and appropriate conferences.
Article
Oncology
Burak Ucpinar, Miller Rich, Kennedy E. Okhawere, Shirin Razdan, Osama Zaytoun, Laura Zuluaga, Indu Saini, Michael D. Stifelman, Ronney Abaza, Daniel D. Eun, Akshay Bhandari, Ashok K. Hemal, James Porter, Simone Crivellero, Ahmed Mansour, Phillip M. Pierorazio, Ketan K. Badani
Summary: Robotic partial nephrectomy (RPN) is a safe and feasible procedure for highly complex renal masses. The study showed excellent rates of surgical success and short-term functional outcomes when performed by experienced surgeons. Long-term oncological and functional evaluation is needed to further support this conclusion.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Multidisciplinary Sciences
Haruyuki Ohsugi, Kyojiro Akiyama, Hisanori Taniguchi, Masaaki Yanishi, Motohiko Sugi, Tadashi Matsuda, Hidefumi Kinoshita
Summary: Multiple nephrometry scoring systems exist for predicting surgical complexity and perioperative morbidity, with the R.E.N.A.L. scoring system being one of the most prominent. Despite controversy surrounding their effectiveness in predicting renal function loss after robotic partial nephrectomy, this study found that tumor volume and tumor crossing the axial renal midline were significant predictors of postoperative renal function. Combining these factors led to a more accurate prediction of postoperative renal function compared to previous nephrometry scoring systems.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Tara N. Morgan, Jessica C. Dai, Sam Kusin, Vineeth Kommidi, Alaina Garbens, Jeffrey Gahan, Jeffrey A. Cadeddu
Summary: This study evaluated the safety, efficacy, and early oncologic outcomes of robotic partial nephrectomy (RPN) for pathologic T3a renal cell carcinoma with venous involvement. The results showed that RPN is feasible and safe, with more favorable short-term oncologic outcomes than previously reported.
Review
Oncology
Ruizhen Huang, Chiyu Zhang, Xing Wang, Honglin Hu
Summary: This meta-analysis compared the outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for patients with T2 renal tumors, showing that PN led to lower decline in renal function and improved overall survival compared to RN, but was associated with higher postoperative complication rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Fabrizio Gallo, Simone Sforza, Lorenzo Luciani, Daniele Mattevi, Paolo Barzaghi, Andrea Mari, Fabrizio Di Maida, Alessandro Antonelli, Luca Cindolo, Antonio Galfano, Giovannalberto Pini, Guglielmo Mantica, Maurizio Schenone, Luigi Schips, Filippo Annino, Carlo Terrone, Aldo Massimo Bocciardi, Franco Gaboardi, Andrea Minervini
Summary: Our data indicate that simultaneous bilateral RAPNs could be a safe and feasible procedure with promising results for the treatment of bilateral synchronous renal masses in selected patients and expert hands.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Xiao-Lu Jiang, Kui OuYang, Rui Yang, Xiao-Yang Yu, Dian-Dong Yang, Ji-Tao Wu, Hong-Wei Zhao
Summary: This study assessed the feasibility of using an internal traction technique (ITT) in retroperitoneal robot-assisted partial nephrectomy (rRAPN) for renal ventral tumors. The results showed that ITT reduced warm ischemia time and estimated blood loss compared to the traditional technique, with no other significant differences observed.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Alp Tuna Beksac, Umberto Carbonara, Mahmoud Abou Zeinab, Margaret Meagher, Sij Hemal, Alessandro Tafuri, Gabriele Tuderti, Alessandro Antonelli, Riccardo Autorino, Giuseppe Simone, Ithaar H. Derweesh, Jihad Kaouk
Summary: In this retrospective analysis of 72 patients with recurrent renal masses, redo RAPN was found to be an effective approach with promising perioperative and functional outcomes. However, careful monitoring for distant recurrence is necessary.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Oncology
Kennedy E. Okhawere, Jordan Miller Rich, Burak Ucpinar, Alp Tuna Beksac, Indu Saini, Anthony Deluxe, Laura Zuluaga, Daniel D. Eun, Akshay Bhandari, Ashok K. Hemal, James Porter, Ronney Abaza, Ahmed Mansour, Michael D. Stifelman, Simone Crivellaro, Phillip M. Pierorazio, Osama Zaytoun, Ketan K. Badani
Summary: This study compared the safety and feasibility of retroperitoneal and transperitoneal robotic partial nephrectomy for completely endophytic renal tumors. The results showed that both approaches had similar perioperative and functional outcomes. Therefore, either retroperitoneal or transperitoneal approach could be considered for selected patients with completely endophytic tumors without compromising outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Review
Oncology
Zhi Wen, Li Wang, Jing Huang, Yang Liu, Cai-xia Chen, Chong-jian Wang, Lin-lin Chen, Xue-song Yang
Summary: This study compared the outcomes of partial nephrectomy (PN) and ablation (AT) for the treatment of small solitary renal tumors. The results showed that compared to PN, AT had shorter hospital stays, shorter operating times, lower risks of postoperative creatinine increases and glomerular filtration rate decreases, less postoperative new-onset chronic kidney disease, and less intraoperative blood loss. However, the risk of local recurrence was higher in the AT group, while the risk of distant metastasis was higher in the PN group. Overall survival, postoperative dialysis rate, and tumor-specific survival were not different between the two groups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
Adil Mellouki, Imad Bentellis, Arnoult Morrone, Nicolas Doumerc, Jean-Baptiste Beauval, Morgane Roupret, Francois-Xavier Nouhaud, Cedric Lebacle, Jean-Alexandre Long, Daniel Chevallier, Brannwel Tibi, Aysha Shaikh, L. Imbert de la Phalecque, Pierre Pillot, Xavier Tillou, Jean-Christophe Bernhard, Matthieu Durand, Youness Ahallal
Summary: This study compared the oncological outcomes of off-clamp and on-clamp robotic partial nephrectomy for renal cell carcinoma and found that the hilar control approach did not have a significant impact on positive surgical margin rate or survival outcomes. Age at surgery was found to be an independent factor affecting positive surgical margin.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Michael Baboudjian, Bastien Gondran-Tellier, Zineddine Khene, Pierre Bigot, Arnaud Mejean, Herve Lang, Cedric Lebacle, Nicolas Doumerc, Franck Bruyere, Francois-Xavier Nouhaud, Idir Ouzaid, Karim Bensalah, Jean Christophe Bernhard, Romain Boissier
Summary: This study assessed the oncological outcomes of renal cell carcinoma (RCC) with tumor thrombus and identified predictive factors of recurrence. The results showed that adjuvant therapy was effective in reducing cancer recurrence risk.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Clement Michiels, Zine-Eddine Khene, Thomas Prudhomme, Astrid Boulenger de Hauteclocque, Francois H. Cornelis, Melanie Percot, Helene Simeon, Laure Dupitout, Henri Bensadoun, Gregoire Capon, Eric Alezra, Vincent Estrade, Franck Bladou, Gregoire Robert, Jean-Marie Ferriere, Nicolas Grenier, Nicolas Doumerc, Karim Bensalah, Jean-Christophe Bernhard
Summary: In robot-assisted partial nephrectomy (RAPN), using three-dimensional model reconstructions for preoperative planning and intraoperative guidance can reduce complications and improve perioperative clinical outcomes.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Astrid Boulenger de Hauteclocque, Loic Ferrer, Damien Ambrosetti, Solene Ricard, Pierre Bigot, Karim Bensalah, Francois Henon, Nicolas Doumerc, Arnaud Mejean, Virginie Verkarre, Charles Dariane, Stephane Larre, Cecile Champy, Alexandre de La Taille, Franck Bruyere, Morgan Roupret, Philippe Paparel, Stephane Droupy, Alexis Fontenil, Jean-Jacques Patard, Xavier Durand, Thibaut Waeckel, Herve Lang, Cedric Lebacle, Laurent Guy, Geraldine Pignot, Matthieu Durand, Jean-Alexandre Long, Thomas Charles, Evanguelos Xylinas, Romain Boissier, Mokrane Yacoub, Thierry Colin, Jean-Christophe Bernhard
Summary: This study assessed the impact of pathological upstaging in renal cell carcinoma patients and evaluated the oncological safety of different surgical approaches. A machine-learning model was developed to predict upstaging. The findings showed that machine-learning technology can be useful in evaluating and predicting upstaging in renal cell carcinoma. Partial nephrectomy did not compromise oncological outcomes in incidental upstaging, even for large tumors.
Article
Oncology
Clement Allenet, Clement Klein, Benjamin Rouget, Gaelle Margue, Gregoire Capon, Eric Alezra, Peggy Blanc, Vincent Estrade, Franck Bladou, Gregoire Robert, Jean-Christophe Bernhard
Summary: The pre-operative neutrophil-to-lymphocyte ratio (NLR) can predict the risk of recurrence in non-metastatic renal cell carcinoma following surgery, and it is a cost-effective and easily accessible biomarker.
Article
Engineering, Biomedical
Kilian Chandelon, Rasoul Sharifian, Salome Marchand, Abderrahmane Khaddad, Nicolas Bourdel, Nicolas Mottet, Jean-Christophe Bernhard, Adrien Bartoli
Summary: This study proposes a method for continuous live augmented reality (AR) assistance in minimally invasive partial nephrectomy (MIPN). The method utilizes camera calibration, manual registration, and a keypoint-based automatic kidney tracking module. Experimental results show that the proposed method outperforms existing tracking methods.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Review
Oncology
Estelle Granet-Vaissiere, Felix Lefort, Charlotte Domblides, Mathieu Larroquette, Alain Ravaud, Jean-Christophe Bernhard, Marine Gross-Goupil
Summary: This article summarizes the data on the combination of antiangiogenic and immune checkpoints in the treatment of clear-cell renal-cell carcinoma. The review provides detailed information on the rationale of combining tyrosine kinase inhibitors and immunotherapy, as well as the pre-clinical and clinical experiences that support the synergistic effect between these two therapeutic targets. The article also discusses the different combinations of pembrolizumab-axitinib, pembrolizumab-lenvatinib, and cabozantinib-nivolumab, and how they can guide clinicians in choosing the appropriate treatment.
Article
Medicine, General & Internal
Cassandre Garnier, Loic Ferrer, Jennifer Vargas, Olivier Gallinato, Eva Jambon, Yann Le Bras, Jean-Christophe Bernhard, Thierry Colin, Nicolas Grenier, Clement Marcelin
Summary: This study compared the performance of machine learning models using bio-clinical, conventional radiologic, and 3D-radiomic features for differentiating benign and malignant solid renal tumors. The results showed that a machine learning model combining clinical, radiologic, and radiomic features had good predictive performance in distinguishing benign from malignant solid renal tumors based on pre-operative multiphasic contrast-enhanced CT examinations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gregoire Cazalas, Clement Klein, Gilles Piana, Eric De Kerviler, Afshin Gangi, Philippe Puech, Cosmina Nedelcu, Remi Grange, Xavier Buy, Marc-Antoine Jegonday, Pierre Bigot, Charles Karim Bensalah, Victor Gaillard, Geraldine Pignot, Philippe Paparel, Lionel Badet, Clement Michiels, Jean Christophe Bernhard, Olivier Rouviere, Nicolas Grenier, Clement Marcelin
Summary: Percutaneous-guided thermal ablation and robotic-assisted partial nephrectomy are effective treatments for T1b renal cancer; however, thermal ablation has a higher local recurrence rate.
EUROPEAN RADIOLOGY
(2023)
Article
Urology & Nephrology
Nicolas Branger, Pierre Bigot, Geraldine Pignot, Vito Lorusso, Francois Audenet, Bastien Parier, Nicolas Doumerc, Martin Brenier, Evanguelos Xylinas, Romain Boissier, Morgan Roupret, Cecile Champy, Francois-Xavier Nouhaud, Herve Lang, Thomas Charles, Richard Mallet, Damien Ambrosetti, Karim Bensalah, Jean-Christophe Bernhard
Summary: The purpose of this study was to describe the clinical features of patients with oncocytoma on renal biopsy, the correlation with final histology on surgically treated patients, and the predictive factors of discrepancy between renal biopsy and final histology. The results showed a significant discrepancy between renal biopsy and final histology, and the main predictive factor was biopsy done outside of the center. Therefore, this information should be discussed with patients before treatment decision.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Abderrahmane Khaddad, Jean-Christophe Bernhard, Gaelle Margue, Clement Michiels, Solene Ricard, Kilian Chandelon, Franck Bladou, Nicolas Bourdel, Adrien Bartoli
Summary: Minimally invasive partial nephrectomy (MIPN) has become the standard treatment for localized kidney tumors. The development of virtual 3D model reconstruction and computer vision has opened up new possibilities for image-guided surgery and augmented reality (AR). However, there is currently no evidence showing that AR can improve clinical outcomes. Further clinical data is needed to evaluate the potential contribution of AR technology to MIPN.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Jean-Christophe Bernhard, Gregoire Robert, Solene Ricard, Julien Rogier, Cecile Degryse, Clement Michiels, Gaelle Margue, Peggy Blanc, Eric Alezra, Vincent Estrade, Gregoire Capon, Franck Bladou, Jean-Marie Ferriere
Summary: Combining RAPN with nurse-led coordinated pathways of care can lead to a shorter hospital stay and reduced costs, facilitating the economic sustainability of robotic assistance.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Ygal Benichou, Francois Audenet, Karim Bensalah, Morgan Roupret, Philippe Paparel, Cedric Lebacle, Franck Bruyere, Jean-Baptiste Beauval, Arnauld Villers, Herve Lang, Xavier Durand, Pierre Bigot, Jean Alexandre Long, Cecile Champy, Alexandre Lavolle, Jean Christophe Bernhard, Eric Alezra
Summary: This study compared the perioperative results of robotic-assisted partial nephrectomy (RAPN) to open surgery in patients with solitary kidney tumors. The study found that there was no significant difference between the two groups in terms of eGFR variation and Trifecta success, but the RAPN group had significantly shorter hospital stay and fewer complications compared to the open surgery group.
WORLD JOURNAL OF UROLOGY
(2023)