期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 129, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2020.115957
关键词
Multiple dimension analytical techniques; Gas chromatography; Mass spectrometry; Comprehensive 2D GC; High resolution; Fatty acids; Triacylglycerols
资金
- Monash University
- Australian Research Council [LP150100465]
- PerkinElmer
- Australian Research Council [LP150100465] Funding Source: Australian Research Council
Single dimension gas chromatography (GC) is widely used for the analysis of a broad variety of lipid samples of a multitude of origins, most often used as a GC method in combination with mass spectrometry (MS). However, adequate characterisation and accurate identification of fatty acids (FAs) and triacylglycerols (TAGs) remain challenging due to their complexity, incomplete resolution on the separation dimension often confounded by sample matrix, and sometimes insufficient MS domain differentiation. The higher resolution of multidimensional separation enables improved quality separations that should translate to better reliability of identification and more precise analytical characterisation of major and minor abundance FA isomers that contribute nutrition and health benefits, and for compounds that can be used for medical and pharmaceutical purposes. Development of advanced multidimensional chromatographic strategies incorporating multiple separations coupled with different detection tools, including multistage-MS (MSn) methods for FA in various foods, environmental and biological samples is described. (C) 2020 Elsevier B.V. All rights reserved.
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