Article
Hematology
Kenan Toprak, Mustafa Kaplangoray, Ali Palice, Mustafa Begenc Tascanov, Mehmet Inanir, Tolga Memioglu, Zafer Kok, Asuman Bicer, Recep Demirbag
Summary: SCUBE1 may be one of the major determinants of thrombotic complications in COVID-19 patients, and inhibiting this peptide could be a therapeutic target for COVID-19 patients.
THROMBOSIS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mariangela Mancini, Gianmarco Randazzo, Gregory Piazza, Fabrizio Dal Moro
Summary: COVID-19 infection can lead to thrombotic complications, especially venous thromboembolism. This case report highlights the occurrence of arterial thrombosis in a patient with COVID-19, causing partial kidney infarction and severe pain. It emphasizes the importance of the risk of recurrent thrombosis in patients with a recent history of COVID-19.
Article
Multidisciplinary Sciences
Sebastian Staubli, Dimitri Raptis, Shahi Ghani, Brian Davidson, Giuseppe Fusai, Charles Imber, Sateesh Iype, David Nasralla, Theodora Pissanou, Sakhawat Rahman, Dinesh Sharma, Pascale Tinguely, Fares Haddad, Miranda Dodd, Chris Dann, David Walker, Joerg-Matthias Pollok
Summary: To address the shortage of treatment capacity caused by COVID-19, the hepatopancreatobiliary unit of the Royal Free Hospital London transferred its practice to independent hospitals in Central London. This study assessed the strategy and found that outsourcing HPB patients to other institutions during the pandemic was safe and resulted in comparable treatment outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Abdel Douiri, Walter Muruet, Ajay Bhalla, Martin James, Lizz Paley, Kaili Stanley, Anthony G. Rudd, Charles D. A. Wolfe, Benjamin D. Bray
Summary: The initial wave of the COVID-19 pandemic in the UK led to a decrease in admissions for acute stroke patients, with older patients and those with less severe strokes being more affected. While quality of stroke care was maintained and even improved in some aspects, there was an increase in inpatient case fatality, especially among patients with confirmed or suspected COVID-19 infections. These findings suggest that hospital avoidance during the pandemic may have resulted in untreated stroke patients with poorer outcomes, highlighting the need for resilient healthcare systems.
Article
Environmental Sciences
Calvin Jephcote, Anna L. Hansell, Kathryn Adams, John Gulliver
Summary: The UK implemented a lockdown in Spring 2020 to reduce person-to-person transmission of SARS-CoV-2 virus. The study found a 69% reduction in traffic during the lockdown period, leading to decreases in NO2 and PM2.5 pollutants while O-3 concentrations increased. Results suggest that sustained improvements in air quality require actions across various sectors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Psychology, Developmental
Yang Hu, Yue Qian
Summary: The study examines the mental health impact of the COVID-19 pandemic on adolescents in the UK, finding different effects based on adolescents' pre-pandemic mental health and sociodemographic backgrounds. During the pandemic, adolescents experienced a decrease in prosocial tendency and an increase in emotional problems, conduct problems, and hyperactivity.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Oncology
Haoyu Wang, Mohammed Elsheikh, Kenneth Gilmour, Victoria Cohen, Mandeep S. Sagoo, Bertil Damato, Rodrigo Anguita, Heinrich Heimann, Rumana Hussain, Paul Cauchi, Vikas Chadha, Julie Connolly, Paul Rundle, Sachin M. Salvi
Summary: The UK Ocular Oncology Services conducted a study on the impact of COVID-19 pandemic on adult eye cancer care in the UK, finding significant reductions in referral and diagnosis numbers during the lockdown period. The study also revealed shifts in treatment choices and an increase in advanced disease cases after the lockdown was lifted.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Gustavo M. Athayde, Airlane P. Alencar
Summary: In this study, a stochastic generalization of the SIRD model is presented using a state space framework, where the mortality, infection, and underreporting rates are allowed to vary over time. The model is applied to the UK COVID-19 data from April 2020 to September 2021, and the estimated trajectories and forecasts of various variables are provided. The estimated infection rate shows a trajectory in waves that aligns with the emergence of new variants and the implementation of social measures. The mortality rate exhibits a significant decrease in 2021, which is attributed to the vaccination program. The estimated underreporting rate is volatile but generally decreasing, suggesting increased testing compared to the early stages of the pandemic. The proportions of the population in susceptible, infected, recovered, and dead groups, as well as the estimated amount of reinfection, are also presented. The estimated trajectory of the effective reproduction rate closely matches the real number of cases and deaths.
Article
Cardiac & Cardiovascular Systems
Prakash Acharya, Sagar Ranka, Prince Sethi, Rajani Bharati, Jinxiang Hu, Amit Noheria, Brahmajee K. Nallamothu, Salim S. Hayek, Kamal Gupta
Summary: This study used data from the AHA COVID-19 CVD registry to conduct a study on patients with COVID-19, and found that older age, Black race, and Hispanic ethnicity are independent predictors of IHCA. Although the incidence of IHCA is lower in ICU patients, a significant proportion of IHCA events in patients with COVID-19 occur in non-ICU settings, with a lower survival rate.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Virology
Farah Yasmin, Syed Hasan Ali, Irfan Ullah
Summary: Norovirus, a global enteric virus primarily responsible for gastroenteritis outbreaks, is currently causing outbreaks in the UK, which poses significant challenges to the National Health Service. Primary challenges include increased strain on healthcare services, rising cases in educational and care facilities, and lack of an effective vaccine, emphasizing the need for increased public awareness, precautions, and reporting.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Allergy
Adrian M. Shields, Siobhan O. Burns, Sinisa Savic, Alex G. Richter
Summary: Patients with PID and symptomatic SID have higher morbidity and mortality risks from COVID-19 compared to the general population, requiring enhanced protective measures.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Rheumatology
Deepa J. Arachchillage, Indika Rajakaruna, Charis Pericleous, Philip L. R. Nicolson, Mike Makris, Mike Laffan
Summary: Patients with autoimmune disease (AD) admitted with COVID-19 showed differences in laboratory findings and clinical outcomes compared to patients without AD. Those with severe rheumatologic AD had higher mortality rates and elevated levels of anemia, renal impairment, LDH, CRP, which are associated with increased mortality in COVID-19 patients.
Article
Multidisciplinary Sciences
Lea Ellwardt, Patrick Prag
Summary: The study identified four different trajectories of psychological distress during the COVID-19 pandemic in the UK: continuously low, temporarily elevated, repeatedly elevated, and continuously elevated distress. Nearly two fifths of the population experienced severely elevated risks of distress during the pandemic. Long-term distress was highest among younger people, women, people living without a partner, those who had no work or lost income, and those with previous health conditions or COVID-19 symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Studies
David Keen
Summary: The paper discusses how disasters are now affecting Western democracies and highlights reasons why democracy has not been particularly protective in the cases of the UK and the US, such as redefining disaster, the influence of neoliberalism, and limitations in information dissemination. Furthermore, disasters should not be seen as a discredit to democracy but rather as an opportunity for a reinvigoration of democracy to avoid the misuse of emergency powers.
Article
Health Care Sciences & Services
Mansour Almuqbil, Ali Ibrahim Almoteer, Alwaleed Mohammed Suwayyid, Abdulaziz Hussain Bakarman, Raed Fawaz Alrashed, Majed Alrobish, Fahad Alasalb, Abdulaziz Abdulrahman Alhusaynan, Mohammed Hadi Alnefaie, Abdullah Saud Altayar, Saad Ebrahim Alobid, Moneer E. Almadani, Ahmed Alshehri, Adel Alghamdi, Syed Mohammed Basheeruddin Asdaq
Summary: This study aimed to analyze the characteristics of COVID-19 patients in the ICU of a multispecialty hospital in Saudi Arabia. The findings showed that male patients and those with diabetes and hypertension had a higher risk of severe illness and death. Despite a significant number of intubated patients, the study center's ICU had a lower fatality rate due to excellent healthcare management.
Article
Anesthesiology
Kamen Valchanov, Florian Falter, Shane George, Christiana Burt, Andrew Roscoe, Choo Ng, Martin Besser, Shuaib Nasser
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2019)
Letter
Hematology
Stephen MacDonald, Rajani Chengal, Anida Hanxhiu, Emily Symington, Karen Sheares, Martin Besser, Will Thomas
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Surgery
Jason M. Ali, Martin Besser, Martin Goddard, Yasir Abu-Omar, Pedro Catarino, Sai Bhagra, Marius Berman
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Hematology
Stephen MacDonald, Alfie Wright, Frederik Beuche, Kate Downes, Martin Besser, Emily Symington, Anne Kelly, Will Thomas
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2020)
Article
Anesthesiology
W. Zghaibe, S. Scheuermann, K. Munting, G. Blaudszun, M. Besser, E. Ortmann, A. A. Klein
Article
Engineering, Biomedical
Zihui Tan, Martin Besser, Simon Anderson, Caroline Newey, Ray Iles, John Dunning, Florian Falter
Article
Cardiac & Cardiovascular Systems
D. White, S. MacDonald, T. Bull, M. Hayman, R. de Monteverde-Robb, D. Sapsford, A. Lavinio, J. Varley, A. Johnston, M. Besser, W. Thomas
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2020)
Review
Oncology
Martin W. Besser
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Hematology
Danielle White, Stephen MacDonald, Tara Edwards, Chris Bridgeman, Megan Hayman, Megan Sharp, Sally Cox-Morton, Emily Duff, Swati Mahajan, Chloe Moore, Melissa Kirk, Richard Williams, Martin Besser, Will Thomas
Summary: This study aimed to explore thrombin generation in COVID-19 patients using a novel analyzer. Critical patients showed increased levels of fibrinogen, CRP, interleukin-6, and D-dimer compared to noncritical patients. Although critical patients had right-shifted thrombin generation, there were no significant differences in key thrombin generation parameters. Increased levels of tPA, TFPI, and VEGF in critical patients may indicate endothelial dysfunction or heparin-induced effects.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Letter
Hematology
Daniel M. Gleghorn, Orisadare Olayiwola, Anisa Omer, Roderick Lynn, David Norcliffe, Mark Robinson
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Akalanka Ranasinghe, Mohanja Ketheeswaran, Muhammad Rafiq, Megan Sharp, Danielle Davies, Fabio Falconieri, Samail Shahjahan, John Hogan, Andrew Klein, Martin Besser
Article
Medicine, General & Internal
Wan Yung Siu, William Thomas, Rikin Trivedi, Alexandra Hogan, Umbareen Siddiqi, Anita Sarker, Martin Wolfgang Besser
CLINICAL CASE REPORTS
(2020)
Article
Medicine, General & Internal
Matthew M. A. Waite, Anthony W. Martinelli, Stephen D. Preston, Emma Gudgin, Emily Symington, Robert C. Rintoul, Adam Peryt, Patrick Coughlin, Paul Hayes, David Gilligan, Martin Besser
CLINICAL CASE REPORTS
(2019)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
