Article
Radiology, Nuclear Medicine & Medical Imaging
Robert M. Kwee, Hugo J. A. Adams, Thomas C. Kwee
Summary: The frequency of PE in patients with COVID-19 is highest in the ICU, followed by general wards and the ED. PE in COVID-19 is more commonly located in peripheral than in central pulmonary arteries, which suggests local thrombosis to play a major role. D-dimer assessment may help to select patients with COVID-19 for CTPA, using D-dimer cutoff levels of at least 1000 mu g/L.
EUROPEAN RADIOLOGY
(2021)
Article
Immunology
Yingli Liu, Dan Si, Pingping Bai, Li Zhu, Lili Zhang, Qi Chen, Yong Qi
Summary: This study identified common genes shared by COVID-19 and PE, and identified CXCL10 as a potential cause of susceptibility to PE in COVID-19 patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Mohammed AlSheef, Abdul Rehman Z. Zaidi, Majid Abonab, Mona Obaid, Khalid Bawazir, Syed Ziauddin A. Zaidi, Ghaydaa J. Kullab, Sultan Alawfi, Mushira Enani
Summary: This report highlights the potential serious complications that COVID-19 can cause, emphasizing the importance of vigilance for this disease. The patient in the case study experienced massive pulmonary embolism and acute stroke, drawing attention from the medical community.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Simone Birocchi, Marco Manzoni, Gian Marco Podda, Giovanni Casazza, Marco Cattaneo
Summary: The meta-analysis results highlight a disproportion in the prevalence of PE among all VTE events in COVID-19 patients, likely reflecting pulmonary artery occlusion by pulmonary thrombi, rather than emboli from peripheral vein thrombi.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Critical Care Medicine
Michael A. Mazzeffi, Jonathan H. Chow, Kenichi Tanaka
Summary: Patients with severe COVID-19 often develop hypercoagulability, which can improve with anticoagulant therapy. Viscoelastic coagulation testing provides an opportunity to tailor anticoagulant therapy based on individual coagulation status.
Article
Acoustics
Anabel Franco-Moreno, Maria Herrera-Morueco, Beatriz Mestre-Gomez, Nuria Munoz-Rivas, Ane Abad-Motos, Danilo Salazar-Chiriboga, Mercedes Duffort-Falco, Pilar Medrano-Izquierdo, Ana Bustamante-Fermosel, Virginia Pardo-Guimera, Mariano Ulla-Anes, Juan Torres-Macho
Summary: Several reports have noted a high risk of pulmonary embolism in COVID-19 patients, particularly in the intensive care unit. This study found a low incidence of deep venous thrombosis in COVID-19 patients with PE, suggesting that the primary cause of PE in these patients may be a local thromboinflammatory response induced by the virus.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Critical Care Medicine
Hooman D. Poor
Summary: COVID-19 is associated with a significantly increased risk of pulmonary thrombosis, possibly driven by a hypercoagulable state and vascular injury. Some patients with COVID-19 may have hypoxemia that is disproportionate to impairment in lung compliance. Diagnosing PE in patients with COVID-19 can be challenging, leading many hospitals to implement aggressive anticoagulation protocols.
Article
Hematology
Jeeyune Bahk, Abdul Rehman, Kam Sing Ho, Bharat Narasimhan, Hafiza Noor Ul, Ain Baloch, Jiafang Zhang, Rowena Yip, Robert Lookstein, David J. Steiger
Summary: A retrospective case-control study found that 40.8% of COVID-19 patients had a pulmonary embolism (PE), and the presence of PE was associated with certain clinical characteristics and biomarkers. These findings can aid in the early identification and reduction of PE-related mortality in COVID-19 patients.
THROMBOSIS JOURNAL
(2023)
Article
Clinical Neurology
Wendy C. Ziai, Sung-Min Cho, Michelle C. Johansen, Bahattin Ergin, Mona N. Bahouth
Summary: In critically ill patients with COVID-19 infection, lower than expected cerebral blood flow velocities were observed despite low arterial oxygen content and hematocrit, not associated with suppression of cardiac output. Higher levels of C-reactive protein were positively correlated with blood flow velocities.
Article
Cardiac & Cardiovascular Systems
Angelo Porfidia, Carolina Mosoni, Rosa Talerico, Enrica Porceddu, Andrea Lupascu, Paolo Tondi, Francesco Landi, Roberto Pola
Summary: PE is a common complication in COVID-19 patients, but there is a lack of clear guidelines for diagnosing PE. While many COVID-19 patients may have indications for CTPA, only a small percentage actually undergo this examination, and there are no significant clinical differences between those who do and those who do not.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Hematology
Gregoire Longchamp, Sara Manzocchi-Besson, Alban Longchamp, Marc Righini, Helia Robert-Ebadi, Marc Blondon
Summary: The incidence of VTE in COVID-19 hospitalized patients is high, especially in ICU patients. Screening and absence of anticoagulation are associated with a higher VTE incidence.
THROMBOSIS JOURNAL
(2021)
Article
Immunology
Jon Salmanton-Garcia, Rosanne Sprute, Jannik Stemler, Michele Bartoletti, Damien Dupont, Maricela Valerio, Carolina Garcia-Vidal, Iker Falces-Romero, Marina Machado, Sofia de la Villa, Maria Schroeder, Irma Hoyo, Frank Hanses, Kennio Ferreira-Paim, Daniele Roberto Giacobbe, Jacques F. Meis, Jean-Pierre Gangneux, Azucena Rodriguez-Guardado, Spinello Antinori, Ertan Sal, Xhorxha Malaj, Danila Seidel, Oliver A. Cornely, Philipp Koehler
Summary: This study found that most patients with coronavirus disease-associated pulmonary aspergillosis (CAPA) are diagnosed shortly after admission, with the majority being treated in the ICU. Azole-resistant strains of Aspergillus fumigatus were common in patients, and voriconazole was the main treatment choice. The overall mortality rate was approximately 52.2%, with about one third of deaths attributed to CAPA.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Respiratory System
Ivana Blazic, Chiara Cogliati, Nicola Flor, Guy Frija, Michael Kawooya, Michele Umbrello, Sam Ali, Marie-Laure Baranne, Young-Jae Cho, Richard Pitcher, Ivan Vollmer, Emilie van Deventer, Maria del Rosario Perez
Summary: This review article discusses the role of lung ultrasound in COVID-19 patients for diagnosis and disease management. Lung ultrasound is a simple imaging procedure that helps identify COVID-19 patients early and informs treatment decisions. It can be performed in various clinical settings and has advantages such as non-ionising radiation and repeatability. However, the physical proximity between the patient and the operator is a limitation, and availability of trained staff is a major barrier. Training, advocacy, and awareness can help promote the use of lung ultrasound in COVID-19 management.
Article
Hematology
Lara N. Roberts, Annakan Navaratnam, Roopen Arya, Tim W. R. Briggs, William K. Gray
Summary: The aim of this study was to examine the incidence of venous thromboembolism (VTE) in patients hospitalized with COVID-19 in England. The study found that VTE was a common complication in hospitalized patients and was associated with longer hospital stays and higher mortality rates.
THROMBOSIS RESEARCH
(2022)
Review
Virology
Xiucui Han, Qing Ye
Summary: In addition to affecting the lungs, SARS-CoV-2 can also frequently damage the kidneys, mainly manifesting as kidney tubular injury and proteinuria. Diagnosis and treatment of kidney complications should be strengthened to reduce patient mortality.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)