Article
Biochemistry & Molecular Biology
Kuo-An Chu, Chang-Ching Yeh, Chun-Hsiang Hsu, Chien-Wei Hsu, Fu-Hsien Kuo, Pei-Jiun Tsai, Yu-Show Fu
Summary: This study compared the effectiveness of human umbilical cord Wharton's jelly-derived mesenchymal stem cells (HUMSCs) versus adipose tissue-derived mesenchymal stem cells (ADMSCs) for reversing pulmonary fibrosis in rats. The results showed that HUMSCs had better effects on lung function improvement and collagen degradation, as well as alveolar regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiaoyun Wu, Yongxu Mu, Jingyi Yao, Fuhong Lin, Daocheng Wu, Zhijie Ma
Summary: The study revealed that ADSCs from UC patients exhibited defective immunosuppression, indicating their unsuitability for autologous transplantation in treating UC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Akihito Tanaka, Kazuhiro Furuhashi, Kumiko Fujieda, Kayaho Maeda, Shoji Saito, Tetsushi Mimura, Yosuke Saka, Tomohiko Naruse, Takuji Ishimoto, Tomoki Kosugi, Fumie Kinoshita, Yachiyo Kuwatsuka, Shinobu Shimizu, Yasuhiro Nakai, Shoichi Maruyama
Summary: This study aims to evaluate the safety and efficacy of ADR-001 in adult patients with refractory IgA nephropathy.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Mingzhu Liang, Di Zhang, Danna Zheng, Wenfang He, Juan Jin
Summary: Chronic kidney disease (CKD) is characterized by a gradual loss of kidney function for more than 3 months. Preventing renal fibrosis is crucial for the treatment of CKD. This study found that miR-374a-5p, which is under-expressed in patients with CKD, may play an important role in CKD by exhibiting anti-apoptotic effects in renal tissues. The researchers demonstrated that exosomal miR-374a-5p inhibited the progression of renal fibrosis by regulating the MAPK6/MK5/YAP axis.
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Article
Biotechnology & Applied Microbiology
Zilong Zhang, Jin Shang, Qinyan Yang, Zonglin Dai, Yuxin Liang, Chunyou Lai, Tianhang Feng, Deyuan Zhong, Haibo Zou, Lelin Sun, Yuhao Su, Su Yan, Jie Chen, Yutong Yao, Ying Shi, Xiaolun Huang
Summary: This study suggests that exosomes derived from human adipose mesenchymal stem cells (hADMSCs-Exo) have significant therapeutic effects on liver fibrosis and cirrhosis. The researchers found that hADMSCs-Exo can inhibit the proliferation of activated hepatic stellate cells, effectively suppress the expression of profibrogenic proteins and epithelial-to-mesenchymal transition (EMT), and improve liver function and reduce liver inflammation. The key mechanism of hADMSCs-Exo in anti-hepatic fibrosis is the inhibition of the PI3K/AKT/mTOR signaling pathway and the regulation of choline metabolism.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Immunology
Ibrahim Kassis, Moriel Ben-Zwi, Panayiota Petrou, Michele Halimi, Dimitrios Karussis
Summary: The combination treatment of Fingolimod with mesenchymal stem cells showed synergistic clinical beneficial effects in the EAE model, indicating a potential synergism between Fingolimod and MSC in improving the benefits for progressive forms of MS.
IMMUNOLOGY LETTERS
(2021)
Review
Engineering, Biomedical
Nityanand Prakash, Jiseong Kim, Jieun Jeon, Siyeon Kim, Yoshie Arai, Alvin Bacero Bello, Hansoo Park, Soo-Hong Lee
Summary: The use of mesenchymal stem cells (MSCs) in clinical applications has significantly increased in the past decade due to their differentiation potential and immunomodulatory properties. However, the heterogeneity among MSC sources, as well as limitations in adult-sourced MSCs, have posed challenges for their effective use. Recent research has focused on generating MSCs from pluripotent stem cells (PSCs), such as induced pluripotent stem cells (iPSCs), to overcome these limitations.
BIOMATERIALS RESEARCH
(2023)
Article
Oncology
Zhenbo Tu, Antoine E. Karnoub
Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elia Bari, Fulvio Tartara, Fabio Cofano, Giuseppe di Perna, Diego Garbossa, Sara Perteghella, Marzio Sorlini, Delia Mandracchia, Lorella Giovannelli, Paolo Gaetani, Maria Luisa Torre, Lorena Segale
Summary: The study found that the mesenchymal stem cell-secretome Lyosecretome has a significant improvement effect on the osteoinductive and osteoconductive properties of titanium cages, leading to increased mineralized matrix when used during culturing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wee Kiat Ong, Smarajit Chakraborty, Shigeki Sugii
Summary: Human ASCs exhibit heterogeneity due to factors such as nomenclature, tissue depots, donor characteristics, species differences, study design, and tools used, with actual differences in resident cell types. Efforts to understand and standardize this heterogeneity are crucial for supporting therapeutic strategies and regulatory considerations in clinical use of ASCs.
Article
Materials Science, Biomaterials
Yangyang Dai, Liaobing Xin, Sentao Hu, Shiqian Xu, Dong Huang, Xiaoying Jin, Jianmin Chen, Rachel Wah Shan Chan, Ernest Hung Yu Ng, William Shu Biu Yeung, Lie Ma, Songying Zhang
Summary: By constructing a porous scaffold composed of ADMSCs, endometrial regeneration can be promoted, and fertility can be restored.
REGENERATIVE BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ariadna Pielok, Martyna Kepska, Zofia Steczkiewicz, Sylwia Grobosz, Lynda Bourebaba, Krzysztof Marycz
Summary: This study compared the expression differences between adipose-derived stem cells (ASCs) and equine hoof progenitor cells (HPCs) under standard culture conditions and in an inflammatory environment. The results showed that HPCs exhibited different cell cycle distribution, mitochondrial dynamics, and oxidative stress levels compared to ASCs, but there were no significant differences in the expression of apoptotic and immunomodulatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Elisabetta Xue, Antonina Minniti, Tobias Alexander, Nicoletta Del Papa, Raffaella Greco
Summary: Systemic sclerosis is a disease characterized by autoimmune responses, vasculopathy, and tissue fibrosis. Currently available drugs have limited effects, so cellular therapies have become an important area of research.
Article
Genetics & Heredity
Cecile Luxembourger, Adeline Ruyssen-Witrand, Chayma Ladhari, Cecile Rittore, Yannick Degboe, Jean-Francis Maillefert, Philippe Gaudin, Hubert Marotte, Daniel Wendling, Christian Jorgensen, Alain Cantagrel, Arnaud Constantin, Delphine Nigon, Isabelle Touitou, Jacques-Eric Gottenberg, Yves-Marie Pers
PHARMACOGENOMICS JOURNAL
(2019)
Review
Pharmacology & Pharmacy
Yassin Tachikart, Olivier Malaise, Marcus Mumme, Christian Jorgensen, Jean-Marc Brondello
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Laurine Valot, Marie Maumus, Titouan Montheil, Jean Martinez, Daniele Noel, Ahmad Mehdi, Gilles Subra
Article
Cell Biology
Olivier Malaise, Yassin Tachikart, Michael Constantinides, Marcus Mumme, Rosanna Ferreira-Lopez, Sandra Noack, Christian Krettek, Daniele Noel, Jing Wang, Christian Jorgensen, Jean-Marc Brondello
Article
Engineering, Biomedical
Maxime Ruiz, Karine Toupet, Marie Maumus, Pauline Rozier, Christian Jorgensen, Daniele Noel
Article
Chemistry, Applied
Rui Yu, Yan Zhang, Mihail Barboiu, Marie Maumus, Daniele Noel, Christian Jorgensen, Suming Li
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Pauline Rozier, Marie Maumus, Claire Bony, Alexandre Thibault Jacques Maria, Florence Sabatier, Christian Jorgensen, Philippe Guilpain, Daniele Noel
Summary: This study demonstrates that T beta-Fb is a relevant model for mimicking the main characteristics of SSc fibroblasts and investigating the mechanism of action of ASCs. Furthermore, ASC-derived EVs were shown to be more effective than parental cells, suggesting that the TGF beta 1-induced pro-fibrotic environment may alter the function of ASCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marie Maumus, Guillaume Fonteneau, Maxime Ruiz, Said Assou, Hassan Boukhaddaoui, Philippe Pastoureau, Frederic De Ceuninck, Christian Jorgensen, Daniele Noel
Summary: NMB is a newly identified chondroinductive bioactive factor that upregulates the key chondrogenic transcription factor Sox9 through modulation of the Ca2+ signaling pathway and calcineurin activity. NMB plays a significant role in chondrogenesis.
CELL AND BIOSCIENCE
(2021)
Review
Cell Biology
Amel Nasri, Florent Foisset, Engi Ahmed, Zakaria Lahmar, Isabelle Vachier, Christian Jorgensen, Said Assou, Arnaud Bourdin, John De Vos
Summary: Mesenchymal cells play crucial roles in lung development, regeneration, and diseases, especially in chronic obstructive pulmonary disease.
Article
Medicine, General & Internal
Radjiv Goulabchand, Audrey Gabelle, Xavier Ayrignac, Nicolas Malafaye, Pierre Labauge, Daniele Noel, Jacques Morel, Camille Roubille, Lucie Barateau, Philippe Guilpain, Thibault Mura
Summary: A nationwide retrospective study in France using the health insurance database showed that patients with primary Sjogren's syndrome (pSS) have a higher risk of hospitalization for neurological diseases, including dementia, multiple sclerosis (MS), encephalitis, and peripheral neuropathy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yujie Song, Christian Jorgensen
Summary: This review highlights the potential of mesenchymal stromal cells (MSCs) in treating osteoarthritis (OA), focusing on their chondrogenic and immunomodulatory potential. The review provides an overview of the effects of MSCs in preclinical and clinical studies of OA treatment, comparing different MSC sources. Furthermore, the review summarizes the current evidence for the assessment of cartilage in OA using magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy.
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Article
Cell & Tissue Engineering
Noemie Petitjean, Patrick Canadas, Christian Jorgensen, Pascale Royer, Simon Le Floc'h, Daniele Noel
Summary: This study aimed to investigate the impact of mechanical stimulation on chondrocytes derived from mesenchymal stromal cells in their own extracellular matrix.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Polymer Science
Laurine Valot, Marie Maumus, Luc Brunel, Jean Martinez, Muriel Amblard, Daniele Noel, Ahmad Mehdi, Gilles Subra
Summary: Researchers have developed a biomimetic chemical hydrogel based on silylated collagen-mimetic synthetic peptides, which successfully encapsulated MSCs and improved mechanical properties, resulting in prolonged survival of the embedded cells and enhanced expression of chondrocyte markers. This long-standing hybrid hydrogel shows promise as a synthetic and modular scaffold for cartilage tissue engineering.