Article
Chemistry, Physical
Mei Zhu, Moxia Li, Mengke Su, Jianfang Liu, Bingwu Liu, Yongjie Ge, Honglin Liu, Jiawen Hu
Summary: The instability of hot spots is a key limiting factor for the poor spectral reproducibility of SERS. Hot spots exhibit stability thresholds to excitation power, duration, and wavelength. Lowering the excitation power below the threshold or deliberately removing unstable hot spots can significantly improve the stability and reproducibility of SERS signals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Correction
Chemistry, Physical
Xuan-Hung Pham, Eunil Hahm, Tae Han Kim, Hyung-Mo Kim, Sang Hun Lee, SangChul Lee, Homan Kang, Ho-Young Lee, Dae Hong Jeong, Hak Soo Choi, Bong-Hyun Jun
Summary: The author name and corresponding affiliation in the original version of this article were mistakenly labeled.
Article
Green & Sustainable Science & Technology
Meng He, Zhihao Li, Yujie Guo, Maofeng Zhang, Zhengdong Zhu, Xiaoyi Shi, Konghao Han, Youju Huang, Honglin Liu
Summary: Researchers demonstrated a method of shrinking three-dimensional (3D) hot spot droplets on a hydrophobic substrate for the quantitative and multiplex detection of pesticide residues using portable Raman spectrometer. The shrunk droplets, consisting of analyte solution and AgNPs sol, simultaneously increased the density of plasmonic hot spots and immobilized target molecules. The proposed strategy exhibited excellent SERS sensitivity for the analysis of pesticides down to 10(-8) m and achieved quantitative analysis and multi-component detection of pesticide residues on honeysuckle surface.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Yazan Bdour, Graham Beaton, Juan Gomez-Cruz, Oscar Cabezuelo, Kevin Stamplecoskie, Carlos Escobedo
Summary: A surface-enhanced Raman scattering (SERS) active metasurface composed of metallic nanohole arrays and metallic nanoparticles has been developed. The metasurface can operate in aqueous environments, achieving an enhancement factor of 1.83 x 10(9) for Rhodamine 6G, and enabling the detection of malachite green at a concentration of 0.46 ppb.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Han-Kyu Choi, Sang-Min Park, Jeeyoon Jeong, Hankyul Lee, Gyu Jin Yeon, Dai-Sik Kim, Zee Hwan Kim
Summary: In this study, a simple photolithographic method was demonstrated to generate highly sensitive SERS hot spot structures at desired positions. The solid-state dewetting of an Ag thin film using a continuous-wave laser resulted in the formation of closely packed assemblies of hemispherical Ag nanoislands with substantial plasmonic-field enhancement. These hot spot structures can be utilized as position-specific chemical-sensing elements in integrated analytical devices.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Fan-Ching Chien, Ting Fu Zhang, Chi Chen, Thi Anh Nguyet Nguyen, Song-Yu Wang, Syuan Miao Lai, Chia-Hua Lin, Chun-Kai Huang, Cheng-Yi Liu, Kun-Yu Lai
Summary: This study addresses the reliability issue of SERS detection by greatly expanding the effective area of hot spot with conformally nano-structured InGaN. By introducing wafer-scale charge coupling at the molecule/metal/semiconductor interface, the SERS-active surface spreading has been increased, allowing for better capture of trace molecules and stabilized signals.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Analytical
Lourdes Martinez Rojas, Yanqui Qu, Lili He
Summary: This study describes the capability of a solvent-mediated liquid-liquid extraction method to improve the detection of OTA in food matrices using surface-enhanced Raman spectroscopy. A simple extraction method based on sample acidification and addition of chloroform not only extracts OTA from wine and wheat, but also facilitates the uniform distribution of nanoparticles, leading to an enhancement of detection signals and reproducibility.
Article
Engineering, Environmental
Mengxiang Song, Deming Huang, Nan Huo, Essy Kouadio Fodjo, Wei Deng, Dan Li
Summary: This study developed a stimulus-responsive three-dimensional microgel decorated with nanoparticles, which allows precise control of hot spots region by regulating temperature and moisture. It can simultaneously regulate structures and capture target molecules, as well as self-clean, achieving recyclable and reliable SERS analysis of solid samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Awatef Ouhibi, Amal Raouafi, Nathalie Lorrain, Mohammed Guendouz, Noureddine Raouafi, Adel Moadhen
Summary: A novel SERS-powered aptasensing substrate was developed for ultra-sensitive and selective detection of PSA, utilizing vertically aligned silicon nanowires decorated with silver nanoparticles. This platform shows high sensitivity, selectivity, and stability, with a detection limit of 0.1 μg.L-1, making it suitable for detecting PSA in blood serum samples of healthy subjects and ill patients.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Applied
Luqing Li, Qingqing Cui, Menghui Li, Tiehan Li, Shuci Cao, Shuai Dong, Yujie Wang, Qianying Dai, Jingming Ning
Summary: This study synthesized stable and sensitive hemp spherical AgNPs as the SERS substrate for the simultaneous and rapid detection of adulteration in black tea. The AgNPs showed satisfactory stability over 60 days with an enhancement factor of 108. Among the different screening methods, CARS-PLS exhibited superior performance for the quantification of the colorants with high accuracy and precision.
Article
Chemistry, Physical
Juanjuan Liu, Roozbeh Siavash Moakhar, Sara Mahshid, Fartash Vasefi, Sebastian Wachsmann-Hogiu
Summary: A novel metallic substrate was developed for dual functional sensing via ElectroChemistry (EC) and Surface Enhanced Raman Spectroscopy (SERS), successfully demonstrating detection of chlorfenapyr with a certain level of sensitivity. This platform could pave the way for cost-effective and portable detection of other analytes while meeting residue tolerance limits according to US regulations.
APPLIED SURFACE SCIENCE
(2021)
Article
Spectroscopy
Duong Thanh Nguyen, Linh Phuong Nguyen, Phuong Duc Luu, Thai Quoc Vu, Hoa Quynh Nguyen, Tan Phat Dao, Tri Nhut Pham, Toan Quoc Tran
Summary: Potato, one of the most important food crops globally, faces the challenge of being protected from harmful insects and illnesses using pesticides, such as difenoconazole, which have severe effects on human health and the environment. This study developed a method using silver nanoparticles decorated cicada wing substrates for surface-enhanced Raman scattering measurements to detect trace amounts of difenoconazole in potatoes. The results showed that the proposed method had a high detection sensitivity and could detect difenoconazole at levels lower than the specified limits in the EU and Vietnam.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Jieshuang Zheng, Jinghui Yan, Xiaohua Qi, Xiaohua Zhang, Yunhui Li, Mingqiang Zou
Summary: The research shows that AgNPs/ MIL-101 (Fe) nanocomposites as SERS substrates exhibit strong enhancement effects and can stably detect molecules in different concentrations and environments. In addition, the time stability of the material is influenced by the placement time of AgNPs.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biophysics
Jiwei Wang, Jingjing Fu, Han Chen, Ali Wang, Yuting Ma, Hanrong Yan, Yuting Li, Dehong Yu, Fenglei Gao, Shibao Li
Summary: In this study, a surface-enhanced Raman scattering (SERS)-fluorescence (FL) dual-spectral sensor was developed based on the nanoscale photophysical properties of AuNPs. This sensor enables rapid imaging and accurate quantification of intracellular miRNAs, showing high sensitivity, specificity, and reproducible stability. It has the potential to be a reliable tool for monitoring biomolecular dynamics in living cells.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Spectroscopy
Shaoyun Chen, Qi Li, Du Tian, Pai Ke, Xinxin Yang, Qingyun Wu, Jian Chen, Chenglong Hu, Hongbing Ji
Summary: The evaporation-induced aggregation was used to assemble long silver nanowires into a highly aligned structure to achieve uniform hot spots for SERS detection. The glass slide with well-aligned silver nanowires acted as a high sensitivity and excellent reproducibility SERS substrate for detecting analytes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).