Article
Environmental Sciences
Joao Marcos de Lima-Faria, Victoria Costa da Silva, Lee Chen Chen, Diego Sefani Teodoro Martinez, Simone Maria Teixeira de Saboia-Morais
Summary: The cellular and tissue behavior of fishes in response to Iron oxide nanoparticles (IONPs) and their associations with agrochemicals were evaluated. The results showed that the accumulation of iron was greater in the IONP treatment group and the mixtures with GBHs. Tissue integrity assessments demonstrated an intense accumulation of lipids, formation of necrotic zones and leukocyte infiltrates in all the treated groups, with a greater quantity of lipids in the IONP + GLY and IFe groups. The damage caused to animal livers by IONP mixtures is reversible, providing promising results for safe environmental remediation practices using nanoparticles.
Review
Immunology
Gabriela H. Da Silva, Lidiane S. Franqui, Romana Petry, Marcella T. Maia, Leandro C. Fonseca, Adalberto Fazzio, Oswaldo L. Alves, Diego Stefani T. Martinez
Summary: 2D materials, with their unique physicochemical properties, are being increasingly utilized in various fields such as energy, health, and environment, particularly in nano-imaging applications. As interest in 2D materials continues to grow, the assessment of their impact on the immune system becomes increasingly crucial.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Leandro S. Bortolozzo, Francine Coa, Latif U. Khan, Aline M. Z. Medeiros, Gabriela H. Da Silva, Fabricio S. Delite, Mathias Strauss, Diego Stefani T. Martinez
Summary: This study evaluated the chemical degradation of graphene oxide by sodium hypochlorite and its effects on the toxicity of nematodes. The degraded product, NaClO-GO, showed lower toxicity at all endpoints compared to GO, with improved colloidal stability in the environment. Enhanced dark-field hyperspectral microscopy also confirmed oral uptake of both materials by the nematodes.
Article
Chemistry, Physical
Fengkai Ruan, Jie Zeng, Hanying Yin, Shengwei Jiang, Xisen Cao, Naying Zheng, Changshun Han, Chuchu Zhang, Zhenghong Zuo, Chengyong He
Summary: This study suggests that BPQDs alter various biological processes, potentially leading to ferroptosis. The results indicate that BPQDs cause lipid peroxidation, mitochondrial dysfunction, and iron overload. Recognition of modified mRNAs by YTHDF2 ultimately results in ferroptosis.
Review
Chemistry, Multidisciplinary
Jie Liu, Yuan-Yuan Liu, Chen-Si Li, Aoneng Cao, Haifang Wang
Summary: Both understanding the interaction between nanomaterials and cells and assessing their safety require a comprehensive understanding of how nanomaterials enter, transport within, and exit cells. While the uptake and trafficking of nanoparticles (NPs) have been extensively studied, the exocytosis of NPs has received less attention. However, exocytosis is a vital process for regulating NP content in cells and determining their toxicity. A thorough understanding of exocytosis mechanisms and influencing factors is crucial for NP safety assessment and the design of effective NP-based materials.
Review
Chemistry, Multidisciplinary
Junguang Wu, Xuejing Cui, Pu Chun Ke, Monika Mortimer, Xiaoyu Wang, Lin Bao, Chunying Chen
Summary: Parkinson's disease is a complex multi-factorial disease with no cure, only mitigative therapies available at present. The development of nanomedicine has provided new opportunities for finding neuroprotective and neurorestorative therapies for PD. By exploring various mechanisms underlying PD pathology and discussing nanomaterial-based treatment strategies, there is potential for targeted therapies to be developed in the future.
Article
Environmental Sciences
Pieter van Broekhuizen, Arto Saeaemaenen, Daan Schuurbiers, Panagiotis Isigonis, Keld A. Jensen, Dana Kuehnel, Kees Le Blansch
Summary: A research team has jointly developed a nano risk governance framework that is applicable to the development and use of nanomaterials, providing feasible guidance for stakeholders. The usefulness of this framework was tested through a case study on rubber tyres.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Review
Engineering, Environmental
Fan Zhang, Zhuang Wang, Willie J. G. M. Peijnenburg, Martina G. Vijver
Summary: This review examines the toxicity of mixtures of engineered nano particles (ENPs) to different species. The majority of joint effects were found to be antagonistic, with a smaller percentage being synergistic or additive effects. Plants were more likely to experience antagonistic effects when exposed to mixtures of ENPs. Factors influencing the joint response include the chemical composition of the mixtures, stability of the suspensions, type and trophic level of organisms tested, exposure concentrations and time, toxicity endpoints, and abiotic field conditions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Diego Stefani T. Martinez, Laura-Jayne A. Ellis, Gabriela H. Da Silva, Romana Petry, Aline M. Z. Medeiros, Hossein Hayat Davoudi, Anastasios G. Papadiamantis, Adalberto Fazzio, Antreas Afantitis, Georgia Melagraki, Iseult Lynch
Summary: This paper discusses the toxicological effects of nanomaterials and contaminant mixtures on aquatic ecosystems and the complexity of mixture risk assessment. Daphnia magna plays an important role as a model organism in mixture studies.
Article
Environmental Sciences
Dimitra-Danai Varsou, Laura-Jayne A. Ellis, Antreas Afantitis, Georgia Melagraki, Iseult Lynch
Summary: The study presents eco-toxicological read-across models for predicting the toxicity of differently aged nanomaterials on Daphnia magna, with the finding that presence of natural organic matter in the medium reduces the toxicity. Nanomaterials were grouped into freshly dispersed and 2-year-aged categories, with in silico analysis identifying key features driving toxicity in each group. The predictive models have been validated and are recommended for regulatory purposes.
Article
Nanoscience & Nanotechnology
Melanie Kah, Linda J. Johnston, Rai S. Kookana, Wendy Bruce, Andrea Haase, Vera Ritz, Jordan Dinglasan, Shareen Doak, Hemda Garelick, Vladimir Gubala
Summary: Nanopesticides are advancing in research and development and appearing on the market, prompting the need for a comprehensive framework and guidance for human health risk assessments. The study suggests adapting existing pesticide frameworks, identifying relevant nanopesticide entities and their concentrations, and addressing additional data requirements based on the nature of the nanopesticides. The tiered approach proposed in the framework aims to support regulators and industry in making informed decisions on nanopesticide submissions.
NATURE NANOTECHNOLOGY
(2021)
Article
Medicine, Legal
Eric A. J. Bleeker, Elmer Swart, Hedwig Braakhuis, Maria Luisa Fernandez Cruz, Steffi Friedrichs, Ilse Gosens, Frank Herzberg, Keld Alstrup Jensen, Frank von der Kammer, Jolinde A. B. Kettelarij, Jose Maria Navas, Kirsten Rasmussen, Kathrin Schwirn, Maaike Visser
Summary: This paper provides an overview of the development and adaptation of EU chemicals legislation, guidance, and test guidelines for nanomaterials to promote their safe use. Eleven action needs were identified by a group of experts, covering twenty-two specific information requirements relevant to multiple regulatory areas. These needs focused on resolving issues related to dispersion stability and dosing in toxicity testing, degradation and transformation of organic nanomaterials, and cellular reactivity of nanomaterials. Addressing these issues will lead to better test methods for regulatory compliance and ensure the validity of hazard and risk assessments of nanomaterials. The study emphasizes the importance of a structured process for identifying information needs and generating knowledge, preferably as part of risk governance and connected to technological innovation policy.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Hania Rehman, Muhammad Ramzan, Muhammad Zia Ul Haq, Jinsoo Hwang, Kyoung-Bae Kim
Summary: This study addresses the lack of literature on the impact of risk management on the relationship between corporate governance and a firm's financial performance, particularly in emerging markets. It found that risk management partially mediates the relationship between board size and financial performance, as well as between foreign ownership and financial performance.
Article
Chemistry, Multidisciplinary
Shareen H. Doak, Martin J. D. Clift, Anna Costa, Christiaan Delmaar, Ilse Gosens, Sabina Halappanavar, Sean Kelly, Willie J. G. M. Pejinenburg, Barbara Rothen-Rutishauser, Roel P. F. Schins, Vicki Stone, Lang Tran, Martina G. Vijver, Ulla Vogel, Wendel Wohlleben, Flemming R. Cassee
Summary: The European Green Deal aims to build a more sustainable, climate neutral, and circular economy by 2050. To achieve this, the European Commission has released the Chemicals Strategy for Sustainability, which sets targets for innovation in addressing challenges posed by hazardous chemicals and animal testing. The PATROLS project has developed innovative tools to support the safe and sustainable development of new nano-enabled products.
Article
Chemistry, Multidisciplinary
Elina Buitrago, Anna Maria Novello, Alke Fink, Michael Riediker, Barbara Rothen-Rutishauser, Thierry Meyer
Summary: Research in nanoscience is constantly introducing new nanomaterials and processes, but the current risk assessment of nanomaterial processes is slow and challenging due to lack of safety data sheets, exposure estimations, and difficulties in measurement. Using banding-based risk assessment tools in laboratory environments is an efficient way to evaluate occupational risks associated with nanomaterials. This three-step control banding approach provides a method for determining hazard bands, evaluating work exposure, and updating protective measures for working with nanomaterials in research environments.
Article
Chemistry, Multidisciplinary
Yu Qi, Yucai Chen, Tian Xia, Iseult Lynch, Sijin Liu
Summary: Ambient fine particles, as a major air pollutant, have generated significant concerns regarding public health. Recent studies have made progress in understanding their biological effects and mechanisms. However, challenges remain in investigating exposure pathways, translocation in the human body, and the correlation between environmental exposure concentration and internal fate of particles. Furthermore, more research is needed on particle biotransformation and differentiation from biological macromolecules. This review highlights the current knowledge gaps and proposes future research directions to support fundamental studies and policy making.
Letter
Toxicology
P. Marx-Stoelting, G. Riviere, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Canas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. Norager, A. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle, P. Sanders
Summary: Current approaches for chemical risk assessment are facing challenges due to the increasing number and changing types of chemicals. Next-generation risk assessment is seen as the way forward, but incorporating new scientific insights and innovative approaches is challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) aims to address these challenges and consolidate Europe's research and innovation capacity in chemical risk assessment.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Hicham Meskher, Hussain Chaudhery Mustansar, Amrit Kumar Thakur, Ravishankar Sathyamurthy, Iseult Lynch, Punit Singh, Tan Kim Han, Rahman Saidur
Summary: Biosensors, especially those enhanced with nanomaterials such as CNTs, have shown promising application in the fast diagnosis of COVID-19. CNT-based field-effect transistors possess ultra-sensitivity and low-noise detection capacity, allowing for immediate analyte determination even at early infection stages.
NANOSCALE ADVANCES
(2023)
Article
Nanoscience & Nanotechnology
Cristian Salvador, Patrizia Andreozzi, Gabriela Romero, Iraida Loinaz, Damien Dupin, Sergio E. Moya
Summary: Small interference RNA (siRNA) is a gene modulation tool that can silence genes associated with genetic disorders. However, the instability of siRNA in the blood and its difficulty in reaching the cytosol limit its therapeutic potential. Polyamine-based nanoparticles, particularly polyallylamine hydrochloride (PAH), show promise in gene delivery. In this study, PAH was chemically modified with oleic acid to improve cell viability and siRNA transfection efficiency. The PAH-oleic acid substitutes were effective in silencing the CD47 protein, making them a potential candidate for immunotherapy.
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemical Research Methods
Oihane Mitxelena-Iribarren, Xabier Bujanda, Laura Zabalza, Janire Alkorta, Aitziber Lopez-Elorza, Raquel Gracia, Damien Dupin, Sergio Arana, Jesus Ruiz-Cabello, Maite Mujika
Summary: This article describes the manufacturing and functionalization of a microfluidic device to simulate blood vessels for testing new treatments for pulmonary arterial hypertension. The device is made using a wire with a circular section to determine the channel dimensions, and cells are seeded using rotary cell culture for homogeneous cell seeding on the inner wall. This method provides a simple and reproducible way to generate in vitro blood vessel models.
BIOTECHNOLOGY JOURNAL
(2023)
Review
Environmental Sciences
Aala Azari, Jeroen A. J. Vanoirbeek, Frank Van Belleghem, Brent Vleeschouwers, Peter H. M. Hoet, Manosij Ghosh
Summary: The pervasive pollution of microplastics and nano plastics (M/NPs) in indoor and outdoor atmospheres poses difficulties for comparing their prevalence due to various methodologies and non-standardization. This review extracts data from PubMed and Embase databases to analyze sampling strategies, identification methods, and reporting data for quantifying M/NPs. It primarily focuses on different methods for collecting atmospheric M/NPs and the analytical tools used for identification. The review identifies challenges and recommends further method development to support standardized and comparable future research.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Arbab Ali, Rabia Javed, Sahar Farhangi, Tufail Shah, Sana Ullah, Noor ul Ain, Tao Liu, Iseult Lynch, Faisal Raza, Peng Zhang, YuKui Rui
Summary: The tumor microenvironment is a complex system in which conventional drug delivery strategies have limitations. The development of nano-based drug delivery has provided solutions by offering controlled release in this environment. This review focuses on the use of metal phenolic networks as pH-sensitive drug carriers in the tumor microenvironment, providing insights and exploring potential applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Miren Aguirre, Nicholas Ballard, Edurne Gonzalez, Shaghayegh Hamzehlou, Haritz Sardon, Marcelo Calderon, Maria Paulis, Radmila Tomovska, Damien Dupin, Ren H. Bean, Timothy E. Long, Jose R. Leiza, Jose M. Asua
Summary: The water-based emulsion polymerization process has led to the continuous growth in commercial use of polymer colloids due to its high efficiency and versatility in production. This perspective highlights the challenges in synthesis and application of polymer colloids, including the transition towards sustainable feedstocks and reduced environmental impact in their primary applications, as well as the design and application of novel polymer colloids in emerging areas. Unconventional processing techniques utilizing the unique colloidal nature are also presented.
Article
Nanoscience & Nanotechnology
G. del Giudice, A. Serra, L. A. Saarimaeki, K. Kotsis, I. Rouse, S. A. Colibaba, K. Jagiello, A. Mikolajczyk, M. Fratello, A. G. Papadiamantis, N. Sanabria, M. E. Annala, J. Morikka, P. A. S. Kinaret, E. Voyiatzis, G. Melagraki, A. Afantitis, K. Taemm, T. Puzyn, M. Gulumian, V. Lobaskin, I. Lynch, A. Federico, D. Greco
Summary: By performing a meta-analysis of various engineered nanoparticle exposure studies, the authors identify common patterns of gene regulation that impact the transcriptomic response. Deregulation of immune functions is observed as a prominent response, with binding sites for zinc finger transcription factors C2H2 identified in the promoter regions of these genes. These findings suggest that the innate immune system has a conserved response to nanomaterials, potentially influenced by evolutionary exposure to natural nano-sized matter.
NATURE NANOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Mingshu Li, Li Gao, Jason C. White, Christy L. Haynes, Tana L. O'Keefe, Yukui Rui, Sami Ullah, Zhiling Guo, Iseult Lynch, Peng Zhang
Summary: Increasing the capacity of biological nitrogen fixation (BNF) is an effective strategy to enhance food security and reduce the carbon and nitrogen footprint of agriculture. Nanotechnology offers several pathways to successfully enhance BNF.
NATURE NANOTECHNOLOGY
(2023)
Article
Environmental Sciences
Manosij Ghosh, Katrijn Broothaerts, Steven Ronsmans, Ingrid Barcena Roig, Jef Scheepers, Mustafa Dikmen, Emily Rose Ciscato, Carolina Blanch, Michelle Plusquin, Unni C. Nygaard, Camilla Sandal Sejbaek, Karin S. Hougaard, Peter HM. Hoet
Summary: The article titled "Translation: Data Management Challenges and Solutions in the EXIMIOUS Project" discusses the difficulties faced by researchers in collecting and analyzing large volumes of data within collaborative projects. However, with the guidance and support from partner institutes, the researchers have been able to overcome these challenges and establish a data management framework that ensures data integrity, accessibility, and compliance with ethical and legal regulations.
ENVIRONMENTAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Alicja Mikolajczyk, Uladzislau Zhdan, Sylvain Antoniotti, Adam Smolinski, Karolina Jagiello, Piotr Skurski, Moussab Harb, Tomasz Puzyn, Jaroslaw Polanski
Summary: Retrosynthesis is a valuable tool for simplifying the synthesis planning of organic molecules, and computer-assisted methods have enhanced its effectiveness. With the integration of computer technologies, retrosynthesis can now include database mining, reaction prediction, machine learning, and other data science tools, enabling the consideration of inorganic compounds and nanoparticles. The development of greener and more sustainable chemistry is also supported by retrosynthesis, as it allows for the selection of environmentally friendly processes and reactants. Additionally, recent advancements in computer technologies provide a chance to accurately control green and sustainable metrics at an early stage, leading to the emergence of predictive green and sustainable methods.
Article
Nanoscience & Nanotechnology
Cristian Salvador, Patrizia Andreozzi, Gabriela Romero, Iraida Loinaz, Damien Dupin, Sergio E. Moya
Summary: Small interference RNA (siRNA) is a gene modulation tool that can silence genes related to genetic disorders. Polyamine-based nanoparticles, particularly polyallylamine hydrochloride (PAH) covalently functionalized with oleic acid, show promise in gene delivery and siRNA transfection. The substitution of PAH with oleic acid improves cell viability and siRNA transfection efficiency, particularly in silencing the CD47 protein for potential use in immunotherapy.
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Anita Sosnowska, Natalia Bulawska, Dominika Kowalska, Tomasz Puzyn
Summary: This study assesses 38 in silico models developed for PFAS, including 22 physicochemical models and 8 toxic and ecotoxic models. Through evaluation based on QMRF, 22 models were identified as scientifically valid and usable for predicting new compounds. The study helps identify remaining gaps and needs in predictive models for PFAS.
Article
Multidisciplinary Sciences
Nirosha Ganesan, Steven Ronsmans, Peter Hoet
Summary: The detection of antigen specific lymphocyte responses plays a vital role in diagnosing various diseases. This study evaluated the suitability of the Be-specific LPT and CFSE assay in detecting beryllium sensitivity in sarcoidosis patients with suspected beryllium exposure. The results showed that both LPT and CFSE assay are suitable for detecting beryllium sensitivity in sarcoidosis patients, but CFSE assay has an advantage in identifying the relevant proliferating lymphocyte populations.